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Jun Li,1,* Di He,1,* Jiazhou Yu,2,* Shuohua Chen,3 Qiong Wu,1 Zongxue Cheng,1 Qiaohui Wei,1 Yuying Xu,1 Yimin Zhu,1,4 Shouling Wu3 1Department of Epidemiology & Biostatistics and Department of Respiratory Diseases of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China; 3Department of Cardiology, Kailuan General Hospital, Tangshan, People’s Republic of China; 4Cancer Center, Zhejiang University, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shouling Wu, Department of Cardiology, Kailuan General Hospital, 57 Xinhua East Road, Tangshan, People’s Republic of China, Email drwusl@163.com Yimin Zhu, Department of Respiratory Diseases, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, People’s Republic of China, Email zhuym@zju.edu.cnBackground: Two novel systemic inflammation indices, SII and SIRI, are associated with increased risk of cardiovascular diseases (CVD). However, SII and SIRI are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. This study aims to examine the association between the dynamic status of SII and SIRI and risk of CVD.Methods: This prospective study included a total of 45,809 subjects without MI, stroke and cancer prior to or in 2010 (baseline of this study). The dynamic status of SII and SIRI during 2006, 2008, and 2010 was assessed by dynamic trajectories (primary exposure), annual increase, and average value. The outcome was CVD incidence during 8.6 years’ follow-up. Multiple Cox regression models were used to calculate the adjusted hazard ratios (HRs) and confidence intervals (95% CIs).Results: Four dynami

Ziqi Jin,1,* Qiong Wu,1,* Shuohua Chen,2,* Jingli Gao,3 Xiaolan Li,3 Xuhui Zhang,4 Yaohan Zhou,1 Di He,1 Zongxue Cheng,1 Yimin Zhu,1,5,6 Shouling Wu7 1Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, People’s Republic of China; 2Health Care Center, Kailuan Group, Tangshan 063000, People’s Republic of China; 3Department of Intensive Medicine, Kailuan General Hospital, Tangshan 063000, People’s Republic of China; 4Hangzhou Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, People’s Republic of China; 5Department of Respiratory Diseases, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310060, People’s Republic of China; 6Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, People’s Republic of China; 7Department of Cardiology, Kailuan General Hospital, Tangshan, 063000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shouling WuDepartment of Cardiology, Kailuan General Hospital, 57 Xinhua East Road, Tangshan, People’s Republic of ChinaEmail drwusl@163.comYimin ZhuDepartment of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, 388 Yu-Hang-Tang Road, Hangzhou, 310058 Zhejiang, People’s Republic of ChinaTel + 0086-571-88208194Email zhuym@zju.edu.cnBackground: SII and SIRI are two novel systemic inflammation indexes that were suggested in predicting poor outcomes in cancers. However, no studies have examined their effect on cardiovascular diseases (CVDs) and all-cause mortality. Thus, this study aims to investigate associations between SII, SIRI, and the risks for CVDs and all-cause mortality.Methods: A total of 85,154 participants from the Kailuan cohort were included and followed up for incidents of CVDs (including MI, stroke