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3. Preparation of Temperature-Sensitive Hollow Fiber Membrane and Its Detection as a Cell Carrier

Author

Wang, Hao, Sun, Yiyi, Wang, Jingwen, Yuan, Yuhuang, Cheng, Yuen Yee, Li, Xiangqin, Song, Kedong, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Li, Shaofan, editor

Published
2024
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12. Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma.

Author

Zhand, Sareh, Liao, Jiayan, Castorina, Alessandro, Yuen, Man-Lee, Ebrahimi Warkiani, Majid, and Cheng, Yuen-Yee

Subjects
CIRCULAR RNA, MESOTHELIOMA, BIOMARKERS, GENE expression, DIAGNOSIS, EXTRACELLULAR vesicles
Abstract

Pleural mesothelioma (PM) is a highly aggressive tumor that is caused by asbestos exposure and lacks effective therapeutic regimens. Current procedures for PM diagnosis are invasive and can take a long time to reach a definitive result. Small extracellular vesicles (sEVs) have been identified as important communicators between tumor cells and their microenvironment via their cargo including circular RNAs (circRNAs). CircRNAs are thermodynamically stable, highly conserved, and have been found to be dysregulated in cancer. This study aimed to identify potential biomarkers for PM diagnosis by investigating the expression of specific circRNA gene pattern (hsa_circ_0007386) in cells and sEVs using digital polymerase chain reaction (dPCR). For this reason, 5 PM, 14 non-PM, and one normal mesothelial cell line were cultured. The sEV was isolated from the cells using the gold standard ultracentrifuge method. The RNA was extracted from both cells and sEVs, cDNA was synthesized, and dPCR was run. Results showed that hsa_circ_0007386 was significantly overexpressed in PM cell lines and sEVs compared to non-PM and normal mesothelial cell lines (p < 0.0001). The upregulation of hsa_circ_0007386 in PM highlights its potential as a diagnostic biomarker. This study underscores the importance and potential of circRNAs and sEVs as cancer diagnostic tools. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Leptospermum extract (QV0) suppresses pleural mesothelioma tumor growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

Author

Shi, Huaikai, primary, Zhang, Le, additional, Yu, Ta-Kun, additional, Zhuang, Ling, additional, Ke, Helen, additional, Johnson, Ben, additional, Rath, Emma, additional, Lee, Kenneth, additional, Klebe, Sonja, additional, Kao, Steven, additional, Qin, Karl Lijun, additional, Pham, Hong Ngoc Thuy, additional, Vuong, Quan, additional, and Cheng, Yuen Yee, additional

Published
2023
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26. Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growthin vitroandin vivoby mitochondrial dysfunction associated apoptosis

Author

Shi, Huaikai, primary, Zhang, Le, additional, Yu, Ta-Kun, additional, Zheng, Ling, additional, Ke, Helen, additional, Johnson, Ben, additional, Rath, Emma, additional, Lee, Kenneth, additional, Klebe, Sonja, additional, Kao, Steven, additional, Qin, Karl Lijun, additional, Pham, Hong Ngoc Thuy, additional, Vuong, Quan, additional, and Cheng, Yuen Yee, additional

Published
2022
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32. 3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies

Author

Shi, Huaikai, primary, Rath, Emma M., additional, Lin, Ruby C. Y., additional, Sarun, Kadir Harun, additional, Clarke, Candice Julie, additional, McCaughan, Brian C., additional, Ke, Helen, additional, Linton, Anthony, additional, Lee, Kenneth, additional, Klebe, Sonja, additional, Maitz, Joanneke, additional, Song, Kedong, additional, Wang, Yiwei, additional, Kao, Steven, additional, and Cheng, Yuen Yee, additional

Published
2022
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33. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing

Author

Shi, Huaikai, primary, Tsai, Kevin H.‐Y., additional, Ma, Duncan, additional, Wang, Xiaosuo, additional, Desai, Reena, additional, Parungao, Roxanne J., additional, Hunt, Nicholas J., additional, Cheng, Yuen Yee, additional, Zhang, Hao, additional, Xu, Ye, additional, Simanainen, Ulla, additional, Tan, Qian, additional, Cooper, Mark S., additional, Handelsman, David J., additional, Maitz, Peter K., additional, and Wang, Yiwei, additional

Published
2022
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36. The Current Understanding Of Asbestos-Induced Epigenetic Changes Associated With Lung Cancer

Author

Cheng, Yuen Yee, Rath, Emma M, Linton, Anthony, Yuen, Man Lee, Takahashi, Ken, and Lee, Kenneth

Subjects
lung cancer, DNA methylation, microRNA, FISH, immunohistochemistry, Review, respiratory system, epigenetic biomarkers, fluorescence in situ hybridization, respiratory tract diseases, IHC
Abstract

Asbestos is a naturally occurring mineral consisting of extremely fine fibres that can become trapped in the lungs after inhalation. Occupational and environmental exposures to asbestos are linked to development of lung cancer and malignant mesothelioma, a cancer of the lining surrounding the lung. This review discusses the factors that are making asbestos-induced lung cancer a continuing problem, including the extensive historic use of asbestos and decades long latency between exposure and disease development. Genomic mutations of DNA nucleotides and gene rearrangements driving lung cancer are well-studied, with biomarkers and targeted therapies already in clinical use for some of these mutations. The genes involved in these mutation biomarkers and targeted therapies are also involved in epigenetic mechanisms and are discussed in this review as it is hoped that identification of epigenetic aberrations in these genes will enable the same gene biomarkers and targeted therapies to be used. Currently, understanding of how asbestos fibres trapped in the lungs leads to epigenetic changes and lung cancer is incomplete. It has been shown that oxidoreduction reactions on fibre surfaces generate reactive oxygen species (ROS) which in turn damage DNA, leading to genetic and epigenetic alterations that reduce the activity of tumour suppressor genes. Epigenetic DNA methylation changes associated with lung cancer are summarised in this review, and some of these changes will be due to asbestos exposure. So far, little research has been carried out to separate the asbestos driven epigenetic changes from those due to non-asbestos causes of lung cancer. Asbestos-associated lung cancers exhibit less methylation variability than lung cancers in general, and in a large proportion of samples variability has been found to be restricted to promoter regions. Epigenetic aberrations in cancer are proving to be promising biomarkers for diagnosing cancers. It is hoped that further understanding of epigenetic changes in lung cancer can result in useful asbestos-associated lung cancer biomarkers to guide treatment. Research is ongoing into the detection of lung cancer epigenetic alterations using non-invasive samples of blood and sputum. These efforts hold the promise of non-invasive cancer diagnosis in the future. Efforts to reverse epigenetic aberrations in lung cancer by epigenetic therapies are ongoing but have not yet yielded success.

Published
2020

38. Stratified Disk Microrobots with Dynamic Maneuverability and Proton-Activatable Luminescence for in Vivo Imaging

Author

Liu, Yuan, primary, Lin, Gungun, additional, Bao, Guochen, additional, Guan, Ming, additional, Yang, Liu, additional, Liu, Yongtao, additional, Wang, Dejiang, additional, Zhang, Xun, additional, Liao, Jiayan, additional, Fang, Guocheng, additional, Di, Xiangjun, additional, Huang, Guan, additional, Zhou, Jiajia, additional, Cheng, Yuen Yee, additional, and Jin, Dayong, additional

Published
2021
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40. The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)

Author

Yuen, Man Lee, primary, Zhuang, Ling, additional, Rath, Emma M., additional, Yu, Takun, additional, Johnson, Ben, additional, Sarun, Kadir Harun, additional, Wang, Yiwei, additional, Kao, Steven, additional, Linton, Anthony, additional, Clarke, Candice Julie, additional, McCaughan, Brian C., additional, Takahashi, Ken, additional, Lee, Kenneth, additional, and Cheng, Yuen Yee, additional

Published
2021
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43. Absence of NPM1 promoter hypermethylation in human myelodysplastic syndrome

Author

Cheng, Yuen-Yee, Chau, David, Chan, Thomas, Gill, Harinder, Liang, Raymond, Kwong, Yok-Lam, and Tse, Eric

Subjects
Myelodysplastic syndromes -- Genetic aspects, Myelodysplastic syndromes -- Development and progression, Myelodysplastic syndromes -- Research, Gene mutations -- Research, Methylation -- Genetic aspects, Methylation -- Research, Promoters (Genetics) -- Research, Health
Published
2010

44. The Current Understanding Of Asbestos-Induced Epigenetic Changes Associated With Lung Cancer

Author

Cheng,Yuen Yee, Rath,Emma M, Linton,Anthony, Yuen,Man Lee, Takahashi,Ken, Lee,Kenneth, Cheng,Yuen Yee, Rath,Emma M, Linton,Anthony, Yuen,Man Lee, Takahashi,Ken, and Lee,Kenneth

Abstract

Yuen Yee Cheng, 1, 2 Emma M Rath, 3 Anthony Linton, 1, 2, 4 Man Lee Yuen, 1 Ken Takahashi, 1 Kenneth Lee 1, 2, 4  1Asbestos Disease Research Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; 2Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; 3Garvan Institute of Medical Research, Sydney, New South Wales, Australia; 4Concord Repatriation General Hospital, Sydney, New South Wales, AustraliaCorrespondence: Yuen Yee ChengAsbestos Disease Research Institute, PO Box 3628, Rhodes, New South Wales 2139, AustraliaTel +61 2 9767 9800Fax +61 2 9767 9860Email yycheng@adri.org.auAbstract: Asbestos is a naturally occurring mineral consisting of extremely fine fibres that can become trapped in the lungs after inhalation. Occupational and environmental exposures to asbestos are linked to development of lung cancer and malignant mesothelioma, a cancer of the lining surrounding the lung. This review discusses the factors that are making asbestos-induced lung cancer a continuing problem, including the extensive historic use of asbestos and decades long latency between exposure and disease development. Genomic mutations of DNA nucleotides and gene rearrangements driving lung cancer are well-studied, with biomarkers and targeted therapies already in clinical use for some of these mutations. The genes involved in these mutation biomarkers and targeted therapies are also involved in epigenetic mechanisms and are discussed in this review as it is hoped that identification of epigenetic aberrations in these genes will enable the same gene biomarkers and targeted therapies to be used. Currently, understanding of how asbestos fibres trapped in the lungs leads to epigenetic changes and lung cancer is incomplete. It has been shown that oxidoreduction reactions on fibre surfaces generate reactive oxygen species (ROS) which in turn damage DNA, leading to genetic and epigenetic alterations that reduce th

Published
2020

49. CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescence In Situ Hybridisation

Author

Cheng, Yuen Yee, primary, Yuen, Man Lee, additional, Rath, Emma M., additional, Johnson, Ben, additional, Zhuang, Ling, additional, Yu, Ta-kun, additional, Aleksova, Vesna, additional, Linton, Anthony, additional, Kao, Steven, additional, Clarke, Candice Julie, additional, McCaughan, Brian C., additional, Takahashi, Ken, additional, and Lee, Kenneth, additional

Published
2020
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