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19 results on '"Cheng, Yuanjun"'

9. Increased Expression of TAP Is Predictive of Poor Prognosis in Patients with Non-Small Cell Lung Cancer

Author

Cheng, Yuanjun, Chen, Yongbing, Zang, Guohui, Chen, Bin, Yao, Jie, Zhang, Wenguang, Wang, Haibing, Yu, Liu, He, Pinghai, Zhang, Youming, and Wu, Hanqing

Subjects
Cancer Management and Research, cancer, prognosis, predictive, TAP, Original Research, tumor abnormal protein, lung, respiratory tract diseases
Abstract

Yuanjun Cheng, 1 Yongbing Chen, 2 Guohui Zang, 1 Bin Chen, 1 Jie Yao, 1 Wenguang Zhang, 1 Haibing Wang, 1 Liu Yu, 1 Pinghai He, 1 Youming Zhang, 1 Hanqing Wu 1 1Department of Cardiothoracic Surgery, People’s Hospital of Chizhou, Chizhou, People’s Republic of China; 2Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of ChinaCorrespondence: Yuanjun Cheng3 Baiya Road, Guichi District, Chizhou 247000, Anhui Province, People’s Republic of ChinaEmail cyjlfqr1985@163.com Background: The most common cancer among humans is lung cancer. Non-small cell lung cancer (NSCLC) comprises the majority of these cases. In the development and progression of cancers across the spectrum, tumor abnormal protein (TAP) plays crucial roles. Additionally, in the advancement of the bladder and colorectal cancers, the involvement of glycoproteins like TAP is present. However, it is worth noting that current literature has yet to clarify the clinical significance of the TAP in NSCLC.Methods: In the present study, to evaluate the relative level of TAP, we utilized a TAP detection agent in 154 cases of NSCLC and normal patients who underwent surgical resection anytime from March 2013 to January 2019 at the People’s Hospital ofChizhou.Results: Our results demonstrated that in NSCLC patients, the expression level of TAP was significantly higher than in normal patients. Moreover, after surgery, TAP expression was significantly downregulated in NSCLC patients. TAP expression is associated with an array of factors, which include the patient’s sex, history of smoking use, tumor size, pTNM, distant cancer, metastasis of lymph nodes, invasive and aggressive indicator pleural invasion, and differentiation degree of NSCLC. Additionally, TAP has no association with the patient’s age, history of drinking, location of the tumor, hypertension, and diabetes. In NSCLC patients, a poor overall survival rate within 5 years is significantly correlated with the increased TAP expression. For NSCLC patients, an independent prognostic factor is the TAP, which is confirmed using the multivariate survival analysis.Conclusion: In the malignant progression of NSCLC, our results demonstrate how the promoting role of the upregulated TAP expression takes place. Hence, a therapeutic aim for NSCLC and a potential biomarker for NSCLC progress is a TAP.Keywords: tumor abnormal protein, TAP, lung, cancer, prognosis, predictive

Published
2020

14. Surgical treatment of an esophageal bronchogenic cyst with massive upper digestive tract hematoma without esophagectomy: a case report and the review of the literature

Author

Cheng,Yuanjun, Chen,Donglai, Shi,Li, Yang,Wentao, Sang,Yonghua, Duan,Shanzhou, Chen,Yongbing, Cheng,Yuanjun, Chen,Donglai, Shi,Li, Yang,Wentao, Sang,Yonghua, Duan,Shanzhou, and Chen,Yongbing

Abstract

Yuanjun Cheng,1,* Donglai Chen,2,* Li Shi,1 Wentao Yang,1 Yonghua Sang,1 Shanzhou Duan,1 Yongbing Chen1 1Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China; 2Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China *These authors contributed equally to this work Abstract: Esophageal bronchogenic cysts are extremely rare. Here we report a case of massive upper digestive tract hematoma and bronchogenic cyst mimicking aortic dissection that was safely removed without esophagectomy. A 30-year-old man was referred to our hospital for the treatment of a mediastinal cystic tumor located in the submucosa of the distal esophagus. His chief complaints were dysphagia > 1 week and severe persistent upper abdominal pain mimicking aortic dissection with constant vomiting for 1 day after gastroscopy examination. The serum level of carbohydrate antigen (CA)199 was > 1,000 U/mL and CA125 was 4,816 U/mL. Hemoglobin levels decreased from 122 g/L to 85 g/L in 5 days. Imaging examinations detected a huge hematoma of the gastric wall. Preoperative diagnosis was difficult. Although the pain indicated a possible aortic dissection, the abnormal levels of tumor biomarkers suggested malignancy. The patient underwent left thoracotomy. The cyst showed an exophytic lesion connected to the esophageal wall at the level of the gastroesophageal junction. Muddy brown contents were obtained by aspiration of the mass intraoperatively. Because enucleation could not be performed, esophageal myotomy in the distal esophagus and partial resection of the cyst were selected. Histopathological examination indicated a bronchogenic cyst of the esophagus. At a follow-up visit 3 months later, the patient had no signs of disease recurrence or any complaints. Postoperative tumor biomarkers returned to normal range. The present report summarizes the clinical details of the case and reviews th

Published
2018

19. [Effect of High-frequency Chest Wall Oscillatory on Lung Function in Patient 
After Single Port Video-assisted Thoracoscopic Surgery Lobectomy].

Author

Zhu X, Cheng Y, Yang W, Chen Y, and Shi L

Subjects
Adult, Aged, Case-Control Studies, Female, Forced Expiratory Volume, High-Frequency Ventilation, Humans, Lung surgery, Lung Neoplasms physiopathology, Male, Middle Aged, Pneumonectomy, Respiratory Function Tests, Thoracic Surgery, Video-Assisted, Thoracic Wall surgery, Young Adult, Lung physiopathology, Lung Neoplasms surgery
Abstract

Background: It has been confirmed that high-frequency chest wall oscillatory (HFCWO) is a new type of auxiliary sputum discharge device. However, up to now, the specific therapeutic effect of HFCWO is still uncertain. This study aimed to compare the changes of the sputum volume before and after the treatment of HFCWO, and to investigate the effect of HFCWO on lung function and arterial blood gas analysis after single port video-assisted thoracoscopic surgery lobectomy (S-VATS)., Methods: A total of 90 patients with S-VATS lobectomy were collected in the Second Affiliated Hospital of Soochow University from January 2017 to December 2017, which were randomly divided into the experimental group with HFCWO (n=45) and the control group (n=45) with routine clapping, respectively. The sputum volume of the two groups was measured 5 days before operation. Lung function and arterial blood gas analysis was measured before and 7th days after surgery., Results: The sputum volume was higher in the experimental group than that of the control group after surgery, there was statistically significant difference for the first three days (P<0.05). There was no statistically significant difference between the two groups in forced expiratory volume in one second (FEV₁), forced vital capacity (FVC) and oxygen partial pressure (PaO₂) before surgery (P>0.05); Compared with those before surgery, FEV₁, FVC and PaO₂ decreased in both groups after surgery (P<0.05); However, FEV₁, FVC and PaO₂ in the experimental group were higher than those in the control group (P<0.05); There was no statistically significant difference in preoperative and postoperative partial pressure of carbon dioxide (PaCO₂) between the two groups (P>0.05)., Conclusions: HFCWO can significantly increase the amount of sputum excretion, improve lung function and alleviate hypoxia status after S-VATS lobectomy. This study provides a promising approach for HFCWO toward hypoxia status after S-VATS lobectomy.
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Published
2018
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