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47 results on '"Cheng, Woei"'

12. Contributors

Author

Banga, Ajay K., primary, Berrill, Alex, additional, Biddlecombe, Jamie, additional, Bracewell, Daniel, additional, Caliceti, Paolo, additional, Chan, Hak-Kim, additional, Cheng, Woei Ping, additional, Dufès, Christine, additional, Herwadkar, Anushree, additional, Lip Kwok, Philip Chi, additional, Olejnik, Orest, additional, Paliwal, Shivani Rai, additional, Paliwal, Rishi, additional, Pereira, Patrícia, additional, Pooga, Margus, additional, Räägel, Helin, additional, Rekha, M.R., additional, Ritthidej, Garnpimol C., additional, Salmaso, Stefano, additional, Schmidt, Elke, additional, Sharma, Chandra P., additional, Thompson, Colin, additional, van der Walle, Christopher F., additional, and Vyas, Suresh P., additional

Published
2011
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24. Novel fluorescent amphiphilic poly(allylamine) and their supramacromolecular self-assemblies in aqueous media.

Author

Hoskins, Clare, Lin, Paul Kong Thoo, Tetley, Laurence, and Cheng, Woei Ping

Subjects
POLYMERS, NANOPARTICLES, DRUG delivery systems, STEREOCHEMISTRY, MOLECULAR weights, NAPHTHALENE
Abstract

Fluorescent amphiphilic polymers were produced by grafting different types and levels of hydrophobic pendant groups with intrinsic fluorescent properties (fluorenylmethoxy carbonyl (Fmoc), dimethylamino-1-naphthalenesulfonyl (Dansyl), and naphthalene (Naphth) to a water soluble homopolymer backbone, polyallylamine (PAA). Non-fluorescent hydrophobic pendant group (cholesteryl moieties) were also grafted onto PAA. The polymers were characterized with elemental analysis, NMR and FTIR spectroscopy. All polymers formed self-assemblies by probe sonication in water with sizes ranging from 120 to 199 nm and TEM images showed the presence of spherical particles. The critical aggregation concentration (CAC) varied from 0.093 to 1.5 mg ml−1 depending on the type of hydrophobic pendant groups. The Cholesteryl and Dansyl polymers showed the presence of one CAC while the Fmoc and Naphth grafted polymers revealed the presence of two CACs. The first CAC observed was possibly due to intermolecular aggregation while the second CAC at the higher polymer concentration was the result of excimer formation revealed by their fluorescent spectra. We reasoned that Naphth and Fmoc aromatic pendant groups possess a flat stereochemistry, thus allowing π- π stacking at higher concentrations. The presence of the N-dimethylamino group in the Dansyl moiety gives rise to a 3D structure, thus hindering any stacking. The understanding of the supramolecular assemblies formed by these fluorescent amphiphilic polymers will aid in the engineering of advanced materials with superior functionality for biomedical applications. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2012
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25. Polyelectrolyte Nanoparticles with High Drug Loading Enhance the Oral Uptake of Hydrophobic Compounds

Author

Ping Cheng, Woei, I. Gray, Alexander, Tetley, Laurence, Le Bich Hang, Thi, G. Schätzlein, Andreas, and F. Uchegbu, Ijeoma

Abstract

In the pharmaceutical industry, orally active compounds are required to have sufficient water solubility to enable dissolution within the gastrointestinal tract prior to absorption. Limited dissolution within the gastrointestinal tract often reduces the bioavailability of hydrophobic drugs. To improve gastrointestinal tract dissolution, nonaqueous solvents are often used in the form of emulsions and microemulsions. Here, we show that oil-free polyelectrolyte nanosystems (micellar dispersions and 100−300 nm particles) prepared from poly(ethylenimines) derivatized with cetyl chains and quaternary ammonium groups are able to encapsulate high levels of hydrophobic drug (0.20 g of drug per g of polymer) for over 9 months, as demonstrated using cyclosporine A (log P = 4.3). The polyelectrolytes facilitate the absorption of hydrophobic drugs within the gastrointestinal tract by promoting drug dissolution and by a hypothesized mechanism involving paracellular drug transport. Polyelectrolyte nanoparticle drug blood levels are similar to those obtained with commercial microemulsion formulations. The polyelectrolytes do not promote absorption by inhibition of the P-glycoprotein efflux pump.

Published
2006

27. Nanoparticles in Medical Imaging

Author

El-Hamadi, Mazen, Schätzlein, Andreas G., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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29. Gene and Ribonucleic Acid Therapy

Author

Iemsam-Arng, Jayanant, Kong, Xiao, Schätzlein, Andreas G., Uchegbu, Ijeoma F., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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30. Anti-infectives

Author

Mohamed-Ahmed, Abeer H. A., Ginn, Claire, Croft, Simon L., Brocchini, Stephen, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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31. Vaccines

Author

Perrie, Yvonne, Kaur, Randip, Henriksen-Lacey, Malou, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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32. Cancer Chemotherapy

Author

Nakamura, Hideaki, Maeda, Hiroshi, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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34. Active Targeting

Author

Lopez, Dolores Remedios Serrano, Lalatsa, Aikaterini, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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36. Polymeric Nanoparticles

Author

Uchegbu, Ijeoma F., Lalatsa, Aikaterini, Wong, Dennis, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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37. Polymer-Drug Conjugates

Author

Fante, Cristina, Greco, Francesca, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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38. Polymersomes and Filomicelles

Author

Oltra, Núria Sancho, Loverde, Sharon M., Harada, Takamasa, Mahmud, Abdullah, Rajagopal, Karthikan, Discher, Dennis E., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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39. Niosomes

Author

Marianecci, Carlotta, Di Marzio, Luisa, Rinaldi, Federica, Esposito, Sara, Carafa, Maria, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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41. Solid Lipid Nanoparticles (SLN™)

Author

Souto, Eliana B., Fangueiro, Joana F., Müller, Rainer H., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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42. Liposomes

Author

Kalra, Jessica, Bally, Marcel B., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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44. Porous Silicon Nanoparticles

Author

Santos, Hélder A., Mäkilä, Ermei, Bimbo, Luis M., Almeida, Patrick, Hirvonen, Jouni, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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45. Introduction

Author

Uchegbu, Ijeoma F., Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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46. Drug Nanocrystals

Author

Peltonen, Leena, Uchegbu, Ijeoma F., editor, Schätzlein, Andreas G., editor, Cheng, Woei Ping, editor, and Lalatsa, Aikaterini, editor

Published
2013
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47. pH-triggered reversible "stealth" polycationic micelles.

Author

Gu J, Cheng WP, Liu J, Lo SY, Smith D, Qu X, and Yang Z

Subjects
Cations, Polyethylene Glycols chemistry, Hydrogen-Ion Concentration, Micelles
Abstract

Amphiphilic polycations with a "stealth" cationic nature have been designed and synthesized by the PEGylation of polycationic amphiphile via a novel pH responsible benzoic imine linker. The linkage is stable in aqueous solution at physiological pH but cleaves in slight acidic conditions such as the extracellular environment of solid tumor and endosomes. The polymeric micelle formed from the amphiphilic "stealth" polycation contains a pH-switchable cationic surface driven by the reversible detachment/reattachment of the shielding PEG chains due to the cleavage/formation process of the imine linkage. At physiological pH, the micellar surface was shielded by the PEG corona, leading to lower cytotoxicity and less hemolysis, whereas in a mild acidic condition like in endosomes or solid tumors, the deshielding of the PEG chains exposed the positive charge on the micellar surface and retained the membrane disrupting ability. The amphiphilic "stealth" polycation is potentially useful as a drug targeting system toward tumors via endocytosis and trafficked through the endosomal pathway.

Published
2008
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