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Impact loading has been associated with running-related injuries, and gait retraining has been suggested as a means of reducing impact loading and lowering the risk of injury. However, gait retraining can lead to increased perceived awkwardness and effort. The influence of specifically trained and self-selected running gait modifications on acute impact loading, perceived awkwardness and effort is currently unclear. Sixteen habitual rearfoot/midfoot runners performed forefoot strike pattern, increased step rate, anterior trunk lean and self-selected running gait modifications on an instrumented treadmill based on real-time biofeedback. Impact loading, perceived awkwardness and effort scores were compared among the four gait retraining conditions. Self-selected gait modification reduced vertical average loading rate (VALR) by 25.3%, vertical instantaneous loading rate (VILR) by 27.0%, vertical impact peak (VIP) by 16.8% as compared with baseline. Forefoot strike pattern reduced VALR, VILR and peak tibial acceleration. Increased step rate reduced VALR. Anterior trunk lean did not reduce any impact loading. Self-selected gait modification was perceived as less awkward and require less effort than the specifically trained gait modification (p < 0.05). These findings suggest that self-selected gait modification could be a more natural and less effortful strategy than specifically trained gait modification to reduce acute impact loading, while the clinical significance remains unknown. [ABSTRACT FROM AUTHOR]

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.

We aimed at assessing the validity and test-retest reliability of the inertial measurement unit-based Vmaxpro sensor compared with a Vicon 3D motion capture system and the T-Force sensor during an incremental 1-repetition maximum (1RM) test and at submaximal loads. Nineteen subjects reported to the laboratory for the 1RM test sessions, whereas 15 subjects carried out another 3 sessions consisting of 3 repetitions with 4 different intensities (30, 50, 70, and 90% of 1RM) to determine the intra- and interday reliability. The Vmaxpro sensor showed high validity (Vicon: R² =0.935; T-Force: R² = 0.968) but an overestimation of the mean velocities (MVs) of 0.06 ± 0.08 m·s-1 and 0.06 ± 0.06 m·s-1 compared with Vicon and T-Force, respectively. Regression analysis indicated a systematic bias that is increasing with higher MVs. The intraclass correlation coefficients (ICCs) for Vmaxpro were moderate to high for intraday (ICC: 0.662-0.938; p &8804#; 0.05) and for interday (ICC: 0.568-0.837; p ≤ 0.05) reliability, respectively. The Vmaxpro is a valid and reliable measurement device that can be used to monitor movement velocities within a training session. However, practitioners should be cautious when assessing movement velocities on separate days because of the moderate interday reliability. [ABSTRACT FROM AUTHOR]

This study assessed the associations of maximal isometric strength and movement economy in 126 recreationally active men and women. Oxygen consumption was assessed through a graded treadmill test with 4-minute increments (4–12 km∙h−1). Maximal isometric leg extensor, leg flexor and handgrip strength were assessed by isometric dynamometry. Models of best fit for gross oxygen cost and gross caloric unit cost were observed across the majority of velocities when the leg extensor/flexor strength ratio and handgrip strength were combined (R2 = 0.207–0.525 and R2 = 0.152–0.475, respectively). Additionally, the oxygen cost differed statistically for the majority of velocities when participants were split by the median of leg extensor strength (12.3–26.3 ml∙kg−1∙km−1, p < 0.05) and the average of all strength variables (13.9–30.3 ml∙kg−1∙km−1, p < 0.05). Our data underline the importance of maintaining maximal strength in order to perform activities with low to moderate oxygen demands. [ABSTRACT FROM AUTHOR]