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1. A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

Author

Dimitriou, Florentia, Cheng, Phil F., Saltari, Annalisa, Schaper-Gerhardt, Katrin, Staeger, Ramon, Haunerdinger, Veronika, Sella, Federica, Tastanova, Aizhan, Urban, Christian, Dettwiler, Susanne, Mihic-Probst, Daniela, Matter, Christian M., Michielin, Olivier, Gutzmer, Ralf, Long, Georgina V., Becher, Burkhard, Levesque, Mitchell P., and Dummer, Reinhard

Published
2024
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3. Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

Author

Wang, Chen, Zeng, Qun, Gül, Zeynep Melis, Wang, Sisi, Pick, Robert, Cheng, Phil, Bill, Ruben, Wu, Yan, Naulaerts, Stefan, Barnoud, Coline, Hsueh, Pei-Chun, Moller, Sofie Hedlund, Cenerenti, Mara, Sun, Mengzhu, Su, Ziyang, Jemelin, Stéphane, Petrenko, Volodymyr, Dibner, Charna, Hugues, Stéphanie, Jandus, Camilla, Li, Zhongwu, Michielin, Olivier, Ho, Ping-Chih, Garg, Abhishek D., Simonetta, Federico, Pittet, Mikaël J., and Scheiermann, Christoph

Published
2024
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5. Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Author

Haake, Markus, Haack, Beatrice, Schäfer, Tina, Harter, Patrick N., Mattavelli, Greta, Eiring, Patrick, Vashist, Neha, Wedekink, Florian, Genssler, Sabrina, Fischer, Birgitt, Dahlhoff, Julia, Mokhtari, Fatemeh, Kuzkina, Anastasia, Welters, Marij J. P., Benz, Tamara M., Sorger, Lena, Thiemann, Vincent, Almanzar, Giovanni, Selle, Martina, Thein, Klara, Späth, Jacob, Gonzalez, Maria Cecilia, Reitinger, Carmen, Ipsen-Escobedo, Andrea, Wistuba-Hamprecht, Kilian, Eichler, Kristin, Filipski, Katharina, Zeiner, Pia S., Beschorner, Rudi, Goedemans, Renske, Gogolla, Falk Hagen, Hackl, Hubert, Rooswinkel, Rogier W., Thiem, Alexander, Roche, Paula Romer, Joshi, Hemant, Pühringer, Dirk, Wöckel, Achim, Diessner, Joachim E., Rüdiger, Manfred, Leo, Eugen, Cheng, Phil F., Levesque, Mitchell P., Goebeler, Matthias, Sauer, Markus, Nimmerjahn, Falk, Schuberth-Wagner, Christine, von Felten, Stefanie, Mittelbronn, Michel, Mehling, Matthias, Beilhack, Andreas, van der Burg, Sjoerd H., Riedel, Angela, Weide, Benjamin, Dummer, Reinhard, and Wischhusen, Jörg

Published
2023
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6. Diagnostic performance of augmented intelligence with 2D and 3D total body photography and convolutional neural networks in a high-risk population for melanoma under real-world conditions: A new era of skin cancer screening?

Author

Cerminara, Sara E., Cheng, Phil, Kostner, Lisa, Huber, Stephanie, Kunz, Michael, Maul, Julia-Tatjana, Böhm, Jette S., Dettwiler, Chiara F., Geser, Anna, Jakopović, Cécile, Stoffel, Livia M., Peter, Jelissa K., Levesque, Mitchell, Navarini, Alexander A., and Maul, Lara Valeska

Published
2023
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12. Data from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy

Author

Zila, Nina, primary, Eichhoff, Ossia M., primary, Steiner, Irene, primary, Mohr, Thomas, primary, Bileck, Andrea, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Gillet, Ludovic, primary, Sajic, Tatjana, primary, Goetze, Sandra, primary, Friedrich, Betty, primary, Bortel, Patricia, primary, Strobl, Johanna, primary, Reitermaier, René, primary, Hogan, Sabrina A., primary, Martínez Gómez, Julia M., primary, Staeger, Ramon, primary, Tuchmann, Felix, primary, Peters, Sophie, primary, Stary, Georg, primary, Kuttke, Mario, primary, Elbe-Bürger, Adelheid, primary, Hoeller, Christoph, primary, Kunstfeld, Rainer, primary, Weninger, Wolfgang, primary, Wollscheid, Bernd, primary, Dummer, Reinhard, primary, French, Lars E., primary, Gerner, Christopher, primary, Aebersold, Ruedi, primary, Levesque, Mitchell P., primary, and Paulitschke, Verena, primary

Published
2024
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13. Supplementary Fig. S2 from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy

Author

Zila, Nina, primary, Eichhoff, Ossia M., primary, Steiner, Irene, primary, Mohr, Thomas, primary, Bileck, Andrea, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Gillet, Ludovic, primary, Sajic, Tatjana, primary, Goetze, Sandra, primary, Friedrich, Betty, primary, Bortel, Patricia, primary, Strobl, Johanna, primary, Reitermaier, René, primary, Hogan, Sabrina A., primary, Martínez Gómez, Julia M., primary, Staeger, Ramon, primary, Tuchmann, Felix, primary, Peters, Sophie, primary, Stary, Georg, primary, Kuttke, Mario, primary, Elbe-Bürger, Adelheid, primary, Hoeller, Christoph, primary, Kunstfeld, Rainer, primary, Weninger, Wolfgang, primary, Wollscheid, Bernd, primary, Dummer, Reinhard, primary, French, Lars E., primary, Gerner, Christopher, primary, Aebersold, Ruedi, primary, Levesque, Mitchell P., primary, and Paulitschke, Verena, primary

Published
2024
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14. Supplementary Table S1 from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy

Author

Zila, Nina, primary, Eichhoff, Ossia M., primary, Steiner, Irene, primary, Mohr, Thomas, primary, Bileck, Andrea, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Gillet, Ludovic, primary, Sajic, Tatjana, primary, Goetze, Sandra, primary, Friedrich, Betty, primary, Bortel, Patricia, primary, Strobl, Johanna, primary, Reitermaier, René, primary, Hogan, Sabrina A., primary, Martínez Gómez, Julia M., primary, Staeger, Ramon, primary, Tuchmann, Felix, primary, Peters, Sophie, primary, Stary, Georg, primary, Kuttke, Mario, primary, Elbe-Bürger, Adelheid, primary, Hoeller, Christoph, primary, Kunstfeld, Rainer, primary, Weninger, Wolfgang, primary, Wollscheid, Bernd, primary, Dummer, Reinhard, primary, French, Lars E., primary, Gerner, Christopher, primary, Aebersold, Ruedi, primary, Levesque, Mitchell P., primary, and Paulitschke, Verena, primary

Published
2024
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17. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Kaur, Amanpreet, Webster, Marie R, Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H, Dang, Vanessa M, Appleton, Jessica, O’Connell, Michael P, Cheng, Phil, Valiga, Alexander A, Morissette, Rachel, McDonnell, Nazli B, Ferrucci, Luigi, Kossenkov, Andrew V, Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H, Lehrmann, Elin, Becker, Kevin G, Flaherty, Keith T, Frederick, Dennie T, Wargo, Jennifer A, Cooper, Zachary A, Tetzlaff, Michael T, Hudgens, Courtney, Aird, Katherine M, Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S, Chan, Matthew, Menzies, Alexander M, Long, Georgina V, Johnson, Douglas B, Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W, Bosenberg, Marcus, Ribas, Antoni, and Weeraratna, Ashani T

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Adult, Aging, Animals, Cell Line, Tumor, Culture Media, Conditioned, DNA Damage, DNA-(Apurinic or Apyrimidinic Site) Lyase, Disease Progression, Drug Resistance, Neoplasm, Fibroblasts, Humans, Indoles, Male, Melanoma, Membrane Proteins, Mice, Microphthalmia-Associated Transcription Factor, Middle Aged, Molecular Targeted Therapy, Neoplasm Metastasis, Neovascularization, Pathologic, Oxidative Stress, Phenotype, Reactive Oxygen Species, Sulfonamides, Tumor Microenvironment, Vemurafenib, Wnt Signaling Pathway, Wnt1 Protein, beta Catenin, General Science & Technology
Abstract

Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumour progression have been largely unexplored. Since dermal fibroblasts can have profound impacts on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive melanoma metastasis and response to targeted therapy. Here we find that aged fibroblasts secrete a Wnt antagonist, sFRP2, which activates a multi-step signalling cascade in melanoma cells that results in a decrease in β-catenin and microphthalmia-associated transcription factor (MITF), and ultimately the loss of a key redox effector, APE1. Loss of APE1 attenuates the response of melanoma cells to DNA damage induced by reactive oxygen species, rendering the cells more resistant to targeted therapy (vemurafenib). Age-related increases in sFRP2 also augment both angiogenesis and metastasis of melanoma cells. These data provide an integrated view of how fibroblasts in the aged microenvironment contribute to tumour progression, offering new possibilities for the design of therapy for the elderly.

Published
2016

18. Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy

Author

Zila, Nina, primary, Eichhoff, Ossia M., additional, Steiner, Irene, additional, Mohr, Thomas, additional, Bileck, Andrea, additional, Cheng, Phil F., additional, Leitner, Alexander, additional, Gillet, Ludovic, additional, Sajic, Tatjana, additional, Goetze, Sandra, additional, Friedrich, Betty, additional, Bortel, Patricia, additional, Strobl, Johanna, additional, Reitermaier, René, additional, Hogan, Sabrina A., additional, Martínez Gómez, Julia M., additional, Staeger, Ramon, additional, Tuchmann, Felix, additional, Peters, Sophie, additional, Stary, Georg, additional, Kuttke, Mario, additional, Elbe-Bürger, Adelheid, additional, Hoeller, Christoph, additional, Kunstfeld, Rainer, additional, Weninger, Wolfgang, additional, Wollscheid, Bernd, additional, Dummer, Reinhard, additional, French, Lars E., additional, Gerner, Christopher, additional, Aebersold, Ruedi, additional, Levesque, Mitchell P., additional, and Paulitschke, Verena, additional

Published
2023
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22. Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Author

Vergara, Ismael A., Mintoff, Christopher P., Sandhu, Shahneen, McIntosh, Lachlan, Young, Richard J., Wong, Stephen Q., Colebatch, Andrew, Cameron, Daniel L., Kwon, Julia Lai, Wolfe, Rory, Peng, Angela, Ellul, Jason, Dou, Xuelin, Fedele, Clare, Boyle, Samantha, Arnau, Gisela Mir, Raleigh, Jeanette, Hatzimihalis, Athena, Szeto, Pacman, Mooi, Jennifer, Widmer, Daniel S., Cheng, Phil F., Amann, Valerie, Dummer, Reinhard, Hayward, Nicholas, Wilmott, James, Scolyer, Richard A., Cho, Raymond J., Bowtell, David, Thorne, Heather, Alsop, Kathryn, Cordner, Stephen, Woodford, Noel, Leditschke, Jodie, O’Brien, Patricia, Dawson, Sarah-Jane, McArthur, Grant A., Mann, Graham J., Levesque, Mitchell P., Papenfuss, Anthony T., and Shackleton, Mark

Published
2021
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23. Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma

Author

Ferretti, Lorenza P., primary, Böhi, Flurina, additional, Leslie Pedrioli, Deena M., additional, Cheng, Phil F., additional, Ferrari, Elena, additional, Baumgaertner, Petra, additional, Alvarado-Diaz, Abdiel, additional, Sella, Federica, additional, Cereghetti, Alessandra, additional, Turko, Patrick, additional, Wright, Roni H., additional, De Bock, Katrien, additional, Speiser, Daniel E., additional, Ferrari, Roberto, additional, Levesque, Mitchell P., additional, and Hottiger, Michael O., additional

Published
2023
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24. Educational level-dependent melanoma awareness in a high-risk population in Switzerland

Author

M. Müller, Alina, primary, Gössinger, Elisabeth, primary, Cerminara, Sara, primary, Kostner, Lisa, primary, Amaral, Margarida, primary, Huber, Stephanie, primary, P. Passweg, Lea, primary, Garcia Moreno, Laura, primary, Bodenmann, Daniel, primary, Kunz, Michael, primary, P Levesque, Mitchell, primary, Maul, Julia-Tatjana, primary, F. Cheng, Phil, primary, Navarini, Alexander, primary, and Valeska Maul-Duwendag, Lara, primary

Published
2023
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27. SMAD signaling promotes melanoma metastasis independently of phenotype switching

Author

Tuncer, Eylul, Calcada, Raquel R., Zingg, Daniel, Varum, Sandra, Cheng, Phil, Freiberger, Sandra N., Deng, Chu-Xia, Kleiter, Ingo, Levesque, Mitchell P., Dummer, Reinhard, and Sommer, Lukas

Subjects
Cancer treatment -- Analysis, Transforming growth factors -- Analysis, Bone morphogenetic proteins -- Analysis, Melanoma -- Genetic aspects -- Development and progression -- Analysis, Cancer metastasis -- Genetic aspects -- Development and progression -- Analysis, Genetic research, Tumors, Phenotypes, Health care industry
Abstract

The development of metastatic melanoma is thought to require the dynamic shifting of neoplastic cells between proliferative and invasive phenotypes. Contrary to this conventional 'phenotype switching' model, we now show that disease progression can involve malignant melanoma cells simultaneously displaying proliferative and invasive properties. Using a genetic mouse model of melanoma in combination with in vitro analyses of melanoma cell lines, we found that conditional deletion of the downstream signaling molecule Smad4, which abrogates all canonical TGF- [beta] signaling, indeed inhibited both tumor growth and metastasis. Conditional deletion of the inhibitory signaling factor Smad7, however, generated cells that are both highly invasive and proliferative, indicating that invasiveness is compatible with a high proliferation rate. In fact, conditional Smad7 deletion led to sustained melanoma growth and at the same time promoted massive metastasis formation, a result consistent with data indicating that low SMAD7 levels in patient tumors are associated with a poor survival. Our findings reveal that modulation of SMAD7 levels can overcome the need for phenotype switching during tumor progression and may thus represent a therapeutic target in metastatic disease., Introduction Despite recent progress in therapy, melanoma has remained by far the deadliest skin cancer, with a 5-year survival rate of only 15% to 20% (1). There is increasing evidence [...]

Published
2019
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30. Educational level-dependent melanoma awareness in a high-risk population in Switzerland

Author

Mueller, Alina Miriam, primary, Goessinger, Elisabeth Victoria, additional, Cerminara, Sara Elisa, additional, Kostner, Lisa, additional, Amaral, Margarida, additional, Huber, Stephanie Marie, additional, Passweg, Lea Pauline, additional, Moreno, Laura Garcia, additional, Bodenmann, Daniel, additional, Kunz, Michael, additional, Levesque, Mitchell Paul, additional, Maul, Julia-Tatjana, additional, Cheng, Phil Fang, additional, Navarini, Alexander Andreas, additional, and Maul, Lara Valeska, additional

Published
2023
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31. Figure S8 from Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression

Author

Saltari, Annalisa, primary, Dzung, Andreas, primary, Quadri, Marika, primary, Tiso, Natascia, primary, Facchinello, Nicola, primary, Hernández-Barranco, Alberto, primary, Garcia-Silva, Susana, primary, Nogués, Laura, primary, Stoffel, Corinne Isabelle, primary, Cheng, Phil F., primary, Turko, Patrick, primary, Eichhoff, Ossia M., primary, Truzzi, Francesca, primary, Marconi, Alessandra, primary, Pincelli, Carlo, primary, Peinado, Héctor, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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32. Data from Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression

Author

Saltari, Annalisa, primary, Dzung, Andreas, primary, Quadri, Marika, primary, Tiso, Natascia, primary, Facchinello, Nicola, primary, Hernández-Barranco, Alberto, primary, Garcia-Silva, Susana, primary, Nogués, Laura, primary, Stoffel, Corinne Isabelle, primary, Cheng, Phil F., primary, Turko, Patrick, primary, Eichhoff, Ossia M., primary, Truzzi, Francesca, primary, Marconi, Alessandra, primary, Pincelli, Carlo, primary, Peinado, Héctor, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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33. Suppl. Figure S12 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

Author

Eichhoff, Ossia M., primary, Stoffel, Corinne I., primary, Käsler, Jan, primary, Briker, Luzia, primary, Turko, Patrick, primary, Karsai, Gergely, primary, Zila, Nina, primary, Paulitschke, Verena, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Bileck, Andrea, primary, Zamboni, Nicola, primary, Irmisch, Anja, primary, Balazs, Zsolt, primary, Tastanova, Aizhan, primary, Pascoal, Susana, primary, Johansen, Pål, primary, Wegmann, Rebekka, primary, Mena, Julien, primary, Othman, Alaa, primary, Viswanathan, Vasanthi S., primary, Wenzina, Judith, primary, Aloia, Andrea, primary, Saltari, Annalisa, primary, Dzung, Andreas, primary, Krauthammer, Michael, primary, Schreiber, Stuart L., primary, Hornemann, Thorsten, primary, Distel, Martin, primary, Snijder, Berend, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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34. Suppl.Figure S16 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

Author

Eichhoff, Ossia M., primary, Stoffel, Corinne I., primary, Käsler, Jan, primary, Briker, Luzia, primary, Turko, Patrick, primary, Karsai, Gergely, primary, Zila, Nina, primary, Paulitschke, Verena, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Bileck, Andrea, primary, Zamboni, Nicola, primary, Irmisch, Anja, primary, Balazs, Zsolt, primary, Tastanova, Aizhan, primary, Pascoal, Susana, primary, Johansen, Pål, primary, Wegmann, Rebekka, primary, Mena, Julien, primary, Othman, Alaa, primary, Viswanathan, Vasanthi S., primary, Wenzina, Judith, primary, Aloia, Andrea, primary, Saltari, Annalisa, primary, Dzung, Andreas, primary, Krauthammer, Michael, primary, Schreiber, Stuart L., primary, Hornemann, Thorsten, primary, Distel, Martin, primary, Snijder, Berend, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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35. Table ST9 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

Author

Eichhoff, Ossia M., primary, Stoffel, Corinne I., primary, Käsler, Jan, primary, Briker, Luzia, primary, Turko, Patrick, primary, Karsai, Gergely, primary, Zila, Nina, primary, Paulitschke, Verena, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Bileck, Andrea, primary, Zamboni, Nicola, primary, Irmisch, Anja, primary, Balazs, Zsolt, primary, Tastanova, Aizhan, primary, Pascoal, Susana, primary, Johansen, Pål, primary, Wegmann, Rebekka, primary, Mena, Julien, primary, Othman, Alaa, primary, Viswanathan, Vasanthi S., primary, Wenzina, Judith, primary, Aloia, Andrea, primary, Saltari, Annalisa, primary, Dzung, Andreas, primary, Krauthammer, Michael, primary, Schreiber, Stuart L., primary, Hornemann, Thorsten, primary, Distel, Martin, primary, Snijder, Berend, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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39. Supplementary Data from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

Author

Eichhoff, Ossia M., primary, Stoffel, Corinne I., primary, Käsler, Jan, primary, Briker, Luzia, primary, Turko, Patrick, primary, Karsai, Gergely, primary, Zila, Nina, primary, Paulitschke, Verena, primary, Cheng, Phil F., primary, Leitner, Alexander, primary, Bileck, Andrea, primary, Zamboni, Nicola, primary, Irmisch, Anja, primary, Balazs, Zsolt, primary, Tastanova, Aizhan, primary, Pascoal, Susana, primary, Johansen, Pål, primary, Wegmann, Rebekka, primary, Mena, Julien, primary, Othman, Alaa, primary, Viswanathan, Vasanthi S., primary, Wenzina, Judith, primary, Aloia, Andrea, primary, Saltari, Annalisa, primary, Dzung, Andreas, primary, Krauthammer, Michael, primary, Schreiber, Stuart L., primary, Hornemann, Thorsten, primary, Distel, Martin, primary, Snijder, Berend, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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40. Supplementary Figure Legend from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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41. Supplementary Fig. 5 from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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42. Supplementary Figure Legends from Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma

Author

Hogan, Sabrina A., primary, Courtier, Anaïs, primary, Cheng, Phil F., primary, Jaberg-Bentele, Nicoletta F., primary, Goldinger, Simone M., primary, Manuel, Manuarii, primary, Perez, Solène, primary, Plantier, Nadia, primary, Mouret, Jean-François, primary, Nguyen-Kim, Thi Dan Linh, primary, Raaijmakers, Marieke I.G., primary, Kvistborg, Pia, primary, Pasqual, Nicolas, primary, Haanen, John B.A.G., primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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44. Supplementary Fig. 3 from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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45. Figure S3 from Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma

Author

Hogan, Sabrina A., primary, Courtier, Anaïs, primary, Cheng, Phil F., primary, Jaberg-Bentele, Nicoletta F., primary, Goldinger, Simone M., primary, Manuel, Manuarii, primary, Perez, Solène, primary, Plantier, Nadia, primary, Mouret, Jean-François, primary, Nguyen-Kim, Thi Dan Linh, primary, Raaijmakers, Marieke I.G., primary, Kvistborg, Pia, primary, Pasqual, Nicolas, primary, Haanen, John B.A.G., primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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46. Data from Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma

Author

Hogan, Sabrina A., primary, Courtier, Anaïs, primary, Cheng, Phil F., primary, Jaberg-Bentele, Nicoletta F., primary, Goldinger, Simone M., primary, Manuel, Manuarii, primary, Perez, Solène, primary, Plantier, Nadia, primary, Mouret, Jean-François, primary, Nguyen-Kim, Thi Dan Linh, primary, Raaijmakers, Marieke I.G., primary, Kvistborg, Pia, primary, Pasqual, Nicolas, primary, Haanen, John B.A.G., primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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47. Supplementary Fig. 6 from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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48. Supplementary Fig. 4 from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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49. Supplementary Table 1 from Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

Author

Freiberger, Sandra N., primary, Cheng, Phil F., primary, Iotzova-Weiss, Guergana, primary, Neu, Johannes, primary, Liu, Qinxiu, primary, Dziunycz, Piotr, primary, Zibert, John R., primary, Dummer, Reinhard, primary, Skak, Kresten, primary, Levesque, Mitchell P., primary, and Hofbauer, Günther F.L., primary

Published
2023
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50. Data from In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms

Author

Teh, Jessica L.F., primary, Cheng, Phil F., primary, Purwin, Timothy J., primary, Nikbakht, Neda, primary, Patel, Prem, primary, Chervoneva, Inna, primary, Ertel, Adam, primary, Fortina, Paolo M., primary, Kleiber, Ines, primary, HooKim, Kim, primary, Davies, Michael A., primary, Kwong, Lawrence N., primary, Levesque, Mitch P., primary, Dummer, Reinhard, primary, and Aplin, Andrew E., primary

Published
2023
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