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Aim: The aim of this work is to examine the effectiveness of a psychoeducational intervention on self‐efficacy (primary outcome), anxiety, depression, treatment adherence, and health‐related quality of life (HRQoL) of patients undergoing haemodialysis. Methods: A two‐group randomized controlled trial of 124 patients (65 and 59 patients in the intervention and control groups, respectively) recruited from a tertiary hospital in Singapore was conducted. Data were collected from January 2015 to June 2016. Outcomes were measured at baseline and 1, 3, and 6 months after the intervention. General linear model was used to analyse data. Results: Our findings showed significant group effect on HRQoL (effects of kidney disease on daily life; p = 0.041), time effect on all outcomes (p < 0.05; except for treatment adherence behaviours and HRQoL [burden of kidney disease]), and group * time interaction effect on anxiety (p = 0.040) and depression (p = 0.003), with the intervention group reporting better outcomes. Conclusions: The positive effects of our intervention on patients' self‐efficacy, psychological well‐being, treatment adherence attitudes, and HRQoL implied its potential use in dialysis/renal centres to improve patients' self‐care and health outcomes. Summary statement: What is already known about this topic? Patients undergoing haemodialysis commonly encounter physical and psychological health challenges due to the complexity of the disease and long‐term treatment regimens.Improving self‐efficacy in self‐care could improve patients' psychological well‐being, treatment adherence, and health‐related quality of life among these patients.Limited literature is available on how psychoeducational intervention can improve health outcomes of patients undergoing haemodialysis. What this paper adds? The psychoeducational intervention positively reduced haemodialysis patients' anxiety and depression and improved treatment adherence attitude and health‐related quality of life. The implications of this paper: The psychoeducational programme could be integrated into routine care in renal or dialysis centres to enhance the health outcomes of patients undergoing haemodialysis.Future studies should incorporate technology in the delivery of psychoeducational interventions to improve their accessibility and sustainability. [ABSTRACT FROM AUTHOR]