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Your search keyword '"Cheng, Chun-Wen"' showing total 361 results
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361 results on '"Cheng, Chun-Wen"'

1. Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms

Author

Sy, Cheng Len, Chen, Pao-Yu, Cheng, Chun-Wen, Huang, Ling-Ju, Wang, Ching-Hsun, Chang, Tu-Hsuan, Chang, Yi-Chin, Chang, Chia-Jung, Hii, Ing-Moi, Hsu, Yu-Lung, Hu, Ya-Li, Hung, Pi-Lien, Kuo, Chen-Yen, Lin, Pei-Chin, Liu, Po-Yen, Lo, Ching-Lung, Lo, Shih-Hao, Ting, Pei-Ju, Tseng, Chien-Fang, Wang, Hsiao-Wei, Yang, Ching-Hsiang, Lee, Susan Shin-Jung, Chen, Yao-Shen, Liu, Yung-Ching, and Wang, Fu-Der

Published
2022
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2. A hospital cluster of COVID-19 associated with a SARS-CoV-2 superspreading event

Author

Huang, Li-Yueh, Chiu, Yueh-Pi, Hou, Kuei-Chu, Chen, Mei-Lien, Huang, Yu-Chuan, Tsai, Li-Mei, Su, Yu-Hua, Wu, Hsiu-Ping, Liu, Shu-Ling, Wang, Hsiao-Ni, Chang, Li-Fang, Shen, Shu-Hui, Hung, Yun-Chi, Liu, En-Chi, Chen, Yi-Chuan, Yeh, Chiu-Lan, Chang, Hsiao-Chi, Chen, Yu-Ching, Wu, Ya-Ting, Wang, Ching-Yu, Lu, Yi-Rong, Ge, Mao-Cheng, Yang, Jeng-How, Wu, Yen-Mu, Huang, Po-Yen, Wu, Ting-Shu, Cheng, Chun-Wen, Chen, Chih-Jung, Huang, Chung-Guei, Tsao, Kuo-Chien, Lin, Chun-Sui, Chung, Ting-Ying, Lai, Chi-Chun, Yang, Cheng - Ta, Chen, Yi-Ching, and Chiu, Cheng-Hsun

Published
2022
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18. Multiplexed transcriptional profiling of Dermatophagoides house dust mites allergens in human epithelium cells.

Author

Lin, Chia‐Yang, Cheng, Chun‐Wen, Ko, Jiunn‐Liang, Lue, Ko‐Huang, and Liu, Yu‐Fan

Subjects
HOUSE dust mites, DERMATOPHAGOIDES, ALLERGENS, IMMUNOGLOBULIN E, TYPE 1 diabetes, ALLERGIES
Abstract

Allergic asthma, a chronic disease characterized by airway inflammation, poses a significant public health concern. It is well‐established that house dust mites (HDMs) are common inducers of allergic responses in individuals, particularly children. In central Taiwan, our research team observed that over 80% of allergic children exhibited sensitization to various HDMs species. This investigation aims to bridge the gap between these observations and a better understanding of the early fundamental mechanisms for preventing allergic diseases. Specifically, our study delves into the impact of crude extracts of HDMs on human epithelial BEAS‐2B cells. Our findings, based on RNA sequencing (RNA‐seq) analysis, shed light on how three major Dermatophagoides HDMs allergens activate a common Toll‐like receptor signaling pathway in human epithelial cells within a 4‐h treatment. During this process, the nuclear transcription factor NF‐κB translocated into the cell nucleus within 30 min of allergen stimulation, triggering the expression of pro‐inflammatory genes such as IL‐6 and IL‐8 over 4 h. Additionally, when the cells were treated with specific Dermatophagoides microceras (Der m) allergens, it resulted in the upregulation of genes that regulate type 1 diabetes mellitus (T1DM) signaling pathways. This led to the mediation of IL‐12A inflammation. Furthermore, there was an increase in gene sets associated with cilia function and the microtubule cytoskeleton in human epithelial cells after treatment with a combination of Der m allergens and Dexamethasone. Additionally, OMICs analysis was conducted to examine the effects of HDMs allergenic stimulation on human epidermal cells. We aimed to improve our understanding of the molecular mechanisms within cells and identify potential targets and natural products in the treatment of asthma caused by HDMs allergens. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Research into Teachers' Receptivity for Arts Infused Curricula in Taiwan

Author

Giffen Cheng, Yueh Hsiu, Chou, Wen-Shou, and Cheng, Chun Wen

Abstract

The main purpose of this study was to understand the common attitudes and behaviours of teachers in Taiwan with regard to the implementation of arts infused curricula, as well as the individual problems these teachers encounter. From these results, we extracted reference data for the benefit of schools and policymakers in promoting arts infused curricula. The model of receptivity theory and the interrelated factors of influence shown therein were particularly useful in interpreting the attitudes and behaviours of teachers with regard to arts infused education. Teacher receptivity theory is usually applied to measure the relationships between the implementation of a new curriculum and the attitudes/viewpoints of teachers with regard to the new curriculum. With the aid of teacher receptivity theory, this study explored the difficulties and obstacles faced by teachers when implementing arts infused curricula, as well as the attitudes, behavioural intentions and considerations of these teachers. The methodology of this study included both a review of the literature and in-depth interviews. Using the interview data, this research compiled 16 key factors of consideration for teachers with regard to arts infused curricula. These factors influence the attitudes and behaviour of teachers in relation to these curricula.

Published
2014
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43. Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.

Author

Liao, Wen-Ling, Liu, Yu-Fan, Ying, Tsung-Ho, Shieh, Jia-Ching, Hung, Yueh-Tzu, Lee, Huei-Jane, Shen, Chen-Yang, and Cheng, Chun-Wen

Subjects
URSOLIC acid, CANCER stem cells, BREAST cancer, CANCER cells, WESTERN immunoblotting, EPITHELIAL-mesenchymal transition, TRITERPENES
Abstract

The stemness and metastasis of cancer cells are crucial features in determining cancer progression. Argonaute-2 (AGO2) overexpression was reported to be associated with microRNA (miRNA) biogenesis, supporting the self-renewal and differentiation characteristics of cancer stem cells (CSCs). Ursolic acid (UA), a triterpene compound, has multiple biological functions, including anticancer activity. In this study, we find that UA inhibits the proliferation of MDA-MB-231 and MCF-7 breast cancer cell lines using the CCK-8 assay. UA induced a significant decrease in the fraction of CSC in which it was examined by changes in the expression of stemness biomarkers, including the Nanog and Oct4 genes. UA altered invasion and migration capacities by significant decreases in the levels of epithelial-to-mesenchymal transition (EMT) proteins of slug and vimentin. Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro. Mechanically, UA increases PTEN expression to inactivate the FAK/PI3K/Akt/mTOR signaling pathway and the decreased level of c-Myc in quantitative RT-PCR and Western blot imaging analyses. Our current understanding of the anticancer potential of UA in interrupting between EMT programming and the state of CSC suggests that UA can contribute to improvements in the clinical practice of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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