Search

Your search keyword '"Cheng, Alexandre P."' showing total 24 results
Start Over Author "Cheng, Alexandre P."
24 results on '"Cheng, Alexandre P."'

1. Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

Author

Widman, Adam J., Shah, Minita, Frydendahl, Amanda, Halmos, Daniel, Khamnei, Cole C., Øgaard, Nadia, Rajagopalan, Srinivas, Arora, Anushri, Deshpande, Aditya, Hooper, William F., Quentin, Jean, Bass, Jake, Zhang, Mingxuan, Langanay, Theophile, Andersen, Laura, Steinsnyder, Zoe, Liao, Will, Rasmussen, Mads Heilskov, Henriksen, Tenna Vesterman, Jensen, Sarah Østrup, Nors, Jesper, Therkildsen, Christina, Sotelo, Jesus, Brand, Ryan, Schiffman, Joshua S., Shah, Ronak H., Cheng, Alexandre Pellan, Maher, Colleen, Spain, Lavinia, Krause, Kate, Frederick, Dennie T., den Brok, Wendie, Lohrisch, Caroline, Shenkier, Tamara, Simmons, Christine, Villa, Diego, Mungall, Andrew J., Moore, Richard, Zaikova, Elena, Cerda, Viviana, Kong, Esther, Lai, Daniel, Malbari, Murtaza S., Marton, Melissa, Manaa, Dina, Winterkorn, Lara, Gelmon, Karen, Callahan, Margaret K., Boland, Genevieve, Potenski, Catherine, Wolchok, Jedd D., Saxena, Ashish, Turajlic, Samra, Imielinski, Marcin, Berger, Michael F., Aparicio, Sam, Altorki, Nasser K., Postow, Michael A., Robine, Nicolas, Andersen, Claus Lindbjerg, and Landau, Dan A.

Published
2024
Full Text
View/download PDF

3. Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C

Author

Loy, Conor J, Sotomayor-Gonzalez, Alicia, Servellita, Venice, Nguyen, Jenny, Lenz, Joan, Bhattacharya, Sanchita, Williams, Meagan E, Cheng, Alexandre P, Bliss, Andrew, Saldhi, Prachi, Brazer, Noah, Streithorst, Jessica, Suslovic, William, Hsieh, Charlotte J, Bahar, Burak, Wood, Nathan, Foresythe, Abiodun, Gliwa, Amelia, Bhakta, Kushmita, Perez, Maria A, Hussaini, Laila, Anderson, Evan J, Chahroudi, Ann, Delaney, Meghan, Butte, Atul J, DeBiasi, Roberta L, Rostad, Christina A, De Vlaminck, Iwijn, and Chiu, Charles Y

Subjects
Pediatric, Genetics, Rare Diseases, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Inflammatory and immune system, Good Health and Well Being, Humans, Child, Nucleic Acids, COVID-19, RNA, Cell-Free Nucleic Acids, Biomarkers, DNA damage, RNA sequencing, RNA-seq, SARS-CoV-2, bisulfite sequencing, cell damage, cell-free DNA, cell-free RNA, clinical severity, coronavirus disease 2019, disease biomarkers, host response, immune response, multisystem inflammatory syndrome in children, nucleic acid sequencing, pediatric, signaling pathways, systems biology, tissue damage, whole-blood RNA
Abstract

Differential host responses in coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) remain poorly characterized. Here, we use next-generation sequencing to longitudinally analyze blood samples from pediatric patients with COVID-19 or MIS-C across three hospitals. Profiling of plasma cell-free nucleic acids uncovers distinct signatures of cell injury and death between COVID-19 and MIS-C, with increased multiorgan involvement in MIS-C encompassing diverse cell types, including endothelial and neuronal cells, and an enrichment of pyroptosis-related genes. Whole-blood RNA profiling reveals upregulation of similar pro-inflammatory pathways in COVID-19 and MIS-C but also MIS-C-specific downregulation of T cell-associated pathways. Profiling of plasma cell-free RNA and whole-blood RNA in paired samples yields different but complementary signatures for each disease state. Our work provides a systems-level view of immune responses and tissue damage in COVID-19 and MIS-C and informs future development of new disease biomarkers.

Published
2023

5. Peritoneal Effluent Cell-Free DNA Sequencing in Peritoneal Dialysis Patients With and Without Peritonitis

Author

Burnham, Philip, Chen, Fanny, Cheng, Alexandre P., Srivatana, Vesh, Zhang, Lisa T., Edusei, Emmanuel, Albakry, Shady, Botticelli, Brittany, Guo, Xunxi, Renaghan, Amanda, Silberzweig, Jeffrey, Dadhania, Darshana M., Lenz, Joan S., Heyang, Michael, Iliev, Iliyan D., Hayden, Joshua A., Westblade, Lars F., De Vlaminck, Iwijn, and Lee, John R.

Published
2022
Full Text
View/download PDF

8. Abstract 5709: Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoring

Author

Cheng, Alexandre P., primary, Widman, Adam J., additional, Arora, Anushri, additional, Rusinek, Itai, additional, Hooper, William F., additional, Murray, Rebecca, additional, Halmos, Daniel, additional, Langanay, Theophile, additional, Inghirami, Giorgio, additional, Germer, Soren, additional, Marton, Melissa, additional, Helland, Adrienne, additional, Furatero, Rob, additional, McClintock, Jaime, additional, Winterkorn, Lara, additional, Steinsnyder, Zoe, additional, Wang, Yohyoh, additional, Rajagopalan, Srinivas, additional, Alimohamed, Asrar I., additional, Malbari, Murtaza S., additional, Saxena, Ashish, additional, Callahan, Margaret K., additional, Frederick, Dennie T., additional, Spain, Lavinia, additional, Jaimovich, Ariel, additional, Lipson, Doron, additional, Turajlic, Samra, additional, Zody, Michael C., additional, Altorki, Nasser K., additional, Wolchok, Jedd D., additional, Postow, Michael A., additional, Robine, Nicolas, additional, Boland, Genevieve, additional, and Landau, Dan A., additional

Published
2023
Full Text
View/download PDF

10. WITHDRAWN: A gene expression-based diagnostic classifier for identification of severe COVID-19 and multisystem inflammatory syndrome in children (MIS-C)

Author

Sotomayor-Gonzalez, Alicia, primary, Loy, Conor J., additional, Nguyen, Jenny, additional, Servellita, Venice, additional, Bhattacharya, Sanchita, additional, Lenz, Joan, additional, Williams, Meagan, additional, Suslovic, Will, additional, Cheng, Alexandre P., additional, Bliss, Andrew, additional, Saldhi, Prachi, additional, Streithorst, Jessica, additional, Huh, Hee Jae, additional, Foresythe, Abiodun, additional, Oseguera, Miriam, additional, de la Cruz, Katrina, additional, Brazer, Noah, additional, Wood, Nathan, additional, Hsieh, Charlotte, additional, Bahar, Burak, additional, Gliwa, Amelia, additional, Bhakta, Kushmita, additional, Perez, Maria A., additional, Anderson, Evan J., additional, Chahroudi, Ann, additional, Delaney, Meghan, additional, Butte, Atul J., additional, DeBiasi, Roberta, additional, Rostad, Christina A., additional, De Vlaminck, Iwijn, additional, and Chiu, Charles, additional

Published
2022
Full Text
View/download PDF

11. UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism

Author

Chandrasekaran, Ramya, primary, Mathieu, Colleen, additional, Sheth, Rishi, additional, Cheng, Alexandre P., additional, Fong, David, additional, McCormack, Robert, additional, El-Gabalawy, Hani, additional, Alishetty, Suman, additional, Paige, Mikell, additional, and Hoemann, Caroline D., additional

Published
2022
Full Text
View/download PDF

12. WITHDRAWN: Nucleic acid biomarkers of immune response and cell and tissue damage in COVID-19 and MIS-C

Author

Loy, Conor J., primary, Sotomayor-Gonzalez, Alicia, additional, Servellita, Venice, additional, Nguyen, Jenny, additional, Lenz, Joan, additional, Bhattacharya, Sanchita, additional, Williams, Meagan, additional, Cheng, Alexandre P., additional, Bliss, Andrew, additional, Saldhi, Prachi, additional, Brazer, Noah, additional, Streithorst, Jessica, additional, Suslovic, William, additional, Hsieh, Charlotte, additional, Bahar, Burak, additional, Wood, Nathan, additional, Foresythe, Abiodun, additional, Gliwa, Amelia, additional, Bhakta, Kushmita, additional, Perez, Maria A., additional, Hussaini, Laila, additional, Anderson, Evan J., additional, Chahroudi, Ann, additional, Delaney, Meghan, additional, Butte, Atul J., additional, DeBiasi, Roberta, additional, Rostad, Christina A., additional, De Vlaminck, Iwijn, additional, and Chiu, Charles Y., additional

Published
2022
Full Text
View/download PDF

13. Measurement Biases Distort Cell-Free DNA Fragmentation Profiles and Define the Sensitivity of Metagenomic Cell-Free DNA Sequencing Assays

Author

Chang, Adrienne, primary, Mzava, Omary, additional, Lenz, Joan S, additional, Cheng, Alexandre P, additional, Burnham, Philip, additional, Motley, S Timothy, additional, Bennett, Crissa, additional, Connelly, John T, additional, Dadhania, Darshana M, additional, Suthanthiran, Manikkam, additional, Lee, John R, additional, Steadman, Amy, additional, and De Vlaminck, Iwijn, additional

Published
2021
Full Text
View/download PDF

15. Peritoneal Effluent Cell-Free DNA Sequencing in Peritoneal Dialysis Patients With and Without Peritonitis

Author

Burnham, Philip, primary, Chen, Fanny, additional, Cheng, Alexandre P., additional, Srivatana, Vesh, additional, Zhang, Lisa T., additional, Edusei, Emmanuel, additional, Albakry, Shady, additional, Botticelli, Brittany, additional, Guo, Xunxi, additional, Renaghan, Amanda, additional, Silberzweig, Jeffrey, additional, Dadhania, Darshana M., additional, Lenz, Joan S., additional, Heyang, Michael, additional, Iliev, Iliyan D., additional, Hayden, Joshua A., additional, Westblade, Lars F., additional, De Vlaminck, Iwijn, additional, and Lee, John R., additional

Published
2021
Full Text
View/download PDF

20. The Reply

Author

Cheng, Matthew P., primary, Cheng, Alexandre P., additional, and Lee, Todd C., additional

Published
2018
Full Text
View/download PDF

24. Cell-Free DNA Tissues-of-Origin by Methylation Profiling Reveals Significant Cell, Tissue and Organ-Specific injury related to COVID-19 Severity

Author

Cheng, Alexandre Pellan, Cheng, Matthew Pellan, Gu, Wei, Lenz, Joan Sesing, Hsu, Elaine, Schurr, Erwin, Bourque, Guillaume, Bourgey, Mathieu, Ritz, Jerome, Marty, Francisco M., Chiu, Charles Y., Vinh, Donald Cuong, and De Vlaminck, Iwijn

Abstract

COVID-19 primarily affects the lungs, but evidence of systemic disease with multi-organ involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue, and organ specific injury due to COVID-19.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results