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923 results on '"Chen Zhongjian"'

1. Current Status and Progress on Diagnosis and Treatment of Malignant Peritoneal Mesothelioma

Author

LI Na, CHEN Zhongjian, and MAO Weimin

Subjects
malignant peritoneal mesothelioma, diagnosis, therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Malignant peritoneal mesothelioma(MPM) is a rare and aggressive tumor and highly associated with asbestos exposure. Due to the wide application of asbestos materials in the early stage, the incidence of MPM is increasing now. The symptoms of MPM are atypical, so most of patients are in the late stage when diagnosed. And the prognosis is so poor that the median survival time is only 12 months. Now the main treatment of MPM is CRS-HIPEC, at the same time, a number of immune and targeted treatments are under study. This article reviews the current status of treatment on MPM, aiming to improve the understandings of this disease and provide a reference for the clinical diagnosis and treatment.

Published
2020
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31. The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Author

Song, Yongli, Guerrero-Juarez, Christian F, Chen, Zhongjian, Tang, Yichen, Ma, Xianghui, Lv, Cong, Bi, Xueyun, Deng, Min, Bu, Lina, Tian, Yuhua, Liu, Ruiqi, Zhao, Ran, Xu, Jiuzhi, Sheng, Xiaole, Du, Sujuan, Liu, Yeqiang, Zhu, Yunlu, Shan, Shi-jun, Chen, Hong-duo, Zhao, Yiqiang, Zhou, Guangbiao, Shuai, Jianwei, Ren, Fazheng, Xue, Lixiang, Ying, Zhaoxia, Dai, Xing, Lengner, Christopher J, Andersen, Bogi, Plikus, Maksim V, Nie, Qing, and Yu, Zhengquan

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Cancer, 2.1 Biological and endogenous factors, Adult, Aged, Animals, Antibiotics, Antineoplastic, Biomarkers, Breast Neoplasms, Female, Humans, Male, Mice, Middle Aged, Nerve Tissue Proteins, Paget Disease, Extramammary, RNA-Binding Proteins, Sirolimus, TOR Serine-Threonine Kinases, Clinical Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD. Interestingly, we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin, and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels. Using this mouse model, we identified novel biomarkers of Paget-like cells that translated to human Paget cells. Furthermore, single-cell trajectory, RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion, supporting the in situ transformation theory of disease pathogenesis. Mechanistically, the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion, and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice. Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans, suggesting mTOR inhibition as a novel therapeutic treatment in PD.

Published
2020

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