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27. Risk Factors and Prognosis in Patients with COVID-19 and Liver Injury: A Retrospective Analysis

Author

Shen,Jia-Xin, Zhuang,Ze-Hao, Zhang,Qiao-Xian, Huang,Jiao-Feng, Chen,Gong-Ping, Fang,Ying-Ying, Cheng,Ai-Guo, Shen,Jia-Xin, Zhuang,Ze-Hao, Zhang,Qiao-Xian, Huang,Jiao-Feng, Chen,Gong-Ping, Fang,Ying-Ying, and Cheng,Ai-Guo

Abstract

Jia-Xin Shen,1 Ze-Hao Zhuang,1 Qiao-Xian Zhang,2 Jiao-Feng Huang,3 Gong-Ping Chen,4 Ying-Ying Fang,5 Ai-Guo Cheng6 1Endoscopy Center, First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 2Nursing Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Liver Research Center, First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 5Department of Tuberculosis, Third People’s Hospital of Yichang, Yichang, People’s Republic of China; 6Department of Critical Care, Third People’s Hospital of Yichang, Yichang, People’s Republic of ChinaCorrespondence: Ze-Hao ZhuangEndoscopy Center, First Affiliated Hospital of Fujian Medical University, 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian Province, People’s Republic of ChinaTel +86-131-7803-2412Fax +89-59187981370Email zhuang203@yeah.netPurpose: COVID-19 is a new infectious disease with global spread. The aim of the present study was to explore possible risk factors and evaluate prognosis in COVID-19 with liver injury.Methods: A retrospective study was conducted on 356 COVID-19 patients in the Third People’s Hospital of Yichang, Hubei, China. Clinical characteristics and laboratory tests between patients with and without liver injury were compared, while risk factors of COVID-19–related liver injury were analyzed. Univariate and multivariate Cox regression analyses were conducted to identify risk factors of in-hospital death.Results: Of the patients with liver injury, severe and critical types of COVID-19 comprised 12.43% and 14.69%, respectively, higher than in patients without liver injury (both P< 0.05). CRP and male sex

Published
2021

36. Association between obstructive sleep apnea and non‐alcoholic fatty liver disease in pediatric patients: a meta‐analysis.

Author

Chen, Li‐Da, Chen, Meng‐Xue, Chen, Gong‐Ping, Lin, Xue‐Jun, Huang, Jie‐Feng, Zeng, Ai‐Ming, Huang, Ya‐Ping, and Lin, Qi‐Chang

Subjects
ASPARTATE aminotransferase, NON-alcoholic fatty liver disease, INFLAMMATION, MEDICAL information storage & retrieval systems, LIVER, MEDLINE, META-analysis, CHILDHOOD obesity, ONLINE information services, SLEEP apnea syndromes, SYSTEMATIC reviews, FIBROSIS, ALANINE aminotransferase, DESCRIPTIVE statistics, DISEASE complications, DISEASE risk factors, CHILDREN
Abstract

Summary: Background: Some studies have reported a relationship between obstructive sleep apnea (OSA) and non‐alcoholic fatty liver disease (NAFLD) in pediatric population. However, this issue remains controversial. Objectives: The purpose of the present study was to investigate the association between OSA and NAFLD in pediatric population. Methods: We systematically searched PubMed, Web of Science, Embase for eligible studies. The data involving markers of NAFLD including alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic inflammation, hepatic fibrosis of both OSA group and control group were extracted. Pooled standardised mean difference (SMD) and weighted mean difference (WMD) were appropriately calculated through a fixed or random‐effect model. Results: Nine cross‐sectional studies with 1133 children and adolescents were included. OSA was significantly associated with ALT, AST, and NAFLD fibrosis stage, but not NAFLD inflammation grade. Subgroup analysis indicated that both mild OSA and severe OSA were significantly associated with elevated ALT and AST. Furthermore, in the studies with all main confounding factors (age, gender, and BMI) matched, OSA group had higher ALT and AST levels than control group. Conclusions: This meta‐analysis suggested that OSA was associated with NAFLD evidenced by elevated liver enzymes and progressive hepatic fibrosis in pediatric population. Screening and monitoring of NAFLD in pediatric patients with obesity‐related OSA are necessary. [ABSTRACT FROM AUTHOR]

Published
2021
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49. The relationship between excessive daytime sleepiness and metabolic syndrome in severe obstructive sleep apnea syndrome.

Author

Huang, Jie‐feng, Chen, Li‐Da, Lin, Qi‐Chang, Chen, Gong‐Ping, Yu, Yao‐Hua, Huang, Jian‐Chai, and Zhao, Jian‐Ming

Subjects
DROWSINESS, SLEEP apnea syndromes, METABOLIC syndrome, POLYSOMNOGRAPHY, SLEEP disorder diagnosis
Abstract

Background Excessive daytime sleepiness ( EDS), which is commonly considered a cardinal sign of obstructive sleep apnea ( OSA), may lead to an increased rate of metabolic syndrome ( MetS), and be an independent risk factor for cardiovascular morbidity and mortality. The aim of this cross-sectional study was to examine the role of EDS in MetS and its components by researching severe OSA patients. Methods The records of 175 consecutive patients who underwent standard polysomnography and diagnosed severe OSA were included. Subjective daytime sleepiness was assessed using the Epworth sleepiness scale ( ESS). Fasting glucose, lipids, insulin and polysomnography parameters were measured. A metabolic score was counted as the total number of the positive diagnostic criteria of MetS for each subject, which indicated the level of metabolic disorder. Results The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein-cholesterol and MetS (78.2% vs 28.6%) was significantly higher among EDS group compared with control group. Compared with non- EDS patients, patients with EDS showed significantly higher metabolic score (3.22 ± 0.94 vs 1.96 ± 1.06). After adjustment for confounders, ESS score, log insulin and age significantly predicted the metabolic score (β = 0.567, P = 0.000; β = 0.197, P = 0.001 and β = 0.118, P = 0.048, respectively). Conclusion EDS was independently correlated with the sum of metabolic components in severe OSA patients. Our study suggested that EDS might be a potentially useful clinical marker to identify patients with severe OSA at risk of MetS. [ABSTRACT FROM AUTHOR]

Published
2016
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