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290 results on '"Chen, Zhenbing"'

26. Biohybrid Nanorobots Carrying Glycoengineered Extracellular Vesicles Promote Diabetic Wound Repair through Dual‐Enhanced Cell and Tissue Penetration.

Author

Yan, Chengqi, Feng, Kai, Bao, Bingkun, Chen, Jing, Xu, Xiang, Jiang, Guoyong, Wang, Yufeng, Guo, Jiahe, Jiang, Tao, Kang, Yu, Wang, Cheng, Li, Chengcheng, Zhang, Chi, Nie, Pengjuan, Liu, Shuoyuan, Machens, Hans‐Günther, Zhu, Linyong, Yang, Xiaofan, Niu, Ran, and Chen, Zhenbing

Subjects
WOUND healing, EXTRACELLULAR vesicles, DRUG delivery systems, AMMONIUM chloride, ENDOTHELIAL cells, TISSUES
Abstract

Considerable progress has been made in the development of drug delivery systems for diabetic wounds. However, underlying drawbacks, such as low delivery efficiency and poor tissue permeability, have rarely been addressed. In this study, a multifunctional biohybrid nanorobot platform comprising an artificial unit and several biological components is constructed. The artificial unit is a magnetically driven nanorobot surface modified with antibacterial 2‐hydroxypropyltrimethyl ammonium chloride chitosan, which enables the entire platform to move and has excellent tissue penetration capacity. The biological components are two‐step engineered extracellular vesicles that are first loaded with mangiferin, a natural polyphenolic compound with antioxidant properties, and then glycoengineered on the surface to enhance cellular uptake efficiency. As expected, the platform is more easily absorbed by endothelial cells and fibroblasts and exhibits outstanding dermal penetration performance and antioxidant properties. Encouraging results are also observed in infected diabetic wound models, showing improved wound re‐epithelialization, collagen deposition, angiogenesis, and accelerated wound healing. Collectively, a biohybrid nanorobot platform that possesses the functionalities of both artificial units and biological components serves as an efficient delivery system to promote diabetic wound repair through dual‐enhanced cell and tissue penetration and multistep interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Single-cell transcriptome analysis reveals distinct cell populations in dorsal root ganglia and their potential roles in diabetic peripheral neuropathy.

Author

Guo, Guojun, Chen, Jing, Shen, Qixiao, and Chen, Zhenbing

Subjects
SATELLITE cells, DORSAL root ganglia, NEUROGLIA, CELL populations, CELL analysis
Abstract

Diabetic peripheral neuropathy (DPN) is a common complication associated with diabetes, and can affect quality of life considerably. Dorsal root ganglion (DRG) plays an important role in the development of DPN. However, the relationship between DRG and the pathogenesis of DPN still lacks a thorough exploration. Besides, a more in-depth understanding of the cell type composition of DRG, and the roles of different cell types in mediating DPN are needed. Here we conducted single-cell RNA-seq (scRNA-seq) for DRG tissues isolated from healthy control and DPN rats. Our results demonstrated DRG includes eight cell-type populations (e.g., neurons, satellite glial cells (SGCs), Schwann cells (SCs), endothelial cells, fibroblasts). In the heterogeneity analyses of cells, six neuron sub-types, three SGC sub-types and three SC sub-types were identified, additionally, biological functions related to cell sub-types were further revealed. Cell communication analysis showed dynamic interactions between neurons, SGCs and SCs. We also found that the aberrantly expressed transcripts in sub-types of neurons, SGCs and SCs with DPN were associated with diabetic neuropathic pain, cell apoptosis, oxidative stress, etc. In conclusion, this study provides a systematic perspective of the cellular composition and interactions of DRG tissues, and suggests that neurons, SGCs and SCs play vital roles in the progression of DPN. Our data may provide a valuable resource for future studies regarding the pathophysiological effect of particular cell type in DPN. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Ingrown toenail treated by the modified howard-dubois technique: Long-term follow-up results

Author

Tian, Jia, Chen, Zhenbing, and Li, Jin

Subjects
Excision (Surgery) -- Methods -- Patient outcomes, Nails, Ingrowing -- Care and treatment -- Patient outcomes, Health
Abstract

Byline: Jia. Tian, Zhenbing. Chen, Jin. Li Background: According to the Mozena classification system, stage IIb and stage III ingrown toenail cases are considered as severe ones; however, limited options [...]

Published
2022

34. White adipose tissue‐derived small extracellular vesicles: A new potential therapeutic reagent for accelerating diabetic wound healing

Author

Zhang, Chi, primary, Jiang, Tao, additional, Jiang, Guoyong, additional, Xu, Xiang, additional, Yan, Chengqi, additional, Kang, Yu, additional, Xiang, Xuejiao, additional, Liu, Shuoyuan, additional, Nie, Pengjuan, additional, Zhang, Maojie, additional, Chen, Jing, additional, Yuan, Meng, additional, Xu, Yingpeng, additional, Yang, Xiaofan, additional, and Chen, Zhenbing, additional

Published
2023
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38. On-skin biosensors for noninvasive monitoring of postoperative free flaps and replanted digits

Author

Wu, Hao, primary, Li, Zhuo, additional, Xu, Zhao, additional, Huang, Xin, additional, Guo, Wei, additional, Zhao, Jun, additional, Zhang, Jinwen, additional, Liu, Shaoyu, additional, Tang, Miao, additional, Qiu, Yuqi, additional, Yang, Ganguang, additional, Zhu, Juntong, additional, Liu, Lili, additional, Wu, Yingjie, additional, Lei, Wei, additional, Zhou, Pan, additional, Yin, Zhouping, additional, Chen, Zhenbing, additional, and Liu, Yutian, additional

Published
2023
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47. Exosomes from Adipose Stem Cells Promote Diabetic Wound Healing through the eHSP90/LRP1/AKT Axis

Author

Ren, Sen, primary, Chen, Jing, additional, Guo, Jiahe, additional, Liu, Yutian, additional, Xiong, Hewei, additional, Jing, Boping, additional, Yang, Xiaofan, additional, Li, Gongchi, additional, Kang, Yu, additional, Wang, Cheng, additional, Xu, Xiang, additional, Liu, Zhenyu, additional, Zhang, Maojie, additional, Xiang, Kaituo, additional, Li, Chengcheng, additional, Li, Qianyun, additional, Machens, Hans-Günther, additional, and Chen, Zhenbing, additional

Published
2022
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49. Mitochondrial dysfunction and oxidative stress in diabetic wound.

Author

Jiang, Guoyong, Jiang, Tao, Chen, Jing, Yao, Haibo, Mao, Renqun, Yang, Xiaofan, Chen, Zhenbing, and Li, Wenqing

Subjects
OXIDATIVE stress, MITOCHONDRIA, DIABETIC foot, WOUNDS & injuries, CELLULAR signal transduction
Abstract

Diabetic wounds nowadays have become a major health challenge with the changes of the disease spectrum. Mitochondria are closely associated with stubborn nonhealing diabetic wounds for their vital role in energy metabolism, redox homeostasis, and signal transduction. There is significant mitochondrial dysfunction and oxidative stress in diabetic wounds. However, the contribution of mitochondrial dysfunction in oxidative stress induced nonhealing diabetic wound is still not fully understood. In this review, we will briefly summarize the current knowledge of the reported signaling pathways and therapeutic strategies involved in mitochondrial dysfunction in diabetic wounds. The findings provide further understanding of strategies that focus on mitochondria in diabetic wound treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Nanobiotechnology: Applications in Chronic Wound Healing

Author

Jiang,Tao, Li,Qianyun, Qiu,Jinmei, Chen,Jing, Du,Shuang, Xu,Xiang, Wu,Zihan, Yang,Xiaofan, Chen,Zhenbing, and Chen,Tongkai

Subjects
International Journal of Nanomedicine
Abstract

Tao Jiang,1,* Qianyun Li,1,* Jinmei Qiu,2 Jing Chen,1 Shuang Du,2 Xiang Xu,1 Zihan Wu,1 Xiaofan Yang,1 Zhenbing Chen,1 Tongkai Chen2 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenbing Chen, Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, People’s Republic of China, Tel +86 13871103730, Email zbchen@hust.edu.cn Tongkai Chen, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, 510405, People’s Republic of China, Tel +86 20 36585707, Email chentongkai@gzucm.edu.cnAbstract: Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.Keywords: nanobiotechnology, chronic wound healing, scaffold systems, cell-carrying systems, stimuli-responsive systems

Published
2022

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