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33. Association Between Interleukin-12 and Sarcopenia

Author

Chen,Yuan-Yuei, Kao,Tung-Wei, Chiu,Yi-Lin, Peng,Tao-Chun, Yang,Hui-Fang, Chen,Wei-Liang, Chen,Yuan-Yuei, Kao,Tung-Wei, Chiu,Yi-Lin, Peng,Tao-Chun, Yang,Hui-Fang, and Chen,Wei-Liang

Abstract

Yuan-Yuei Chen,1– 3 Tung-Wei Kao,3 Yi-Lin Chiu,4 Tao-Chun Peng,3 Hui-Fang Yang,3 Wei-Liang Chen3,4 1Department of Pathology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 2Department of Pathology, Tri-Service General Hospital Songshan Branch, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 3Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 4Department of Biochemistry, National Defense Medical Center, Taiwan, Republic of ChinaCorrespondence: Wei-Liang ChenDivision of Geriatric Medicine, Department of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, Number 325, Section 2, Chang-Gong Road, Nei-Hu District, Taipei, 114, TaiwanTel +886-2-87923311 ext. 16567Fax +886-2-87927057Email weiliang0508@gmail.comBackground: Emerging studies have proposed that cytokines secreted following macrophage polarization may contribute to skeletal muscle aging. The current study primarily aimed to determine whether these cytokines have an impact on the progression of sarcopenia in an elderly population.Methods: In total, 120 elderly adults aged 65 years and older who underwent health examinations from 2015 to 2019 were included in this retrospective study. Sarcopenia was based on the criteria proposed by the European Working Group on Sarcopenia in Older People in 2019. Macrophages and cytokines datasets were obtained from Gene Expression Omnibus (GEO) database. Comprehensive assessments were performed for muscle strength, muscle mass, gait speed, tumor growth factor-β (TGF-β), and interleukin-12 (IL-12). Thereafter, the association between sarcopenia and cytokines was analyzed using regression models.Results: Low muscle strength and low-speed gait were negatively associated with I

Published
2021

43. Trajectories of returning to work and its impact on survival in survivors with oral cancer: A 5-year follow-up study.

Author

Chen, Yuan‐Yuei, Wang, Chung‐Ching, Wu, Wei‐Te, Lai, Ching‐Huang, Ho, Ching‐Liang, Hsu, Ya‐Yuan, Chen, Wei‐Liang, Chen, Yuan-Yuei, Wang, Chung-Ching, Wu, Wei-Te, Lai, Ching-Huang, Ho, Ching-Liang, Hsu, Ya-Yuan, and Chen, Wei-Liang

Subjects
*ORAL cancer, *CANCER patients, *PROPORTIONAL hazards models, *SOCIODEMOGRAPHIC factors, *RESEARCH, *MOUTH tumors, *TIME, *RESEARCH methodology, *RETROSPECTIVE studies, *EVALUATION research, *MEDICAL cooperation, *TUMOR classification, *SOCIOECONOMIC factors, *COMPARATIVE studies, *KAPLAN-Meier estimator, *EMPLOYMENT, *EMPLOYMENT reentry, *COMORBIDITY, *LONGITUDINAL method
Abstract

Background: A return to work (RTW) is a challenge for survivors of oral cancer. Further light could be shed on the RTW of patients with oral cancer, which remains largely uninvestigated. The objective of this study was to investigate the trajectories of RTW and their impact on survival in workers with oral cancer.Methods: In total, 12,222 workers who were newly diagnosed with oral cancer were identified during the period from 2004 to 2015 and were included in this cohort study. The associations between independent variables and RTW were analyzed using Cox proportional hazard models.Results: Overall, 8793 workers returned to work in the first years after a diagnosis of oral cancer. Chemotherapy (hazard ratio [HR], 0.88; 95% CI, 0.78-0.99) and radiation therapy (HR, 0.83; 95% CI, 0.75-0.92) were inversely associated with RTW. Patients who had received surgical treatment (HR, 1.24; 95% CI, 1.01-1.53) were more likely to RTW. Employees with stage I (HR, 1.66; 95% CI, 1.47-1.87), stage II (HR, 1.52; 95% CI, 1.35-1.72), and stage III (HR, 1.32; 95% CI, 1.16-1.51) disease were associated with an increased likelihood of RTW in the fifth year after diagnosis. Kaplan-Meier survival analysis demonstrated better survival for the RTW group versus the non-RTW group in patients with stage III and IV oral cancer (P < .001). The fully adjusted HR indicated that the RTW group had significantly better outcomes than the non-RTW group in all-cause mortality (P < .001; HR, 0.36; 95% CI, 0.33-0.39).Conclusions: Sociodemographic and medical factors affect the RTW of cancer survivors. RTW may have a beneficial effect on survival of patients with oral cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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