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23 results on '"Chen, Yiliu"'

4. Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells

Author

Wu Yingchao, Pi Dajin, Zhou Shuyao, Yi Zhongjia, Dong Yangyang, Wang Wuhong, Ye Huan, Chen Yiliu, Zuo Qian, and Ouyang Mingzi

Subjects
pyroptosis, ferroptosis, ginsenoside Rh3, Stat3/p53/NRF2 axis, colorectal cancer, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Ginsenoside Rh3 (GRh3) is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors. However, its antitumor role remains to be elucidated. The aim of this study is to explore the mechanisms underlying the tumor suppressive activity of GRh3 from the perspective of pyroptosis and ferroptosis. GRh3 eliminates colorectal cancer (CRC) cells by activating gasdermin D (GSDMD)-dependent pyroptosis and suppressing solute carrier family 7 member 11 (SLC7A11), resulting in ferroptosis activation through the Stat3/p53/NRF2 axis. GRh3 suppresses nuclear factor erythroid 2-related factor 2 (NRF2) entry into the nucleus, leading to the decrease of heme oxygenase 1 (HO-1) expression, which in turn promotes NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and caspase-1 expression. Finally, caspase-1 activates GSDMD-dependent pyroptosis. Furthermore, GRh3 prevents NRF2 from entering the nucleus, which suppresses SLC7A11, causing the depletion of glutathione (GSH) and accumulation of iron, lipid reactive oxygen species (ROS) and malondialdehyde (MDA), and eventually leading to ferroptosis in CRC cells. In addition, GRh3 effectively inhibits the proliferation of CRC cells in vitro and in nude mouse models. Collectively, GRh3 triggers pyroptotic cell death and ferroptotic cell death in CRC cells via the Stat3/p53/NRF2 axis with minimal harm to normal cells, showing great anticancer potential.

Published
2023
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5. MNN: A Universal and Efficient Inference Engine

Author

Jiang, Xiaotang, Wang, Huan, Chen, Yiliu, Wu, Ziqi, Wang, Lichuan, Zou, Bin, Yang, Yafeng, Cui, Zongyang, Cai, Yu, Yu, Tianhang, Lv, Chengfei, and Wu, Zhihua

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Machine Learning
Abstract

Deploying deep learning models on mobile devices draws more and more attention recently. However, designing an efficient inference engine on devices is under the great challenges of model compatibility, device diversity, and resource limitation. To deal with these challenges, we propose Mobile Neural Network (MNN), a universal and efficient inference engine tailored to mobile applications. In this paper, the contributions of MNN include: (1) presenting a mechanism called pre-inference that manages to conduct runtime optimization; (2)deliveringthorough kernel optimization on operators to achieve optimal computation performance; (3) introducing backend abstraction module which enables hybrid scheduling and keeps the engine lightweight. Extensive benchmark experiments demonstrate that MNN performs favorably against other popular lightweight deep learning frameworks. MNN is available to public at: https://github.com/alibaba/MNN., Comment: Accepted by MLSys 2020

Published
2020

8. Protective Effect of CD137 Deficiency Against Postinfarction Cardiac Fibrosis and Adverse Cardiac Remodeling by ERK1/2 Signaling Pathways

Author

Zang, Guangyao, Chen, Yiliu, Guo, Ge, Wan, Aijun, Li, Bo, and Wang, Zhongqun

Abstract

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. The specific role of CD137 in the development of post-MI myocardial fibrosis remains unclear. Thus, this study aimed to elucidate the effects of CD137 signaling using CD137 knockout mice and in vitro experiments. CD137 expression levels progressively increased in the heart after MI, particularly in myofibroblast, which play a key role in fibrosis. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared with wild-type mice at day 28 post-MI. The use of Masson's trichrome and picrosirius red staining demonstrated a reduction in the infarct area and collagen volume fraction in CD137 knockout mice. Furthermore, the expression of alpha-smooth muscle actin and collagen I, key markers of fibrosis, was decreased in heart tissues lacking CD137. In vitro experiments supported these findings because CD137 depletion attenuated cardiac fibroblast differentiation, and migration, and collagen I synthesis. In addition, the administration of CD137L recombinant protein further promoted alpha-smooth muscle actin expression and collagen I synthesis, suggesting a profibrotic effect. Notably, the application of an inhibitor targeting the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway attenuated the profibrotic effects of CD137L. To conclude, this study provides evidence that CD137 plays a significant role in promoting myocardial fibrosis after MI. Inhibition of CD137 signaling pathways may hold therapeutic potential for mitigating pathological cardiac remodeling and improving post-MI cardiac function.

Published
2024
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18. 'It’s all right, it’s all right' : An observation study about children’s peer culture in free play based on Corsaro’s theories

Author

Cheng, Linda and Chen, Yiliu

Subjects
interaktion, artefakter, Förskoledidaktik, tolkande reproduktion, förskola, lärande, fri lek, lek, agens, kamratkultur, regler, strategier, Educational Sciences, kamratallianser, Utbildningsvetenskap
Abstract

Syftet med vårt examensarbete är att undersöka och öka kunskap om barns kamratkulturer i fri lek med fokus på fysiska artefakter, regler och strategier. För att undersöka detta använder vi oss av Corsaros teorier som teoretiskt perspektiv. Studien utförs i en barngrupp utifrån en svensk förskolekontext i inomhusmiljöer. Genom etnografisk ansats, alltså med en kvalitativ metod, undersöker vi hur barn i kamratkulturer interagerar med varandra, deras användning av fysiska artefakter, strategier och regler under fri lek i form av observationer. Studien betonar också lekens betydelse i förskolan för barns utveckling och lärande med koppling till Lpfö 18 (2018, ss.5–19) där det beskrivs hur leken har en väsentlig roll i förskolans vardag. Resultatet visar på att barn är flitiga aktörer som använder olika strategier både för att skydda sin kamratkultur och för att träda in i pågående aktiviteter med bl.a. artefakter, regler och tillträdesstrategier.

Published
2019

20. ”Ingen fara, ingen fara” : En observationsstudie om barns kamratkulturer i fri lek utifrån Corsaros teorier.

Author

Cheng, Linda, Chen, Yiliu, Cheng, Linda, and Chen, Yiliu

Abstract

Syftet med vårt examensarbete är att undersöka och öka kunskap om barns kamratkulturer i fri lek med fokus på fysiska artefakter, regler och strategier. För att undersöka detta använder vi oss av Corsaros teorier som teoretiskt perspektiv. Studien utförs i en barngrupp utifrån en svensk förskolekontext i inomhusmiljöer. Genom etnografisk ansats, alltså med en kvalitativ metod, undersöker vi hur barn i kamratkulturer interagerar med varandra, deras användning av fysiska artefakter, strategier och regler under fri lek i form av observationer. Studien betonar också lekens betydelse i förskolan för barns utveckling och lärande med koppling till Lpfö 18 (2018, ss.5–19) där det beskrivs hur leken har en väsentlig roll i förskolans vardag. Resultatet visar på att barn är flitiga aktörer som använder olika strategier både för att skydda sin kamratkultur och för att träda in i pågående aktiviteter med bl.a. artefakter, regler och tillträdesstrategier.

Published
2019

23. Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats.

Author

Huang A, Xiao G, Chen Y, Hu Z, Lee PH, Huang Y, Zhuang Z, Zhang Y, Qing P, and Zhao C

Subjects
Animals, Rats, Medicine, Chinese Traditional, RNA, Messenger genetics, Acupuncture Therapy, Melatonin, Sleep Initiation and Maintenance Disorders genetics, Sleep Initiation and Maintenance Disorders therapy
Abstract

Background: In clinics, Ziwuliuzhu acupuncture is widely considered an effective method of treating insomnia; however, there is currently limited information available regarding its possible mechanisms. Although the method of Ziwuliuzhu acupuncture possesses a unique rhythmic pattern., Objectives: In this study, we have creatively combined the traditional Chinese medicine of Ziwuliuzhu with a modern biological rhythm to investigate the internal mechanism of insomnia., Methods: Pathological tissue from the hypothalamus was analyzed using hematoxylin-eosin staining. The level of TNF (tumor necrosis factor)-α in the SCN (suprachiasmatic nucleus) area of the hypothalamus was detected in situ using the TUNEL fluorescence staining assay. The concentration of hypothalamic melatonin was detected using the enzyme-linked immunosorbent assay (ELISA). The mRNA expression of Clock and Bmal1 was measured using RT-qPCR., Results: In the Ziwuliuzhu acupuncture groups, the structural damage in the hypothalamic neurons was alleviated compared to the model group and the expression of inflammatory factors was reduced. The mRNA expression levels of Clock and Bmal1 were significantly increased ( p < 0.05). The concentration of melatonin was significantly increased ( p < 0.001). Although there were no significant differences between the treatment groups (diazepam group, Nazi group, Najia group, and routine group) ( p > 0.05)., Conclusion: Ziwuliuzhu acupuncture alleviated neuronal damage and modulated the inflammatory reaction in the hypothalamus of rats with insomnia. Moreover, Ziwuliuzhu acupuncture increased the expression levels of Clock and Bmal1 mRNA, and MT content. This study has potentially highlighted one of the mechanisms through which Ziwuliuzhu acupuncture can be used to treat insomnia.

Published
2023
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