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459 results on '"Chen, Yi-Ming Arthur"'

2. Molecular epidemiology of hepatitis B, hepatitis C, and HIV-1 co-infections in Ethiopia: Implications for disease burden and intervention strategies

Author

Bezabeh, Asmamaw, Berhe, Rezene, Medhin, Girmay, Taddesse, Gizachew, Bane, Abate, Redae, Berhane, Zealiyas, Kidist, Gelibo, Terefe, Challa, Feyissa, Belay, Yohannes, Kassa, Desta, Bekele, Abebe, Gebremicael, Gebremedhin, Girma, Mulu, Getaneh, Yimam, Kidane, Eleni, Chalchisa, Dinkinesh, Adane, Sisay, Abdella, Saro, Tollera, Getachew, Hailu, Messay, Weldemariam, Atsbeha Gebreegziabxier, Lin, Su-I, Li, Wei-You, Wolday, Dawit, Yang, Ming-Hui, Alemu, Yibeltal Assefa, Sarusi, Deborah, Maayan, Shlomo, Chen, Yi-Ming Arthur, Chuang, Kuo-Pin, Tyan, Yu-Chang, and Dai, Chia-Yen

Published
2024
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4. Patients infected by tuberculosis and human immunodeficiency virus facing their disease, their reactions to disease diagnosis and its implication about their families and communities, in Burkina Faso: a mixed focus group and cross sectional study

Author

Méda, Ziemlé Clément, Somé, Télesphore, Sombié, Issiaka, Maré, Daouda, Morisky, Donald E, and Chen, Yi-Ming Arthur

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Prevention, Clinical Research, Rare Diseases, Mind and Body, Tuberculosis, HIV/AIDS, Behavioral and Social Science, Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Adult, Burkina Faso, Coinfection, Cross-Sectional Studies, Female, Focus Groups, HIV, HIV Infections, Health Services Accessibility, Humans, Male, Middle Aged, Mycobacterium tuberculosis, Patient Education as Topic, Prejudice, Rural Population, Social Isolation, Social Stigma, Tuberculosis, Pulmonary, Urban Population, Discrimination, Gender, Global health, Healer, Preventive medicine, Stigmatization, Biochemistry and Cell Biology, Other Medical and Health Sciences, Bioinformatics, Biomedical and clinical sciences
Abstract

BackgroundPatients facing tuberculosis (TB) and human immunodeficiency virus (HIV) infection receive particular care. Despite efforts in the care, misconceptions about TB and HIV still heavily impact patients, their families and communities. This situation severely limits achievement of TB and HIV programs goals. This study reports current situation of TB patients and patients living with HIV/AIDS (PLWHA) facing their disease and its implications, by comparing results from both qualitative and quantitative study design.MethodsCross sectional study using mixed methods was used and excluded patients co-infected by TB and HIV. Focus group included 96 patients (6 patients per group) stratified by setting, disease profile and gender; from rural (Orodara Health District) and urban (Bobo Dioulasso) areas, all from Hauts-Bassins region in Burkina Faso. Quantitative study included 862 patients (309 TB patients and 553 PLWHA) attending TB and HIV care facilities in two main regions (Hauts-Bassins and Centre) of Burkina Faso.ResultsA content analysis of reports found TB patients and PLWHA felt discriminated and stigmatized because of misconceptions with its aftermaths (rejection, emotional and financial problems), mainly among PLWHA and women patients. PLWHA go to healers when facing limited solutions in health system. There are fewer associations for TB patients, and less education and sensitization sessions to give them opportunity for sharing disease status and learning from other TB patients. TB patients and PLWHA still need to better understand their disease and its implication. Access to care (diagnosis and treatment) remains one of the key issues in health system, especially for PLWHA. Individual counseling is centered among PLWHA but not for TB patients. With research progress and experiences sharing, TB patients and PLWHA have some hope to implement their life project, and to receive psychosocial and nutritional support.ConclusionDespite international aid, TB patients and PLWHA are facing misconceptions effects. There is a need to reinforce health education towards patients and healers, inside community, health centers and associations, and for specific settings. International aid must be adapted to specific targets and strategies implementing programs. Maintaining psychosocial and nutritional support is crucial for better outcomes of medication adherence. Individual counseling has to be centered among TB patients and PLWHA.

Published
2016

7. Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

Author

Wang, Sheng-Fan, Tsao, Ching-Han, Lin, Yu-Ting, Hsu, Daniel K, Chiang, Meng-Lin, Lo, Chia-Hui, Chien, Fan-Ching, Chen, Peilin, Chen, Yi-Ming Arthur, Chen, Huan-Yuan, and Liu, Fu-Tong

Subjects
Infectious Diseases, HIV/AIDS, Infection, Calcium-Binding Proteins, Cell Cycle Proteins, Endosomal Sorting Complexes Required for Transport, Galectin 3, HIV-1, Protein Binding, Virus Replication, gag Gene Products, Human Immunodeficiency Virus, Alix, galectin-3, viral budding, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology
Abstract

Galectin-3 has been reported to regulate the functions of a number of immune cell types. We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release. We hypothesized that galectin-3 plays a role in HIV-1 viral budding. Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding. We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells. Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix. HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions. We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix. Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association.

Published
2014

9. A Case-control Study of HIV Infection Among Incarcerated Female Drug Users: Impact of Sharing Needles and Having Drug-using Sexual Partners

Author

Peng, Eugene Yu-Chang, Yeh, Ching-Ying, Cheng, Shu-Hsing, Morisky, Donald E, Lan, Yu-Ching, Chen, Yi-Ming Arthur, Lyu, Shu-Yu, and Malow, Robert M

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Research, Drug Abuse (NIDA only), Substance Misuse, HIV/AIDS, Infectious Diseases, Infection, Good Health and Well Being, Adult, Aged, Case-Control Studies, Female, HIV Infections, Humans, Middle Aged, Needle Sharing, Sexual Behavior, Sexual Partners, Substance Abuse, Intravenous, case-control, female drug users, HIV, sharing needles, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences
Abstract

Background/purposeTaiwan experienced a rapid surge in human immunodeficiency virus (HIV) among injection drug users (IDUs) from 2003 to 2005. The male-to-female ratio of HIV cases decreased from 20:1 in 2003 to 6:1 in 2006. This change is primarily due to increasing numbers of female injection drug users in Taiwan. Our primary objective was to identify the risk factors associated with HIV infection among incarcerated female drug users.MethodsA case-control design involved recruitment of all eligible HIV-infected female inmates from all 24 prisons in Taiwan from November to December, 2007. Eligible HIV seronegative controls were chosen within the same prison and matched to the cases by age (within 3 years) and by history of illicit drug use. A subsample of these matches was randomly selected since there were many more eligible controls than HIV-infected cases. An anonymous self-administered questionnaire was completed with assistance from trained research assistants.ResultsA total of 114 cases and 149 control participants were recruited, with a response rate of 82% and 54%. Injectable heroin use was significantly greater (p = 0.02) among HIV-infected cases (93.0%) than un-infected controls (84.6%). Compared to seronegative controls, HIV-infected cases were more likely to share drug paraphernalia and have drug-using sexual partners. Multiple logistic regression analysis revealed that the number of imprisonments (between 2-5 times; OR = 5.23), sharing mainly dilutes (OR= 63.47), and sharing dilutes concurrently with needles (OR= 127.33) significantly predicted HIV seroconversion, after controlling for age and years of education.ConclusionSharing needles/dilutes and practicing unsafe intercourse with drug-using sexual partners places female drug users at considerable risk.

Published
2011

36. High prevalence of HIV-1 transmitted drug resistance and factors associated with time to virological failure and viral suppression in Taiwan

Author

Huang, Szu-Wei, primary, Shen, Mei-Chen, additional, Wang, Wen-Hung, additional, Li, Wei-You, additional, Wang, Jen-Hsien, additional, Tseng, Cheng-Yin, additional, Liu, Po-Yu, additional, Wang, Lih-Shinn, additional, Lee, Yu-Lin, additional, Chen, Yi-Ming Arthur, additional, Lee, Chun-Yuan, additional, Lu, Po-Liang, additional, and Wang, Sheng-Fan, additional

Published
2021
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49. Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure–Activity Relationship Analysis

Author

Kant, Rajni, primary, Yang, Ming-Hui, additional, Tseng, Chih-Hua, additional, Yen, Chia-Hung, additional, Li, Wei-You, additional, Tyan, Yu-Chang, additional, Chen, Marcelo, additional, Tzeng, Cherng-Chyi, additional, Chen, Wei-Cheng, additional, You, Kaiting, additional, Wang, Wen-Chieh, additional, Chen, Yeh-Long, additional, and Chen, Yi-Ming Arthur, additional

Published
2021
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