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32 results on '"Chen, Yedan"'

11. Pathologic nodal metastasis assessment using tumour‐derived molecular features in patients with lung adenocarcinoma

Author

Wang, Shijie, primary, Zhou, Zhiwei, additional, Wang, Song, additional, Guo, Rongyun, additional, Ma, Zeming, additional, Zhao, Dachuan, additional, Wang, Liang, additional, Liu, Yinan, additional, Ma, Yuanyuan, additional, Zhang, Jianzhi, additional, Wang, Sha, additional, Chen, Yedan, additional, Ou, Qiuxiang, additional, and Chen, Jinfeng, additional

Published
2024
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12. Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

Author

Liu, Si-Yang, Bao, Hua, Wang, Qun, Mao, Wei-Min, Chen, Yedan, Tong, Xiaoling, Xu, Song-Tao, Wu, Lin, Wei, Yu-Cheng, Liu, Yong-Yu, Chen, Chun, Cheng, Ying, Yin, Rong, Yang, Fan, Ren, Sheng-Xiang, Li, Xiao-Fei, Li, Jian, Huang, Cheng, Liu, Zhi-Dong, Xu, Shun, Chen, Ke-Neng, Xu, Shi-Dong, Liu, Lun-Xu, Yu, Ping, Wang, Bu-Hai, Ma, Hai-Tao, Yan, Hong-Hong, Dong, Song, Zhang, Xu-Chao, Su, Jian, Yang, Jin-Ji, Yang, Xue-Ning, Zhou, Qing, Wu, Xue, Shao, Yang, Zhong, Wen-Zhao, and Wu, Yi-Long

Published
2021
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14. In situ MgO nanoparticle-doped Janus electrospun dressing against bacterial invasion and immune imbalance for irregular wound healing.

Author

Zhou, Tao, Chen, Yedan, Fu, Liangmin, Wang, Shan, Ding, Haihu, Bai, Qiaosheng, Guan, Jingjing, and Mao, Yingji

Subjects
WOUND healing, BACTERIAL diseases, MAGNESIUM oxide, ELECTROSPINNING, HEALING, POLYCAPROLACTONE
Abstract

Owing to the unpredictable size of wounds and irregular edges formed by trauma, nanofibers' highly customizable and adherent in situ deposition can contribute to intervention in the healing process. However, electrospinning is limited by the constraints of conventional polymeric materials despite its potential for anti-inflammatory and antimicrobial properties. Here, inspired by the Janus structure and biochemistry of nanometal ions, we developed an in situ sprayed electrospinning method to overcome bacterial infections and immune imbalances during wound healing. The bilayer fiber scaffold has a hydrophobic outer layer composed of polycaprolactone (PCL) and a hydrophilic inner layer composed of gelatin, poly(L-lactic acid) (PLLA), and magnesium oxide nanoparticles, constituting the PCL/PLLA-gelatin-MgO (PPGM) electrospun scaffold. This electrospun scaffold blocked the colonization and growth of bacteria and remained stable on the wound for continuous anti-inflammatory properties to promote wound healing. Furthermore, PPGM electrospinning modulated collagen deposition and the inflammatory microenvironment in the full-thickness skin model, significantly accelerating vascularization and epithelialization progression. This personalized Janus electrospun scaffold has excellent potential as a new type of wound dressing for first aid and wound healthcare. [ABSTRACT FROM AUTHOR]

Published
2024
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15. sj-docx-1-tej-10.1177_20417314231180050 – Supplemental material for Disc regeneration by injectable fucoidan-methacrylated dextran hydrogels through mechanical transduction and macrophage immunomodulation

Author

Li, Weifeng, Zhou, Pinghui, Yan, Bomin, Qi, Meiyao, Chen, Yedan, Shang, Lijun, Guan, Jianzhong, Zhang, Li, and Mao, Yingji

Subjects
Dentistry not elsewhere classified, Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tej-10.1177_20417314231180050 for Disc regeneration by injectable fucoidan-methacrylated dextran hydrogels through mechanical transduction and macrophage immunomodulation by Weifeng Li, Pinghui Zhou, Bomin Yan, Meiyao Qi, Yedan Chen, Lijun Shang, Jianzhong Guan, Li Zhang and Yingji Mao in Journal of Tissue Engineering

Published
2023
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17. Identification of TCR rearrangements specific for genetic alterations in EGFR-mutated non-small cell lung cancer: results from the ADJUVANT-CTONG1104 trial

Author

Chen, Cunte, primary, Liu, Siyang Maggie, additional, Chen, Yedan, additional, Ou, Qiuxiang, additional, Bao, Hua, additional, Xu, Ling, additional, Zhang, Yikai, additional, Zhang, Jia-Tao, additional, Zhong, Wenzhao, additional, Zhou, Qing, additional, Yang, Xue-Ning, additional, Shao, Yang, additional, Wu, Yi-Long, additional, Liu, Si-Yang, additional, and Li, Yangqiu, additional

Published
2022
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20. Poor prognosis of intra‐tumoural TRBV6‐6 variants in EGFR‐mutant NSCLC: Results from the ADJUVANT‐CTONG1104 trial

Author

Chen, Cunte, primary, Liu, Siyang Maggie, additional, Chen, Yedan, additional, Han, Ming, additional, Ou, Qiuxiang, additional, Bao, Hua, additional, Xu, Ling, additional, Zhang, Yikai, additional, Zhang, Jia‐Tao, additional, Zhong, Wenzhao, additional, Zhou, Qing, additional, Yang, Xue‐Ning, additional, Shao, Yang, additional, Wu, Yi‐Long, additional, Liu, Si‐Yang, additional, and Li, Yangqiu, additional

Published
2022
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21. Predictive value of TCR Vβ-Jβ profile for adjuvant gefitinib in EGFR mutant NSCLC from ADJUVANT-CTONG 1104 trial

Author

Chen, Cunte, primary, Liu, Si-Yang Maggie, additional, Chen, Yedan, additional, Ou, Qiuxiang, additional, Bao, Hua, additional, Xu, Ling, additional, Zhang, Yikai, additional, Zhong, Wenzhao, additional, Zhou, Qing, additional, Yang, Xue-Ning, additional, Shao, Yang, additional, Wu, Yi-Long, additional, Liu, Si-Yang, additional, and Li, Yangqiu, additional

Published
2022
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23. Factors influencing quality of life and work of male nurses in Hainan Province: logistic regression analysis

Author

Zou, Yan, Wang, Haiyan, Chen, Yedan, Xie, Hai, Chen, Yingyao, and Wang, Guangwei

Subjects
Original Article
Abstract

Objective: The purpose of this study was to explore the factors affecting the quality of life and work of male nurses in Hainan Province, so as to provide a theoretical basis to improve the motivation of male nurses, reduce job-hopping intentions, and maintain the stability of labor force. Methods: A total of 393 male and 393 female nurses with registered nurse qualifications from 53 hospitals in Hainan Province were selected as the research subjects. The distribution in various hospital departments, quality of life, stress coping ability, social support and job satisfaction were compared. The factors affecting the quality of life of male nurses were analyzed. Results: Male nurses worked mainly in the intensive care unit (ICU), operating rooms and emergency departments, while female nurses worked mainly in general wards. There were significant differences in physical function, general health, social functioning, and mental health between male and female nurses (P0.05). Male nurses scored significantly lower than female nurses in objective support, subjective support, support utilization and total score (P

Published
2021

24. Genomic Signatures Define Three Subtypes of EGFR-Mutant Stage II-III NSCLC With Distinct Adjuvant Therapy Outcomes

Author

Si-Yang Liu, Ying Cheng, Fan Yang, Cheng Huang, Jian Li, Song-Tao Xu, Lin Wu, Ping Yu, Yongyu Liu, Qing Zhou, Hua Bao, Jian Su, Yang Shao, Xiao-Fei Li, Yu-Cheng Wei, Chun Chen, Xue Wu, Shi-Dong Xu, H. Ma, Ke-Neng Chen, Wei-Min Mao, Lunxu Liu, Wen-Zhao Zhong, Rong Yin, Shengxiang Ren, Hong-Hong Yan, Song Dong, Bu-Hai Wang, Shun Xu, Chen Yedan, Xu-Chao Zhang, Xue-Ning Yang, Qun Wang, Jin-Ji Yang, Zhidong Liu, Yi-Long Wu, and Xiaoling Tong

Subjects
Text mining, business.industry, Mutant, Adjuvant therapy, Cancer research, Biology, Stage ii, business, respiratory tract diseases
Abstract

The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival (DFS) of resected EGFR-mutant stage II-IIIA non-small cell lung cancer (NSCLC). However, not all patients experienced favorable clinical outcomes with TKI, raising the necessity for further biomarker assessment. By comprehensive genomic profiling of 171 tumor tissues from the ADJUVANT trial, five predictive biomarkers were identified (TP53 exon4/5 mutations, RB1 alterations, and copy number gains of NKX2-1, CDK4, and MYC. Then we integrated them into the Multiple-gene INdex to Evaluate the Relative benefit of Various Adjuvant therapies (MINERVA) score, which categorized patients into three subgroups with relative disease-free survival and overall survival benefits from either adjuvant gefitinib or chemotherapy (Highly TKI-Preferable, TKI-Preferable, and Chemotherapy-Preferable groups). This study demonstrates that predictive genomic signatures could potentially stratify resected EGFR-mutant NSCLC patients and provide precise guidance towards future personalized adjuvant therapy.

Published
2021
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25. Genomic Signatures Define Three Subtypes of EGFR-Mutant Stage II-III NSCLC With Distinct Adjuvant Therapy Outcomes

Author

Liu, Si-Yang, primary, Bao, Hua, additional, Wang, Qun, additional, Mao, Weimin, additional, Chen, Yedan, additional, Tong, Xiaoling, additional, Xu, Song-Tao, additional, Wu, Lin, additional, Wei, Yu-Cheng, additional, Liu, Yong-Yu, additional, Chen, Chun, additional, Cheng, Ying, additional, Yin, Rong, additional, Yang, Fan, additional, Ren, Shengxiang, additional, Li, Xiao-Fei, additional, Li, Jian, additional, Huang, Cheng, additional, Liu, Zhidong, additional, Xu, Shun, additional, Chen, Ke-Neng, additional, Xu, Shi-Dong, additional, Liu, Lunxu, additional, Yu, Ping, additional, Wang, Bu-Hai, additional, Ma, Haitao, additional, Yan, Hong-hong, additional, Dong, Song, additional, Zhang, Xu-Chao, additional, Su, Jian, additional, Yang, Jin-Ji, additional, Yang, Xue-Ning, additional, Zhou, Qing, additional, Wu, Xue, additional, Shao, Yang, additional, Zhong, Wen-Zhao, additional, and Wu, Yi-Long, additional

Published
2021
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27. Utilizing phenotypic characteristics of metastatic brain tumors to predict the probability of circulating tumor DNA detection from cerebrospinal fluid.

Author

Li, Meichen, primary, Li, Delan, additional, Hou, Xue, additional, Zhang, Xiangheng, additional, Wang, Na, additional, Liang, Jianzhong, additional, Chen, Jing, additional, Wang, Kaicheng, additional, Wang, Fufeng, additional, Chen, Yedan, additional, Zhang, Xian, additional, Bao, Hua, additional, Wu, Xue, additional, Wang, Xiaonan, additional, Shao, Yang, additional, and Chen, Likun, additional

Published
2020
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28. Genomic profiling identified novel prognostic biomarker in Chinsese glioma patients.

Author

Li, Hainan, primary, Shan, Changguo, additional, Fan, Chongzhu, additional, Wu, Shengnan, additional, Lai, Mingyao, additional, Cai, Linbo, additional, Zhu, Dan, additional, Wang, Fufeng, additional, Chen, Yedan, additional, Shi, Yuqian, additional, Liu, Kaihua, additional, Zhang, Xian, additional, Bao, Hua, additional, Wu, Xue, additional, Wang, Xiaonan, additional, Shao, Yang, additional, and Li, Zhi, additional

Published
2020
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30. Genomic Signature for Personalized Adjuvant Therapy in Resected EGFR-Mutant Stage II-III Non-Small Cell Lung Cancer: Results from Phase 3 ADJVANT/CTONG1104 Study

Author

Liu, Si-Yang, primary, Bao, Hua, additional, Wang, Qun, additional, Mao, Wei-Min, additional, Chen, Yedan, additional, Tong, Xiaoling, additional, Wu, Lin, additional, Chen, Chun, additional, Cheng, Ying, additional, Yan, Hong-Hong, additional, Dong, Song, additional, Zhang, Xu-Chao, additional, Su, Jian, additional, Yang, Jin-Ji, additional, Yang, Xue-Ning, additional, Zhou, Qing, additional, Wu, Xue, additional, Shao, Yang, additional, Zhong, Wen-Zhao, additional, and Wu, Yi-Long, additional

Published
2020
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31. In situMgO nanoparticle-doped Janus electrospun dressing against bacterial invasion and immune imbalance for irregular wound healing

Author

Zhou, Tao, Chen, Yedan, Fu, Liangmin, Wang, Shan, Ding, Haihu, Bai, Qiaosheng, Guan, Jingjing, and Mao, Yingji

Abstract

Owing to the unpredictable size of wounds and irregular edges formed by trauma, nanofibers’ highly customizable and adherent in situdeposition can contribute to intervention in the healing process. However, electrospinning is limited by the constraints of conventional polymeric materials despite its potential for anti-inflammatory and antimicrobial properties. Here, inspired by the Janus structure and biochemistry of nanometal ions, we developed an in situsprayed electrospinning method to overcome bacterial infections and immune imbalances during wound healing. The bilayer fiber scaffold has a hydrophobic outer layer composed of polycaprolactone (PCL) and a hydrophilic inner layer composed of gelatin, poly(L-lactic acid) (PLLA), and magnesium oxide nanoparticles, constituting the PCL/PLLA-gelatin-MgO (PPGM) electrospun scaffold. This electrospun scaffold blocked the colonization and growth of bacteria and remained stable on the wound for continuous anti-inflammatory properties to promote wound healing. Furthermore, PPGM electrospinning modulated collagen deposition and the inflammatory microenvironment in the full-thickness skin model, significantly accelerating vascularization and epithelialization progression. This personalized Janus electrospun scaffold has excellent potential as a new type of wound dressing for first aid and wound healthcare.

Published
2024
Full Text
View/download PDF

32. Factors influencing quality of life and work of male nurses in Hainan Province: logistic regression analysis.

Author

Zou Y, Wang H, Chen Y, Xie H, Chen Y, and Wang G

Abstract

Objective: The purpose of this study was to explore the factors affecting the quality of life and work of male nurses in Hainan Province, so as to provide a theoretical basis to improve the motivation of male nurses, reduce job-hopping intentions, and maintain the stability of labor force., Methods: A total of 393 male and 393 female nurses with registered nurse qualifications from 53 hospitals in Hainan Province were selected as the research subjects. The distribution in various hospital departments, quality of life, stress coping ability, social support and job satisfaction were compared. The factors affecting the quality of life of male nurses were analyzed., Results: Male nurses worked mainly in the intensive care unit (ICU), operating rooms and emergency departments, while female nurses worked mainly in general wards. There were significant differences in physical function, general health, social functioning, and mental health between male and female nurses (P<0.05), and female nurses had significantly higher Physical Component Summary and Mental Component Summary scores than male nurses (P<0.05). There was no significant difference in coping styles between male and female nurses in stressful working environments (P>0.05). Male nurses scored significantly lower than female nurses in objective support, subjective support, support utilization and total score (P<0.05), and male nurses exhibited significantly lower job satisfaction than female nurses (P<0.05). Univariate and multivariate analyses showed that years of experience, work unit, monthly income, social support and job satisfaction were the independent risk factors affecting the quality of life of male nurses., Conclusion: Male nurses in Hainan Province mostly worked in departments with high work intensity and pressure, and the overall quality of life, social support and job satisfaction were significantly lower than those of female nurses. Therefore, psychological guidance for male nurses should be strengthened, the salary of male nurses should be increased, higher social support should be provided, to reduce job burnout and thus improve their quality of life., Competing Interests: None., (AJTR Copyright © 2022.)

Published
2022

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