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11. Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study.

Author

Huang, Ze-Gui, Gao, Jing-Wei, Chen, Zhi-Teng, Zhang, Hai-Feng, You, Si, Xiong, Zhuo-Chao, Wu, Yu-Biao, Gao, Qing-Yuan, Wang, Jing-Feng, Chen, Yang-Xin, Zhang, Shao-Ling, and Liu, Pin-Ming

Subjects
PROPORTIONAL hazards models, TYPE 2 diabetes, CARDIOVASCULAR diseases risk factors, LDL cholesterol, HEART failure
Abstract

OBJECTIVE: The impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D) was evaluated in this study. RESEARCH DESIGN AND METHODS: This prospective study included 11,949 individuals diagnosed with T2D, matched with 47,796 non-T2D control study participants from the UK Biobank cohort. The degree of comprehensive risk factor control was assessed on the basis of the major cardiovascular risk factors, including blood pressure, BMI, LDL cholesterol, hemoglobin A1c, renal function, smoking, diet, and physical activity. Cox proportional hazards models were used to measure the associations between the degree of risk factor control and HF risk. Irwin's restricted mean was used to evaluate HF-free survival time. RESULTS: During a median follow-up of 12.3 years, 702 individuals (5.87%) with T2D and 1,402 matched control participants (2.93%) developed HF. Each additional risk factor controlled was associated with an average 19% lower risk of HF. Optimal control of at least six risk factors was associated with a 67% lower HF risk (hazard ratio [HR] 0.33; 95% CI 0.20, 0.54). BMI was the primary attributable risk factor for HF. Notably, the excess risk of HF associated with T2D could be attenuated to levels comparable to those of non-T2D control participants when individuals had a high degree of risk factor control (HR 0.66; 95% CI 0.40, 1.07), and they exhibited a longer HF-free survival time. CONCLUSIONS: Comprehensive management of risk factors is inversely associated with HF risk, and optimal risk factor control may prolong HF-free survival time among individuals with T2D. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Sleep Patterns and Traditional Cardiovascular Health Metrics: Joint Impact on Major Adverse Cardiovascular Events in a Prospective Cohort Study

Author

You, Si, primary, Zhang, Hai‐Feng, additional, Zhang, Shao‐Ling, additional, Gao, Qing‐Yuan, additional, Cai, Yang‐Wei, additional, Huang, Ze‐Gui, additional, Wu, Yu‐Biao, additional, Chen, Yang‐Xin, additional, Wang, Jing‐Feng, additional, Gao, Jing‐Wei, additional, and Liu, Pin‐Ming, additional

Published
2024
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15. Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study

Author

Huang, Ze‐Gui, primary, Gao, Jing‐Wei, additional, Zhang, Hai‐Feng, additional, You, Si, additional, Xiong, Zhuo‐Chao, additional, Wu, Yu‐Biao, additional, Guo, Da‐Chuan, additional, Wang, Jing‐Feng, additional, Chen, Yang‐Xin, additional, Zhang, Shao‐Ling, additional, and Liu, Pin‐Ming, additional

Published
2024
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28. Glycolysis Inhibition Alleviates Cardiac Fibrosis After Myocardial Infarction by Suppressing Cardiac Fibroblast Activation

Author

Chen, Zhi-Teng, primary, Gao, Qing-Yuan, additional, Wu, Mao-Xiong, additional, Wang, Meng, additional, Sun, Run-Lu, additional, Jiang, Yuan, additional, Guo, Qi, additional, Guo, Da-Chuan, additional, Liu, Chi-Yu, additional, Chen, Si-Xu, additional, Liu, Xiao, additional, Wang, Jing-Feng, additional, Zhang, Hai-Feng, additional, and Chen, Yang-Xin, additional

Published
2021
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31. Additional file 1 of C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia

Author

Chen, Jia-Yuan, Zhu, Xiao-Lin, Liu, Wen-Hao, Xie, Yong, Zhang, Hai-Feng, Wang, XiaoQiao, Ying, Ru, Zhi-Teng Chen, Mao-Xiong Wu, Qiu, Qiong, Wang, Jing-Feng, and Chen, Yang-Xin

Abstract

Additional file 1: Figure S1. Comparison of neointima thickness in the presence of wild-type and CRPTG PVAT transplantation without wire injury. Figure S2. Comparison of plama mouse C-reactive protein in WT mice received wild-type and CRPTG PVAT transplantation. Figure S3. Comparison of plama mouse CXCL-7 in CRPTG and wild-type mice.

Published
2020
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32. Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation

Author

Gao, Qing-Yuan, primary, Zhang, Hai-Feng, additional, Tao, Jun, additional, Chen, Zhi-Teng, additional, Liu, Chi-Yu, additional, Liu, Wen-Hao, additional, Wu, Mao-Xiong, additional, Yin, Wen-Yao, additional, Gao, Guang-Hao, additional, Xie, Yong, additional, Yang, Ying, additional, Liu, Pin-Ming, additional, Wang, Jing-Feng, additional, and Chen, Yang-Xin, additional

Published
2021
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34. Interleukin‐33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin‐like growth factor‐binding protein 3

Author

Wu, Mao‐Xiong, primary, Wang, Shao‐Hua, additional, Xie, Yong, additional, Chen, Zhi‐Teng, additional, Guo, Qi, additional, Yuan, Wo‐Liang, additional, Guan, Chang, additional, Xu, Cheng‐Zhang, additional, Huang, Yu‐Na, additional, Wang, Jing‐Feng, additional, Zhang, Hai‐Feng, additional, and Chen, Yang‐Xin, additional

Published
2020
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35. Long non-coding RNA Linc00092 inhibits cardiac fibroblast activation by altering glycolysis in an ERK-dependent manner

Author

Chen, Zhi-Teng, primary, Zhang, Hai-Feng, additional, Wang, Meng, additional, Wang, Shao-Hua, additional, Wen, Zhu-Zhi, additional, Gao, Qing-Yuan, additional, Wu, Mao-Xiong, additional, Liu, Wen-Hao, additional, Xie, Yong, additional, Mai, Jing-Ting, additional, Yang, Ying, additional, Wang, Jing-Feng, additional, and Chen, Yang-Xin, additional

Published
2020
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39. Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress

Author

Zhang Hai-Feng, Xie Shuang-Lun, Chen Yang-Xin, Mai Jing-Ting, Wang Jing-Feng, Zhu Wa-Li, and Zhu Li-Guang

Subjects
Chronic heart failure, Interleukin-33, Soluble ST2, Oxidative stress, Medicine
Abstract

Abstract Background Interleukin-33 (IL-33) has been linked to chronic heart failure (CHF) in animal studies, but data on serum IL-33 levels in human CHF are not available. We analyzed levels of IL-33 in serum, and investigated the possible role of IL-33 in oxidative stress. Methods A total of 191 subjects with advanced systolic CHF (CHF group), 175 patients with pre-existing cardiac diseases but no CHF (non-CHF group), and 177 healthy controls (HC group) were enrolled. Serum levels of IL-33, soluble ST2 (sST2) and N-terminal-pro-brain natriuretic peptide (NT-proBNP), malondialdehyde (MDA) content, erythrocyte superoxide dismutase (eSOD) activity, as well as left ventricular ejection fraction (LVEF), were determined. The exact form of IL-33 in serum was identified. Effects of IL-33 and sST2 on MDA content and SOD activity in angiotensin (Ang II)-stimulated AC16 cells were assessed. Results Serum levels of IL-33 and sST2 were elevated in CHF patients, whereas IL-33/sST2 ratios were decreased. In CHF patients, pre-existing cardiac diseases and medications used upon hospital admission did not affect IL-33 concentrations or the IL-33/sST2 ratio. Full-length IL-33, which could not be detected in serum from HC and barely detected in non-CHF patients, was significantly up-regulated in CHF patients. IL-33 levels were positively correlated with markers of CHF severity. IL-33/sST2 ratios were slightly and negatively related to MDA concentrations. IL-33 directly reduced MDA and enhanced SOD activity in Ang II-stimulated AC16 cells, which were greatly attenuated by sST2. Conclusions Serum levels of IL-33, especially the full-length form, were elevated in CHF patients whereas IL-33 bioactivity was reduced. In advanced CHF, IL-33 may exert anti-oxidation effects, which may be overwhelmed by concurrently elevated levels of sST2.

Published
2012
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41. Interleukin‐33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin‐like growth factor‐binding protein 3.

Author

Wu, Mao‐Xiong, Wang, Shao‐Hua, Xie, Yong, Chen, Zhi‐Teng, Guo, Qi, Yuan, Wo‐Liang, Guan, Chang, Xu, Cheng‐Zhang, Huang, Yu‐Na, Wang, Jing‐Feng, Zhang, Hai‐Feng, and Chen, Yang‐Xin

Subjects
INSULIN-like growth factor-binding proteins, ENDOPLASMIC reticulum, DIABETIC cardiomyopathy, INTERLEUKIN-33, AUTOPHAGY, SOMATOMEDIN C
Abstract

Prolonged endoplasmic reticulum (ER) stress is the key driving force behind diabetic cardiomyopathy (DCM). Autophagy is extensively implicated in adaptive mechanisms for cell survival. Interleukin‐33 (IL‐33) is known to be a potent cardiac protector, but its roles in DCM, ER stress, and autophagy are currently unknown. We aimed to explore the effects of IL‐33 on DCM and characterize the roles that ER stress and autophagy play in DCM. The effects of IL‐33 on DCM, ER stress, and autophagy were characterized both in db/db mice and in palmitic acid (PA)‐treated cardiomyocytes. The manipulators of ER stress and autophagy were used to clarify their roles in DCM remittance conferred by IL‐33. Gene expression analysis was used to identify IL‐33‐dependent regulators of ER stress and autophagy. Both db/db mice and PA‐treated cells presented with enhanced levels of ER stress, apoptosis, and lipid deposition, as well as impaired autophagy, all of which could be reversed by IL‐33. Treatment with IL‐33 improved the cardiac diastolic function of diabetic mice. Nonselective autophagy inhibitors, such as 3‐methyladenine (3‐MA) or wortmannin, abolished the protective effects of IL‐33, resulting in an increase in both ER stress and apoptosis. Strikingly, insulin‐like growth factor‐binding protein 3 (IGFBP3) was identified as the gene most significantly differentially expressed between IL‐33 and control groups. Knockdown of IGFBP3 expression, similar to the effect of nonselective autophagy inhibitors, resulted in high levels of ER stress, impaired autophagy, and apoptosis that were not rescued upon treatment with IL‐33. IL‐33 abates DCM by alleviating ER stress and promoting autophagy. IGFBP3 is essential for IL‐33‐induced ER stress resolution and autophagic enhancement during DCM. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Macrophage-derived foam cells impair endothelial barrier function by inducing endothelial-mesenchymal transition via CCL-4

Author

Yang, Ying, primary, Luo, Nian-Sang, additional, Ying, Ru, additional, Xie, Yong, additional, Chen, Jia-Yuan, additional, Wang, Xiao-Qiao, additional, Gu, Zhen-Jie, additional, Mai, Jing-Ting, additional, Liu, Wen-Hao, additional, Wu, Mao-Xiong, additional, Chen, Zhi-Teng, additional, Fang, Yong-Biao, additional, Zhang, Hai-Feng, additional, Zuo, Zhi-Yi, additional, Wang, Jing-Feng, additional, and Chen, Yang-Xin, additional

Published
2017
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46. High density lipoprotein from coronary artery disease patients caused abnormal expression of long non-coding RNAs in vascular endothelial cells

Author

Liu, Xiang, primary, Wang, Tian-Tian, additional, Li, Yan, additional, Shi, Mao-Mao, additional, Li, Hua-Ming, additional, Yuan, Hao-Xiang, additional, Mo, Zhi-Wei, additional, Chen, Jing, additional, Zhang, Bin, additional, Chen, Yang-Xin, additional, Wang, Jing-Feng, additional, Dai, Wei-Ping, additional, Xu, Ying-Qi, additional, Wang, Zhi-Ping, additional, Zhang, Xi, additional, Ou, Zhi-Jun, additional, and Ou, Jing-Song, additional

Published
2017
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