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With the deepening of environmental governance, the overall environmental quality of the region has been improved. However, internal environmental inequality, especially urban–rural environmental inequality, has continued to come to the fore. Nevertheless, there are still few studies on how to mitigate the increasing urban–rural environmental inequality. On the basis of examining the urban–rural environmental inequality in China's environmental emission reduction investment dimension, this research verified the impact and mechanism of informal regulatory forces (grassroots party organizations) in alleviating urban–rural environmental inequality. In particular, based on an empirical analysis of data from the Chinese Private Enterprise Survey (CPES) 2006–2014, this study found that (1) investment in environmental management of polluting enterprises in rural areas is significantly lower than in urban areas, and the trend of urban–rural environmental inequality is intensifying; (2) urban–rural environmental inequality is more pronounced at the enterprise level in areas with larger enterprises and greater environmental enforcement and that urban-centered environmental regulatory policies continue to exacerbate urban–rural environmental inequality; and (3) the embeddedness of regional party organizations can narrow the gap between urban and rural environmental protection investment by private enterprises and alleviate urban–rural environmental inequality. The specific pathway is to improve rural enterprises' social responsibility awareness and policy implementation. Based on the above findings, this paper argues that a gradual break with "urban-centered environmentalism" is the fundamental solution to urban–rural environmental inequality. However, in the current context of limited resources for formal environmental regulation, the power of informal environmental regulation can still mitigate these effects. [ABSTRACT FROM AUTHOR]

Background: Adaptive immunity is an important disease mediator of pulmonary vascular remodeling during pulmonary hypertension (PH) development, especially T‐cells lymphocytes. However, data for bibliometric analysis of T cell immunity in PH is currently vacant. This aimed to provide a comprehensive and visualized view of T‐cells research in PH pathogenesis and to lay a solid foundation for further studies. Methods: The data was acquired from the Web of Science Core Collection database. Web of Science analytic tool was used to analysis the publication years, authors, journals, countries, and organizations. CiteSpace 6.2.R3, VOSviewer 1.6.16, and Scimago Graphica 1.0.35.0 were applied to conduct a visualization bibliometric analysis about authors, countries, institutions, journals, references, and keywords. Results: Nine hundred and eight publications from 1992 to 2022 were included in the analysis. The results showed that Humbert Marc was the most prolific author. American Journal of Physiology Lung Cellular and Molecular Physiology had the most related articles. The institution with the most articles was Udice French Research University. The United States was far ahead in the article output. Keywords analysis showed that "Pulmonary hypertension" was the most usually appeared keyword in the relevant literature, and included "T‐cells", "Regulatory T cells", and "Activated T cell." "miRNA" of reference co‐citation clustering analysis demonstrated the possible T‐cell immunity activation mechanisms in PH. The most cited literature was published in the European Heart Journal by Galie N in 2016. The strongest citation burst of keyword is "gene expression" and terms such as "vascular remodeling," "growth," "proliferation," and "fibrosis" are among the list, indicating that T‐cells interact with stromal vascular cells to induce pulmonary vascular remodeling. The strongest burst of cited reference is "Galie N, 2016." Conclusions: T‐cell immunity is an important pathogenesis mechanism for PH development, which may have interaction with miRNAs and stromal vascular cells, but the possible T‐cell immunity activation mechanisms in PH need to be investigated further. [ABSTRACT FROM AUTHOR]

Due to the large amount of waste generated by urban construction, the transportation of construction waste has a significant impact on urban traffic. Understanding the transportation trajectory of garbage trucks can improve the management of transportation routes and reduce traffic accidents. This study analyzes electric waybill and state data of garbage trucks to identify hot nodes of construction waste transportation, where the volume of garbage trucks is relatively high. Management should strengthen the hot nodes to reduce traffic accidents. First, several machine learning methods are used to improve the prediction accuracy of electric waybill generation, where the garbage truck recorded on the electric waybill is regarded as a working truck. Second, the transportation trajectory of working trucks is extracted, and its spatiotemporal characteristics are further analyzed. Hot nodes are found based on density clustering. Finally, a case study is conducted based on the Shenzhen construction waste transportation system. The results show that the XGBoost model can improve the accuracy of the generation of waybill to 90.5% compared with the decision tree model, random forest, and GBDT. Moreover, the density clustering model can discover the hot nodes of construction waste transportation. Considering the minimum number of samples and the neighborhood radius, the clustering number is determined as 100. The ratio of noise points is determined as 0.79. The results can provide decision support for the management of electronic waybill and garbage truck transportation., Author(s): Jun Bi [1,2]; Qiuyue Sai (corresponding author) [2]; Fujun Wang [2]; Yakun Chen [2] 1. Introduction Along with urbanization, the renovation and expansion of construction have produced a large [...]

Abstract Progerin is a truncated form of lamin A. It is identified in patients with Hutchinson-Gilford progeria syndrome (HGPS), a disease characterized by accelerated aging. The contribution of progerin toward aging has been shown to be related to increased DNA damages. Since aging is one major risk factor for carcinogenesis, and genomic instability is a hallmark of malignant cancers, we investigated the expression of progerin in human cancer cells, and whether its expression contributes to carcinogenesis. Using RT-PCR and Western blotting, we detected the expression of progerin in prostate PC-3, DU145 and LNCaP cells at mRNA and protein levels. Ectopic progerin expression did not cause cellular senescence in PC-3 or MCF7 cells. PC-3 cells progerin transfectants were sensitized to DNA damage agent camptothecin (CPT); and persistent DNA damage responses were observed, which might be caused by progerin induced defective DNA damage repair. In addition, progerin transfectants were more tumorigenic in vivo than vector control cells. Our study for the first time describes the expression of progerin in a number of human cancer cell lines and its contributory role in tumorigenesis.

The article explores a confidential group-lending dataset from a Chinese commercial bank based on a policy shock of China's government; and evidences that social capital determinants, proxied by consanguinity, geographical and business relationship, play significant roles in improving the repayment performance of small group-loan, meanwhile commercial bank can earn favourable benefits. Our results enlighten that commercial financial institutions can alleviate poverty by combining small group-loan with the guarantees of social capital together. [ABSTRACT FROM AUTHOR]