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382 results on '"Chen, Xiuqin"'

4. Analysis of risk factors for multi-drug resistant bacterial infections and prevention and control based on logistic regression analysis

Author

Guo Changcheng, Jia Liping, Li Yan, Chen Xiuqin, and Yang Kun

Subjects
logistic regression, multilayer neural network, convolutional network model, multi-drug resistant bacteria, preventive control, 68t27, Mathematics, QA1-939
Abstract

Logistic regression and neural networks have developed rapidly in recent years, and the poor diet of people in modern society has led to the emergence of various diseases in which drug-resistant bacterial infections occur during treatment, so this paper proposes logistic regression to analyze risk factors and preventive control of multi-drug-resistant bacterial infections. A logistic regression model was established to determine the magnitude of the effect of each factor on the dependent variable based on the standardized values, and the prevalence was recoded in the prediction stage, with the screened indicators serving as factors and covariates. The number of neurons in the input and output layers is determined, and the weights are continuously adjusted in iterations to calculate the average error rate between the actual number of morbidities and the predicted values. The gradient explosion and dispersion problems of in-depth analysis are solved by selecting the maximum probability for classification. The error values were calculated by using the cost function, adjusting the model parameters, comparing the errors between predicted and observed values, and updating the weights with the hidden layer error values, thus improving the accuracy of the model for analyzing risk factors of multi-drug resistant bacterial infections and preventing and controlling the deterioration of the disease. The analysis of the results showed that the logistic regression analysis method, using the area of the ROC curve as a discriminant, yielded an AUC of 0.831 in this study, which combined with the neural network model to predict multi-drug resistant bacteria infections with a higher accuracy of 85.6%, identify the potential risk of multi-drug resistant bacteria occurrence, and prevent the aggravation of the infection.

Published
2024
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13. Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

Author

Yan, Pianpian, primary, Chelliah, Ramachandran, additional, Jo, Kyoung Hee, additional, Chen, Xiuqin, additional, Tyagi, Akanksha, additional, Jo, Hyeon Yeong, additional, Elahi, Fazle, additional, Woo, Nam Chan, additional, Wook, Min Seung, additional, and Oh, Deog Hwan, additional

Published
2024
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26. Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureusbiofilm on food contact surface

Author

Yan, Pianpian, Chelliah, Ramachandran, Jo, Kyoung Hee, Chen, Xiuqin, Tyagi, Akanksha, Jo, Hyeon Yeong, Elahi, Fazle, Woo, Nam Chan, Wook, Min Seung, and Oh, Deog Hwan

Abstract

Slightly acidic electrolyzed water (SAEW) has proven to be an efficient and novel sanitizer in food and agriculture field. This study assessed the efficacy of SAEW (30 mg/L) at 40 °C on the inactivation of foodborne pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA) biofilm. Furthermore, the underlying mechanism of MRSA biofilm under heated SAEW at 40 °C treatment on metabolic profiles was investigated. The results showed that the heated SAEW at 40 °C significantly effectively against foodborne pathogens of 1.96–7.56 (lg (CFU/g)) reduction in pork, chicken, spinach, and lettuce. The heated SAEW at 40 °C treatment significantly reduced MRSA biofilm cells by 2.41 (lg (CFU/cm2)). The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell membranes. Global metabolic response of MRSA biofilms, treated by SAEW at 40 °C, revealed the alterations of intracellular metabolites, including amino acids, organic acid, fatty acid, and lipid. Moreover, signaling pathways involved in amino acid metabolism, energy metabolism, nucleotide synthesis, carbohydrate metabolites, and lipid biosynthesis were functionally disrupted by the SAEW at 40 °C treatment. As per our knowledge, this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

Published
2024
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28. Probiotic Effector Compounds: Current Knowledge and Future Perspectives

Author

Eric Banan-Mwine Daliri, Fred Kwame Ofosu, Chen Xiuqin, Ramachandran Chelliah, and Deog-Hwan Oh

Subjects
microbiota, gut barrier functions, immune system, cholesterol reduction, nervous system, Microbiology, QR1-502
Abstract

Understanding the mechanism behind probiotic action will enable a rational selection of probiotics, increase the chances of success in clinical studies and make it easy to substantiate health claims. However, most probiotic studies over the years have rather focused on the effects of probiotics in health and disease, whereas little is known about the specific molecules that trigger effects in hosts. This makes it difficult to describe the detailed mechanism by which a given probiotic functions. Probiotics communicate with their hosts through molecular signaling. Meanwhile, since the molecules produced by probiotics under in vitro conditions may differ from those produced in vivo, in vitro mechanistic studies would have to be conducted under conditions that mimic gastrointestinal conditions as much as possible. The ideal situation would, however, be to carry out well-designed clinical trials in humans (or the target animal) using adequate quantities of the suspected probiotic molecule(s) or adequate quantities of isogenic knock-out or knock-in probiotic mutants. In this review, we discuss our current knowledge about probiotic bacteria and yeast molecules that are involved in molecular signaling with the host. We also discuss the challenges and future perspectives in the search for probiotic effector molecules.

Published
2021
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40. Acidity-Driven Bidirectional Room-Temperature Spin-State Switch and Fluorescence Modulation of a Mononuclear Fe(II) Complex

Author

Chen Xiuqin, Ming-Liang Tong, Yi-Shan Ye, Xin Bao, and Kai-Yan Shen

Subjects
Materials science, Spin states, Chemical physics, Fluorescence modulation, General Chemistry
Abstract

Room-temperature switchable materials showing multiple responses toward external stimuli are highly desired. Herein, we report bidirectional spin-state switch and fluorescence modulation of an Fe(I...

Published
2021

46. Additional file 1 of Sleep characteristic profiles and the correlation with spectrum of metabolic syndrome among older adult: a cross-sectional study

Author

Liu, Xin, Huang, Limei, Wu, Qiang, Chen, Yingwei, Chen, Xiuqin, Chen, Hao, Gao, Junling, and Xiao, Qianyi

Abstract

Additional file 1: Table S1.The association between sleep efficiency and MetS and MetS compinents. (Included the participants whosesleep efficiency greater than 1 and classified them into group of sleep efficiency≥ 85%.).

Published
2022
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