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This paper focuses on modeling mixed traffic flow that comprises human-driven vehicles (HV), adaptive cruise control (ACC) vehicles, and cooperative adaptive cruise control (CACC) vehicles in the off-ramp diverging area. The car-following behaviors of HVs, ACC vehicles, and CACC vehicles are modeled using an intelligent driver model (IDM), ACC car-following model, and CACC car-following model, respectively. The lane-changing behaviors of different types of vehicles in off-ramp diverging areas are modeled using the anticipatory lane change (ALC) model and the mandatory lane change (MLC) model. These models are important for describing the interaction among different types of vehicles in mixed traffic. The safety and efficiency of mixed traffic flow are analyzed by integrating the developed car-following models and lane-changing models in numerical simulation. A one-way, two-lane scenario is established for the simulation. The results reveal that when the proportion of CACC vehicles is about 0.6, the safety and general operating efficiency of mixed traffic flow in the off-ramp area deteriorate significantly. Increasing the conservative MLC zone length can improve the average speed of traffic flow. Guiding drivers in changing lanes is one way to improve the efficiency of traffic flow. [ABSTRACT FROM AUTHOR]

Background: In recent years, elucidating the actual state of the liver nervous system has attracted attention, owing to clinical needs, such as liver transplantation. Conventional methods for studying the intrahepatic nerve distribution mostly use liver tissue sections, specific markers for immunohistological studies, or anterograde/retrograde tracing in animals. However, knowledge of the three-dimensional structure of intrahepatic innervation is vague or speculative., Materials and Methods: In this study, Suncus murinus (Suncus) (n = 10) were perfused and fixed, the livers were excised, and the liver parenchyma was carefully removed, leaving only the intrahepatic vasculature. Specimens were prepared to study the three-dimensional structure of Suncus intrahepatic and hilar innervation by whole-mount immunohistochemical staining using a neurofilament protein antibody., Results: After the nerves running along the intrahepatic arterial system entered the liver parenchyma from the hepatic hilum, they maintained a relatively rich distribution along the interlobular arteries until the distal end. The innervation of the portal system began to decrease after entering the liver parenchyma and decreased significantly after reaching the deep parts. By the time it reached the end of the interlobular vein, there was very little left. The number of nerves running along the intrahepatic bile duct system was significantly reduced after entering the porta hepatis, and innervation was difficult to observe after completely entering the liver parenchyma., Conclusions: Whole-mount immunohistochemical analyses with an anti-NFP antibody showed that intrahepatic innervation mainly accompanied the hepatic interlobular arteries and extended to their terminal ends. Neuronal regulation is very important in the functional regulation of intrahepatic nutritional vessels. However, there were very few NFP-immunoreactive nerves accompanying the intrahepatic bile duct system, possibly suggesting that the functional regulation of the intrahepatic biliary system mainly relies on hormones and neuropeptides.