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26. Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials.

Author

Huang, Dongqing, Liao, Wang, Li, Jun, Chen, Tongkai, Wang, Xinlu, Zhao, Ruiyue, Zhang, Lingyan, Yu, Xuefeng, Zheng, Dong, and Luan, Ping

Subjects
ALZHEIMER'S disease, OLDER people, DONEPEZIL, NEURODEGENERATION, MEMORY loss, DRUG design
Abstract

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that constitutes the third most common cause of death among elderly individuals. AD patients suffer from behavioral problems regularly, like memory loss, thinking deficits, and cognitive disorders. Currently, the incidence rate of AD has been on the rise worldwide. Therefore, it is imperative to develop effective strategies for the treatment and prevention of AD. The inherent characteristics of low‐dimensional nanomaterials, primarily their smaller size and surface structure, make them well‐suited for fulfilling the essential requirements of therapeutic drug design. Consequently, these nanomaterials offer a highly appealing and alternative approach to treating AD. Here, the low‐dimensional nanomaterials used in the treatment of AD to provide new ideas, methods, and comprehensive perspectives for the management of AD are reviewed. This review will advance the comprehensive understanding of the potential of low‐dimensional nanomaterials in the field of neuro medicine, which also will have a positive impact on future research. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment

Author

Zhao,Yuying, Tan,Hanxu, Zhang,Juping, Pan,Bo, Wang,Neng, Chen,Tongkai, Shi,Yafei, Wang,Zhiyu, Zhao,Yuying, Tan,Hanxu, Zhang,Juping, Pan,Bo, Wang,Neng, Chen,Tongkai, Shi,Yafei, and Wang,Zhiyu

Abstract

Yuying Zhao,1 Hanxu Tan,2 Juping Zhang,1,3 Bo Pan,1 Neng Wang,2 Tongkai Chen,4 Yafei Shi,1,2 Zhiyu Wang1,3,5 1State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2The Research Center for Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 3Guangdong-Hong Kong-Macau Joint Laboratory on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 4Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 5Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Zhiyu Wang; Yafei Shi, Email wangzhiyu@gzucm.edu.cn; shiyafei@gzucm.edu.cnAbstract: Lipid-structured vesicles have been applied for drug delivery system for over 50 years. Based on their origin, lipid-structured vesicles are divided into two main categories, namely synthetic lipid vesicles (SLNVEs) and vesicles of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-cancer drugs, their biocompatibility is poor and degradation of exogenous substances is a potential risk. Unlike SLNVEs, MDVEs have excellent biocompatibility but are limited by a lack of stability and a risk of contamination by dangerous pathogens from donor cells. Since the first discovery of plant-derived vesicles (PDVEs) in carrot cell supernatants in 1967, emerging evidence has shown that PDVEs integrate the advantages of both SLNVEs and MDVEs. Notably, 55 years of dedicated research has indicated that PDVEs are an ideal candidate vesicle fo

Published
2023

39. Nanobiotechnology: Applications in Chronic Wound Healing

Author

Jiang,Tao, Li,Qianyun, Qiu,Jinmei, Chen,Jing, Du,Shuang, Xu,Xiang, Wu,Zihan, Yang,Xiaofan, Chen,Zhenbing, and Chen,Tongkai

Subjects
International Journal of Nanomedicine
Abstract

Tao Jiang,1,* Qianyun Li,1,* Jinmei Qiu,2 Jing Chen,1 Shuang Du,2 Xiang Xu,1 Zihan Wu,1 Xiaofan Yang,1 Zhenbing Chen,1 Tongkai Chen2 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenbing Chen, Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, People’s Republic of China, Tel +86 13871103730, Email zbchen@hust.edu.cn Tongkai Chen, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, 510405, People’s Republic of China, Tel +86 20 36585707, Email chentongkai@gzucm.edu.cnAbstract: Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.Keywords: nanobiotechnology, chronic wound healing, scaffold systems, cell-carrying systems, stimuli-responsive systems

Published
2022

41. Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment

Author

Mo,Yousheng, Liu,Wei, Liu,Piaoxue, Liu,Qiao, Yuan,Zhongyu, Wang,Qi, Yuan,Dongsheng, Chen,Xiao-Jia, Chen,Tongkai, Mo,Yousheng, Liu,Wei, Liu,Piaoxue, Liu,Qiao, Yuan,Zhongyu, Wang,Qi, Yuan,Dongsheng, Chen,Xiao-Jia, and Chen,Tongkai

Abstract

Yousheng Mo,1,* Wei Liu,2,* Piaoxue Liu,2 Qiao Liu,3 Zhongyu Yuan,4 Qi Wang,2 Dongsheng Yuan,2 Xiao-Jia Chen,3 Tongkai Chen2 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-Sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Jia Chen; Tongkai Chen, Email xiaojiachen@um.edu.mo; chentongkai@gzucm.edu.cnBackground: Breast cancer (BC) has the highest global prevalence among all malignancies in women and the second highest prevalence in the overall population. Paclitaxel (PTX), a tricyclic diterpenoid, is effective against BC. However, its poor solubility in water and the allergenicity of its dissolution medium limited its clinical application.Methods: In this work, we established a multifunctional graphene oxide (GO) tumor-targeting drug delivery system using nanosized graphene oxide (nGO) modified with D-tocopherol polyethylene glycol succinate (TPGS) and arginine-glycine-aspartic acid (RGD) for PTX loading.Results: The obtained RGD-TPGS-nGO-PTX was 310.20± 19.86 nm in size; the polydispersity index (PDI) and zeta potential were 0.21± 0.020 and − 23.42 mV, respectively. The mean drug loading capacity of RGD-TPGS-nGO-PTX was 48.78%. RGD-TPGS-nGO-PTX showed satisfactory biocompatibility and biosafety and had no significant toxic effects on zebrafish embryos. Importantly, it exerted excellent cytotoxicity against MDA-MB

Published
2022

45. Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

Author

Zhang, Jing, primary, Hu, Kaili, additional, Di, Liuqing, additional, Wang, Penglong, additional, Liu, Zhidong, additional, Zhang, Jinming, additional, Yue, Pengfei, additional, Song, Wantong, additional, Zhang, Jingwei, additional, Chen, Tongkai, additional, Wang, Zuhua, additional, Zhang, Yongtai, additional, Wang, Xiaoying, additional, Zhan, Changyou, additional, Cheng, Yung-Chi, additional, Li, Xiang, additional, Li, Quan, additional, Fan, Jing-Yu, additional, Shen, Youqing, additional, Han, Jing-Yan, additional, and Qiao, Hongzhi, additional

Published
2021
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46. A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy

Author

Xiang, Menghua, primary, Zhou, Quanming, additional, Shi, Zihan, additional, Wang, Xuan, additional, Li, Mengchu, additional, Jia, Yan, additional, Li, Shaoyun, additional, Yang, Fen, additional, Wang, Wei, additional, Chen, Tongkai, additional, Xu, Xiaojun, additional, Sharma, Bigyan, additional, Nie, Yichu, additional, Xiao, Qicai, additional, and Gao, Liqian, additional

Published
2021
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49. Synergistic Photothermal and Chemical Therapy by Smart Dual‐Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease (Adv. Therap. 7/2021)

Author

Li, Tianzhong, primary, Liu, Yao, additional, Bao, Wenli, additional, Luo, Jingshan, additional, Gao, Lingfeng, additional, Chen, Xiaojia, additional, Wang, Shengpeng, additional, Yu, Jiangtian, additional, Ge, Yanqi, additional, Zhang, Bin, additional, Xie, Ni, additional, Xie, Zhongjian, additional, Chen, Tongkai, additional, and Zhang, Han, additional

Published
2021
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