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2. Contributors

Author

Agarwal, Parul, primary, Balachandran, Vinod P., additional, Bonifant, Challice L., additional, Bullock, Timothy N.J., additional, Burns, William R., additional, Chen, Sophia Y., additional, Delitto, Daniel, additional, Desiderio, Stephen, additional, Farouqa, Jad, additional, Gutierrez, Maria J., additional, Heumann, Thatcher R., additional, Jung, Hyun Min, additional, Manzanero, Silvia, additional, Nabizadeh, Jamileh, additional, Niederhuber, John E., additional, Olayinka, Olamide, additional, Panagides, Nadya, additional, Rojas, Luis A., additional, Rolfe, Barbara E., additional, Rutkowski, Melanie, additional, Sonderegger, Stefan E., additional, Weinstein, Brant M., additional, Woodruff, Trent M., additional, and Zheng, Lei, additional

Published
2024
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8. CLDN18.2 BiTE Engages Effector and Regulatory T Cells for Antitumor Immune Response in Preclinical Models of Pancreatic Cancer

Author

Xu, Yao, Fu, Juan, Henderson, MacKenzie, Lee, Fei, Jurcak, Noelle, Henn, Anja, Wahl, Joachim, Shao, Yingkuan, Wang, Jianxin, Lyman, Melissa, Funes, Vanessa, Espinoza, Birginia, Zhang, Rui, Washington, India, Chen, Sophia Y., Zlomke, Haley, Wang, Junke, Niu, Nan, Li, Pan, Meng, Fengxi, Burns, William, Friedrich, Matthias, Stienen, Sabine, Bailis, Julie M., and Zheng, Lei

Published
2023
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10. HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation

Author

Chia, Lionel, Wang, Bowen, Kim, Jung-Hyun, Luo, Li Z., Shuai, Shuai, Herrera, Iliana, Chen, Sophia Y., Li, Liping, Xian, Lingling, Huso, Tait, Heydarian, Mohammad, Reddy, Karen, Sung, Woo Jung, Ishiyama, Shun, Guo, Gongbo, Jaffee, Elizabeth, Zheng, Lei, Cope, Leslie M., Gabrielson, Kathy, Wood, Laura, and Resar, Linda

Subjects
Transcription factors -- Physiological aspects -- Health aspects, Fibroblast growth factors -- Genetic aspects -- Health aspects, Pancreatic cancer -- Development and progression -- Genetic aspects, Health care industry
Abstract

High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how they function in cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by dense desmoplastic stroma composed predominantly of cancer-associated fibroblasts and fibrotic tissue. Here, we uncover an epigenetic program whereby HMGA1 upregulates FGF19 during tumor progression and stroma formation. HMGA1 deficiency disrupts oncogenic properties in vitro while impairing tumor inception and progression in KPC mice and subcutaneous or orthotopic models of PDAC. RNA sequencing revealed HMGA1 transcriptional networks governing proliferation and tumor-stroma interactions, including the FGF19 gene. HMGA1 directly induces FGF19 expression and increases its protein secretion by recruiting active histone marks (H3K4me3, H3K27Ac). Surprisingly, disrupting FGF19 via gene silencing or the FGFR4 inhibitor BLU9931 recapitulates most phenotypes observed with HMGA1 deficiency, decreasing tumor growth and formation of a desmoplastic stroma in mouse models of PDAC. In human PDAC, overexpression of HMGA1 and FGF19 defines a subset of tumors with extremely poor outcomes. Our results reveal what we believe is a new paradigm whereby HMGA1 and FGF19 drive tumor progression and stroma formation, thus illuminating FGF19 as a rational therapeutic target for a molecularly defined PDAC subtype., Introduction Pancreatic ductal adenocarcinoma (PDAC) has emerged as a major public health problem in industrialized countries, and its incidence is rising (1-3). PDAC is predicted to become the second leading [...]

Published
2023
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17. Prevalence of cannabis use disorder and perioperative outcomes in adult colectomy patients: A propensity score‐matched analysis.

Author

Lo, Brian D., Chen, Sophia Y., Stem, Miloslawa, Papanikolaou, Angelos, Gabre‐Kidan, Alodia, Safar, Bashar, Efron, Jonathan E., and Atallah, Chady

Subjects
*MARIJUANA abuse, *COLECTOMY, *PROPENSITY score matching, *LENGTH of stay in hospitals, *HOSPITAL charges, *ADULTS
Abstract

Background: The decriminalization of cannabis across the United States has led to an increased number of patients reporting cannabis use prior to surgery. However, it is unknown whether preoperative cannabis use disorder (CUD) increases the risk of postoperative complications among adult colectomy patients. Methods: Adult patients undergoing an elective colectomy were retrospectively analyzed from the National Inpatient Sample database (2004–2018). To control for potential confounders, patients with CUD, defined using ICD‐9/10 codes, were propensity score matched to patients without CUD in a 1:1 ratio. The association between preoperative CUD and composite morbidity, the primary outcome of interest, was assessed. Subgroup analyses were performed after stratification by age (≥50 years). Results: Among 432,018 adult colectomy patients, 816 (0.19%) reported preoperative CUD. The prevalence of CUD increased nearly three‐fold during the study period from 0.8/1000 patients in 2004 to 2.0/1000 patients in 2018 (P‐trend<0.001). After propensity score matching, patients with CUD exhibited similar rates of composite morbidity (140 of 816; 17.2%) as those without CUD (151 of 816; 18.5%) (p = 0.477). Patients with CUD also had similar anastomotic leak rates (CUD: 5.64% vs. No CUD: 6.25%; p = 0.601), hospital lengths of stay (CUD: 5 days, IQR 4–7 vs. No CUD: 5 days, IQR 4–7) (p = 0.415), and hospital charges as those without CUD. Similar findings were seen among patients aged ≥50 years in the subgroup analysis. Conclusions: Though the prevalence of CUD has increased drastically over the past 15 years, preoperative CUD was not associated with an increased risk of composite morbidity among adult patients undergoing an elective colectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Short-Stay Left Colectomy for Colon Cancer: Is It Safe?

Author

Papanikolaou, Angelos, Chen, Sophia Y., Radomski, Shannon N., Stem, Miloslawa, Brown, Lawrence B., Obias, Vincent J., Graham, Ada E., and Chung, Haniee

Subjects
*CONTINUING education units, *PEARSON correlation (Statistics), *PATIENT safety, *PATIENT readmissions, *KRUSKAL-Wallis Test, *TREATMENT effectiveness, *CANCER patients, *DESCRIPTIVE statistics, *RETROSPECTIVE studies, *CHI-squared test, *MANN Whitney U Test, *COLON tumors, *ODDS ratio, *SURGICAL complications, *ELECTIVE surgery, *MEDICAL records, *ACQUISITION of data, *LENGTH of stay in hospitals, *CONFIDENCE intervals, *DATA analysis software, *COLECTOMY, *EVALUATION
Abstract

BACKGROUND: Advances in surgical practices have decreased hospital length of stay (LOS) after surgery. This study aimed to determine the safety of short-stay (≤24-hour) left colectomy for colon cancer patients in the US. STUDY DESIGN: Adult colon cancer patients who underwent elective left colectomies were identified using the American College of Surgeons NSQIP database (2012 to 2021). Patients were categorized into 4 LOS groups: LOS 1 day or less (≤24-hour short stay), 2 to 4, 5 to 6, and 7 or more. Primary outcomes were 30-day postoperative overall and serious morbidity. Secondary outcomes were 30-day mortality and readmission. Multivariable logistic regression was performed to explore the association between LOS and overall and serious morbidity. RESULTS: A total of 15,745 patients who underwent left colectomies for colon cancer were identified with 294 (1.87%) patients undergoing short stay. Short-stay patients were generally younger and healthier with lower 30-day overall morbidity rates (LOS ≤1 day: 3.74%, 2 to 4: 7.38%, 5 to 6: 16.12%, and ≥7: 37.64%, p < 0.001). Compared with patients with LOS 2 to 4 days, no differences in mortality and readmission rates were observed. On adjusted analysis, there was no statistical difference in the odds of overall (LOS 2 to 4 days: odds ratio 1.90, 95% CI 1.01 to 3.60, p = 0.049) and serious morbidity (LOS 2 to 4 days: odds ratio 0.86, 95% CI 1.42 to 1.76, p = 0.672) between the short-stay and LOS 2 to 4 days groups. CONCLUSIONS: Although currently performed at low rates in the US, short-stay left colectomy is safe for a select group of patients. Attention to patient selection, refinement of clinical pathways, and close follow-up may enable short-stay colectomies to become a more feasible reality. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Contributors

Author

Abcarian, Ariane M., Abcarian, Herand, Abdulhai, Mohamad A., Abularrage, Christopher J., AbuRahma, Ali F., AbuRahma, Zachary T., Adams, David B., Adams, Laura M., Adams, Reid B., Adekeye, Adeseye, Adrales, Gina L., Ahrendt, Gillian M., Ahrendt, Steven A., Ahuja, Nita, Akshintala, Venkata S., Efishat, Mohammad Al, Alam, Hasan B., Albaugh, Vance L., Albutt, Katherine, Alimi, Yewande, Alobuia, Wilson M., Alsaad, Ranim, Alvarenga, Emanuela Silva, Alverdy, John C., Amin, Avani, Andolfi, Ciro, Antognoli, Lauren, Aravind, Pathik, Arnold, Margaret W., Professor, Associate, Atallah, Chady, Axtell, Andrea L., Azad, Nilofer, Azizad, Omaira, Bales, Alison M., Barbul, Adrian, Barie, Philip S., Barnes, Emilie C., Barnes, Stephen L., Barnett, Erica, Basho, Reva, Bass, Gary A., Battafarano, Richard J., Bayard, Solange, Bedine, Marshall S., Behrns, Kevin E., Beliveau, Lauren, Benjamin, Elizabeth R., Berger, David, III, James H. Black, Blair, Alex B., Bomman, Shivanand, Bonds, Morgan, Boutros, Marylise, Brilliant, Justin, Britt, L.D., Broccard, Sacha P., Brock, Malcolm V., Broderick, Ryan C., Broderick, Stephen R., Brown, Lawrence B., Buckley, Jill C., Bunn, Corinne, Burke, Mark S., Burkhart, Richard A., Burnim, Michael S., Burns, William Reece, Bush, Errol L., Busuttil, Ronald W., Buyske, Jo, Calhoun, Kristine E., Calotta, Nicholas A., Cambria, Richard P., Camp, Melissa S., Cao, Yilin (Linda), Carp, Ned Z., Casciani, Fabio, Chaikof, Elliot L., Chatila, Ahmed, Chen, Sophia Y., Chi, Albert, Chilton, Timothy D., Cholewczynski, Walter, Choti, Michael A., Christensen, Joani, Christopher, Adrienne N., Chudnovets, Anna, Cintron, Jose R., Clary, Bryan M., Cloyd, Jordan M., Cocanour, Christine S., Coimbra, Raul, Colakoglu, Salih, Conyers, Julie A., III, Edward E. Cornwell, Coté, Gregory A., Cribari, Chris, Cronin, Patricia A., Crosby, Patrick, Cross, Alisa, Cunningham, Steven C., Dani, Hasan, Dardik, Alan, Darrach, Halley, Davidson, Whitney A., deAngeli, Katherine, Deery, Sarah E., Delitto, Daniel J., DeMeester, Tom R., Dempsey, Daniel T., Dennahy, Isabel S., Dent, Daniel L., DePeralta, Danielle K., Desai, Niraj M., DeSouza, Melissa Louise, DeStefano, Lauren M., Diggs, Laurence P., Dillon, Conor, DiNorcia, Joseph, Doherty, Gerard M., Donahue, James M., Done, Joy Zhou, Doucet, Jay J., Duh, Quan-Yang, Duncan, Mark D., Eckardt, Mark A., Edil, Barish H., Efron, David T., Efron, Jonathan E., Ehlers, Anne P., Eisenson, Daniel L., Haddi, S. James El, Moheb, Mohamad El, El-Diwany, Ramy, Elsey, James K., Elterman, Joel, Enumah, Zachary Obinna, Euhus, David M., Evans, Douglas B., C, Donald, Fadoul, Mikael A., Fagenholz, Peter J., Famularo, Marissa, Fang, Sandy Hwang, Farber, Alik, Fasano, Genevieve, Feliciano, David V., Feller-Kopman, MD, FACP, David J., Fergus, Kirkpatrick Beekman, Fernandez, Carlos, Fichera, Alessandro, Fischer, John P., Fish, Adam, Fisichella, P. Marco, Jr., James W. Fleshman, Florecki, Katherine L., Fong, Yuman, Fong, Zhi Ven, Fransman, Ryan B., Freischlag, Julie A., Frost, Christopher, Gabre-Kidan, Alodia, Gahtan, Vivian, Jr, Edward Hines, Galandiuk, Susan, Jr, Hiram C. Polk, Jr., Samuel M. Galvagno, Gao, Raisa, Garibaldi, Brian T., Garrido, Danon E., Gearhart, Susan L., Gemignani, Mary L., Georgiades, Christos, German, Zachary, Gewertz, Bruce L., Ghanem, Omar M., Giglia, Joseph S., Giuliano, Armando E., Glebova, Natalia O., Gleisner, Ana, Goeddel, Lee A., Goldberg, Eric M., Gonzalez, Reyna, Gore, Amy V., Goverman, Jeremy, Grandhi, Miral Sadaria, Grant, Michael D., Gray, Richard J., Greer, Jonathan B., Grewal, Mahip, Grimes, Chassidy, Grucz, Traci M., Grunwald, Matthew D., Guillem, Jose G., Gunter, Rebecca L., Gupta, NavYash, Habib, Joseph R., Habibi, Mehran, Hagen, Edward R., Haghshenas, Jafar, Halandras, Pegge M., Hamilton, James P., Hammami, Muhammad, Han, Britta Jean, Han, Misop, Handley, Guy, Harmon, John W., Harris, Andrew, Jr, James E. Harris, Harrison, Jon M., Haugen, Christine, Haut, Elliott R., Hayden, Dana, He, Jin, Herbella, Fernando A.M., Herman, Joseph M., Hickey, Sean, Hicks, Caitlin W., Hindin, David, Hines, O. Joe, Ho, Jessie, Hodin, Richard A., Houng, Abraham P., House, Michael G., Hoyt, David B., Hu, Yinin, Ijaz, Nadia, Inaba, Kenji, Ivey, Gabriel D., Jacobs, Lisa K., Janssen, Claire, Javed, Ammar A., John, Amballur David, Johnson, Eric K., Johnson, Wali Rashad, Johnston, Fabian M., Jones, Ronald C., Joseph, Bellal, Joshi, Girish P., Kaafarani, Haytham, Kalloo, Anthony N., Kaplan, Lewis J., Karzai, Shkala, Kashyap, Vikram S., Katlic, Mark, Kattah, Michael G., Kaups, Krista L., Kavousi, Yasaman, Kawaji, Qingwen, Kebaish, Khaled M., Kebebew, Electron, Kelley, Scott R., Kennard, Kaitlyn, Kent, Alistair J., Khadaroo, Rachel G., Khalifeh, Ali H., MD, Maria Abou Khalil, Khan, Hamza, Khan, Maryam Ali, Khan, Sameer, Khashab, Mouen A., Khodorskiy, Dmitriy O., Khreiss, Mohammad R., Kim, Jina, Kim, Joseph, Kim, Karen M., King, Elizabeth Gherardi, Kinny-Köster, Benedict, Klimberg, V. Suzanne, Koganti, Deepika, Kokosis, George, Kolarich, Andrew R., Kozarek, Richard, Krepline, Ashley, Kulkarni, Swati A., Kumbhari, Vivek, Kunisaki, Shaun M., Kwakye, Gifty, Ladd, Mitchell R., Lafaro, Kelly J., Laheru, Daniel A., Lancaster, William P., Lange, Julie R., Ledgerwood, Anna M., Lee, Christina, Lee, Eliza J., Lee, Grace C., Lee, Hanjoo, Levin, Adam S., Liddell, Robert P., Lillemoe, Heather A., Lillemoe, Keith D., Lipsett, Pamela A., Liveris, Anna, Livingston, David H., Loiacono, Laurie Anne, Lombardi, Joseph V., Low, Gregory K., Lowenfeld, Lea, Lucas, Charles E., Lum, Ying Wei, Lumati, Juliet Siena, Lyons, Gray R., MacGillivray, Thomas E., Magnuson, Thomas H., Mahdi, Elaa, Makary, Martin A., Malas, Mahmoud B., Mallon, William C., Manahan, Michele Ann, Manson, Paul N., Mansour, M. Ashraf, Mantilla, Nathalie, Manukyan, Mariuxi C., Markmann, James F., Maroun, Christopher A., Martin, Matthew J., Martin, Niels D., Martyak, Michael, Matar, Regina, Mathisen, Douglas J., Mathur, Aarti, Matsushima, Kazuhide, Mawn, J. Greg, McCarthy, Mary C., McCarthy, Patrick M., McDermott, Katherine, McFadden, David W., McGuire, Sean P., McHenry, Christopher R., McIntosh, Erin E., Melton-Meaux, Genevieve B., Meneshian, Avedis, Menon, Raman, Metkus Jr, Thomas S., Michelassi, Fabrizio, Mony, Shruti, Morgan, Katherine A., Morgan, Ryan B., Morris, Carol D., Morse, Christopher R., Muniappan, Ashok, II, Peter Muscarella, Mutch, Matthew, Muñoz-Largacha, Juan A., Nam, Arthur J., Narang, Amol Kumar, Nasr, Isam W., Nawalaniec, James T., Nehs, Matthew A., Nelson, Adam, Nettles, Brenda S., Newman, Lisa Ann, Nezami, Nariman, Nguyen, Dennis C., Nguyen, Hien T., Nicholson, Jake A., Nizam, Wasay, Novitsky, Yuri W., Oelschlager, Brant K., Ogilvie, Jennifer B., Jr., John A. Olson, Olson, Kristofor A., O’Mara, Charles S., Oseni, Tawakalitu O., Osgood, Greg M., Ostrosky-Zeichner, Luis, Ottmann, Shane, Pappas, Theodore N., Paranjape, Charudutt, Park, Adrian E., Park, Pauline K., Pastoriza, Jessica M., Patel, Purvi P., Patel, Shirali T., Patti, Marco G., Pawlik, Timothy M., Pearl, Gregory J., Jr., Walter Pegoli, Perler, Bruce A., Perrier, Nancy D., Philosophe, Benjamin, Pitt, Henry A., Plichta, Jennifer K., Podolsky, Dina, Politano, Amani D., Port, Elisa, Postol, Carolyn R., Prabhu, Ajita S., Preiss, Joshua E., Prescott, Jason D., Price, Leigh Ann, Price, Matthew D., Prushik, Scott G., Pugh, Carla M., Qaqish, T. Robert, Qasim, Zaffer, Quick, Jacob A., Radisic, Amanda, Radomski, Shannon N., Rasmussen, Todd E., Reddy, Abhinav V., Reed, Christopher R., Regelsberger-Alvarez, Christina Maria, Reifsnyder, Thomas, Reilly, Linda M., Riall, Taylor S., Ricci, John Peter, Robles, Anamaria J., Rodgers, Douglas, Roginsky, Alexandra B., Rojas-Khalil, Yesenia, Rokosh, Rae S., Rosati, Riccardo, Rose, J. Bart, Rosenberger, Laura H., Ross, Robert C., Rosson, Gedge D., Roy, Rishi A., Rozycki, Grace S., Ryan, Colleen M., Sachdeva, Uma M., Sacks, Bethany C., Sacks, Justin M., Sahli, Zeyad T., Sakran, Joseph V., Sanders, David, Sarr, Michael G., Sawyer, Robert G., Sbayi, Samer, Scalea, Thomas M., Schauer, Philip R., Scheurlen, Katharina M., Schimpf, Dennis K., Schlachter, Todd R., Schonefeld, Sally, Schulick, Andrew, Schulick, Richard D., Schweitzer, Michael A., Sell, Naomi M., Senagore, Anthony J., Shah, Aamir S., Shah, Adil A., Shames, Brian D., Sharma, Ashwyn K., Sheridan, Robert, Shirali, Aditya S., Shmelev, Artem, Shoham, Shmuel, Shores, Jaimie T., Sicklick, Jason K., Sieber, Frederick, Simmons, Justin M., Sims, Sarah S., Singh, Vikesh K., Smeds, Matthew R., Nikolhaus Smith, John, Smith, Thomas J., Jr., Thomas W. Smith, Sorrentino, Anthony, Sosa, Julie Ann, Spaniolas, Konstantinos, Sperry, Jason, Steele, Scott R., Stem, Jonathan M., Stevens, Jane, Stevens, Kent Allen, Stonko, David P., Streiff, Michael B., Stringfield, Sarah, Strosberg, David S., Su, Amanda, Subramanian, Madhu, Suresh, Visakha, Susarla, Srinivas M., Sutton, Whitney, Swanstrom, Lee L., Talamini, Mark A., Tam, Vernissia, Tamburini, Nicola, Tan, Li Ting, Tanabe, Kenneth K., Tang, Rebecca, Tchou, Julia, Teixeira, Pedro G., Thiboutot, Jeffrey, Thompson, Jon S., Thornblade, Lucas W., Thorsen, Amy J., Torres, Crisanto M., Tsai, Susan, Tsitsiou, Yvonne, Tsung, Eric, Tufaro, Anthony, Tulla, Kiara A., Tunder, Kelly H., Udelsman, Brooks V., Vane, Marissa, Velmahos, George, Vernamonti, Jack P., Vollmer, Charles M., Jr., Vora, Halley, Vosler, Peter S., Walsh, Christi M., Wang, Xuanji, Warshaw, Andrew L., Wasicek, Philip J., Weeks, Sharon R., Weiser, Roi, Weiss, Clifford R., Weiss, Eric G., Weiss, Matthew J., Weld, Ethel D., Weller, Jennine H., Weltz, Adam S., Wesson, Russel N., Wexner, Steven D., Whitman, Glenn J.R., Whittaker, David R., Wick, Elizabeth C., Wilder, Fatima G., Williams, Austin D., Williams, Timothy K., Wiseman, James E., Witthaus, Michael W., Wogsland, Aric, Wolfgang, Christopher L., Wong, Daniel J., Wong, Virginia L., Wood, Douglas E., Wright, Cameron D., Wu, Clement, Wu, Lawrence W., Yang, Stephen C., Ye, Linda, Yeo, Heather L., Young, Stephanie, Zaydfudim, Victor M., Zeiger, Martha A., Zenilman, Michael E., Zhu, Jay, Zuberi, Maaz K., and Zyromski, Nicholas J.

Published
2023
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47. National trends and outcomes of total proctocolectomy and completion proctectomy ileal pouch-anal anastomosis procedures for ulcerative colitis.

Author

Chen SY, Radomski SN, Stem M, Done JZ, Caturegli G, Atallah C, Efron JE, and Safar B

Subjects
Adult, Humans, Retrospective Studies, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Steroids, Obesity complications, Anastomosis, Surgical adverse effects, Treatment Outcome, Proctocolectomy, Restorative adverse effects, Proctocolectomy, Restorative methods, Colitis, Ulcerative surgery, Colitis, Ulcerative complications, Colonic Pouches adverse effects
Abstract

Aim: The purpose of this study is to assess US operative trends and outcomes of ulcerative colitis (UC) patients undergoing total proctocolectomy with ileal pouch-anal anastomosis (TPC-IPAA) or completion proctectomy with IPAA (CP-IPAA)., Methods: Adult UC patients who underwent TPC-IPAA or CP-IPAA were analysed retrospectively using the 2016-2020 American College of Surgeons National Surgical Quality Improvement Program database. Factors associated with 30-day overall and serious morbidity were identified using multivariable logistic regression., Results: A total of 1696 patients were identified, with 958 patients (56.5%) undergoing TPC-IPAA and 738 (43.5%) undergoing CP-IPAA. A greater proportion of TPC-IPAAs were performed each year (except in 2019) compared to CP-IPAAs over the study period (P trend <0.001). Unadjusted analysis showed comparable rates of overall (20.8% vs. 24.4%, P = 0.076) and serious morbidity (14.3% vs. 12.7%, P = 0.352) between TPC-IPAA and CP-IPAA patients. Robotic TPC-IPAA had no differences in complications compared to laparoscopic and open approaches. Robotic CP-IPAA had higher anastomotic leak rates and longer hospital length of stay compared to laparoscopic and open approaches. Obesity was associated with increased odds of overall and serious morbidity for patients who underwent TPC-IPAA. Steroid/immunosuppressive therapy was associated with increased odds of overall and serious morbidity for patients who underwent CP-IPAA., Conclusions: Obese patients should be informed of their increased morbidity risk and offered counselling on weight loss prior to surgery when feasible. Patients on steroid/immunosuppressive therapy within 30 days preoperatively should not undergo CP-IPAA or should delay surgery until they can be safely off those medications., (© 2024 Association of Coloproctology of Great Britain and Ireland.)

Published
2024
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