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173 results on '"Chen, Si-Min"'

24. Potential of Polyethyleneimine as an Adjuvant To Prepare Long-Term and Potent Antifungal Nanovaccine

Author

Jin, Zhao, primary, Dong, Yi-Ting, additional, Liu, Shuang, additional, Liu, Jie, additional, Qiu, Xi-Ran, additional, Zhang, Yu, additional, Zong, Hui, additional, Hou, Wei-Tong, additional, Guo, Shi-Yu, additional, Sun, Yu-Fang, additional, Chen, Si-Min, additional, Dong, Hai-Qing, additional, Li, Yong-Yong, additional, An, Mao-Mao, additional, and Shen, Hui, additional

Published
2022
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28. Effects of Dendrobium officinale ultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

Author

Shi, Meng-Lin, primary, Yan, Mei-Qiu, additional, Su, Jie, additional, Yu, Jing-Jing, additional, Ye, Sen-Yu, additional, Fu, Meng, additional, Hu, Xue-Ling, additional, Niu, Zhuang-Wei, additional, Wu, Wen-Yan, additional, Chen, Si-Min, additional, Chen, Su-Hong, additional, Chen, Jian-Zhen, additional, and Lv, Gui-Yuan, additional

Published
2022
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30. Low ferroptosis score predicts chemotherapy responsiveness and immune‐activation in colorectal cancer.

Author

Lv, Yang, Feng, Qing‐Yang, Zhang, Zhi‐Yuan, Zheng, Peng, Zhu, De‐xiang, Lin, Qi, Chen, Si‐min, Mao, Yi‐Hao, Xu, Yu‐Qiu, Ji, Mei‐ling, Xu, Jian‐Min, and He, Guo‐dong

Subjects
COLORECTAL cancer, PROGRESSION-free survival, IMMUNOSTAINING, ADJUVANT chemotherapy, T cells
Abstract

Background: Existing studies for ferroptosis and prognosis in colorectal cancer (CRC) were limited. In this study, we aim to investigate the prognostic role of ferroptosis markers in patients with CRC and exploration of its micro‐environmental distributions. Methods: Immunohistochemical staining was performed for CRC patients' tissue microarray. Selection and prognostic validation of markers were based on mRNA data from the cancer genome atlas (TCGA) database. Gene Set Enrichment Analysis (GSEA) was performed to indicate relative immune landmarks and hallmarks. Ferroptosis and immune contexture were examined by CIBERSORT. Survival outcomes were analyzed by Kaplan‐Meier analysis and cox analysis. Results: A panel of 42 genes was selected. Through mRNA expression difference and prognosis analysis, GPX4, NOX1 and ACSL4 were selected as candidate markers. By IHC, increased GPX4, decreased NOX1 and decreased FACL4 indicate poor prognosis and worse clinical characteristics. Ferroptosis score based on GPX4, NOX1 and ACSL4 was constructed and validated with high C‐index. Low ferroptosis score can also demonstrate the better progression free survival and better adjuvant chemotherapy (ACT) responsiveness. Moreover, tumor with low ferroptosis score tend to be infiltrated with more CD4+ T cells, CD8+ T cells and less M1 macrophage. Finally, we found that IFN‐γ was potentially the central molecule at the crossroad between ferroptosis and onco‐immune response. Conclusion: Ferroptosis plays important role on CRC tumor progression, ACT response and prognosis. Ferroptosis contributes to immune‐supportive responses and IFN‐γ was the central molecule for this process. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Dectin-1 Facilitates IL-18 Production for the Generation of Protective Antibodies Against Candida albicans

Author

Shen, Hui, primary, Yu, Yuetian, additional, Chen, Si-Min, additional, Sun, Juan-Juan, additional, Fang, Wei, additional, Guo, Shi-Yu, additional, Hou, Wei-Tong, additional, Qiu, Xi-Ran, additional, Zhang, Yu, additional, Chen, Yuan-Li, additional, Wang, Yi-Da, additional, Hu, Xin-Yu, additional, Lu, Liangjing, additional, Jiang, Yuan-Ying, additional, Zou, Zui, additional, and An, Mao-Mao, additional

Published
2020
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38. Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography

Author

Cao, Su-E, primary, Zhang, Lin-Qi, additional, Kuang, Si-Chi, additional, Shi, Wen-Qi, additional, Hu, Bing, additional, Xie, Si-Dong, additional, Chen, Yi-Nan, additional, Liu, Hui, additional, Chen, Si-Min, additional, Jiang, Ting, additional, Ye, Meng, additional, Zhang, Han-Xi, additional, and Wang, Jin, additional

Published
2020
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39. Shegan-Mahuang Decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2/Th17 cells but upregulating CD4+FoxP3+ Tregs

Author

Lin, Cheng-Chuang, primary, Wang, Yuan-Yuan, additional, Chen, Si-Min, additional, Liu, Yun-Tao, additional, Li, Ji-Qiang, additional, Li, Fang, additional, Dai, Jie-Chen, additional, Zhang, Tong, additional, Qiu, Feifei, additional, Liu, Huazhen, additional, Dai, Zhenhua, additional, and Zhang, Zhong-De, additional

Published
2020
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40. How Sustainable is the Foreign Direct Investment? In the Case of Malaysia

Author

Cheong Chooi Mei, Rifqi Maulida, Noor Azryani Auzairy, and Chen Si Min

Subjects
education.field_of_study, Granger causality, Negative relationship, Corporate governance, Population, Sustainability, International economics, Business, Foreign direct investment, Investment (macroeconomics), education, Human capital
Abstract

Foreign Direct Investment (FDI) is one of the economic indicators of a country. Having a sustainable FDI would lead to a sustainable economy. In order to sustain the FDI, its determinants and how the changes in those determinants affect the FDI must be analyzed carefully. Once the impact of the determinants is known, then the next steps of making decisions or policies related to sustainable FDI, could easily and effectively be done. Different from previous studies, this paper examines to what extent the inflows of FDI would be related and affected by the environment, social and governance (ESG) factors, the vital sources for sustainable investment. The environment, social and governance factors include natural environment, natural resources, human capital, population, infrastructure, trade openness, and corruption. Those annual time series data were analyzed by using the ordinary least square regression and Granger causality analyses. The findings show that majority of the changes in those determinants have significant relationship with the FDI inflows. Many of the determinants are positively related to the FDI except for trade openness which is having negative relationship with FDI. However, changes in natural resources and infrastructure have no significant relation with the inflows of FDI. The result suggests that an emerging country like Malaysia, must continue enhancing those social, environmental and governance factors in the country to encourage the incoming of sustainable FDI, thus to develop sustainable economy.

Published
2018
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42. Composite control of the SiC arc welding power source based on the expert system and neuron PID

Author

Wang Zhen-min, Chen Si-min, Zeng Zhi-jing, and Zhong Qi-ming

Subjects
lcsh:GE1-350, Computer science, 0211 other engineering and technologies, PID controller, 02 engineering and technology, Welding, 010501 environmental sciences, computer.software_genre, 01 natural sciences, Expert system, law.invention, Power (physics), law, Control theory, Inverter, 021108 energy, Arc welding, computer, lcsh:Environmental sciences, Energy (signal processing), 0105 earth and related environmental sciences
Abstract

A third generation wide-band-gap SiC semiconductor device is used in the SiC arc welding power source, which has a higher inverter frequency and greatly improves the dynamic characteristics of the arc welding power source, providing opportunities for control algorithm optimization. A composite control method of the arc welding power source combining the expert system and single neuron Proportional-Integral-Derivative (PID) is proposed in this paper, aimed at the fact that the proportional cofficient of neuron PID can hardly be adapted to rapid welding current changes. The SiC arc welding power source is taken as the plant of study in this paper. A mathematical model of the arc welding power source-arc system is established, and the controller of the arc welding power source based on the neuron PID and corresponding expert rules are defined to adjust the proportional coefficient of neuron PID Finally, the neuron PID controller (SNC) and the composite controller based on the expert system and neuron PID (ESNC) are simulated and verified. The results show that compared with the neuron PID algorithm, this method can adjust the proportional neuron PID coefficient in real time according to the welding current and has a better adaptive ability and superior tracking performance for arc welding power source control.

Published
2021
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45. Red ginseng ameliorates lipotoxicity-induced renal fibrosis in hyperuricemia mice.

Author

Zhang, Ying-Ling, Chen, Si-Min, Song, Yi-Jie, Islam, Md Ariful, Rao, Pei-Li, Zhu, Meng-Jie, Gu, Wen-Yi, Xu, Yu, and Xu, Hong-Xi

Subjects
*BIOLOGICAL models, *KIDNEY function tests, *FLUORESCENT dyes, *CREATININE, *LIPIDS, *BODY weight, *HYPERURICEMIA, *TREATMENT effectiveness, *DIETARY fats, *BLOOD urea nitrogen, *DESCRIPTIVE statistics, *GLYCOPROTEINS, *CHRONIC kidney failure, *PLANT extracts, *FIBROSIS, *MICE, *RNA, *IMMUNOHISTOCHEMISTRY, *ANIMAL experimentation, *URIC acid, *GENE expression profiling, *GROWTH factors, *GINSENG, *STAINS & staining (Microscopy), *COMPARATIVE studies, *BENZOPYRANS, *OBESITY, *SEQUENCE analysis, *BIOMARKERS
Abstract

Chronic kidney disease can be caused by numerous diseases including obesity and hyperuricemia (HUA). Obesity may exacerbate the renal injury caused by HUA. Red ginseng, a steamed products of Panax ginseng Meyer root, is known for its remarkable efficacy in improving metabolic syndrome, such as maintaining lipid metabolic balance. However, the role of red ginseng on hyperuricemia-induced renal injury in obese cases remains unclear. This study aimed to investigate the action of red ginseng extract (RGE) on lipotoxicity-induced renal injury in HUA mice. A high-fat diet (HFD)-induced obesity model was employed to initially investigate the effects of RGE on body weight, TC, OGTT, renal lipid droplets, and renal function indices such as uric acid, creatinine, and urea nitrogen. Renal structural improvement was demonstrated by H&E staining. Subsequently, an animal model combining obesity and HUA was established to further study the impact of RGE on OAT1 and ACC1 expression levels. The mechanisms underlying renal injury regulation by RGE were postulated on the basis of RNA sequencing, which was verified by immunohistochemical (including F4/80, Ki67, TGF-β1, α-SMA, and E-cadherin), Masson, and Sirius red staining. RGE modulated HFD-induced weight gain, glucose metabolism, and abnormalities of uric acid, urea nitrogen, and creatinine. RGE alleviated the more severe renal histopathological changes induced by obesity combined with HUA, with down-regulated the protein levels of ACC1, F4/80, Ki67, TGF-β1, and α-SMA, and up-regulated OAT1 and E-cadherin. RGE has ameliorative effects on chronic kidney disease caused by obesity combined with HUA by maintaining lipid balance and reducing renal inflammation and fibrosis. [Display omitted] • RGE improved metabolic disorders and renal injury induced by obesity and obesity combination with hyperuricemia. • RGE ameliorated obesity-induced lipid accumulation in the kidney. • RGE improved renal inflammation and fibrosis exacerbated by lipotoxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Temperature dependence of the current conduction mechanisms in ferroelectric Pb(Zr[sub 0.53],Ti[sub 0.47])O[sub 3] thin films.

Author

Juan, Trevor Pi-chun, Chen, Si-min, and Lee, Joseph Ya-min

Subjects
*FERROELECTRICITY, *SCHOTTKY barrier diodes, *FERROELECTRIC devices, *CAPACITORS, *INTEGRATED circuits, *RANDOM access memory
Abstract

The temperature dependence of the current conduction mechanisms in Au/Pb(Zr[sub 0.53],Ti[sub 0.47])O[sub 3]/Pt (Au/PZT/Pt) metal–insulator–metal thin-film capacitors was investigated. The dominant current conduction mechanism from 300 to 375 K is space-charge-limited current (SCLC) due to holes and changes to Schottky emission in the temperature range of 400 to 500 K above the electric field of 0.2 MV/cm. It is observed that the transition voltage (V[sub tr]) of SCLC conduction decreases with increasing temperature. Shallow hole trap levels vary from 0.3 to 0.19 eV above the valence-band edge as the temperature varies from 300 to 375 K. The trap-filled-limited voltage (V[sub TFL]) increases with increasing temperature. The deep trap level extracted from V[sub TFL] is positioned at 0.39 eV above the valence-band edge. The Au/PZT barrier height extracted from Schottky emission is 0.85 eV. An energy band diagram of the Au/PZT/Pt system is proposed to explain the current–voltage characteristics. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2004
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