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Stimuli-responsive supramolecular chemotherapy, particularly in response to cancer biomarkers, has emerged as a promising strategy to overcome the limitations associated with traditional chemotherapy. Spermine (SPM) is known to be overexpressed in certain cancers. In this study, we introduced a novel supramolecular chemotherapy system triggered by SPM. The system featured pyridine salts of a diphenylanthracene derivative (PyEn) and a complementary water-soluble pillar[5]arene (WP5C5) with long alkyl chains. The diphenylanthracene unit of PyEn is effectively encapsulated within the long alkyl chains of WP5C5, resulting in a substantial reduction in the cytotoxicity of PyEn towards normal cells. The therapeutic effect of PyEn is selectively triggered intracellularly through SPM, leading to the endosomal release of PyEn and concurrent in situ cytotoxicity. This supramolecular chemotherapy system exhibits notable tumor inhibition against SPM-overexpressed cancers with reduced side effects on normal tissues. The supramolecular strategy for intracellular activation provides a novel tool with potential applications in chemotherapeutic interventions, offering enhanced selectivity and reduced cytotoxicity to normal cells. [ABSTRACT FROM AUTHOR]

Organic frameworks face a trade‐off between the framework stability and the bond dynamics, which necessitates the development of innovative linkages that can generate stable frameworks without hindering efficient synthesis. Although iodine(I)‐based halogen‐bonded organic frameworks (XOFs) have been developed, constructing XOFs based on bromine(I) is desirable yet challenging due to the high sensitivity of bromine(I) species. In this work, we present the inaugural construction of stable bromine(I)‐bridged two‐dimensional (2D) halogen‐bonded organic frameworks, XOF(Br)−TPy−BF4/OTf, based on sensitive [N⋅⋅⋅Br⋅⋅⋅N]+ halogen bonds. The formation of XOF(Br)−TPy−BF4/OTf was monitored by 1H NMR, XPS, IR, SEM, TEM, HR‐TEM, SEAD. Their framework structures were established by the results from PXRD, theoretical simulations and SAXS. More importantly, XOF(Br) displayed excellent chemical and thermal stabilities. They exhibited stable two‐dimensional framework structures in various organic solvents and aqueous media, even over a wide pH range (pH 3–12), while the corresponding model compounds BrPy2BF4/OTf decomposed quickly even in the presence of minimal water. Furthermore, the influence of the counterions were investigated by replacing BF4 with OTf, which improved the stability of XOF(Br). This characteristic enabled XOF(Br) to serve as an efficient oxidizing reagent in aqueous environments, in contrast with the sensitivity of BrPy2BF4/OTf, which performed well only in organic media. This study not only deepens our fundamental understanding of organic frameworks but also opens new avenues for the development and application of multifunctional XOFs. [ABSTRACT FROM AUTHOR]

Understanding the influence of connection knots on the properties of organic frameworks is pivotal in exploring their functions and potential applications. In this study, we demonstrate the design and preparation of a novel porphyrin-based halogen-bonded organic framework, XOF-ZnTPP, utilizing [N⋯I+⋯N] halogen bonds. XOF-ZnTPP has been comprehensively characterized, revealing a well-defined orderly crystalline structure. This framework exhibits pronounced photophysical activity and an enhanced yield of singlet oxygen (1O2), compared with the monomeric precursor, ZnTPP. This increase in 1O2 generation is mainly attributed to the heavy atom effect, among the unique structural features of the framework, supported by DFT calculations. Moreover, XOF-ZnTPP demonstrates superior catalytic efficacy in the aerobic oxidative coupling of amines with outstanding recyclability and stability. This research offers insights into the impact of the connection motifs on organic frameworks, which may help to extend their functions and applications. [ABSTRACT FROM AUTHOR]

Crystalline porous materials have received extensive attention due to their fascinating structures and wide range of applications. We report a novel diphase two-dimensional (2D) halogen-bonded organic framework (XOF-TPP) based on 1,3,6,8-tetra(pyridin-4-yl)pyrene (TPP). XOF-TPP was constructed through [N···I+ ···N] interactions between the pyridyl groups of TPP and iodonium cations. The formation of XOF-TPP was monitored by X-ray photoelectron spectroscopy, IR spectroscopy, powder X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy, and simulated theoretically. Small-angle X-ray scattering indicated that the XOF-TPP exists as a 2D periodic structure. This diphase 2D halogen-bonded organic framework has promise for practical applications in supramolecular functional materials. [ABSTRACT FROM AUTHOR]

Due to the fascinating structures and wide applications, porous materials with open frameworks have attracted more and more attentions. Herein, a novel two‐dimensional (2D) halogen‐bonded organic framework (XOF–TPPE) was successfully designed and fabricated by iodonium‐bridged N⋅⋅⋅I+⋅⋅⋅N interactions between pyridyl groups and I+ for the first time. The formation of XOF–TPPE and its linear analogue was monitored by 1H NMR, UV–Vis, X‐ray photoelectron spectroscopy (XPS), IR, SEM, TEM, HRTEM and selected‐area electron diffraction (SAED). The structural model of XOF–TPPE was established based on powder X‐ray diffraction (PXRD) data and theoretical simulations. Significantly, synchrotron small‐angle X‐ray scattering (SAXS), DLS and UV–Vis spectroscopy experiments suggested that XOF–TPPE still maintains a stable 2D framework structure in solutions. This research opens up a novel avenue for the development of organic frameworks materials, and may bring new promising applications for the field of porous materials. [ABSTRACT FROM AUTHOR]

Keywords: Charge Transport; Host-Guest Interaction; Pillararenes; Self-Assembled Monolayers; Supramolecular Electronics EN Charge Transport Host-Guest Interaction Pillararenes Self-Assembled Monolayers Supramolecular Electronics 1 1 1 04/26/23 20230502 NES 230502 B Non-covalent interaction modulation b is a promising strategy to guide the design of applicable (supra)molecular electronics. Charge Transport, Host-Guest Interaction, Pillararenes, Self-Assembled Monolayers, Supramolecular Electronics A rare investigation of the relationship between host-guest interaction and supramolecular charge transport is reported by Cunlan Guo, Shigui Chen et al. in their Research Article (e202216987). [Extracted from the article]

Charge Transport, Host-Guest Interaction, Pillararenes, Self-Assembled Monolayers, Supramolecular Electronics Keywords: Charge Transport; Host-Guest Interaction; Pillararenes; Self-Assembled Monolayers; Supramolecular Electronics EN Charge Transport Host-Guest Interaction Pillararenes Self-Assembled Monolayers Supramolecular Electronics 1 1 1 04/26/23 20230502 NES 230502 B Non-covalent interaction modulation b is a promising strategy to guide the design of applicable (supra)molecular electronics. A rare investigation of the relationship between host-guest interaction and supramolecular charge transport is reported by Cunlan Guo, Shigui Chen et al. in their Research Article (e202216987). [Extracted from the article]