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AbstractEnvironment plays an important role in non-verbal communication for human-virtual agent interaction. Existing research explores the influence of an agent’s appearance and attributes to enhance human-virtual agent communication. However, there is no common practice for dynamically adjusting the surrounding environments of the virtual agent. In this paper, we introduce a real-time virtual agent environment generation system (VAEnvGen), which contributes to the field by enhancing users’ content perception and improving task performance through dynamic environment adjustment. The system dynamically analyzes both the appropriate communication environment and filters the key information according to the current context. Leveraging Large Language Models, it generates a pseudo-3D background space to create an engaging atmosphere and a dynamic foreground content space for vivid key information display, thereby significantly enhancing content perception. For widespread adoption and flexibility, VAEnvGen is developed as a web application. We further evaluate the impact of VAEnvGen on content perception, user attention, and subjective satisfaction through a mixed-design user study with 50 participants. Quantitative and qualitative results reveal significant improvements in content perception, task completion time, and user satisfaction when using VAEnvGen. The system effectively redistributes user attention from subtitles and the virtual agent itself to the dynamically generated background and key foreground information, leading to a more immersive and less fatiguing user experience. [ABSTRACT FROM AUTHOR]

Background: Cervical cancer is the fourth most common cancer among women worldwide. Cervical cancer usually develops from human papillomavirus (HPV) infection, which leads to cervical intraepithelial neoplasia (CIN1/2/3) and eventually invasive cervical cancer. Therefore, early-screening and detection of cervical lesions are crucial for preventing and treating cervical cancer. However, different regions have different levels of medical resources and availability of diagnostic methods. There is a need to compare the efficiency of different methods and combinations for detecting cervical lesions and provide recommendations for the optimal screening and detection strategies. Methods: The current clinical methods for screening and detection of cervical lesions mainly include TruScreen (TS), Thinprep cytologic test (TCT), HPV testing, and colposcopy, but their sensitivity and specificity vary and there is no standard protocol recommended. In this study, we retrospectively reviewed 2286 female samples that underwent cervical biopsy and compared the efficiency of different methods and combinations for detecting cervical lesions. Results: HPV screening showed the highest sensitivity for identifying women with CIN2+ cervical lesions compared with other single methods. Our results also showed the importance and necessary of the secondary diagnostic test like TCT and TS as a triage method before colposcopy examination and guided biopsy. Conclusions: Our study provides recommendations for the optimal screening and detection strategies for cervical lesions in different regions with different levels of development. As a non-invasive, easily operated, and portable device, TS is a promising tool to replace TCT for detecting cervical lesions in the health care center with insufficient medical resources., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)