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1,380 results on '"Chen, Mu-Hong"'

11. Sexually Transmitted Infection among Adolescents and Young Adults with Autism Spectrum Disorder: A Nationwide Longitudinal Study

Author

Li, Juo-Chi, Tsai, Shih-Jen, Chen, Tzeng-Ji, and Chen, Mu-Hong

Abstract

The association between autism spectrum disorder (ASD) and subsequent sexually transmitted infections (STIs) and the potential effects of medications on STI risk remain unknown. In all, 5076 adolescents and young adults with ASD and 57,060 age-/sex-matched individuals without ASD were enrolled between 2001 and 2009 and followed-up to the end of 2011 for identification of subsequent STIs. The results revealed that patients with ASD were prone to acquiring an STI [hazard ratio (HR) 3.36] compared with the comparison group. Long-term use of atypical antipsychotics was associated with a lower risk of acquiring an STI later in life compared with nonuse (HR 0.34). We recommend that clinicians closely monitor risky sexual behaviors and STI risk in patients with ASD.

Published
2023
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12. Inflammatory Bowel Disease and Neurodegenerative Diseases.

Author

Lu, Ching-Liang, Wang, Yen-Po, Zhang, Bing, Kim, Jin, Chen, Mu-Hong, and Wang, Hohui

Subjects
Dementia, Gut-brain axis, Inflammatory bowel diseases, Multiple sclerosis, Parkinson disease, Humans, Neurodegenerative Diseases, Retrospective Studies, Inflammatory Bowel Diseases, Inflammation, Comorbidity
Abstract

A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and confirmed the relevance of IBD and chronic neurodegeneration in clinical medicine. In this review, we expound upon the current knowledge on the gut-microbiome-brain axis, highlighting several plausible mechanisms linking IBD with neurodegeneration. We also summarize the known associations between IBD with Parkinson disease, Alzheimer disease, vascular dementia and ischemic stroke, and multiple sclerosis in a clinical context. Finally, we discuss the implications of an improved understanding of the gut-microbiome-brain axis in preventing, diagnosing, and managing neurodegeneration among IBD and non-IBD patients.

Published
2023

21. All-Cause Mortality and Suicide Mortality in Autistic Individuals: An Entire Population Longitudinal Study in Taiwan

Author

Tsai, Shih-Jen, Chang, Wen-Han, Cheng, Chih-Ming, Liang, Chih-Sung, Bai, Ya-Mei, Hsu, Ju-Wei, Huang, Kai-Lin, Su, Tung-Ping, Chen, Tzeng-Ji, and Chen, Mu-Hong

Abstract

Evidence suggests increased mortality rates among autistic individuals. However, risks of mortality, including natural-cause, suicide, and accident mortalities, among autistic individuals remain unclear. Among the entire Taiwanese population (N = 29,253,529), between 2003 and 2017, 45,398 autistic individuals were identified and 1:4 matched to 181,592 non-autistic individuals based on birth year and sex. All-cause mortality, including natural-cause, accident, and suicide mortalities, was assessed from 2003 to 2017 between the two cohorts. Cox regression models were used to investigate the mortality risk between autistic and non-autistic individuals. Autistic individuals had increased likelihoods (hazard ratio, 95% confidence interval) of all-cause mortality (3.43, 3.00-3.92), natural-cause mortality (4.73, 3.99-5.60), and suicide mortality (3.67, 2.37-5.68) compared with non-autistic individuals. In particular, autistic males were more likely to die by suicide (hazard ratio: 3.81, 95% confidence interval: 2.37-6.13), and autistic females were more likely to die of accident (hazard ratio: 5.07, 95% confidence interval: 2.54-10.13) compared with non-autistic individuals. Appropriate and effective medical and mental health care is recommended for autistic individuals.

Published
2023
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47. International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators

Author

Price, Rebecca B., Kissel, Nicholas, Baumeister, Andrew, Rohac, Rebecca, Woody, Mary L., Ballard, Elizabeth D., Zarate, Jr, Carlos A., Deakin, William, Abdallah, Chadi G., Feder, Adriana, Charney, Dennis S., Grunebaum, Michael F., Mann, J. John, Mathew, Sanjay J., Gallagher, Bronagh, McLoughlin, Declan M., Murrough, James W., Muthukumaraswamy, Suresh, McMillan, Rebecca, Sumner, Rachael, Papakostas, George, Fava, Maurizio, Hock, Rebecca, Phillips, Jennifer L., Blier, Pierre, Shiroma, Paulo, Šóš, Peter, Su, Tung-Ping, Chen, Mu-Hong, Tiger, Mikael, Lundberg, Johan, Wilkinson, Samuel T., and Wallace, Meredith L.

Published
2022
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