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438 results on '"Chen, Marcelo"'

3. Retrieval of intrarenal coiled and ruptured guidewire by retrograde intrarenal surgery: A case report and literature review

Author

Chen Bo-Han, Chang Tsung-Hsin, Chen Marcelo, and Chen Yu-Hsin

Subjects
intrarenal foreign body, retrograde intrarenal surgery, percutaneous nephrostomy drainage, Medicine
Abstract

Foreign bodies in the kidney have rarely been reported. However, they can be a clinical problem for urologists. We report on a patient with a residual segment of guidewire coating embedded in the renal parenchyma following computed tomography (CT)-guided percutaneous nephrostomy drainage (PCND), and our successful minimally invasive management with retrograde intrarenal surgery (RIRS).

Published
2021
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5. Clinical factors predicting ureteral stent failure in patients with external ureteral compression

Author

Wu Kuan Ju, Chen Yi Zhong, Chen Marcelo, and Chen Yu-Hsin

Subjects
external ureteral compression, double j, hydronephrosis, pyuria, prediction factors, Medicine
Abstract

Double-J stent (DJ) placement is usually the treatment of choice for relieving external compression of the ureter. However, in some cases DJ function may become impaired and a percutaneous nephrostomy (PCN) may be required. Previous studies have reported different predictive factors for choosing PCN or DJ insertion as the initial treatment. In this study, we analyzed the risk factors for DJ failure in patients with external ureteral compression. Our results showed that the patients with moderate and severe hydronephrosis (p-value = 0.0171 and 0.0249, respectively), preexisting pyuria (p-value = 0.0128), or lower ureter obstruction (p-value = 0.0305) were more prone to DJ laterality. Age was also an important predictor. Urologists should pay more attention to these patients and consider PCN as the initial treatment.

Published
2021
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6. Rare paratesticular aggressive angiomyxoma mimicking an epididymal tumor in an 82-year-old man: Case report

Author

Chen Chi-Fang, Wang Tao-Yeuan, Chen Marcelo, and Lin Yung-Chieh

Subjects
aam, deep angiomyxoma, mesenchymal tumor, paratesticular mass, older, Medicine
Abstract

Aggressive angiomyxoma (AAM) is a rare mesenchymal myxoid tumor, and most cases occur in the pelvic region or perineum of adult females. AAM is very rare in males. Most of these cases have been diagnosed in patients aged 30–60 years, and the tumors involved the pelvic cavity, scrotum, or spermatic cord. AAM can mimic inguinal hernia, hydrocele, or paratesticular neoplasm. Four male cases have been reported with paratesticular AAM mimicking a testicular/epididymal tumor, and to the best of our knowledge, this is the oldest patient in the literature. Because of its rarity, making an exact diagnosis before surgery is difficult. Herein, we present a case of AAM in an 82-year-old man and review the literature.

Published
2021
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11. Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC

Author

Lin Tsu-Feng, Lin Wun-Rong, Chen Marcelo, Dai Shuen-Han, Sun Fang-Ju, Tsai Wei-Kung, and Chiu Allen W.

Subjects
chromophobe renal cell carcinoma, nuclear grading system, fuhrman nuclear grade, chromophobe tumor grade, Medicine
Abstract

Chromophobe renal cell carcinoma (chRCC) has a favorable prognosis. Due to irregular nuclei and nuclear pleomorphism, chRCC has a high Fuhrman nuclear grade (FNG). The chromophobe tumor grade (CTG) is a novel three-tier grading system that has been reported to be a better prognosticator than the traditional FNG. We compared the two nuclear grading systems in terms of patients’ clinical outcomes.

Published
2019
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15. Molecular Profiling of Prostatic Acinar Morphogenesis Identifies PDCD4 and KLF6 as Tissue Architecture–Specific Prognostic Markers in Prostate Cancer

Author

Li, Chi-Rong, Su, Jimmy J-M, Wang, Wei-Yu, Lee, Michael T-L, Wang, Ting-Yun, Jiang, Kuan-Ying, Li, Chein-Feng, Hsu, Jong-Ming, Chen, Chi-Kuan, Chen, Marcelo, Jiang, Shih-Sheng, Weaver, Valerie M, and Tsai, Kelvin K-C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Genetics, Biotechnology, Prostate Cancer, Urologic Diseases, Cancer, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Acinar Cells, Aged, Apoptosis Regulatory Proteins, Biomarkers, Tumor, Cell Differentiation, Epithelial Cells, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Kruppel-Like Factor 6, Kruppel-Like Transcription Factors, Male, Middle Aged, Morphogenesis, Organ Specificity, Prognosis, Prostate, Prostatic Neoplasms, Proto-Oncogene Proteins, RNA-Binding Proteins, Recurrence, Medical and Health Sciences, Pathology, Biomedical and clinical sciences, Health sciences
Abstract

Histopathological classification of human prostate cancer (PCA) relies on the morphological assessment of tissue specimens but has limited prognostic value. To address this deficiency, we performed comparative transcriptome analysis of human prostatic acini generated in a three-dimensional basement membrane that recapitulates the differentiated morphological characteristics and gene expression profile of a human prostate glandular epithelial tissue. We then applied an acinar morphogenesis-specific gene profile to two independent cohorts of patients with PCA (total n = 79) and found that those with tumors expressing this profile, which we designated acini-like tumors, had a significantly lower risk of postoperative relapse compared with those tumors with a lower correlation (hazard ratio, 0.078; log-rank test P = 0.009). Multivariate analyses showed superior prognostic prediction performance using this classification system compared with clinical criteria and Gleason scores. We prioritized the genes in this profile and identified programmed cell death protein 4 (PDCD4) and Kruppel-like factor 6 (KLF6) as critical regulators and surrogate markers of prostatic tissue architectures, which form a gene signature that robustly predicts clinical prognosis with a remarkable accuracy in several large series of PCA tumors (total n = 161; concordance index, 0.913 to 0.951). Thus, by exploiting the genomic program associated with prostate glandular differentiation, we identified acini-like PCA and related molecular markers that significantly enhance prognostic prediction of human PCA.

Published
2013

17. Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature

Author

Yang Ti-Yuan, Wang Tao-Yeuan, Chen Marcelo, Sun Fang-Ju, Chiu Allen W., and Chen Yu-Hsin

Subjects
penile calciphylaxis, penile gangrene, penectomy, end-stage renal disease, microcalcification, Medicine
Abstract

Penile calciphylaxis is a rare cause of penile gangrene that presents in patients with end-stage renal disease. The rates of comorbidity and mortality of penile calciphylaxis are extremely high. Unlike other penile gangrene, such as Fournier’s gangrene, the benefit of aggressive surgical therapy is controversial. Here we present a case of penile calciphylaxis in a 43-year-old man with end-stage renal disease on hemodialysis. He received total penectomy but died due to multisystem complications 2 weeks after surgery. We review the literature on the management options and outcomes in patients with penile calciphylaxis.

Published
2018
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