Search

Your search keyword '"Chen, Liubo"' showing total 29 results
Start Over Author "Chen, Liubo"
29 results on '"Chen, Liubo"'

3. mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1.

Author

Du, Yushen, Hultquist, Judd F, Zhou, Quan, Olson, Anders, Tseng, Yenwen, Zhang, Tian-Hao, Hong, Mengying, Tang, Kejun, Chen, Liubo, Meng, Xiangzhi, McGregor, Michael J, Dai, Lei, Gong, Danyang, Martin-Sancho, Laura, Chanda, Sumit, Li, Xinming, Bensenger, Steve, Krogan, Nevan J, and Sun, Ren

Subjects
Humans, Influenza A virus, Interferons, Viral Nonstructural Proteins, RNA, Messenger, Virus Replication, Protein Binding, Mutation, Gene Library, Lipid Metabolism, Fatty Acid Synthase, Type I, Gene Ontology, A549 Cells, Pneumonia & Influenza, Influenza, Genetics, Prevention
Abstract

A comprehensive examination of protein-protein interactions (PPIs) is fundamental for the understanding of cellular machineries. However, limitations in current methodologies often prevent the detection of PPIs with low abundance proteins. To overcome this challenge, we develop a mRNA display with library of even-distribution (md-LED) method that facilitates the detection of low abundance binders with high specificity and sensitivity. As a proof-of-principle, we apply md-LED to IAV NS1 protein. Complementary to AP-MS, md-LED enables us to validate previously described PPIs as well as to identify novel NS1 interactors. We show that interacting with FASN allows NS1 to directly regulate the synthesis of cellular fatty acids. We also use md-LED to identify a mutant of NS1, D92Y, results in a loss of interaction with CPSF1. The use of high-throughput sequencing as the readout for md-LED enables sensitive quantification of interactions, ultimately enabling massively parallel experimentation for the investigation of PPIs.

Published
2020

7. Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo

Author

Wang, Sihan, primary, Zhang, Tian-hao, additional, Hu, Menglong, additional, Tang, Kejun, additional, Sheng, Li, additional, Hong, Mengying, additional, Chen, Dongdong, additional, Chen, Liubo, additional, Shi, Yuan, additional, Feng, Jun, additional, Qian, Jing, additional, Sun, Lifeng, additional, Ding, Kefeng, additional, Sun, Ren, additional, and Du, Yushen, additional

Published
2023
Full Text
View/download PDF

11. sj-pdf-2-ccx-10.1177_10732748211066309 ��� Supplemental Material for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study

Author

Wang, Sihan, Chen, Liubo, Chen, Dongdong, Chao, Jian, Shao, Yangliu, Tang, Kejun, and Chen, Wenteng

Subjects
endocrine system, viruses, FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental Material, sj-pdf-2-ccx-10.1177_10732748211066309 for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study by Sihan Wang, Liubo Chen, Dongdong Chen, Jian Chao, Yangliu Shao, Kejun Tang and Wenteng Chen in Cancer Control

Published
2021
Full Text
View/download PDF

12. sj-pdf-1-ccx-10.1177_10732748211066309 ��� Supplemental Material for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study

Author

Wang, Sihan, Chen, Liubo, Chen, Dongdong, Chao, Jian, Shao, Yangliu, Tang, Kejun, and Chen, Wenteng

Subjects
endocrine system, viruses, FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-ccx-10.1177_10732748211066309 for Effect of Marital Status on the Survival of Patients With Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Study by Sihan Wang, Liubo Chen, Dongdong Chen, Jian Chao, Yangliu Shao, Kejun Tang and Wenteng Chen in Cancer Control

Published
2021
Full Text
View/download PDF

15. Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice

Author

Chen, Haiyan, primary, Chen, Liubo, additional, Wang, Xin, additional, Ge, Xiaoxu, additional, Sun, Lifeng, additional, Wang, Zhanhuai, additional, Xu, Xiaoming, additional, Song, Yongmao, additional, Chen, Jing, additional, Deng, Qun, additional, Xie, Haiting, additional, Chen, Ting, additional, Chen, Yan, additional, Ding, Kefeng, additional, Wu, Jingjing, additional, and Wang, Jian, additional

Published
2021
Full Text
View/download PDF

19. Exosomal ANGPTL1 Attenuates Colorectal Cancer Liver Metastasis by Regulating Kupffer Cell Secretion Pattern and Impeding MMP9 Induced Vascular Leakiness

Author

Jiang, Kai, primary, Chen, Haiyan, additional, Fang, Yimin, additional, Chen, Liubo, additional, Zhong, Chenhan, additional, Bu, Tongtong, additional, Dai, Siqi, additional, Pan, Xiang, additional, Fu, Dongliang, additional, Qian, Yucheng, additional, Wei, Jingsun, additional, and Ding, Kefeng, additional

Published
2020
Full Text
View/download PDF

20. Exosomal ANGPTL1 Attenuates CRC Liver Metastasis by Regulating Kupffer Cell Secretion Pattern and Impeding MMP9 induced vascular leakiness.

Author

Jiang, Kai, primary, Chen, Haiyan, additional, Fang, Yimin, additional, Chen, Liubo, additional, Zhong, Chenhan, additional, Bu, Tongtong, additional, Dai, Siqi, additional, Pan, Xiang, additional, Fu, Dongliang, additional, Qian, Yucheng, additional, Wei, Jingsun, additional, and Ding, Kefeng, additional

Published
2020
Full Text
View/download PDF

22. FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms

Author

Lu, Wei, primary, Fu, Dongliang, additional, Kong, Xiangxing, additional, Huang, Zhiheng, additional, Hwang, Maxwell, additional, Zhu, Yingshuang, additional, Chen, Liubo, additional, Jiang, Kai, additional, Li, Xinlin, additional, Wu, Yihua, additional, Li, Jun, additional, Yuan, Ying, additional, and Ding, Kefeng, additional

Published
2020
Full Text
View/download PDF

26. ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138

Author

Chen, Haiyan, primary, Xiao, Qian, additional, Hu, Yeting, additional, Chen, Liubo, additional, Jiang, Kai, additional, Tang, Yang, additional, Tan, Yinuo, additional, Hu, Wangxiong, additional, Wang, Zhanhuai, additional, He, Jinjie, additional, Liu, Yue, additional, Cai, Yibo, additional, Yang, Qi, additional, and Ding, Kefeng, additional

Published
2017
Full Text
View/download PDF

27. HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model.

Author

Jiang, Kai, Jiao, Yurong, Liu, Yue, Fu, Dongliang, Geng, Haitao, Chen, Liubo, Chen, Haiyan, Shen, Xiangfeng, Sun, Lifeng, and Ding, Kefeng

Subjects
GENETICS of colon cancer, HEPATOCYTE nuclear factors, PROMOTERS (Genetics), LIVER metastasis, LABORATORY mice
Abstract

Hepatocyte nuclear factor 6 (HNF6), as a transcription factor, has been reported to be involved in cell proliferation, carcinogenesis, and tumor metastasis. Here, we demonstrated the role of HNF6 in tumor growth and liver metastasis in colorectal cancer (CRC). Through bioinformatics and clinical samples analysis, we found HNF6 messenger RNA was upregulated both in CRC primary sites and liver metastases, and its high expression indicated poor survival in CRC patients. In vitro studies confirmed that HNF6 promoted cell proliferation and colony formation. What is more, in mouse models, the xenografts grew significantly faster and liver metastasis rate was nearly 45% higher in mice injected with HNF6‐overexpressing cells. Further mechanism exploration showed that HNF6 expression affected cell adhesion and conferred resistance to anoikis in CRC cells. Taken together, HNF6 expression was upregulated in CRC and closely correlated with poor survival. HNF6 promoted CRC cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis. Hepatocyte nuclear factor 6 (HNF6) expression was upregulated in colorectal cancer (CRC) and closely correlated with poor survival. HNF6 promoted CRC cell proliferation and tumor growth, and might enhance liver metastasis via conferring cell resistance to anoikis. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results