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2. Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

Author

Chen, Ling-Wei, Ng, Sharon, Tint, Mya-Thway, Michael, Navin, Sadananthan, Suresh Anand, Ong, Yi Ying, Yuan, Wen Lun, Chen, Ze-Ying, Chen, Chia-Yang, Godfrey, Keith M., Tan, Kok Hian, Gluckman, Peter D., Chong, Yap-Seng, Eriksson, Johan G., Yap, Fabian, Lee, Yung Seng, Fortier, Marielle V., Velan, Sendhil S., and Chan, Shiao-Yng

Published
2024
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5. Scoping review: Exploring the relationship between chrononutrition and glycemic responses in the adult population

Author

Chong, Guey Yong, primary, Kaur, Satvinder, additional, Ruzita, Abd. Talib, additional, Wilfred Mok, Kok Hoe, additional, Tan, Hui Yin, additional, Loy, See Ling, additional, Chen, Ling-Wei, additional, Siah, Woan Yie, additional, Lim, Geok Pei, additional, Chee, Yin Yin, additional, June Lem, Ee Mun, additional, and Koo, Hui Chin, additional

Published
2024
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6. Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero

Author

Ong, Yi Ying, Pang, Wei Wei, Huang, Jonathan Y., Aris, Izzuddin M., Sadananthan, Suresh Anand, Tint, Mya-Thway, Yuan, Wen Lun, Chen, Ling-Wei, Chan, Yiong Huak, Karnani, Neerja, Velan, S. Sendhil, Fortier, Marielle V., Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Tan, Kok Hian, Gluckman, Peter D., Yap, Fabian, Chong, Yap-Seng, Godfrey, Keith M., Chong, Mary F-F., Chan, Shiao-Yng, Eriksson, Johan G., Wlodek, Mary E., Lee, Yung Seng, and Michael, Navin

Published
2022
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8. List of contributors

Author

Alkerwi, Ala'a, primary, Andrews, Chloe, additional, Arent, Shawn M., additional, Aslam, Hajara, additional, Bohn, Torsten, additional, Brigham, Emily, additional, Burch, James B., additional, Cecconello, Chiara, additional, Chandler, Alexa J., additional, Chen, Ling-Wei, additional, Chiriboga, David, additional, Chumanevich, Alexander A., additional, Cintineo, Harry P., additional, Clària Ribas, Pol, additional, Davis, Jessica A., additional, Eustis, Sarah J., additional, Han, Yueh-Ying, additional, Hanson, Corrine, additional, Hébert, James R., additional, Hofseth, Lorne J., additional, Jacka, Felice N., additional, Kopec, Rachel E., additional, Litonjua, Augusto, additional, Lohman, Matthew C., additional, Marx, Wolfgang, additional, McFadden, Bridget A., additional, Monthé-Drèze, Carmen, additional, Murphy, E. Angela, additional, Norling, Lucy V., additional, Orchard, Tonya S., additional, Phillips, Catherine M., additional, Polańska, Kinga, additional, Roberts, Justin, additional, Samouda, Hanen, additional, Sen, Sarbattama, additional, Smith, Lee, additional, Spicer, Malory, additional, Trott, Mike, additional, Vahid, Farhad, additional, Velázquez, Kandy T., additional, Veronese, Nicola, additional, and Wirth, Michael D., additional

Published
2022
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10. Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium

Author

Chen, Ling-Wei, Aubert, Adrien M., Shivappa, Nitin, Bernard, Jonathan Y., Mensink-Bout, Sara M., Geraghty, Aisling A., Mehegan, John, Suderman, Matthew, Polanska, Kinga, Hanke, Wojciech, Jankowska, Agnieszka, Relton, Caroline L., Crozier, Sarah R., Harvey, Nicholas C., Cooper, Cyrus, Hanson, Mark, Godfrey, Keith M., Gaillard, Romy, Duijts, Liesbeth, Heude, Barbara, Hébert, James R., McAuliffe, Fionnuala M., Kelleher, Cecily C., and Phillips, Catherine M.

Published
2021
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15. Higher early pregnancy plasma myo‐inositol associates with increased postprandial glycaemia later in pregnancy: Secondary analyses of the NiPPeR randomized controlled trial.

Author

Chan, Shiao‐Yng, Zhang, Han, Wong, Jui‐Tsung, Chang, Hsin F., Chen, Ling‐Wei, Barton, Sheila J., Nield, Heidi, El‐Heis, Sarah, Kenealy, Timothy, Lavalle, Luca, Ramos‐Nieves, J. Manuel, Godin, Jean‐Philippe, Silva‐Zolezzi, Irma, Cutfield, Wayne S., and Godfrey, Keith M.

Subjects
GESTATIONAL diabetes, PLACENTAL growth factor, INSULIN, SECONDARY analysis, GLUCOSE tolerance tests, BLOOD sugar, PREGNANCY, INSULIN sensitivity
Abstract

Aim: Myo‐inositol supplementation from ~13 weeks' gestation reportedly improves glycaemia regulation in metabolically at‐risk women, with speculation that earlier supplementation might bring further improvement. However, the NiPPeR trial of a myo‐inositol‐containing supplement starting preconception did not lower gestational glycaemia in generally healthy women. We postulated that the earlier timing of supplementation influences the maternal metabolic adaptation for gestational glycaemia regulation. Methods: In total, 585 women were recruited from Singapore, UK and New Zealand for the NiPPeR study. We examined associations of plasma myo‐inositol concentrations at 7 and 28 weeks' gestation with 28 weeks plasma glucose (PG; fasting, and 1 h and 2 h in 75 g oral glucose tolerance test) and insulin indices using linear regression adjusting for covariates. Results: Higher 7‐week myo‐inositol, but not 28‐week myo‐inositol, associated with higher 1 h PG [βadj (95% confidence intervals) 0.05 (0.01, 0.09) loge mmol/L per loge μmol/L, p =.022] and 2 h PG [0.08 (0.03, 0.12), p =.001]; equivalent to 0.39 mmol/L increase in 2 h PG for an average 7‐week myo‐inositol increase of 23.4 μmol/L with myo‐inositol supplementation. Higher 7‐week myo‐inositol associated with a lower 28‐week Stumvoll index (first phase), an approximation of insulin secretion [−0.08 (−0.15, −0.01), p =.020] but not with 28‐week Matsuda insulin sensitivity index. However, the clinical significance of a 7‐week myo‐inositol‐related increase in glycaemia was limited as there was no association with gestational diabetes risk, birthweight and cord C‐peptide levels. In‐silico modelling found higher 28‐week myo‐inositol was associated with lower gestational glycaemia in White, but not Asian, women after controlling for 7‐week myo‐inositol effects. Conclusion: To our knowledge, our study provides the first evidence that increasing first trimester plasma myo‐inositol may slightly exacerbate later pregnancy post‐challenge glycaemia, indicating that the optimal timing for starting prenatal myo‐inositol supplementation needs further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

Author

Chen, Ling-Wei, primary, Ng, Sharon, additional, Tint, Mya-Thway, additional, Michael, Navin, additional, Anand Sadananthan, Suresh, additional, Ying Ong, Yi, additional, Lun Yuan, Wen, additional, Chen, Ze-Ying, additional, Chen, Chia-Yang, additional, Godfrey, Keith M, additional, Hian Tan, Kok, additional, Gluckman, Peter D, additional, Chong, Yap-Seng, additional, Eriksson, Johan G, additional, Yap, Fabian, additional, Seng Lee, Yung, additional, V Fortier, Marielle, additional, Velan, Sendhil S, additional, and Chan, Shiao-Yng, additional

Published
2023
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18. Associations of per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

Author

Loo, Evelyn, primary, Chen, Ling Wei, additional, Ng, Sharon, additional, Tint, Mya Thway, additional, Michael, Navin, additional, Sadananthan, Suresh Anand, additional, Ong, Yi Ying, additional, Yuan, Wen Lun, additional, Chen, Ze Ying, additional, Chen, Chia Yang, additional, Shek, Lynette Pei Chi, additional, Godfrey, Keith, additional, Tan, Kok Hian, additional, Gluckman, Peter D, additional, Chong, Yap Seng, additional, Eriksson, Johan G, additional, Yap, Fabian, additional, Lee, Yung Seng, additional, Fortier, Marielle V, additional, Velan, Sendhil S, additional, and Chan, Shiao Yng, additional

Published
2023
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21. Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium

Author

Chen, Ling-Wei, Aubert, Adrien M., Shivappa, Nitin, Bernard, Jonathan Y., Mensink-Bout, Sara M., Geraghty, Aisling A., Mehegan, John, Suderman, Matthew, Polanska, Kinga, Hanke, Wojciech, Trafalska, Elzbieta, Relton, Caroline L., Crozier, Sarah R., Harvey, Nicholas C., Cooper, Cyrus, Duijts, Liesbeth, Heude, Barbara, Hébert, James R., McAuliffe, Fionnuala M., Kelleher, Cecily C., and Phillips, Catherine M.

Subjects
Birth weight, Low -- Risk factors, Pregnant women -- Food and nutrition, Gestational age -- Health aspects, Prenatal influences -- Health aspects, Diet -- Health aspects, Biological sciences
Abstract

Background Adverse birth outcomes are major causes of morbidity and mortality during childhood and associate with a higher risk of noncommunicable diseases in adult life. Maternal periconception and antenatal nutrition, mostly focusing on single nutrients or foods, has been shown to influence infant birth outcomes. However, evidence on whole diet that considers complex nutrient and food interaction is rare and conflicting. We aim to elucidate the influence of whole-diet maternal dietary inflammatory potential and quality during periconceptional and antenatal periods on birth outcomes. Methods and findings We harmonized and pooled individual participant data (IPD) from up to 24,861 mother-child pairs in 7 European mother-offspring cohorts [cohort name, country (recruitment dates): ALSPAC, UK (1 April 1991 to 31 December 1992); EDEN, France (27 January 2003 to 6 March 2006); Generation R, the Netherlands (1 April 2002 to 31 January 2006); Lifeways, Ireland (2 October 2001 to 4 April 2003); REPRO_PL, Poland (18 September 2007 to 16 December 2011); ROLO, Ireland (1 January 2007 to 1 January 2011); SWS, United Kingdom (6 April 1998 to 17 December 2002)]. Maternal diets were assessed preconceptionally (n = 2 cohorts) and antenatally (n = 7 cohorts). Maternal dietary inflammatory potential and quality were ranked using the energy-adjusted Dietary Inflammatory Index (E-DII) and Dietary Approaches to Stop Hypertension (DASH) index, respectively. Primary outcomes were birth weight and gestational age at birth. Adverse birth outcomes, i.e., low birth weight (LBW), macrosomia, small-for-gestational-age (SGA), large-for-gestational-age (LGA), preterm and postterm births were defined according to standard clinical cutoffs. Associations of maternal E-DII and DASH scores with infant birth outcomes were assessed using cohort-specific multivariable regression analyses (adjusted for confounders including maternal education, ethnicity, prepregnancy body mass index (BMI), maternal height, parity, cigarettes smoking, and alcohol consumption), with subsequent random-effects meta-analyses. Overall, the study mothers had a mean ± SD age of 29.5 ± 4.9 y at delivery and a mean BMI of 23.3 ± 4.2 kg/m.sup.2 . Higher pregnancy DASH score (higher dietary quality) was associated with higher birth weight [[beta](95% CI) = 18.5(5.7, 31.3) g per 1-SD higher DASH score; P value = 0.005] and head circumference [0.03(0.01, 0.06) cm; P value = 0.004], longer birth length [0.05(0.01, 0.10) cm; P value = 0.010], and lower risk of delivering LBW [odds ratio (OR) (95% CI) = 0.89(0.82, 0.95); P value = 0.001] and SGA [0.87(0.82, 0.94); P value < 0.001] infants. Higher maternal prepregnancy E-DII score (more pro-inflammatory diet) was associated with lower birth weight [[beta](95% CI) = -18.7(-34.8, -2.6) g per 1-SD higher E-DII score; P value = 0.023] and shorter birth length [-0.07(-0.14, -0.01) cm; P value = 0.031], whereas higher pregnancy E-DII score was associated with a shorter birth length [-0.06(-0.10, -0.01) cm; P value = 0.026] and higher risk of SGA [OR(95% CI) = 1.18(1.11, 1.26); P value < 0.001]. In male, but not female, infants higher maternal prepregnancy E-DII was associated with lower birth weight and head circumference, shorter birth length, and higher risk of SGA (P-for-sex-interaction = 0.029, 0.059, 0.104, and 0.075, respectively). No consistent associations were observed for maternal E-DII and DASH scores with gestational age, preterm and postterm birth, or macrosomia and LGA. Limitations of this study were that self-reported dietary data might have increased nondifferential measurement error and that causality cannot be claimed definitely with observational design. Conclusions In this cohort study, we observed that maternal diet that is of low quality and high inflammatory potential is associated with lower offspring birth size and higher risk of offspring being born SGA in this multicenter meta-analysis using harmonized IPD. Improving overall maternal dietary pattern based on predefined criteria may optimize fetal growth and avert substantial healthcare burden associated with adverse birth outcomes., Author(s): Ling-Wei Chen 1,*, Adrien M. Aubert 2, Nitin Shivappa 3,4, Jonathan Y. Bernard 2,5, Sara M. Mensink-Bout 6,7, Aisling A. Geraghty 8, John Mehegan 1, Matthew Suderman 9, Kinga [...]

Published
2021
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23. Maternal and paternal dietary quality and dietary inflammation associations with offspring DNA methylation and epigenetic biomarkers of aging in the Lifeways Cross-generation study

Author

Lecorguillé, Marion, primary, Navarro, Pilar, additional, Chen, Ling-Wei, additional, Murrin, Celine, additional, Viljoen, Karien, additional, Mehegan, John, additional, Shivappa, Nitin, additional, Hébert, James R., additional, Kelleher, Cecily C., additional, Suderman, Matthew, additional, and Phillips, Catherine M., additional

Published
2023
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26. Predictors of maternal dietary quality and dietary inflammation during pregnancy: An individual participant data meta-analysis of seven European cohorts from the ALPHABET consortium

Author

Aubert, Adrien M., primary, Chen, Ling-Wei, additional, Shivappa, Nitin, additional, Cooper, Cyrus, additional, Crozier, Sarah R., additional, Duijts, Liesbeth, additional, Forhan, Anne, additional, Hanke, Wojciech, additional, Harvey, Nicholas C., additional, Jankowska, Agnieszka, additional, Kelleher, Cecily C., additional, de Lauzon-Guillain, Blandine, additional, McAuliffe, Fionnuala M., additional, Mensink-Bout, Sara M., additional, Polanska, Kinga, additional, Relton, Caroline L., additional, Suderman, Matthew, additional, Hebert, James R., additional, Phillips, Catherine M., additional, Bernard, Jonathan Y., additional, and Heude, Barbara, additional

Published
2022
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28. Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study

Author

Ong, Yi Ying, primary, Tint, Mya-Thway, additional, Aris, Izzuddin M, additional, Yuan, Wen Lun, additional, Chen, Ling-Wei, additional, Fortier, Marielle V, additional, Choo, Jonathan, additional, Ling, Lieng Hsi, additional, Shek, Lynette, additional, Tan, Kok Hian, additional, Gluckman, Peter D, additional, Yap, Fabian, additional, Chong, Yap-Seng, additional, Godfrey, Keith M, additional, Chong, Mary F-F, additional, Chan, Shiao-Yng, additional, Eriksson, Johan G, additional, Wlodek, Mary E, additional, De Lucia Rolfe, Emanuella, additional, Ong, Ken K, additional, Michael, Navin, additional, and Lee, Yung Seng, additional

Published
2022
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29. Predictors of maternal dietary quality and dietary inflammation during pregnancy:An individual participant data meta-analysis of seven European cohorts from the ALPHABET consortium

Author

Aubert, Adrien M., Chen, Ling Wei, Shivappa, Nitin, Cooper, Cyrus, Crozier, Sarah R., Duijts, Liesbeth, Forhan, Anne, Hanke, Wojciech, Harvey, Nicholas C., Jankowska, Agnieszka, Kelleher, Cecily C., de Lauzon-Guillain, Blandine, McAuliffe, Fionnuala M., Mensink-Bout, Sara M., Polanska, Kinga, Relton, Caroline L., Suderman, Matthew, Hebert, James R., Phillips, Catherine M., Bernard, Jonathan Y., Heude, Barbara, Aubert, Adrien M., Chen, Ling Wei, Shivappa, Nitin, Cooper, Cyrus, Crozier, Sarah R., Duijts, Liesbeth, Forhan, Anne, Hanke, Wojciech, Harvey, Nicholas C., Jankowska, Agnieszka, Kelleher, Cecily C., de Lauzon-Guillain, Blandine, McAuliffe, Fionnuala M., Mensink-Bout, Sara M., Polanska, Kinga, Relton, Caroline L., Suderman, Matthew, Hebert, James R., Phillips, Catherine M., Bernard, Jonathan Y., and Heude, Barbara

Abstract

Background & aims: Maternal diet during pregnancy is a modifiable behaviour which plays an important role in maternal, neonatal and child health outcomes. Thus, knowledge of predictors of dietary quality and dietary inflammatory potential in European countries may contribute to developing maternal diet-related public health policies that target specific at-risk populations in Europe. Methods: We used harmonised data from >26,000 pregnant women enrolled in the ALSPAC, EDEN, Generation R, Lifeways, REPRO_PL, ROLO and SWS cohorts, as part of the ALPHABET consortium. Maternal dietary quality and inflammatory potential were assessed using the Dietary Approaches to Stop Hypertension (DASH) and the energy-adjusted Dietary Inflammatory Index (E-DII). We conducted an individual participant data meta-analysis to investigate the maternal sociodemographic, health and behavioural predictors of maternal diet before and during pregnancy. Results: DASH and E-DII scores were moderately correlated: from −0.63 (95% CI: −0.66, −0.59) to −0.48 (95% CI: −0.49, −0.47) across cohorts. Higher maternal age, education, household income, and physical activity during pregnancy were associated with a better dietary quality and a more anti-inflammatory diet. Conversely, multiparity and smoking during pregnancy were associated with a poorer dietary quality and a more proinflammatory diet. Women with obesity had a poorer pregnancy dietary quality than women with a normal body mass index range. Conclusions: The results will help identify population subgroups who may benefit from targeted public health strategies and interventions aimed at improving women's dietary quality during pregnancy.

Published
2022

30. Maternal diet in pregnancy and child’s respiratory outcomes:an individual participant data meta-analysis of 18 000 children

Author

Mensink-Bout, Sara M., van Meel, Evelien R., de Jongste, Johan C., Annesi-Maesano, Isabella, Aubert, Adrien M., Bernard, Jonathan Y., Chen, Ling Wei, Cooper, Cyrus, Crozier, Sarah, Hanke, Wojciech, Harvey, Nincholas C., Hebert, James R., Heude, Barbara, Jerzynska, Joanna, Kelleher, Cecily C., Mehegan, John, McAuliffe, Fionnuala M., Phillips, Catherine M., Polanska, Kinga, Relton, Caroline L., Shivappa, Nitin, Suderman, Matthew, Jaddoe, Vincent, Duijts, Liesbeth, Mensink-Bout, Sara M., van Meel, Evelien R., de Jongste, Johan C., Annesi-Maesano, Isabella, Aubert, Adrien M., Bernard, Jonathan Y., Chen, Ling Wei, Cooper, Cyrus, Crozier, Sarah, Hanke, Wojciech, Harvey, Nincholas C., Hebert, James R., Heude, Barbara, Jerzynska, Joanna, Kelleher, Cecily C., Mehegan, John, McAuliffe, Fionnuala M., Phillips, Catherine M., Polanska, Kinga, Relton, Caroline L., Shivappa, Nitin, Suderman, Matthew, Jaddoe, Vincent, and Duijts, Liesbeth

Abstract

Rationale Severe fetal malnutrition has been related to an increased risk of respiratory diseases later in life, but evidence for the association of a suboptimal diet during pregnancy with respiratory outcomes in childhood is conflicting. We aimed to examine whether a pro-inflammatory or low-quality maternal diet during pregnancy was associated with child's respiratory health. Methods We performed an individual participant meta-analysis among 18 326 mother-child pairs from seven European birth cohorts. Maternal pro-inflammatory and low-quality diets were estimated by energyadjusted Dietary Inflammatory Index (E-DII) and Dietary Approaches to Stop Hypertension (DASH) scores. Preschool wheezing and school-age asthma were measured using questionnaires and lung function by spirometry. Results After adjustment for lifestyle and sociodemographic factors, we observed that a higher maternal E-DII score (a more pro-inflammatory diet) during pregnancy was associated only with a lower forced vital capacity (FVC) in children (z-score difference -0.05, 95% CI -0.08- -0.02, per interquartile range increase). No linear associations of the maternal E-DII or DASH score with child's wheezing or asthma were observed. In an exploratory examination of the extremes, a very low DASH score (<10th percentile) (a very low dietary quality) was associated with an increased risk of preschool wheezing and a low forced expiratory volume in 1 s/FVC (z-score <-1.64) (OR 1.20, 95% CI 1.06-1.36 and z-score difference 1.40, 95% CI 1.06-1.85, compared to ≥10th percentile), with corresponding population attributable risk fractions of 1.7% and 3.3%, respectively. Conclusion The main results from this individual participant data meta-analysis do not support the hypothesis that maternal pro-inflammatory or low-quality diet in pregnancy are related to respiratory diseases in childhood.

Published
2022

31. Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children

Author

Mensink-Bout, Sara M., primary, van Meel, Evelien R., additional, de Jongste, Johan C., additional, Annesi-Maesano, Isabella, additional, Aubert, Adrien M., additional, Bernard, Jonathan Y., additional, Chen, Ling-Wei, additional, Cooper, Cyrus, additional, Crozier, Sarah R., additional, Hanke, Wojciech, additional, Harvey, Nicholas C., additional, Hébert, James R., additional, Heude, Barbara, additional, Jerzynska, Joanna, additional, Kelleher, Cecily C., additional, Mehegan, John, additional, McAuliffe, Fionnuala M., additional, Phillips, Catherine M., additional, Polanska, Kinga, additional, Relton, Caroline L., additional, Shivappa, Nitin, additional, Suderman, Matthew, additional, Jaddoe, Vincent W.V., additional, and Duijts, Liesbeth, additional

Published
2021
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32. Trajectories of Systolic Blood Pressure in Children: Risk Factors and Cardiometabolic Correlates

Author

Yuan, Wen Lun, primary, Kramer, Michael S., additional, Michael, Navin, additional, Sadananthan, Suresh A., additional, Tint, Mya T., additional, Chen, Ling-Wei, additional, Pang, Wei Wei, additional, Velan, Sendhil S., additional, Godfrey, Keith M., additional, Chong, Yap-Seng, additional, Chong, Mary F.F., additional, Choo, Jonathan T.L., additional, Ling, Lieng Hsi, additional, Eriksson, Johan G., additional, and Lee, Yung Seng, additional

Published
2021
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35. Cardiometabolic Profile of Different Body Composition Phenotypes in Children

Author

Ong, Yi Ying, primary, Huang, Jonathan Y, additional, Michael, Navin, additional, Sadananthan, Suresh Anand, additional, Yuan, Wen Lun, additional, Chen, Ling-Wei, additional, Karnani, Neerja, additional, Velan, S Sendhil, additional, Fortier, Marielle V, additional, Tan, Kok Hian, additional, Gluckman, Peter D, additional, Yap, Fabian, additional, Chong, Yap-Seng, additional, Godfrey, Keith M, additional, Chong, Mary F-F, additional, Chan, Shiao-Yng, additional, Lee, Yung Seng, additional, Tint, Mya-Thway, additional, and Eriksson, Johan G, additional

Published
2021
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37. Pro-inflammatory and low quality maternal diet in pregnancy and the risk of childhood lower lung function and asthma: a meta-analysis of 18,000 children

Author

Mensink-Bout, Rosalie, primary, Van Meel, Evelien R., additional, De Jongste, Johan C., additional, Annesi-Maesano, Isabella, additional, Aubert, Adrien M., additional, Bernard, Jonathan Y., additional, Chen, Ling-Wei, additional, Cooper, Cyrus, additional, Crozier, Sarah R., additional, Hanke, Wojciech, additional, Harvey, Nicholas C., additional, Hébert, James R., additional, Heude, Barbara, additional, Jerzynska, Joanna, additional, Kelleher, Cecily C., additional, Mehegan, John, additional, Mcauliffe, Fionnuala M., additional, Phillips, Catherine M., additional, Polanska, Kinga, additional, Relton, Caroline L., additional, Shivappa, Nitin, additional, Suderman, Matthew, additional, Jaddoe, Vincent W.V., additional, and Duijts, Liesbeth, additional

Published
2020
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39. Maternal dietary quality, inflammatory potential and offspring adiposity throughout childhood: a pooled analysis of 7 European cohorts (ALPHABET consortium)

Author

Chen, Ling-Wei, primary, Aubert, Adrien, additional, Bernard, Jonathan Y., additional, Cooper, Cyrus, additional, Duijts, Liesbeth, additional, Geraghty, Aisling A., additional, Harvey, Nicholas C., additional, Hebert, James R., additional, Heude, Barbara, additional, Kelleher, Cecily C., additional, McAuliffe, Fionnuala M., additional, Mehegan, John, additional, Mensink-Bout, Rosalie, additional, Polanska, Kinga, additional, Relton, Caroline L., additional, Shivappa, Nitin, additional, Suderman, Matthew, additional, and Phillips, Catherine M, additional

Published
2020
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40. Dietary inflammatory index and non-communicable disease risk: a narrative review

Author

Phillips, Catherine M., Chen, Ling Wei, Heude, Barbara, Bernard, Jonathan Y., Harvey, Nicholas C., Duijts, Liesbeth, Mensink-Bout, Sara M., Polanska, Kinga, Mancano, Giulia, Suderman, Matthew, Shivappa, Nitin, and Hébert, James R.

Abstract

There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.

Published
2019

41. Resveratrol enhances chemosensitivity of renal cell carcinoma to paclitaxel

Author

Zhong Sen, Zheng Dan, Guo Jia Ping, Ke Ying Jie, Chen Ling Wei, Zhou Min, and Wang Ying

Subjects
0301 basic medicine, endocrine system, Paclitaxel, Cell Survival, Survivin, Apoptosis, Resveratrol, Inhibitor of apoptosis, complex mixtures, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Humans, Viability assay, Carcinoma, Renal Cell, PI3K/AKT/mTOR pathway, Drug Synergism, Xenograft Model Antitumor Assays, Kidney Neoplasms, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Signal Transduction
Abstract

By restraining proliferation and promoting apoptosis, resveratrol (RES) has anti-tumor effect in various cancers. Here, we examine whether RES exerts similar effect in drug-resistant renal cell carcinoma (RCC). To this end, Caki-1 cells derived from renal carcinoma are subjected to escalated doses of paclitaxel (PTX) to produce the PTX resistant Caki-1PTX cells. Both Caki-1 and Caki-PTX cells are sensitive to PTX, in a dose dependent manner. RES, dose-dependently, suppresses the expression of survivin, a molecular biomarker of cancer and a member of the inhibitor of apoptosis (IAP) family and its co-administration with PTX inhibits the effect of this drug on cell viability. To decipher whether survivin expressed by cancer cells is involved in rendering cells PTX sensitive, survivin is overexpressed. This dramatically counteracts the effects of RES on cell survival in the presence of PTX. Furthermore, decrease of survivin by inhibition of PI3K/AKT pathway significantly inhibits the effect of PTX in Caki-1PTX cells. These data show that RES increases the sensitivity of PTX resistant renal cells to drug treatment.

Published
2019

42. Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium

Author

Aubert, Adrien M., Forhan, Anne, de Lauzon-Guillain, Blandine, Chen, Ling-Wei, Polanska, Kinga, Hanke, Wojciech, Jankowska, Agnieszka, Mensink-Bout, Sara M., Duijts, Liesbeth, Suderman, Matthew, Relton, Caroline L., Crozier, Sarah R., Harvey, Nicholas C., Cooper, Cyrus, McAuliffe, Fionnuala M., Kelleher, Cecily C., Phillips, Catherine M., Heude, Barbara, Bernard, Jonathan Y., Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University College Dublin [Dublin] (UCD), University of Southampton, 3MRC Epidemiology Resource Centre, Pediatrics, Erasmus MC other, and Nofer Institute of Occupational Medicine

Subjects
nutrition, DASH (Dietary Approaches to Stop Hypertension), [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, lcsh:TX341-641, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, pregnancy, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, diet, lcsh:Nutrition. Foods and food supply, human activities, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

The ALPHABET consortium aims to examine the interplays between maternal diet quality, epigenetics and offspring health in seven pregnancy/birth cohorts from five European countries. We aimed to use the Dietary Approaches to Stop Hypertension (DASH) score to assess diet quality, but different versions have been published. To derive a single DASH score allowing cross-country, cross-cohort and cross-period comparison and limiting data heterogeneity within the ALPHABET consortium, we harmonised food frequency questionnaire (FFQ) data collected before and during pregnancy in &ge, 26,500 women. Although FFQs differed strongly in length and content, we derived a consortium DASH score composed of eight food components by combining the prescriptive original DASH and the DASH described by Fung et al. Statistical issues tied to the nature of the FFQs led us to re-classify two food groups (grains and dairy products). Most DASH food components exhibited pronounced between-cohort variability, including non-full-fat dairy products (median intake ranging from 0.1 to 2.2 servings/day), sugar-sweetened beverages/sweets/added sugars (0.3&ndash, 1.7 servings/day), fruits (1.1&ndash, 3.1 servings/day), and vegetables (1.5&ndash, 3.6 servings/day). We successfully developed a harmonized DASH score adapted to all cohorts being part of the ALPHABET consortium. This methodological work may benefit other research teams in adapting the DASH to their study&rsquo, s specificities.

Published
2019

43. Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Author

Phillips, Catherine M., primary, Chen, Ling-Wei, additional, Heude, Barbara, additional, Bernard, Jonathan Y., additional, Harvey, Nicholas C., additional, Duijts, Liesbeth, additional, Mensink-Bout, Sara M., additional, Polanska, Kinga, additional, Mancano, Giulia, additional, Suderman, Matthew, additional, Shivappa, Nitin, additional, and Hébert, James R., additional

Published
2019
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47. Prenatal Tobacco Exposure and Accelerated Offspring Weight and Body Mass Index Trajectories in the First 3 Years of Life

Author

Ng, Sharon, primary, Aris, Izzuddin M., additional, Tint, Mya Thway, additional, Chen, Ling-Wei, additional, Yuan, Wen Lun, additional, Chan, Yiong Huak, additional, Shek, Lynette Pei-Chi, additional, Yap, Fabian, additional, Tan, Kok Hian, additional, Lek, Ngee, additional, Teoh, Oon Hoe, additional, Gluckman, Peter D., additional, Chong, Yap-Seng, additional, Chong, Mary Foong-Fong, additional, Godfrey, Keith M., additional, Lee, Yung Seng, additional, and Chan, Shiao-Yng, additional

Published
2019
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48. Body composition measurement in young children using quantitative magnetic resonance: A comparison with air displacement plethysmography

Author

Chen, Ling-Wei, Mya, Tint, Fortier, Marielle, Aris, Izzuddin M., Shek, Lynette Pei-Chi, Tan, Kok Hian, Rajadurai, Victor Samuel, Gluckman, Peter D., Chong, Yap-Seng, Godfrey, Keith M., Kramer, Michael S., Henry, Jeya K, Yap, Fabian, and Lee, Yung Seng

Subjects
Male, Plethysmography, Singapore, Magnetic Resonance Spectroscopy, Adipose Tissue, Anthropometry, Asian People, Child, Preschool, Body Composition, Humans, Female, Article
Abstract

Quantitative magnetic resonance (QMR) has been increasingly used to measure human body composition, but its use and validation in children is limited.We compared body composition measurement by QMR and air displacement plethysmography (ADP) in preschool children from Singapore's multi-ethnic Asian population (n = 152; mean ± SD age: 5.0 ± 0.1 years).Agreements between QMR-based and ADP-based fat mass and fat mass index (FMI) were assessed using intraclass correlation coefficient (ICC), reduced major axis regression and Bland-Altman plot analyses. Analyses were stratified for the child's sex.Substantial agreement was observed between QMR-based and ADP-based fat mass (ICC: 0.85) and FMI (ICC: 0.82). Reduced major axis regression analysis suggested that QMR measurements were generally lower than ADP measurements. Bland-Altman analysis similarly revealed that QMR-based fat mass were (mean difference [95% limits of agreement]) -0.5 (-2.1 to +1.1) kg lower than ADP-based fat mass and QMR-based FMI were -0.4 (-1.8 to +0.9) kg/mQMR-based fat mass and FMI showed substantial agreement with, but was generally lower than, ADP-based measures in young Asian children.

Published
2017

50. Higher maternal dietary protein intake and the risk for gestational diabetes mellitus in a multi-ethnic Asian cohort

Author

Pang, Wei Wei, Colega, M., Cai, Shirong, Chan, Yiong Huak, Natarajan, Padmapriya, Chen, Ling-Wei, Han, Wee Meng, Tan, Kok Hian, Lee, Yung Seng, Saw, Seang-Mei, Gluckman, Peter D., Godfrey, Keith M., Chong, Yap-Seng, van Dam, Rob M., and Chong, Mary Foong-Fong

Abstract

Background: Dietary protein may affect glucose metabolism through several mechanisms, but results from studies on dietary protein intake and risk of gestational diabetes mellitus (GDM) have been inconsistent.Objective: We examined the cross-sectional associations of dietary protein intake from different food sources during pregnancy with the risk of GDM in a multiethnic Asian population.Methods: We included 980 participants with singleton pregnancies from the Growing Up in Singapore Toward healthy Outcomes (GUSTO) cohort. Protein intake was ascertained from 24-h dietary recall and 3-d food diaries at 26–28 wk gestation. GDM was defined as fasting glucose ≥7.0 mmol/L and/or 2-h postload glucose ≥7.8 mmol/L at 26–28 wk gestation. We evaluated the association of dietary protein intake with GDM risk by substituting carbohydrate with protein in an isocaloric model with the use of multivariable logistic regression analysis.Results: The prevalence of GDM was 17.9% among our participants. After adjustment for potential confounders, a higher total dietary protein intake was associated with a higher risk of GDM; the OR comparing the highest with the lowest quartile of intake was 2.15 (95% CI: 1.27, 3.62; P-trend = 0.016). Higher intake levels of both animal protein (OR: 2.87; 95% CI: 1.58, 5.20; P-trend = 0.001) and vegetable protein (OR: 1.78; 95% CI: 0.99, 3.20; P-trend = 0.009) were associated with a higher risk of GDM. Among the animal protein sources, higher intake levels of seafood protein (OR: 2.17; 95% CI: 1.26, 3.72; P-trend = 0.023) and dairy protein (OR: 1.87; 95% CI: 1.11, 3.15; P-trend = 0.017) were significantly associated with a higher GDM risk.Conclusion: Higher intake levels of both animal and vegetable protein were associated with a higher risk of GDM in Asian women. This trial was registered at clinicaltrials.gov as NCT01174875.

Published
2017

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