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Background: The characteristics of explosion in water are different from those in air and vary in different water depths. It is important to investigate the characteristics and mechanisms of extremity injuries caused by mine blasts in shoals., Methods: A total of ninety New Zealand rabbits were randomly divided into four groups put in different depths of water (land group, midpoint of the thigh in the shoal 1 group, the xiphoid process in the shoal 2 group, and control group). Electric detonators simulating mines were placed under the rabbits' right hindpaw. After detonation, the animals were subjected to morphological examination., Results: The lower third of the calf was almost completely destroyed by the mine blast on land, and only the rabbits' feet and ankles were destroyed in shoals. The skeleton, artery and sciatic nerve were injured more seriously in shoals than those on land., Conclusion: Mine blasts in shoals caused less disruption of the soft tissue than those on land. However, the skeleton was more seriously damaged in shoals since the pressure wave was transmitted with greater intensity and had a stronger shattering effect on the skeleton. Furthermore, the characteristics of extremity injuries varied according to water depths.

Background: Free radical-induced oxidative damage of the brain has been implicated in a number of psychiatric disorders, including post-traumatic stress disorder (PTSD). Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in CAT have been shown to be associated with several diseases, including hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo. The aim of this study was to evaluate the association of CAT gene polymorphisms with PTSD in a case-control study., Materials and Methods: A total of 460 unrelated adult Chinese Han adults, including 287 healthy volunteers and 173 patients with PTSD. Six tag single-nucleotide polymorphisms (tSNPs) were selected from the entire CAT gene through construction of haplotype bins, and they were genotyped using an improved multiplex ligation detection reaction (iMLDR) technique. Allelic frequencies and clinical characteristics were compared in two independent Chinese Han populations., Results: Six tag SNPs were identified in the Chinese Han population and all were common SNPs. However, we could detect no evidence of genetic association between six tag SNPs in the CAT gene and PTSD in the Chinese Han population., Conclusions: This result suggests that six tag SNPs of the CAT gene may not be associated with PTSD, and that CAT gene might not influence the development of PTSD in patients following exposure to a traumatic event, also may be the sample sizes too small to allow a meaningful test.