Search

Your search keyword '"Chen, Kelie"' showing total 157 results
Start Over Author "Chen, Kelie"
157 results on '"Chen, Kelie"'

18. Association between vitamin D/calcium intake and 25-hydroxyvitamin D and risk of ovarian cancer: a dose-response relationship meta-analysis

Author

Xu, Jiawei, Chen, Kelie, Zhao, Fan, Huang, Dongdong, Zhang, Honghe, Fu, Zhiqin, and Xu, Jinming

Subjects
Risk factors, Properties, Health aspects, Calcium (Nutrient) -- Health aspects -- Properties, Vitamin D -- Health aspects -- Properties, Ovarian cancer -- Risk factors, Alfacalcidol -- Health aspects -- Properties, Calcifediol -- Health aspects -- Properties, Calcium, Dietary -- Health aspects -- Properties
Abstract

Author(s): Jiawei Xu [sup.1] , Kelie Chen [sup.1] , Fan Zhao [sup.2] , Dongdong Huang [sup.3] , Honghe Zhang [sup.3] , Zhiqin Fu [sup.4] , Jinming Xu [sup.5] , Yongfeng [...], Background The association between vitamin D/calcium and risk of ovarian cancer is still a debatable point. The aim of our study was to systematically investigate the association between vitamin D/calcium, and the risk of ovarian cancer and estimate their dose-response association quantitatively. Methods PubMed, EMBASE, and Web of Science databases were searched to identify relevant observational studies. Two investigators screened citations and extracted data independently. Data were extracted and the association between vitamin D/calcium and ovarian cancer risk was estimated by calculating pooled relative risks (RRs). Subgroup analyses, publication bias estimation, and dose-response analyses were carried out as well. Results In total, 21 articles involving 980,008 participants were included in our present study. No significant association was observed between total vitamin D intake and ovarian cancer risk (RR: 1.02; 95% CI, 0.89-1.16, p = 0.81). Further subgroup analysis suggested that neither dietary vitamin D intake (RR: 0.80; 95% CI, 0.62-1.03, p = 0.09) nor supplementary vitamin D intake (RR: 0.98; 95% CI, 0.85-1.13, p = 0.80) was associated with the risk of ovarian cancer. As for calcium, total calcium intake was found to be statistically inversely associated with ovarian cancer risk in case-control studies (RR: 0.73; 95% CI, 0.63-0.86, p < 0.001) but not in cohort studies (RR: 1.05; 95% CI, 0.90-1.24, p = 0.52). Besides, supplementation with calcium plus vitamin D was not effective for the prevention of ovarian cancer (p = 0.98). Of note, dose-response analysis based on cohort studies suggested a potential inverse U-shape relationship between calcium intake (including total calcium and dietary calcium) and ovarian cancer risk, which indicated that low dose of calcium intake might reduce ovarian cancer risk while high dose of calcium intake might not. Conclusions Taken together, vitamin D could not decrease the risk of ovarian cancer. The role of calcium intake was not proven for reducing ovarian cancer risk. Besides, no evidence showed combinative use of calcium and vitamin D have additional benefits for ovarian cancer prevention.

Published
2021
Full Text
View/download PDF

35. Identification of metastasis-related long non-coding RNAs in lung cancer through a novel tumor mesenchymal score

Author

Yang, Dexin, primary, Niu, Yuequn, additional, Ni, Heng, additional, Leng, Jing, additional, Xu, Xian, additional, Yuan, Xiaoyu, additional, Chen, Kelie, additional, Wu, Yongfeng, additional, Wu, Han, additional, Lu, Haohua, additional, Xu, Jinming, additional, Wang, Luming, additional, Jiang, Yifan, additional, Cui, Dongyu, additional, Hu, Jian, additional, Xia, Dajing, additional, and Wu, Yihua, additional

Published
2022
Full Text
View/download PDF

37. Identification of a Novel Prognostic Classification Model in Epithelial Ovarian Cancer by Cluster Analysis

Author

Chen, Kelie, Niu, Yuequn, Wang, Shengchao, Fu, Zhiqin, Lin, Hui, Lu, Jiaoying, Meng, Xinyi, Yang, Bowen, Zhang, Honghe, Wu, Yihua, Xia, Dajing, and Lu, Weiguo

Subjects
ovarian cancer, classification, Cancer Management and Research, inflammation, prognosis, heterogeneity, Original Research, cluster analysis
Abstract

Kelie Chen,1,2,* Yuequn Niu,3,* Shengchao Wang,1,* Zhiqin Fu,4 Hui Lin,1,2 Jiaoying Lu,2 Xinyi Meng,2 Bowen Yang,2 Honghe Zhang,1 Yihua Wu,1,2 Dajing Xia,1,2 Weiguo Lu1 1Department of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, People’s Republic of China; 2Department of Toxicology, School of Public Health, School of Medicine, Zhejiang University, Hangzhou 310058, People’s Republic of China; 3Department of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 4Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dajing XiaDepartment of Toxicology, School of Public Health, School of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, People’s Republic of ChinaTel/ Fax +86-0571-88208140Email dxia@zju.edu.cnWeiguo LuDepartment of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People’s Republic of ChinaTel +86-571-8706-1501Fax +86-571-87061878Email lbwg@zju.edu.cnBackground: Heterogeneity plays an essential role in ovarian cancer. Patients with different clinical features may manifest diverse patterns in diagnosis, treatment, and prognosis. The aim of the present study was to identify a novel ovarian cancer–classification model through cluster analysis and assess its significance in prognosis.Methods: Among patients diagnosed with ovarian cancer in the Women’s Hospital School of Medicine, Zhejiang University between January 2014 and May 2019, 328 patients were included in a K-mean cluster analysis and 176 patients followed up. Major clinical indicators, overall survival, and recurrence-free survival in different subgroups were compared.Results: Two clusters for ovarian cancer were identified and grouped as noninflammatory (n=247) and inflammatory subtypes (n=81). Compared with the noninflammatory subgroup, the inflammatory subgroup presented a statistically significantly higher level of median CRP (median (IQR) 20.4 [7.8– 47.3] vs 1.2 [0.4– 3.5], p< 0.001), neutrophil percentage (median (IQR) 76.9 [72.6– 81.3] vs 66.2 [61.0– 72.0], p< 0.001), leukocyte count (median (IQR) 8.9 [7.0– 10.0] vs 6.0 [5.1– 7.2], p< 0.001), fibrinogen (median (IQR) 5.0 [4.4– 6.0] vs 3.4 [2.9– 3.9], p< 0.001), and platelet count (median (IQR) 324 [270– 405] vs 229 [181.5– 269], p< 0.001). During a median follow-up of 52 months, 21 participants (16.3%) died in the noninflammatory group, while 14 (29.8%) died in the inflammatory group (HR 2.15, 95% CI 1.09– 4.23; p=0.024). Death/recurrence was observed in 38 (29.5%) patients from the noninflammatory group and 25 (53.2%) from the inflammatory group (HR 2.32, 95% CI 1.40– 3.85; p< 0.001).Conclusion: Our study revealed a novel classification model of ovarian cancer that features inflammation. Inflammation predicts shorter survival and poorer prognosis, suggesting the significance of inflammation in the management of ovarian cancer.Keywords: ovarian cancer, classification, heterogeneity, cluster analysis, inflammation, prognosis

Published
2020

38. WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

Author

Lu, Guang, primary, Tan, Hayden Weng Siong, additional, Schmauck-Medina, Tomas, additional, Wang, Liming, additional, Chen, Jiaqing, additional, Cho, Yik-Lam, additional, Chen, Kelie, additional, Zhang, Jing-Zi, additional, He, Weifeng, additional, Wu, Yihua, additional, Xia, Dajing, additional, Zhou, Jing, additional, Fang, Evandro F., additional, Fang, Lei, additional, Liu, Wei, additional, and Shen, Han-Ming, additional

Published
2022
Full Text
View/download PDF

39. Additional file 10 of High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

Author

Shen, Yuqing, Lin, Hui, Chen, Kelie, Ge, Wanzhong, Xia, Dajing, Wu, Yihua, and Lu, Weiguo

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Additional file 10: Supplementary Figure 1-6. Relationship of expression of ISG15, SNCA, PLCG2, RHOU, TRIB2 with survival outcome of serous ovarian cancer.

Published
2022
Full Text
View/download PDF

40. LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer

Author

Lin, Hui, primary, Xu, Xian, additional, Chen, Kelie, additional, Fu, Zhiqin, additional, Wang, Shengchao, additional, Chen, Yaqing, additional, Zhang, Honghe, additional, Niu, Yuequn, additional, Chen, Hanwen, additional, Yu, Hongfei, additional, Shao, Jian-zhong, additional, Lu, Weiguo, additional, Wu, Yihua, additional, and Xia, Dajing, additional

Published
2022
Full Text
View/download PDF

43. USH2Amutation and specific driver mutation subtypes are associated with clinical efficacy of immune checkpoint inhibitors in lung cancer

Author

Yang, Dexin, Feng, Yuqin, Lu, Haohua, Chen, Kelie, Xu, Jinming, Li, Peiwei, Wang, Tianru, Xia, Dajing, and Wu, Yihua

Abstract

This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors (ICIs) by conducting systematic literature search in electronic databases up to May 31, 2021. The main outcomes including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and durable clinical benefit (DCB) were correlated with tumor genomic features. A total of 1546 lung cancer patients with available genomic variation data were included from 14 studies. The Kirsten rat sarcoma viral oncogene homolog G12C(KRASG12C) mutation combined with tumor protein P53 (TP53) mutation revealed the promising efficacy of ICI therapy in these patients. Furthermore, patients with epidermal growth factor receptor (EGFR) classical activating mutations (including EGFRL858Rand EGFRΔ19) exhibited worse outcomes to ICIs in OS (adjusted hazard ratio (HR), 1.40; 95% confidence interval (CI), 1.01–1.95; P=0.0411) and PFS (adjusted HR, 1.98; 95% CI, 1.49–2.63; P<0.0001), while classical activating mutations with EGFRT790Mshowed no difference compared to classical activating mutations without EGFRT790Min OS (adjusted HR, 0.96; 95% CI, 0.48–1.94; P=0.9157) or PFS (adjusted HR, 0.72; 95% CI, 0.39–1.35; P=0.3050). Of note, for patients harboring the Usher syndrome type-2A (USH2A) missense mutation, correspondingly better outcomes were observed in OS (adjusted HR, 0.52; 95% CI, 0.32–0.82; P=0.0077), PFS (adjusted HR, 0.51; 95% CI, 0.38–0.69; P<0.0001), DCB (adjusted odds ratio (OR), 4.74; 95% CI, 2.75–8.17; P<0.0001), and ORR (adjusted OR, 3.45; 95% CI, 1.88–6.33; P<0.0001). Our findings indicated that, USH2Amissense mutations and the KRASG12Cmutation combined with TP53mutation were associated with better efficacy and survival outcomes, but EGFRclassical mutations irrespective of combination with EGFRT790Mshowed the opposite role in the ICI therapy among lung cancer patients. Our findings might guide the selection of precise targets for effective immunotherapy in the clinic.

Published
2023
Full Text
View/download PDF

46. Association between vitamin D/calcium intake and 25-hydroxyvitamin D and risk of ovarian cancer: a dose-response relationship meta-analysis

Author

Xu, Jiawei, primary, Chen, Kelie, additional, Zhao, Fan, additional, Huang, Dongdong, additional, Zhang, Honghe, additional, Fu, Zhiqin, additional, Xu, Jinming, additional, Wu, Yongfeng, additional, Lin, Hui, additional, Zhou, Yexinyi, additional, Lu, Weiguo, additional, Wu, Yihua, additional, and Xia, Dajing, additional

Published
2020
Full Text
View/download PDF

47. Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor

Author

Chen, Kelie, primary, Yang, Dexin, additional, Zhao, Fan, additional, Wang, Shengchao, additional, Ye, Yao, additional, Sun, Wenjie, additional, Lu, Haohua, additional, Ruan, Zhi, additional, Xu, Jinming, additional, Wang, Tianru, additional, Lu, Guang, additional, Wang, Liming, additional, Shi, Yu, additional, Zhang, Honghe, additional, Wu, Han, additional, Lu, Weiguo, additional, Shen, Han-Ming, additional, Xia, Dajing, additional, and Wu, Yihua, additional

Published
2020
Full Text
View/download PDF

48. A Novel Scoring System for Pivotal Autophagy-Related Genes Predicts Outcomes after Chemotherapy in Advanced Ovarian Cancer Patients

Author

Niu, Yuequn, primary, Sun, Wenjie, additional, Chen, Kelie, additional, Fu, Zhiqin, additional, Chen, Yaqing, additional, Zhu, Jianqing, additional, Chen, Hanwen, additional, Shi, Yu, additional, Zhang, Honghe, additional, Wang, Liming, additional, Shen, Han-Ming, additional, Xia, Dajing, additional, and Wu, Yihua, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results