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29 results on '"Chen, Jutao"'

2. Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

Author

Wei, Min, primary, Sun, Yanping, additional, Li, Shouzhen, additional, Chen, Yunuo, additional, Li, Longfei, additional, Fang, Minghao, additional, Shi, Ronghua, additional, Tong, Dali, additional, Chen, Jutao, additional, Ma, Yuqian, additional, Qu, Kun, additional, Zhang, Mei, additional, and Xue, Tian, additional

Published
2023
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5. Melanopsin retinal ganglion cells mediate light-promoted brain development

Author

Hu, Jiaxi, primary, Shi, Yiming, additional, Zhang, Jiaming, additional, Huang, Xinfeng, additional, Wang, Qian, additional, Zhao, Hang, additional, Shen, Jiawei, additional, Chen, Zhiping, additional, Song, Wei, additional, Zheng, Ping, additional, Zhan, Shulu, additional, Sun, Yanping, additional, Cai, Pengfei, additional, An, Kai, additional, Ouyang, Changjie, additional, Zhao, Baizhen, additional, Zhou, Qixin, additional, Xu, Lin, additional, Xiong, Wei, additional, Zhang, Zhi, additional, Meng, Jianjun, additional, Chen, Jutao, additional, Ma, Yuqian, additional, Zhao, Huan, additional, Zhang, Mei, additional, Qu, Kun, additional, Hu, Ji, additional, Luo, Minhua, additional, Xu, Fuqiang, additional, Chen, Xiaowei, additional, Xiong, Ying, additional, Bao, Jin, additional, and Xue, Tian, additional

Published
2022
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10. Electrophysiological Characterization of Photoreceptor-Like Cells in Human Inducible Pluripotent Stem Cell-Derived Retinal Organoids During in Vitro Maturation

Author

Li, Lingyun, primary, Zhao, Huan, additional, Xie, Haohuan, additional, Akhtar, Tasneem, additional, Yao, Yichuan, additional, Cai, Yuan, additional, Dong, Kai, additional, Gu, Yonghao, additional, Bao, Jin, additional, Chen, Jutao, additional, Zhang, Mei, additional, Zhong, Kai, additional, Xu, Weiping, additional, and Xue, Tian, additional

Published
2021
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14. Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury

Author

Wang, Chao, primary, Zhang, Jie, additional, Tang, Junchun, additional, Li, Yi-yi, additional, Gu, YanXia, additional, Yu, Ying, additional, Xiong, Jing, additional, Zhao, Xueqing, additional, Zhang, Zheng, additional, Li, Ting-ting, additional, Chen, Jutao, additional, Wan, Qi, additional, and Zhang, Zhaohui, additional

Published
2018
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15. Design and implementation of Marine Electric Propulsion Dynamic Load Simulation System

Author

Chen Jutao, Zheng Hua-yao, and Ye Aibing

Subjects
Dynamic simulation, Engineering, Work (electrical), Electrically powered spacecraft propulsion, business.industry, Propeller, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Simulation system, business, Dynamic load testing, Marine engineering
Abstract

This paper describes the design and implementation of the marine electric propulsion dynamic load simulation system, witch is a real-time hardware-in-the-loop simulation system for marine electric propulsion. Especially, issues about implementing the propeller dynamic load simulation, such as the propeller dynamic load mathematical model, the embedded simulation computer, as well as specific problems and solutions in practical implementation work, are discussed in detail. Finally results of experiment with this system is shown and interpreted.

Published
2008

16. ARM+DSP Embedded System Applied in Marine Electric Propulsion Dynamic Load Simulation System

Author

Chen Jutao, Huang Xue-wu, and Zheng Hua-yao

Subjects
Dynamic simulation, Engineering, Software, Electrically powered spacecraft propulsion, business.industry, Embedded system, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Control engineering, Simulation system, business, Digital signal processing, Dynamic load testing
Abstract

This paper introduces the Marine Electric Propulsion Dynamic Load Simulation System, and puts forward a new type ARM+DSP embedded system to implement the screw load dynamic simulation, which is the vital part of this real-time HIL simulation system. Hardware and software of ARM+DSP embedded system, as well as some problems in practical implementation and corresponding solutions are discussed in detail. Some simulation experiment results produced by the simulation system are also shown in the paper.

Published
2007

17. Ship electric propulsion simulator based on networking technology

Author

Binquan Lu, Zheng Huayao, Huang Xuewu, and Chen Jutao

Subjects
Electric power system, Engineering, Data acquisition, Software, business.industry, Marine propulsion, Control system, Local area network, System integration, business, Simulation, CAN bus
Abstract

According the new ship building tense, a novel electric propulsion simulator (EPS) had been developed in Marine Simulation Center of SMU. The architecture, software function and FCS network technology of EPS and integrated power system (IPS) were described. In allusion to the POD propeller in ship, a special physical model was built. The POD power was supplied from the simulative 6.6 kV Medium Voltage Main Switchboard, its control could be realized in local or remote mode. Through LAN, the simulated feature information of EPS will pass to the physical POD model, which would reflect the real thruster working status in different sea conditions. The software includes vessel-propeller math module, thruster control system, distribution and emergency integrated management, double closed loop control system, vessel static water resistance and dynamic software; instructor main control software. The monitor and control system is realized by real time data collection system and CAN bus technology. During the construction, most devices such as monitor panels and intelligent meters, are developed in lab which were based on embedded microcomputer system with CAN interface to link the network. They had also successfully used in practice and would be suitable for the future demands of digitalization ship.

Published
2006

18. Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability

Author

Zha,Ying-ying, Yang,Bo, Tang,Mingliang, Guo,Qiuchen, Chen,Jutao, Wen,Long-ping, Wang,Ming, Zha,Ying-ying, Yang,Bo, Tang,Mingliang, Guo,Qiuchen, Chen,Jutao, Wen,Long-ping, and Wang,Ming

Abstract

Ying-ying Zha,1 Bo Yang,1 Ming-liang Tang,2 Qiu-chen Guo,1 Ju-tao Chen,1 Long-ping Wen,3 Ming Wang11CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 2Suzhou Institute of NanoTech and NanoBionics, Chinese Academy of Sciences, Suzhou, 3Laboratory of Nano-biology, School of Life Sciences, University of Science and Technology of China, Hefei, People's Republic of ChinaBackground: Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons.Methods and results: Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins.Conclusion: These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.Keywords: fullerenol, nanomaterial, neurotoxicity, neuroprotection, hippocampal neuron

Published
2012

28. Involvement of cyclin D1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2+-induced neuronal death in cultured hippocampal neurons

Author

Li, Chenchen, Xing, Tairan, Tang, Mingliang, Yong, Wu, Yan, Dan, Deng, Hongmin, Wang, Huili, Wang, Ming, Chen, Jutao, and Ruan, Diyun

Subjects
*NEUROTOXIC agents, *APOPTOSIS, *PHOSPHORYLATION, *NERVOUS system
Abstract

Abstract: Lead (Pb) is widely recognized as a neurotoxicant. One of the suggested mechanisms of lead neurotoxicity is apoptotic cell death. And the mechanism by which Pb2+ causes neuronal death is not well understood. The present study sought to examine the obligate nature of cyclin D1/cyclin-dependent kinase 4 (CDK4), phosphorylation of its substrate retinoblastoma protein (pRb) and its select upstream signal phosphoinositide 3-kinase (PI3K)/AKT pathway in the death of primary cultured rat hippocampal neurons evoked by Pb2+. Our data showed that lead treatment of primary hippocampal cultures results in dose-dependent cell death. Inhibition of CDK4 prevented Pb2+-induced neuronal death significantly but was incomplete. In addition, we demonstrated that the levels of cyclin D1 and pRb/p107 were increased during Pb2+ treatment. These elevated expression persisted up to 48 h, returning to control levels after 72 h. We also presented pharmacological and morphological evidences that cyclin D1/CDK4 and pRb/p107 were required for such kind of neuronal death. Addition of the PI3K inhibitor LY294002 (30 μM) or wortmannin (100 nM) significantly rescued the cultured hippocampal neurons from death caused by Pb2+. And that Pb2+-elicited phospho-AKT (Ser473) participated in the induction of cyclin D1 and partial pRb/p107 expression. These results provide evidences that cell cycle elements play a required role in the death of neurons evoked by Pb2+ and suggest that certain signaling elements upstream of cyclin D1/CDK4 are modified and/or required for this form of neuronal death. [Copyright &y& Elsevier]

Published
2008
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