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1. Data from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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2. Supplementary Figures and legends from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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3. Supplementary Table 2 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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4. Supplementary Table 3 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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5. Supplementary Materials and Methods-PJA1-Cancer research from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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6. Supplementary Table 4 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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7. Supplementary Table 1 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, primary, Li, Shulin, primary, Song, Shumei, primary, Nguyen, Bao-Ngoc, primary, Chen, Jiun-Sheng, primary, Shin, Ji-Hyun, primary, Gough, Nancy R., primary, Lin, Paul, primary, Obias, Vincent, primary, He, Aiwu Ruth, primary, Yao, Zhixing, primary, Malta, Tathiane M., primary, Noushmehr, Houtan, primary, Latham, Patricia S., primary, Su, Xiaoping, primary, Rashid, Asif, primary, Mishra, Bibhuti, primary, Wu, Ray-Chang, primary, and Mishra, Lopa, primary

Published
2023
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8. TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

Author

Chen, Jian, Yao, Zhi-Xing, Chen, Jiun-Sheng, Gi, Young Jin, Munoz, Nina M., Kundra, Suchin, Herlong, H. Franklin, Jeong, Yun Seong, Goltsov, Alexei, Ohshiro, Kazufumi, Mistry, Nipun A., Zhang, Jianping, Su, Xiaoping, Choufani, Sanaa, Mitra, Abhisek, Li, Shulin, Mishra, Bibhuti, White, Jon, Rashid, Asif, Wang, Alan Yaoqi, Javle, Milind, Davila, Marta, Michaely, Peter, Weksberg, Rosanna, Hofstetter, Wayne L., Finegold, Milton J., Shay, Jerry W., Machida, Keigo, Tsukamoto, Hidekazu, and Mishra, Lopa

Subjects
Gene mutations -- Health aspects, Gene expression -- Health aspects, Beckwith-Wiedemann syndrome -- Development and progression -- Genetic aspects, Growth factors -- Health aspects, Health care industry
Abstract

Beckwith-Wiedemann syndrome (BWS) is a human stem cell disorder, and individuals with this disease have a substantially increased risk (~800-fold) of developing tumors. Epigenetic silencing of β2-spectrin (βL2SP, encoded by SPTBN1), a SMAD adaptor for TGF-β signaling, is causally associated with BWS; however, a role of TGF-β deficiency in BWS-associated neoplastic transformation is unexplored. Here, we have reported that double-heterozygous [Sptbn1.sup.+/-] [Smad.3.sup.+/-] mice, which have defective TGF-β signaling, develop multiple tumors that are phenotypically similar to those of BWS patients. Moreover, tumorigenesis-associated genes IGF2 and telomerase reverse transcriptase (TERT) were overexpressed in fibroblasts from BWS patients and TGF-β-defective mice. We further determined that chromatin insulator CCCTC-binding factor (CTCF) is TGF-β inducible and facilitates TGF-β-mediated repression of TERT transcription via interactions with β2SP and SMAD3. This regulation was abrogated in TGF-β-defective mice and BWS, resulting in TERT overexpression. Imprinting of the IGF2/H19 locus and the CDKN1C/KCNQ1 locus on chromosome 11p15.5 is mediated by CTCF, and this regulation is lost in BWS, leading to aberrant overexpression of growth-promoting genes. Therefore, we propose that loss of CTCF-dependent imprinting of tumor-promoting genes, such as IGF2 and TERT, results from a defective TGF-β pathway and is responsible at least in part for BWS-associated tumorigenesis as well as sporadic human cancers that are frequently associated with SPTBN1 and SMAD3 mutations., Introduction Beckwith-Wiedemann syndrome (BWS) is a stem cell overgrowth disorder with an estimated prevalence of 1 in 14,000 (1). Its phenotypic expression includes omphalocele, organomegaly, adrenal cytomegaly, hemihyperplasia, and macrosomia, [...]

Published
2016
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10. Aurora B kinase phosphorylates and instigates degradation of p53

Author

Gully, Chris P., Velazquez-Torres, Guermarie, Shin, Ji-Hyun, Fuentes-Mattei, Enrique, Wang, Edward, Carlock, Colin, Chen, Jian, Rothenberg, Daniel, Adams, Henry P., Choi, Hyun Ho, Guma, Sergei, Phan, Liem, Chou, Ping-Chieh, Su, Chun-Hui, Zhang, Fanmao, Chen, Jiun-Sheng, Yang, Tsung-Ying, Yeung, Sai-Ching J., and Lee, Mong-Hong

Published
2012

12. A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk

Author

Yu, Yao, primary, Chang, Kyle, additional, Chen, Jiun-Sheng, additional, Bohlender, Ryan J., additional, Fowler, Jerry, additional, Zhang, Di, additional, Huang, Maosheng, additional, Chang, Ping, additional, Li, Yanan, additional, Wong, Justin, additional, Wang, Huamin, additional, Gu, Jian, additional, Wu, Xifeng, additional, Schildkraut, Joellen, additional, Cannon-Albright, Lisa, additional, Ye, Yuanqing, additional, Zhao, Hua, additional, Hildebrandt, Michelle A.T., additional, Permuth, Jennifer B., additional, Li, Donghui, additional, Scheet, Paul, additional, and Huff, Chad, additional

Published
2021
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13. Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor-Positive Breast Cancer

Author

Fuentes-Mattei, Enrique, Velazquez-Torres, Guermarie, Phan, Liem, Zhang, Fanmao, Chou, Ping-Chieh, Shin, Ji-Hyun, Choi, Hyun Ho, Chen, Jiun-Sheng, Zhao, Ruiying, Chen, Jian, Gully, Chris, Carlock, Colin, Qi, Yuan, Zhang, Ya, Wu, Yun, Esteva, Francisco J., Luo, Yongde, McKeehan, Wallace L., Ensor, Joe, Hortobagyi, Gabriel N., Pusztai, Lajos, Symmans, Fraser W., Lee, Mong-Hong, and Yeung, Sai-Ching Jim

Published
2014
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15. Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study

Author

Zheng, Jiali, primary, Hoffman, Kristi L., additional, Chen, Jiun-Sheng, additional, Shivappa, Nitin, additional, Sood, Akhil, additional, Browman, Gladys J., additional, Dirba, Danika D., additional, Hanash, Samir, additional, Wei, Peng, additional, Hebert, James R., additional, Petrosino, Joseph F., additional, Schembre, Susan M., additional, and Daniel, Carrie R., additional

Published
2020
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17. Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Author

Chen, Jian, primary, Mitra, Abhisek, additional, Li, Shulin, additional, Song, Shumei, additional, Nguyen, Bao-Ngoc, additional, Chen, Jiun-Sheng, additional, Shin, Ji-Hyun, additional, Gough, Nancy R., additional, Lin, Paul, additional, Obias, Vincent, additional, He, Aiwu Ruth, additional, Yao, Zhixing, additional, Malta, Tathiane M., additional, Noushmehr, Houtan, additional, Latham, Patricia S., additional, Su, Xiaoping, additional, Rashid, Asif, additional, Mishra, Bibhuti, additional, Wu, Ray-Chang, additional, and Mishra, Lopa, additional

Published
2020
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18. Abstract 3320: Dietary inflammatory potential in relation to the gut microbiome among persons at varied risk of colorectal neoplasia

Author

Zheng, Jiali, primary, Hoffman, Kristi L., additional, Shivappa, Nitin, additional, Busquets, Jonathan, additional, Chen, Jiun-Sheng, additional, Hanash, Samir, additional, Schembre, Susan, additional, Hébert, James, additional, Petrosino, Joseph, additional, Wei, Peng, additional, and Daniel, Carrie R., additional

Published
2019
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19. High metastatic node number, not extranodal extension, as a node‐related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma

Author

Hsieh, Cheng‐En, primary, Hung, Chia‐Yen, additional, Lin, Chien‐Yu, additional, Chen, Jiun‐Sheng, additional, Chang, Kai‐Ping, additional, Aithala, Sathvik Panambur, additional, Lee, Li‐Yu, additional, Tsang, Ngan‐Ming, additional, Lu, Chang‐Hsien, additional, Chen, Miao‐Fen, additional, Cheng, Yu‐Fan, additional, Yeh, Kun‐Yun, additional, Wang, Cheng‐Hsu, additional, and Chou, Wen‐Chi, additional

Published
2019
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22. Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway

Author

Chen, Jian, primary, Zaidi, Sobia, additional, Rao, Shuyun, additional, Chen, Jiun-Sheng, additional, Phan, Liem, additional, Farci, Patrizia, additional, Su, Xiaoping, additional, Shetty, Kirti, additional, White, Jon, additional, Zamboni, Fausto, additional, Wu, Xifeng, additional, Rashid, Asif, additional, Pattabiraman, Nagarajan, additional, Mazumder, Raja, additional, Horvath, Anelia, additional, Wu, Ray-Chang, additional, Li, Shulin, additional, Xiao, Cuiying, additional, Deng, Chu-Xia, additional, Wheeler, David A., additional, Mishra, Bibhuti, additional, Akbani, Rehan, additional, and Mishra, Lopa, additional

Published
2018
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24. Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma

Author

Hu, Fulan, Yu, Yao, Chen, Jiun-Sheng, Hu, Hao, Scheet, Paul, and Huff, Chad D.

Abstract

PurposeThe contribution of rare genetic variation in the development of soft-tissue sarcoma (STS) remains underexplored. To address this gap, we conducted a whole-exome case-control and somatic-germline interaction study to identify and characterise STS susceptible genes.MethodsThe study involved 219 STS cases from The Cancer Genome Atlas and 3507 controls. All cases and controls were matched genetically onEuropean ancestry based on the 1000 Genomes project. Cross-platform technological stratification was performed with XPAT and gene-based association tests with VAAST 2.ResultsNF1exhibited the strongest genome-wide signal across the six subtypes, with p=1×10−5. We also observed nominally significant association signals for three additional genes of interest, TP53(p=0.0025), RB1(p=0.0281), and MSH2(p=0.0085). BAG1, which has not previously been implicated in STS, exhibited the strongest genome-wide signal after NF1, with p=6×10−5. The association signals for NF1and MSH2were driven primarily by truncating variants, with ORs of 39 (95% CI: 7.1 to 220) for NF1and 33 (95% CI: 2.4 to 460) for MSH2. In contrast, the association signals for RB1and BAG1were driven primarily by predicted damaging missense variants, with estimated ORs of 12 (95% CI: 2.4 to 59) for RB1and 20 (95% CI: 1.4 to 300) for BAG1.ConclusionsOur results confirm that pathogenic variants in NF1, RB1and TP53confer large increases in the risk of developing multiple STS subtypes, provide support for the role of MSH2in STS susceptibility and identify BAG1as a novel candidate STS risk gene.

Published
2021
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26. The somatic mutation landscape of premalignant colorectal adenoma

Author

Lin, Shu-Hong, primary, Raju, Gottumukkala S, additional, Huff, Chad, additional, Ye, Yuanqing, additional, Gu, Jian, additional, Chen, Jiun-Sheng, additional, Hildebrandt, Michelle A T, additional, Liang, Han, additional, Menter, David G, additional, Morris, Jeffery, additional, Hawk, Ernest, additional, Stroehlein, John R, additional, Futreal, Andrew, additional, Kopetz, Scott, additional, Mishra, Lopa, additional, and Wu, Xifeng, additional

Published
2017
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27. High metastatic node number, not extranodal extension, as a node‐related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma.

Author

Tsang, Ngan‐Ming, Hsieh, Cheng‐En, Lin, Chien‐Yu, Lu, Chang‐Hsien, Chen, Miao‐Fen, Cheng, Yu‐Fan, Yeh, Kun‐Yun, Wang, Cheng‐Hsu, Chou, Wen‐Chi, Chen, Jiun‐Sheng, Hung, Chia‐Yen, Chang, Kai‐Ping, Aithala, Sathvik Panambur, and Lee, Li‐Yu

Subjects
SALIVARY glands, CARCINOMA, PROGRESSION-free survival, MULTIVARIATE analysis
Abstract

Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in surgically treated patients with nodal metastatic SGC. Methods: This multicenter cohort included 114 patients with pathologically proven node‐positive SGC between 2000 and 2014. Possible correlations of clinicopathological parameters and outcomes were examined. Results: The median follow‐up was 69 months (range, 11‐173 months). The multivariate analysis identified metastatic node number (1‐2 vs 3‐6; 1‐2 vs ≥7) as an independent predictor for regional control (P = 0.005; P = 0.02), locoregional control (P = 0.008; P = 0.04), distant metastasis‐free survival (P = 0.17; P = 0.006), disease‐free survival (P = 0.05; P = 0.002), and overall survival (P = 0.18; P = 0.009), whereas ENE was not associated with survival outcomes. Conclusions: Metastatic node number, not ENE, is an independent node‐related prognosticator for SGC. Integration of ENE into the American Joint Committee on Cancer 8th edition staging criteria may not improve prognostic performance. [ABSTRACT FROM AUTHOR]

Published
2019
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28. Abstract 2540: Disruption of a TGF-β-CTCF regulated pathway leads to cancer stem cells

Author

Chen, Jian, primary, Yao, Zhixing, additional, Chen, Jiun-Sheng, additional, Gi, Young Jin, additional, Jeong, Yun Seong, additional, Jogunoori, Wilma, additional, Belkin, Mitchell, additional, Mishra, Bibhuti, additional, White, Jon, additional, Mitra, Abhisek, additional, Li, Shulin, additional, Finegold, Milton, additional, Davila, Marta, additional, Shay, Jerry, additional, Machida, Keigo, additional, Tsukamoto, Hidekazu, additional, and Mishra, Lopa, additional

Published
2016
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29. Abstract 4425: Comprehensive study of TGF-β pathway-driven functional molecular characterization of human hepatocellular cancer

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Zhang, Jianping, additional, Gi, YoungJin, additional, Katz, Lior, additional, Shin, Ji-Hyun, additional, Jeong, YunSeong, additional, Belkin, Mitch, additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, White, Jon, additional, Gu, Shoujun, additional, Javle, Milind, additional, Su, Xiaoping, additional, Stroehlein, John, additional, Davila, Marta, additional, Wang, Xuemei, additional, Morris, Jeffrey, additional, Farci, Patrizia, additional, Akbani, Rehan, additional, and Mishra, Lopa, additional

Published
2016
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30. Abstract 3594: The TGF-β effector β2SP depletion abrogates DNA damage repair

Author

Chen, Jian, primary, Shukla, Vivek, additional, Chen, Jiun-Sheng, additional, Panditab, Raj K., additional, Jeong, Yun Seong, additional, Katz, Lior H, additional, Shin, Ji-Hyun, additional, Gi, YoungJin, additional, Kwongc, Lawrence N., additional, Huntb, Clayton R., additional, Farci, Patrizia, additional, Su, Xiaoping, additional, White, Jon, additional, Mishra, Bibhuti, additional, Rashid, Asif, additional, Javle, Milind, additional, Li, Lei, additional, Chen, Junjie, additional, Stroehlein, John R, additional, Davila, Marta, additional, Akbani, Rehan, additional, Machidao, Keigo, additional, Tsukamoto, Hidekazu, additional, Pandita, Tej K., additional, and Mishra, Lopa, additional

Published
2016
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31. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas

Author

Chen, Jian, primary, Raju, Gottumukkala S., additional, Jogunoori, Wilma, additional, Menon, Vipin, additional, Majumdar, Avijit, additional, Chen, Jiun-Sheng, additional, Gi, Young Jin, additional, Jeong, Yun Seong, additional, Phan, Liem, additional, Belkin, Mitchell, additional, Gu, Shoujun, additional, Kundra, Suchin, additional, Mistry, Nipun A., additional, Zhang, Jianping, additional, Su, Xiaoping, additional, Li, Shulin, additional, Lin, Sue-Hwa, additional, Javle, Milind, additional, McMurray, John S., additional, Rahlfs, Thomas F., additional, Mishra, Bibhuti, additional, White, Jon, additional, Rashid, Asif, additional, Beauchemin, Nicole, additional, Weston, Brian R., additional, Shafi, Mehnaz A., additional, Stroehlein, John R., additional, Davila, Marta, additional, Akbani, Rehan, additional, Weinstein, John N., additional, Wu, Xifeng, additional, and Mishra, Lopa, additional

Published
2016
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32. Tu1624 Dysregulated TGF-β Signaling Leads to Genomic Instability and Liver Cancer

Author

Chen, Jian, primary, Shukla, Vivek, additional, Panditab, Raj K., additional, Chen, Jiun-Sheng, additional, Jeong, Yun Seong, additional, Katz, Lior H., additional, Shin, Ji-Hyun, additional, Gi, YoungJin, additional, Kwongc, Lawrence N., additional, Huntb, Clayton R., additional, Farci, Patrizia, additional, Su, Xiaoping, additional, White, Jon, additional, Mishra, Bibhuti, additional, Rashid, Asif, additional, Javle, Milind, additional, Li, Lei, additional, Chen, Junjie, additional, Stroehlein, John R., additional, Davila, Marta L., additional, Akbani, Rehan, additional, Machida, Keigo, additional, Tsukamoto, Hidekazu, additional, Pandita, Tej K., additional, and Mishra, Lopa, additional

Published
2016
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33. Tu1631 A TGF-β-Ctcf Regulated Pathway Suppresses Stem Cell Associated Tumor Progression

Author

Chen, Jian, primary, Yao, Zhixing, additional, Chen, Jiun-Sheng, additional, Gi, YoungJin, additional, Jeong, Yun Seong, additional, Belkin, Mitchell, additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, White, Jon, additional, Mitra, Abhisek, additional, Li, Shulin, additional, Finegold, Milton J., additional, Davila, Marta L., additional, Shay, Jerry, additional, Machida, Keigo, additional, Tsukamoto, Hidekazu, additional, and Mishra, Lopa, additional

Published
2016
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34. Tu1626 Integrated TGF-B Pathway Driven Functional Molecular Portrait of Human Hepatocellular Cancer

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Zhang, Jianping, additional, Gi, YoungJin, additional, Katz, Lior H., additional, Shin, Ji-Hyun, additional, Jeong, Yun Seong, additional, Belkin, Mitchell, additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, White, Jon, additional, Javle, Milind, additional, Su, Xiaoping, additional, Stroehlein, John R., additional, Davila, Marta L., additional, Wang, Xuemei, additional, Morris, Jeffrey, additional, Farci, Patrizia, additional, Akbani, Rehan, additional, and Mishra, Lopa, additional

Published
2016
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36. Abstract 3900: Genomic landscape of human cancer reveals dysregulated TGF-β signaling with prognostic significance

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Zhang, Jianping, additional, Phan, Liem, additional, Muñoz, Nina M., additional, Katz, Lior H, additional, Gi, YoungJin, additional, Menon, Vipin Kumar, additional, Shin, Ji-Hyun, additional, Jeong, Yun Seong, additional, Jogunoori, Wilma, additional, Farci, Patrizia, additional, Shetty, Kirti, additional, Su, Xiaoping, additional, Pandita, Tej K, additional, White, Jon, additional, Mishra, Bibhuti, additional, Zamboni, Fausto, additional, Wu, Xifeng, additional, Rashid, Asif, additional, Li, Shulin, additional, Javle, Milind, additional, Hung, Mien-Chie, additional, Herlong, Franklin, additional, Davila, Marta, additional, Stroehlein, John, additional, Shaw, Kenna R, additional, Wang, Xuemei, additional, Morris, Jeffrey S, additional, Akbani, Rehan, additional, and Mishra, Lopa, additional

Published
2015
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37. Abstract 2334: Disruption of TGF-β-regulated CTCF suppression of telomerase links a human stem cell disorder to tumorigenesis

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Yao, Zhixing, additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, Herlong, Franklin H., additional, Jeong, Yun Seong, additional, Mistry, Nipun A., additional, Zhang, Jianping, additional, Su, Xiaoping, additional, Rashid, Asif, additional, Davila, Marta, additional, Stroehlein, John R., additional, Shay, Jerry W., additional, and Mishra, Lopa, additional

Published
2015
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39. Sa1851 Prognostic Significance of TGF-β Signaling in Human Hepatocellular Carcinoma

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Zhang, Jianping, additional, Gi, YoungJin, additional, Phan, Liem M., additional, Muñoz, Nina M., additional, Katz, Lior H., additional, Shin, Ji-Hyun, additional, Jeong, Yun Seong, additional, Menon, Vipin K., additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, Javle, Milind, additional, Su, Xiaoping, additional, Farci, Patrizia, additional, Shetty, Kirti, additional, Wu, Xifeng, additional, Hung, Mien-Chie, additional, Herlong, Franklin, additional, Davila, Marta L., additional, Stroehlein, John R., additional, Shaw, Kenna R., additional, Wang, Xuemei, additional, Morris, Jeffrey S, additional, Akbani, Rehan, additional, and Mishra, Lopa, additional

Published
2015
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40. 532 A TGF-β-CTCF Regulated Pathway Suppresses Stem Cell Associated Tumor Progression

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Yao, Zhixing, additional, Jogunoori, Wilma, additional, Mishra, Bibhuti, additional, Herlong, Franklin, additional, Jeong, Yun Seong, additional, Mistry, Nipun A, additional, Zhang, Jianping, additional, Su, Xiaoping, additional, Rashid, Asif, additional, Davila, Marta L., additional, Stroehlein, John R., additional, Shay, Jerry W., additional, and Mishra, Lopa, additional

Published
2015
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41. CSN6 drives carcinogenesis by positively regulating Myc stability

Author

Chen, Jian, primary, Shin, Ji-Hyun, additional, Zhao, Ruiying, additional, Phan, Liem, additional, Wang, Hua, additional, Xue, Yuwen, additional, Post, Sean M., additional, Ho Choi, Hyun, additional, Chen, Jiun-Sheng, additional, Wang, Edward, additional, Zhou, Zhongguo, additional, Tseng, Chieh, additional, Gully, Christopher, additional, Velazquez-Torres, Guermarie, additional, Fuentes-Mattei, Enrique, additional, Yeung, Giselle, additional, Qiao, Yi, additional, Chou, Ping-Chieh, additional, Su, Chun-Hui, additional, Hsieh, Yun-Chih, additional, Hsu, Shih-Lan, additional, Ohshiro, Kazufumi, additional, Shaikenov, Tattym, additional, Wang, Huamin, additional, Yeung, Sai-Ching Jim, additional, and Lee, Mong-Hong, additional

Published
2014
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42. Abstract 3927: Obesity induces changes in adipokines profile and activates Akt/mTOR signaling accelerating breast carcinogenesis and tumor growth

Author

Fuentes-Mattei, Enrique, primary, Velazquez-Torres, Guermarie, additional, Phan, Liem, additional, Zhang, Fanmao, additional, Chou, Ping-Chieh, additional, Shin, Ji-Hyun, additional, Choi, Hyun-Ho, additional, Chen, Jiun-Sheng, additional, Zhao, Ruiying, additional, Chen, Jian, additional, Gully, Chris, additional, Carlock, Colin, additional, Qi, Yuan, additional, Zhang, Ya, additional, Wu, Yun, additional, Esteva, Francisco, additional, Luo, Yongde, additional, McKeehan, Wallace L., additional, Ensor, Joe E., additional, Hortobagyi, Gabriel N., additional, Pusztai, Lajos Pusztai, additional, Symmans, W. Fraser, additional, Lee, Mong-Hong, additional, and Yeung, Sai-Ching J., additional

Published
2014
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43. Abstract 2784: Targeting TGF-β regulated E3 ligases: a novel therapeutic approach for primary liver cancer

Author

Chen, Jian, primary, Chen, Jiun-Sheng, additional, Gi, YoungJin, additional, Katz, Lior H, additional, Shin, Ji-Hyun, additional, Phan, Liem, additional, Jogunoori, Wilma, additional, Shukla, Vivek, additional, Mishra, Bibhuti, additional, Li, Shulin, additional, Javle, Milind, additional, Hung, Mien-Chie, additional, and Mishra, Lopa, additional

Published
2014
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47. The somatic mutation landscape of premalignant colorectal adenoma

Author

Lin, Shu-Hong, Raju, Gottumukkala S, Huff, Chad, Ye, Yuanqing, Gu, Jian, Chen, Jiun-Sheng, Hildebrandt, Michelle A T, Liang, Han, Menter, David G, Morris, Jeffery, Hawk, Ernest, Stroehlein, John R, Futreal, Andrew, Kopetz, Scott, Mishra, Lopa, and Wu, Xifeng

Abstract

ObjectiveThere are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma.DesignWhole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients with conventional adenoma or sessile serrated adenoma to characterise the somatic mutation landscape for premalignant colorectal lesions. The identified somatic mutations were compared with those in colorectal cancer (CRC) samples from The Cancer Genome Atlas. A supervised random forest model was employed to identify gene panels differentiating adenoma from CRC.ResultsSimilar somatic mutation frequencies, but distinctive driver mutations, were observed in sessile serrated adenomas and conventional adenomas. The final model included 20 genes and was able to separate the somatic mutation profile of colorectal adenoma and adenocarcinoma with an area under the curve of 0.941.ConclusionThe findings of this project hold potential to better identify patients with adenoma who may be candidates for targeted surveillance programmes and preventive interventions to reduce the incidence of CRC.

Published
2018
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48. Targeting TGF-β signaling in cancer

Author

Katz, Lior H, primary, Li, Ying, additional, Chen, Jiun-Sheng, additional, Muñoz, Nina M, additional, Majumdar, Avijit, additional, Chen, Jian, additional, and Mishra, Lopa, additional

Published
2013
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50. 618 A Novel Somatic Mutation of β2sp Inactivates the TGF-β Pathway and Promotes Alcohol Induced HCC

Author

Chen, Jian, primary, Shukla, Vivek, additional, Li, Ying, additional, Chen, Jiun-Sheng, additional, Katz, Lior H., additional, Majumdar, Avijit, additional, Li, Lei, additional, Hittelman, Walter N., additional, Su, Xiaoping, additional, Chen, Junjie, additional, Wu, Xifeng, additional, Farci, Patrizia, additional, and Mishra, Lopa, additional

Published
2013
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