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Background Method Results Conclusion The potential link between environmental pollutants, including metals, and schizophrenia development remains debated. This study aimed to explore the association between plasma levels of three non‐essential metals—barium (Ba), tungsten (W), and uranium (U)—and schizophrenia risk among Chinese individuals.We recruited a total of 221 patients and 219 healthy controls. Plasma levels of three non‐essential metals were measured using inductively coupled plasma mass spectrometry. We employed unconditional logistic regression and Bayesian kernel machine regression (BKMR) to explore the relationship between exposure to multiple metals and the risk of schizophrenia.Logistic regression analysis revealed that the highest quartile (Q4) of W had an odds ratio (OR) of 1.87 (95% CI: 1.08–3.21) compared to the lowest quartile (Q1), with a significant P‐trend of 0.017. For U, the ORs (95% CI) for Q2, Q3, and Q4 were 2.06 (1.19–3.56), 1.99 (1.15–3.44), and 1.74 (1.00–3.00), respectively. BKMR analyses revealed a progressive increase in the risk of schizophrenia with increasing cumulative levels of the three metals at concentrations below 35%, with U playing a major role in this association. U showed a non‐linear positive correlation with schizophrenia, particularly at the 75th percentile level. Moreover, potential interactions were observed between W and Ba, as well as between W and U.Higher plasma W and U concentrations were positively associated with the risk of schizophrenia, which was potentially related to the severity of symptoms in schizophrenic patients. [ABSTRACT FROM AUTHOR]

This study investigates how Chinese female wanghongs on Douyin self-frame their image and identity, and how interactions between wanghongs and their followers co-frame the image of contemporary female Internet celebrities. We discovered that the four dominant self-frames of wanghongs are beauty, talent, personality traits, and gender expression through a qualitative coding analysis of the selected 30 female wanghongs’ posts and media interview narratives, along with viewer comments. Besides, we found that the co-framing of influencers and fans as a collective strategy assists women in breaking the aesthetic framework of traditional patriarchal culture. Furthermore, when conflicts arise between framing actors like wanghongs, fans, media, and political parties, female wanghongs tend to respond with resistance or compromise. We argue that examining the identity framing process of female wanghongs on social media can reflect the dilemma that Chinese feminists face when attempting to highlight women’s accomplishments in multiple roles. [ABSTRACT FROM AUTHOR]

Spinal cord injury (SCI) is a common traumatic disease of the nervous system. The pathophysiological process of SCI includes primary injury and secondary injuries. An excessive inflammatory response leads to secondary tissue damage, which in turn exacerbates cellular and organ dysfunction. Due to the irreversibility of primary injury, current research on SCI mainly focuses on secondary injury, and the inflammatory response is considered the primary target. Thus, modulating the inflammatory response has been suggested as a new strategy for the treatment of SCI. In this study, microglial cell lines, primary microglia, and a rat SCI model were used, and we found that WKYMVm/FPR2 plays an anti-inflammatory role and reduces tissue damage after SCI by suppressing the extracellular signal-regulated kinases 1 and 2 (ERK1/2) and nuclear factor-κB (NF-κB) signaling pathways. FPR2 was activated by WKYMVm, suppressing the secretion of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) by inhibiting M1 microglial polarization. Moreover, FPR2 activation by WKYMVm could reduce structural disorders and neuronal loss in SCI rats. Overall, this study illustrated that the activation of FPR2 by WKYMVm repressed M1 microglial polarization by suppressing the ERK1/2 and NF-κB signaling pathways to alleviate tissue damage and locomotor decline after SCI. These findings provide further insight into SCI and help identify novel treatment strategies. [ABSTRACT FROM AUTHOR]

We reported here a cobalt‐catalyzed [5+1] annulation with 1,5‐diarylpenta‐1,4‐dien‐3‐ones and 2‐methylquinolines. 3,4,5‐Triarylcyclohexanones were furnished in moderate to good yields and excellent diastereoselectivity under simple reaction conditions. Moreover, we preliminarily studied anticancer activities of the obtained products in vitro by MTT {3‐(4,5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide} assay. [ABSTRACT FROM AUTHOR]

Background: Here we evaluated the feasibility, efficacy, tolerability, and treatment-mediated immune modulation of neoadjuvant everolimus plus letrozole versus chemotherapy in treating postmenopausal patients with ER-positive, HER2-negative breast cancer.Methods: Postmenopausal women with ER-positive, HER2-negative breast cancer who had a primary tumor > 2 cm or positive axillary lymph node(s) proofed by biopsy were randomly (1,1) enrolled to receive neoadjuvant everolimus plus letrozole for 18 weeks or fluorouracil, epirubicin plus cyclophosphamide (FEC) for 6 cycles before surgery. Primary outcome was feasibility of the trial. Secondary outcome included ultrasound response rate, pathological complete response rate, breast-conserving surgery rate, toxicities, treatment-mediated immune modulation and biomarkers.Results: Forty patients were randomized. Completion rate was 90.0% in the neoadjuvant endocrine therapy (NET) arm but 70.0% in the neoadjuvant chemotherapy (NAC) arm. The ultrasound response rate was 65.0% in NET arm and 40.0% in FEC arm, respectively. In terms of the adverse events, clearly favored NET arm. Everolimus plus letrozole increased the ratio of peripheral Tregs to CD4+ T cells and tumor PD-L1 expression, and decreased Ki67 index and tumor-infiltrating Tregs, and patients with a greater increase of tumor-specific CTLs showed more sensitive to NET.Conclusion: This pilot trial showed that neoadjuvant everolimus plus letrozole might achieve a favorable ultrasound response rate with low toxicities in treating postmenopausal ER-positive, HER2-negative breast cancer patients. Everolimus plus letrozole might have positive antitumoral immunity effects. Further large randomized controlled trials are needed to confirm our findings.Trail Registration: A Trial of Neoadjuvant Everolimus Plus Letrozole Versus FEC in Women With ER-positive, HER2-negative Breast Cancer, registered on 07/04/2016 and first posted on 18/04/2016, NCT02742051 . [ABSTRACT FROM AUTHOR]

In this paper, we study some generalized metrizable properties and cardinal invariants in quotient spaces of quasitopological groups. We mainly show that (1) If H is a neutral subgroup of a quasitopological group G such that G / H is Hausdorff, then G / H is weakly first-countable if and only if G / H is symmetrizable; (2) If H is a neutral subgroup of a quasitopological group G such that G / H is a Hausdorff countably compact space of countable pseudocharacter, then G / H is metrizable; (3) If H is a neutral subgroup of a quasitopological group G such that G / H is a q -space, then G / H is a β -space; (4) If H is a closed neutral subgroup of a quasitopological group G , then | G / H | ≤ 2 e (G / H) ψ (G / H). [ABSTRACT FROM AUTHOR]

Osteosarcoma (OS) is a prevalent bone solid malignancy that primarily affects adolescents, particularly boys aged 14–19. This aggressive form of cancer often leads to deadly lung cancer due to its high migration ability. Experimental evidence suggests that programmed cell death (PCD) plays a crucial role in the development of osteosarcoma. Various forms of PCD, including apoptosis, ferroptosis, autophagy, necroptosis, and pyroptosis, contribute significantly to the progression of osteosarcoma. Additionally, different signaling pathways such as STAT3/c‐Myc signal pathway, JNK signl pathway, PI3k/AKT/mTOR signal pathway, WNT/β‐catenin signal pathway, and RhoA signal pathway can influence the development of osteosarcoma by regulating PCD in osteosarcoma cell. Therefore, targeting PCD and the associated signaling pathways could offer a promising therapeutic approach for treating osteosarcoma. [ABSTRACT FROM AUTHOR]

• High salt diet accelerates progression of breast cancer and lung metastasis. • High salt diet increases proportion of Th17 lymphocytes in vivo. • Th17 lymphocytes facilitate progression of breast cancer through IL-17F. • Th17 lymphocytes activate MAPK/ERK signaling pathway through IL-17F. • Application of ERK inhibitor and 1, 25 -vitamin D 3 ameliorates Th17-promoted breast cancer. Dietary patterns are believed to regulate tumor progression by altering the tumor microenvironment. Of note, a high salt diet is a risk factor for various diseases. However, the role of high salt intake in the progression of cancers remains unknown. We constructed an in vivo high salt diet model in MMTV-PyVT mice with spontaneous tumor-forming properties to explore the role of a high salt diet in the progression of breast cancer as well as the modulation of the tumor microenvironment. Also, in vitro experiments were performed to understand the mechanism. High salt diet accelerated the development (P < 0.05) and lung metastasis (P < 0.05) of breast cancer in MMTV-PyVT mice, compared to the normal diet model. Moreover, higher frequency of Th17 cells in circulation, tumor tissue and draining lymph node tissue were observed in the high salt diet model (P < 0.05 for all). In vitro, co-culture with Th17 cells facilitated the proliferation, migration and invasion of MCF-7 human breast cancer cells, while these enhanced aggressive behaviors could be reversed by application of 1,25-vitamin D 3 which could inhibit the differentiation of Th17 cells (P < 0.001 for all). In vitro, co-culture with Th17 cells activated MAPK signaling in MCF-7 cells (P < 0.001 for all). Consistently, activated MAPK/ERK signaling was observed by immunohistochemistry in breast cancer cell nodes in the high salt diet model (P < 0.05 for all). Mechanistically, higher level of IL-17F could be detected in breast tumors and serum from the high salt diet model through qRT-PCR and ELISA (P < 0.05 for all). IL-17F treatment facilitated the proliferation, migration and invasion of MCF-7 human breast cancer cells and activated MAPK/ERK signaling in MCF-7 cells (P < 0.001 for all). Moreover, the tumor-promoting function induced by Th17 cells and IL-17F could be inhibited by the administration of ERK inhibitor (sch772894) (P < 0.001 for all). Lastly, high concentration NaCl-induced Th17 cells promoted the proliferation, migration and invasion of MCF-7 human breast cancer cells and activated MAPK/ERK signaling in MCF-7 cells which could be inhibited by neutralizing anti-IL-17F (P < 0.001 for all). High salt intake accelerates the growth of breast cancer and facilitates lung metastasis, as well as increases the level of Th17 cells. Increased Th17 cells might promote the growth of breast cancer via the secretion of IL-17F to activate the MAPK signaling pathway in breast cancer cells. [ABSTRACT FROM AUTHOR]

Metal oxide-based memristors usually exhibit robust resistive switching characteristics but poor mechanical tolerance, limiting their applications in wearable intelligent electronics. Here, we report a highly flexible and robust hafnium oxide-based memristor by using the ultrathin substrate for wearable in-memory computing. The fabricated memristor can display reliable resistive switching behaviors, including low switching voltage, good endurance, and excellent uniformity, under an extremely bending state with the radius of 0.8 mm. The mechanical behavior of the flexible memristor with varying substrate thickness is systematically analyzed using the finite element method. Moreover, typical synaptic plasticity including long-term potentiation and long-term depression was verified under the extremely bending state. Based on the highly flexible and robust memristor device, a three-layer neural network was constructed using a software simulator, achieving a recognition accuracy of 90.49% for handwritten digit recognition under the bending state. These results demonstrate our robust memristor synapse shows high mechanical flexibility, paving a promising way to realizing wearable in-memory computing. [ABSTRACT FROM AUTHOR]

Neural stem cells (NSCs) transplantation has been considered as a potential strategy to reconnect the neural circuit after spinal cord injury (SCI) but the therapeutic effect was still unsatisfied because of the poor inflammatory micro‐environment of SCI. Previous study reported that neuroprotection and inflammatory immunomodulation were considered to be most important mechanism of NSCs transplantation. In addition, Wnt4 has been considered to be neurogenesis and anti‐inflammatory so that it would be an essential assistant agent for NSCs transplantation. Our single cells sequence indicates that macrophages are the most important contributor of inflammatory response after SCI and the interaction between macrophages and astrocytes may be the most crucial to inflammatory microenvironment of SCI. We further report the first piece of evidence to confirm the interaction between Wnt4‐modified NSCs and macrophages using NSCs‐macrophages co‐cultured system. Wnt4‐modified NSCs induce M2 polarization and inhibit M1 polarization of macrophages through suppression of TLR4/NF‐κB signal pathway; furthermore, M2 cells promote neuronal differentiation of NSCs through MAPK/JNK signal pathway. In vivo, transplantation of Wnt4‐modified NSCs improves inflammatory micro‐environment through induce M2 polarization and inhibits M1 polarization of macrophages to promote axonal regeneration and tissue repair. The current study indicated that transplantation of Wnt4‐modified NSCs mediates M2 polarization of macrophages to promote spinal cord injury repair. Our novel findings would provide more insight of SCI and help with identification of novel treatment strategy. [ABSTRACT FROM AUTHOR]

Levels of eugenol, isoeugenol and methyleugenol were investigated in 216 seawater fish and 321 freshwater fish from wholesale markets. Eugenol was detected in 55 samples with concentrations ranging from 3.11 to 30,690 μg/kg. Isoeugenol was detected only in two samples of grouper at concentrations of 1032 μg/kg and 86.2 μg/kg. Methyleugenol was not detected in any samples. The incidence of anesthetic residue in all the samples was 10.6%. The frequencies of species found with anesthetic residue were higher in seawater fish than in freshwater fish, with rates of 19.4% and 4.7%, respectively. The warm seawater fish such as grouper, sea bass, sea bream, pompano, and red drum should be monitored more closely in the future due to the higher detection frequencies and values of these compounds. Although the results indicate that eugenol or isoeugenol have been used as fish anesthetic to assist with fish handling and fish transport in some species, the human health risk is negligible. [ABSTRACT FROM AUTHOR]

Background: Metabolites secreted by the gut microbiota may play an essential role in microbiota–gut–central nervous system crosstalk. In this study, we explored the changes occurring in the gut microbiota and their metabolites in patients with spinal cord injury (SCI) and analyzed the correlations among them. Methods: The structure and composition of the gut microbiota derived from fecal samples collected from patients with SCI (n = 11) and matched control individuals (n = 10) were evaluated using 16S rRNA gene sequencing. Additionally, an untargeted metabolomics approach was used to compare the serum metabolite profiles of both groups. Meanwhile, the association among serum metabolites, the gut microbiota, and clinical parameters (including injury duration and neurological grade) was also analyzed. Finally, metabolites with the potential for use in the treatment of SCI were identified based on the differential metabolite abundance analysis. Results: The composition of the gut microbiota was different between patients with SCI and healthy controls. At the genus level, compared with the control group, the abundance of UBA1819, Anaerostignum, Eggerthella, and Enterococcus was significantly increased in the SCI group, whereas that of Faecalibacterium, Blautia, Escherichia–Shigella, Agathobacter, Collinsella, Dorea, Ruminococcus, Fusicatenibacter, and Eubacterium was decreased. Forty-one named metabolites displayed significant differential abundance between SCI patients and healthy controls, including 18 that were upregulated and 23 that were downregulated. Correlation analysis further indicated that the variation in gut microbiota abundance was associated with changes in serum metabolite levels, suggesting that gut dysbiosis is an important cause of metabolic disorders in SCI. Finally, gut dysbiosis and serum metabolite dysregulation was found to be associated with injury duration and severity of motor dysfunction after SCI. Conclusions: We present a comprehensive landscape of the gut microbiota and metabolite profiles in patients with SCI and provide evidence that their interaction plays a role in the pathogenesis of SCI. Furthermore, our findings suggested that uridine, hypoxanthine, PC(18:2/0:0), and kojic acid may be important therapeutic targets for the treatment of this condition. [ABSTRACT FROM AUTHOR]

SET domain-containing 2 (SETD2), the primary methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3) in mammals, is associated with many hematopoietic diseases when mutated. Previous works have emphasized its role in maintaining adult hematopoietic stem cells or tumorigenesis, however, whether and how SETD2 regulates erythropoiesis during embryonic development is relatively unexplored. In this study, using a conditional SETD2 knockout (KO) mouse model, we reveal that SETD2 plays an essential role in fetal erythropoiesis. Loss of Setd2 in hematopoietic cells ablates H3K36me3, and leads to anemia with a significant decrease in erythroid cells in the peripheral blood at E18.5. This is due to impaired erythroblast differentiation in both spleen and liver. We also find increased proportions of nucleated erythrocytes in the blood of Setd2 KO embryos. Lastly, we ascribe embryonic erythropoiesis-related genes Vegfc , Vegfr3 , and Prox1 , as likely downstream targets of SETD2 regulation. Our study reveals a critical role of SETD2 in fetal erythropoiesis that precedes adult hematopoiesis, and provide unique insights into the defects in erythroid lineages, such as anemia. • Loss of Setd2 leads to anemia and postnatal death in mice. • SETD2 regulates fetal erythropoiesis, particularly in terminal differentiation of erythroblasts. • SETD2 affects the expression of erythropoiesis-related genes Vegfc , Vegfr3 , and Prox1. • Setd2 's impact on fetal erythropoiesis suggests early intervention for Setd2 mutation-associated hematopoietic diseases. [ABSTRACT FROM AUTHOR]

• A novel MET SEMA domain duplication was identified in a non-small cell lung cancer patient. • Off-label use of the kinase inhibitor crizotinib led to a marked response of the patient. • Cellular analyses provide a functional basis for the oncogenic role of the structural MET alteration. • The novel MET mutation may represent actionable targets in lung cancer patients. Aberrant MET activation, which promotes cell proliferation and tumor metastasis, occurs in many types of cancer and results from multiple mechanisms. A novel MET duplication mutation was found in a non-small cell lung cancer (NSCLC) patient. The clinical response to crizotinib was investigated and the functional relevance was characterized in cellular models. Next-generation sequencing (NGS) was performed on the tumor tissue and circulating tumor DNA (ctDNA) of a patient with advanced NSCLC. In vitro studies including western blot, proliferation assays and colony formation assays were used to confirm the clinical observations. The patient was identified to harbor a duplication of the MET SEMA domain. After a month of treatment, the patient showed a marked response to crizotinib, a multikinase inhibitor with potent activity against MET. Functional in vitro studies demonstrated that expression of MET SEMA duplication in NIH-3T3 cells stimulated the activation of MET signaling. Crizotinib treatment obviously repressed cell proliferation, colony formation, and MET signaling pathway. Crizotinib treatment resulted in a clinical response in a patient with MET SEMA duplication. Results of cellular analyses together with the clinical data suggest that this novel alteration may represent an actionable target in NSCLC patients. [ABSTRACT FROM AUTHOR]

A new aerobic copper-catalyzed three-component synthesis of azaaryl-substituted quinazolines has been developed, which featured inexpensive methylazaarenes as C1 sources, easily available copper salts as the catalysts and O 2 as a sole oxidant. The transformation had very good substrate applicability towards methylazaarenes, and various azaaryl-substituted quinazolines were obtained in moderate to good yields. Image 1 • Copper-catalyzed cascade oxidative cyclization. • O 2 as a sole oxidant. • Available starting materials, good functional group tolerance. [ABSTRACT FROM AUTHOR]

Gas chromatography (GC) coupled with triple quadrupole tandem mass spectrometry (MS/MS) operated in electron ionization mode (EI) has been shown to have advantages in the trace analysis of chemical compounds. Employing the instrument, a method has been built to simultaneously determine eugenol, isoeugenol‚ and methyleugenol, which have been widely used as fish anesthetic, in the fish fillet. Procedure for the sample preparation was achieved by using hexane extraction followed by phenyl solid phase extraction (SPE) cleanup, which was free of such steps as rotary evaporation and nitrogen blowing by taking the volatility of eugenol and its isomers into consideration. The method was validated by conducting recovery studies on fortified fish fillet samples at four concentrations. The linearity in the range of 5–500 μg·L −1 was forced through the origin giving a coefficient of determination ( r 2 ) greater than 0.9982. Limits of detection (LODs) for eugenol, isoeugenol‚ and methyleugenol were 0.4, 1.2‚ and 0.2 μg·kg −1 , respectively. The limits of quantification (LOQs) were 1.2, 4‚ and 0.7 μg·kg −1 for eugenol, isoeugenol‚ and methyleugenol, respectively. The recoveries for eugenol and its isomers ranged from 76.4 to 99.9% with relative standard deviations (RSD) in a range from 2.18 to 15.5%. This method is quick, simple and suitable for determining the residues of eugenol, isoeugenol and methyleugenol simultaneously in batch samples of fish fillet. [ABSTRACT FROM AUTHOR]

Neuropathic pain (NP) is a frequent finding in patients diagnosed with spinal cord injuries (SCIs). To improve our understanding of the maladaptive changes taking place in the lumbar spinal cord that can lead to the development of NP and to find alternative options to treat this condition, we aimed to investigate the effects of voluntary exercise on NP after SCI and to elucidate its potential mechanisms. A rat model of post-SCI NP induced by compression of the posterior or lateral cervical spinal cord was used to evaluate the effects of voluntary exercise by measuring the bilateral withdrawal of the hind paws using the Von Frey filament and Hargreaves tests. The place escape/avoid paradigm was used to evaluate supraspinal pain processing and somatosensory evoked potentials (SEPs) were used to examine disturbances in proprioception. Locomotor function was evaluated using Basso, Beattie, and Bresnahan (BBB) scoring. Pathologic findings in hematoxylin and eosin-stained tissue and magnetic resonance imaging were used to evaluate the morphological changes after SCI. The lesion size within the cervical spinal cord was evaluated by staining with Eriochrome cyanine R. Quantitative polymerase chain reaction and immunohistochemistry were used to assess the expression of calcitonin gene-related peptide (CGRP) and ionized calcium-binding adapter molecule 1 (Iba-1) in the lumbar dorsal horns. All injured rats developed mechanical hypersensitivity, hyposensitivity, and thermal hyperalgesia in the contralateral hind paws at 1 week post-injury. Rats that underwent lateral compression injury developed NP in the ipsilateral hind paws 1 week later than rats with a posterior compression injury. Our findings revealed that voluntary exercise ameliorated mechanical allodynia and thermal hyperalgesia, and significantly improved proprioception as measured by SEP, but had no impact on mechanical hypoalgesia or motor recovery and provided no significant neuroprotection after recovery from an acute SCI. SCI-induced NP was accompanied by increased expression of CGRP and Iba-1 in the lumbar dorsal horn. These responses were reduced in rats that underwent voluntary exercise. Voluntary exercise ameliorates NP that develops in rats after compression injury. Increased expression of CGRP and Iba-1 in the lumbar dorsal horns of rats exhibiting symptoms of NP suggests that microglial activation might play a crucial role in its development. Collectively, voluntary exercise may be a promising therapeutic modality to treat NP that develops clinically in response to SCI. • Voluntary exercise ameliorates NP that develops in rats after compression cervical SCI; • SCI-induced NP was accompanied by increased expression of CGRP and Iba-1 in the lumbar dorsal horn; • Increased expression of CGRP and Iba-1 were reduced in rats that underwent voluntary exercise; • Voluntary exercise may be a promising therapeutic modality to treat NP that develops clinically in response to SCI. [ABSTRACT FROM AUTHOR]

Low fall efficacy can lead to activity restriction and loss of independence, which may cause severe adverse consequences. The purpose of this study was to explore fall efficacy among elders with knee osteoarthritis and influential factors in three communities in Beijing, China. A correlational descriptive study design was used with a sample of 117 participants from July 2014 to November 2014. Results showed that participants had low fall efficacy and that fall efficacy correlated with age, gender, body mass index, marital status, education, disease duration, frequency of falls, number of co-morbidities, pain, stiffness, physical function, depression, lower-extremity muscle strength and balance ( r = −0.594 to 0.234, P < 0.05 to 0.001). Multiple regression analysis revealed that 52% of variance in fall efficacy was explained by fall frequency, age, body mass index, gender, pain and balance function. Findings suggest that strategies to prevent falls, reduce body weight, improve effective pain management and enhance balance function may improve fall efficacy in this population. [ABSTRACT FROM AUTHOR]

• Various modified CL-20 crystalline composites with graphene/polydopamine as the dopants have been prepared; • These CL-20 based composites have improved thermal stability, and lower mechanical sensitivity; • Some of the abovementioned CL-20 based composites have even higher density with exclusion of polymorphic transition; Hexanitrohexaazaisowurtzitane (CL-20) is a well-known high energy density nitramine, but it is of high sensitivity and has the problem of polymorphic transition. In order to reduce the sensitivity of ε-CL-20 and improve the stability of its crystal structure, the polydopamine (PDA)-coated graphene oxide (GO) was used to dope ε-CL-20 crystals by strategy of in-situ coating followed with a solvent-non-solvent crystallization process. It has been shown that modified CL-20 crystals with the best performances are of polygon shape with a smooth surface and with the average diameter of 16 μm, much smaller than that of raw ε-CL-20 (140 μm). In addition, the doping can either improve the polymorphic transition temperature up to 19.0 °C or exclude such a transition due to formation of completely new crystal phase with better stability, depending on the type and content of the dopants. The density of a certain GO@PDA modified CL-20 is even slightly higher than that of pristine ε-CL-20 due to better assembling of the molecules under the nucleation of the dopants. CL-20/PDAG-2 does not show any polymorphic transition peak. Moreover, the XRD spectrum of CL-20/PDAG-2 also demonstrates that it is a completely new crystal phase better than the other four reported ones in terms of thermal stability. [ABSTRACT FROM AUTHOR]