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11 results on '"Chen, Jiareng"'

4. An Aggregation-Induced Emission-Based Dual Emitting Nanoprobe for Detecting Intracellular pH and Unravelling Metabolic Variations in Differentiating Lymphocytes

Author

Huang, Yingying, primary, Zhang, Qin, additional, Lam, Ching Ying Katherine, additional, Li, Chuanqi, additional, Yang, Chen, additional, Zhong, Zhiming, additional, Zhang, Ruolin, additional, Yan, Jiaxiang, additional, Chen, Jiareng, additional, Yin, Bohan, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2024
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5. Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein

Author

Chen, Jiareng, primary, Ho, Willis Kwun Hei, additional, Yin, Bohan, additional, Zhang, Qin, additional, Li, Chuanqi, additional, Yan, Jiaxiang, additional, Huang, Yingying, additional, Hao, Jianhua, additional, Yi, Changqing, additional, Zhang, Yu, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2023
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7. Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

Author

Liu, Yang, Yin, Pengfei, Chen, Jiareng, Cui, Bin, Zhang, Chao, and Wu, Feng

Subjects
Article Subject
Abstract

Conducting polymer-based composites have recently becoming popular in both academic research and industrial practices due to their high conductivity, ease of process, and tunable electrical properties. The multifunctional conducting polymer-based composites demonstrated great application potential for in vivo therapeutics and implantable electronics, including drug delivery, neural interfacing, and minimally invasive electronics. In this review article, the state-of-the-art conducting polymer-based composites in the mentioned biological fields are discussed and summarized. The recent progress on the synthesis, structure, properties, and application of the conducting polymer-based composites is presented, aimed at revealing the structure-property relationship and the corresponding functional applications of the conducting polymer-based composites. Furthermore, key issues and challenges regarding the implantation performance of these composites are highlighted in this paper.

Published
2020
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11. A Biomimetic Upconversion Nanoreactors for Near-infrared Driven H2Release to Inhibit Tauopathy in Alzheimer's Disease Therapy

Author

Zhang, Qin, Li, Chuanqi, Yin, Bohan, Yan, Jiaxiang, Gu, Yutian, Huang, Yingying, Chen, Jiareng, Lao, Xinyue, Hao, Jianhua, Yi, Changqing, Zhou, Yi, Wai Cheung, James Chung, Dexter Wong, Siu Hong, and Yang, Mo

Abstract

Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders, such as Alzheimer's disease (AD), which can be induced by an excess of reactive oxygen species (ROS). As an antioxidant, hydrogen gas (H2) has the potential to mitigate AD by scavenging highly harmful ROS such as •OH. However, conventional administration methods of H2face significant challenges in controlling H2release on demand and fail to achieve effective accumulation at lesion sites. Herein, we report artificial nanoreactors that mimic natural photosynthesis to realize near-infrared (NIR) light-driven photocatalytic H2evolution in situ. The nanoreactors are constructed by biocompatible crosslinked vesicles (CVs) encapsulating ascorbic acid and two photosensitizers, chlorophyll a(Chla) and indoline dye (Ind). In addition, platinum nanoparticles (Pt NPs) serve as photocatalysts and upconversion nanoparticles (UCNP) act as light-harvesting antennas in the nanoreacting system, and both attach to the surface of CVs. Under NIR irradiation, the nanoreactors release H2in situ to scavenge local excess ROS and attenuate tau hyperphosphorylation in the AD mice model. Such NIR-triggered nanoreactors provide a proof-of-concept design for the great potential of hydrogen therapy against AD.

Published
2024
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