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3. Deep Reinforcement Learning Based Mimicry Defense System for IoT Message Transmission

Author

Wang, Zhihao, Jiang, Dingde, Chen, Jianguang, Yang, Wei, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Jiang, Dingde, editor, and Song, Houbing, editor

Published
2022
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4. An Energy-Efficient Dynamic Spectrum Access Approach for Internet of Things Applications

Author

Chen, Jianguang, Jiang, Dingde, Yang, Wei, Fan, Xiaoqian, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Jiang, Dingde, editor, and Song, Houbing, editor

Published
2022
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5. A Dynamic Migration Strategy of SDN Controllers in LEO Networks

Author

Huo, Liuwei, Jiang, Dingde, Yang, Wei, Chen, Jianguang, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Jiang, Dingde, editor, and Song, Houbing, editor

Published
2022
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6. A New End-To-End Network Traffic Reconstruction Approach Based on Different Time Granularities

Author

Yang, Wei, Jiang, Dingde, Chen, Jianguang, Wang, Zhihao, Huo, Liuwei, Zhao, Wenhui, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Jiang, Dingde, editor, and Song, Houbing, editor

Published
2022
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7. Schisandrol A Relaxes the Rat Trachea Via L-Type Ca 2+ Channels and KV Channels.

Author

Xu, Zhiying, Lin, Chengcheng, Sun, Jinghui, Li, He, Zhuang, Wenyue, Chen, Jianguang, Wang, Chunmei, and Wang, Haili

Subjects
POTASSIUM antagonists, CALCIUM ions, POTASSIUM channels, SMOOTH muscle, CALCIUM channels
Abstract

Background: Schisandra chinensis is widely applied in the prevention and treatment of asthma in China, but the material basis for the anti-asthmatic effect of S. chinensis is unclear. Our previous studies found that the lignans from S. chinensis can relax tracheal smooth muscle in rats. Schisandrol A (SCA) is a representative monomer of S. chinensis lignans with high content and activity. Purpose: This study was aimed at further exploring the relaxation effect of SCA and its mechanism on the isolated tracheal smooth muscle of rats through tracheal perfusion experiments. Materials and Methods: The isolated rat tracheal ring was precontracted with acetylcholine (ACh). Then, the impact of SCA on the tension of precontracted tracheal ring was studied. Verapamil (L-type calcium channel blocker) and four potassium channel blockers, including glibenclamide, tetraethylamine, 4-aminopyridine (4-AP), and barium chloride (BaCl2), as well as propranolol (β-adrenergic receptor antagonist), were respectively used to precontract the tracheal ring for investigation. Results: SCA could dose-dependently reduce the ACh-induced contraction of the tracheal ring, and the verapamil and 4-AP could weaken this effect, while BaCl2, glibenclamide, tetraethylamine, and propranolol did not show this effect. Conclusion: SCA can significantly relax the effect of tracheal smooth muscle of rats, and the underlying mechanism might be involved in the blocking of L-type Ca2+ channels and activating the voltage-dependent potassium channels (KV). [ABSTRACT FROM AUTHOR]

Published
2024
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15. Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+Channels and KVChannels

Author

Xu, Zhiying, Lin, Chengcheng, Sun, Jinghui, Li, He, Zhuang, Wenyue, Chen, Jianguang, Wang, Chunmei, and Wang, Haili

Abstract

Background Schisandra chinensis is widely applied in the prevention and treatment of asthma in China, but the material basis for the anti-asthmatic effect of S. chinensis is unclear. Our previous studies found that the lignans from S. chinensis can relax tracheal smooth muscle in rats. Schisandrol A (SCA) is a representative monomer of S. chinensis lignans with high content and activity.Purpose This study was aimed at further exploring the relaxation effect of SCA and its mechanism on the isolated tracheal smooth muscle of rats through tracheal perfusion experiments.Materials and Methods The isolated rat tracheal ring was precontracted with acetylcholine (ACh). Then, the impact of SCA on the tension of precontracted tracheal ring was studied. Verapamil (L-type calcium channel blocker) and four potassium channel blockers, including glibenclamide, tetraethylamine, 4-aminopyridine (4-AP), and barium chloride (BaCl2), as well as propranolol (β-adrenergic receptor antagonist), were respectively used to precontract the tracheal ring for investigation.Results SCA could dose-dependently reduce the ACh-induced contraction of the tracheal ring, and the verapamil and 4-AP could weaken this effect, while BaCl2, glibenclamide, tetraethylamine, and propranolol did not show this effect.Conclusion SCA can significantly relax the effect of tracheal smooth muscle of rats, and the underlying mechanism might be involved in the blocking of L-type Ca2+channels and activating the voltage-dependent potassium channels (KV).

Published
2024
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25. Relaxation Effect of Schisandrol A on Isolated Thoracic Aorta and its Mechanism in Rats.

Author

Qiu, Xudong, Dong, Yang, Wang, Bihan, Yang, Shuo, Sun, Jinghui, Li, He, Chen, Jianguang, Du, Xingxu, and Wang, Chun Mei

Subjects
THORACIC aorta, ENDOTHELIUM, POTASSIUM antagonists, SCHISANDRA chinensis, CHINESE medicine, RYANODINE receptors, RATS, POTASSIUM channels
Abstract

Background: Schisandra chinensis (S. chinensis) is a drug commonly used in the clinical treatment of cardiovascular diseases in Traditional Chinese Medicine. However, the specific components and mechanisms of its action are still unclear. We screened six kinds of lignans from S. chinensis with high content and found that schisandrol A and schisantherin A had a strong vasorelaxant effect. The purpose of this study was to investigate the relaxation and underlying mechanism of schisandrol A in the isolated thoracic aorta of rats. Materials and Methods: Isolated rat endothelium-intact and endothelium-removed thoracic aorta strips were pre-constricted with phenylephrine (PE), and the relaxation of schisandrol A on the strips was observed. Then, the mechanism was explored by pre-incubating the strips with nitric oxide synthetase inhibitor Nɷ-nitro-l-arginine methyl ester (L-NAME), cyclooxygenase inhibitor (indomethacin), potassium channel blockers 4-aminopyridine (4-AP), barium chloride (BaCl2), tetraethylamine (TEA), and glibenclamide, respectively, and changing the calcium concentration in the bath. In addition, expressions of endothelial nitric oxide synthetase (eNOS) mRNA and protein in rat thoracic aorta were detected. Results: Schisandrol A induced both endothelium-dependent and endothelium-independent relaxation of isolated thoracic aorta strips of rats, and the mechanism might be related to promoting the synthesis of NO, inhibiting Ca2+ release from the sarcoplasmic reticulum, and blocking the Ca2+ channels. Conclusion: These discoveries may provide a theoretical basis for the traditional application of S. chinensis to treat cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis and cerebral microbleeds

Author

Yu Zhihui, Ma Jun, Shen Ke, and Chen Jianguang

Abstract

Background: Intracranial atherosclerotic stenosis (ICAS) is one of the important causes of occurrence and recurrence of ischemic stroke worldwide. Combined antiplatelet therapy may increase the risk of intracerebral hemorrhage, especially in patients with intracerebral microhemorrhage,Objective The aim of this study is to investigate the safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) and cerebral microbleeds(CMBs). Methods and Results: 305 patients with sICAS were divided into two groups: 215 patients without CMBs and 90 patients with CMBs. All patients were treated with dual antibody therapy for 3 months according to the existing treatment, and were followed up for half a year. The NIHSS and modified Rankin score (mRS) before and after treatment were compared between the two groups, and the incidence of adverse reactions and bleeding conversion were observed. At the same time, the two groups were compared. Moderate to severe CMBs (>6) increased the risk of bleeding in sICAS. Conclusion For patients with sICAS, it is necessary to conduct head MRI SWI sequence examination to screen out high load CMBs.

Published
2023
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31. Supplemental Methods from SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Author

Fiskus, Warren, primary, Coothankandaswamy, Veena, primary, Chen, Jianguang, primary, Ma, Hongwei, primary, Ha, Kyungsoo, primary, Saenz, Dyana T., primary, Krieger, Stephanie S., primary, Mill, Christopher P., primary, Sun, Baohua, primary, Huang, Peng, primary, Mumm, Jeffrey S., primary, Melnick, Ari M., primary, and Bhalla, Kapil N., primary

Published
2023
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32. Data from SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Author

Fiskus, Warren, primary, Coothankandaswamy, Veena, primary, Chen, Jianguang, primary, Ma, Hongwei, primary, Ha, Kyungsoo, primary, Saenz, Dyana T., primary, Krieger, Stephanie S., primary, Mill, Christopher P., primary, Sun, Baohua, primary, Huang, Peng, primary, Mumm, Jeffrey S., primary, Melnick, Ari M., primary, and Bhalla, Kapil N., primary

Published
2023
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33. Supplemental Figure Legends from SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Author

Fiskus, Warren, primary, Coothankandaswamy, Veena, primary, Chen, Jianguang, primary, Ma, Hongwei, primary, Ha, Kyungsoo, primary, Saenz, Dyana T., primary, Krieger, Stephanie S., primary, Mill, Christopher P., primary, Sun, Baohua, primary, Huang, Peng, primary, Mumm, Jeffrey S., primary, Melnick, Ari M., primary, and Bhalla, Kapil N., primary

Published
2023
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46. Anti- inflammatory effect of Prunus tomentosa Thunb total flavones in LPS-induced RAW264.7 cells

Author

Zhao Dongshuang, Chen Jianguang, Zhang Cheng-yi, Cao Shuang, Fan Ziwei, Chen Xi, and Liu Yuanyuan

Subjects
0301 basic medicine, chemistry.chemical_classification, raw264.7 cells, Traditional medicine, medicine.drug_class, Chemistry, prunus tomentosa thunb total flavones (ptttf), Inflammation, General Chemistry, Flavones, Anti-inflammatory, 03 medical and health sciences, Prunus, 030104 developmental biology, 0302 clinical medicine, inflammation, 030220 oncology & carcinogenesis, Materials Chemistry, medicine, lipids (amino acids, peptides, and proteins), medicine.symptom, QD1-999
Abstract

In this research, we investigated possible anti-inflammatory roles of Prunus tomentosa Thunb Total Flavones (PTTTF) in LPS-induced RAW264.7 cells. PTTTF (4μg/ml and 40μg/ml) was applied to RAW264.7 cells induced with 1μg/ml LPS to test the impact of these flavones on neutrophil phagocytosis in vitro. Levels of prostaglandin E2 (PGE2) and two pro-inflammatory interleukin cytokines (i.e. IL-6 and IL-1β) in the supernatant fraction were tested via Enzyme-linked immunosorbent assays (ELISA). Expression of cyclooxygenases COX-1 and COX-2 was detected via RT-PCR. Superoxide dismutase (SOD) content was determined with a spectrophotometric assay (Micromethod). The results revealed that PTTTF at doses higher than 4μg/ml reduces the content of IL-6, IL-1β and PGE2 (P < 0.05), and elevates the activity of SOD in LPS-induced RAW264.7 cells significantly (P < 0.05). PTTTF at 40μg/ml showed no significant effect on the expression of COX-1(P>0.05) but resulted in a significant inhibition of COX-2 in LPS-induced RAW264.7 cells (P

Published
2019
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47. Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells

Author

Wang, Yongchao, Fiskus, Warren, Chong, Daniel G., Buckley, Kathleen M., Natarajan, Kavita, Rao, Rekha, Joshi, Atul, Balusu, Ramesh, Koul, Sanjay, Chen, Jianguang, Savoie, Andrew, Ustun, Celalettin, Jillella, Anand P., Atadja, Peter, Levine, Ross L., and Bhalla, Kapil N.

Published
2009
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