Search

Your search keyword '"Chen, Hung‐Che"' showing total 15 results
Start Over Author "Chen, Hung‐Che"
15 results on '"Chen, Hung‐Che"'

4. Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-Stokes Raman scattering microscopy

Author

Wu, Yao-Ming, Chen, Hung-Che, Chang, Wei-Tien, Jhan, Jhen-Wei, Lin, Hung-Lung, and Liau, Ian

Subjects
Raman effect -- Research, Microscope and microscopy -- Methods, Fatty liver -- Research, Liver -- Properties, Liver -- Health aspects, Imaging systems -- Methods, Fat -- Properties, Fat -- Health aspects, Tissues -- Properties, Tissues -- Health aspects, Chemistry
Abstract

A fatty liver might progress from being a benign fatty liver, to steatohepatitis, cirrhosis, or even hepatocellular carcinoma. The great prevalence and severe outcome have warranted much investigation of the pathology and the development of effective therapies, which involve animal studies requiring critical evaluation of the hepatic fatty change. Histological examination and wet chemical analysis of liver biopsy specimens are generally employed for this purpose despite numerous procedures being involved. Using coherent anti-Stokes Raman scattering (CARS) microscopy, we have demonstrated the specific imaging of fat droplets in intact liver tissues and extracted the hepatic fat content through image analysis while eliminating laborious procedures required by traditional histopathological examination. The content of hepatic fat measured with CARS imaging was correlated strongly with that determined by biochemical analysis ([R.sup.2]=0.89) over a pathologically significant range of the hepatic fat (from 2% to 20% of the total mass of tissue). Our work validates the quantitative assessment of fat in intact tissue through the use of CARS microscopy. When combined with the increasingly diverse animal models of diseases related to metabolic disorders of lipids, our approach is extensible to enable acquiring important insight into the genetic, environmental, and dietary factors affecting the uptake and accumulation of fat within tissues.

Published
2009

6. Cyano Derivatives of 7‐Aminoquinoline That Are Highly Emissive in Water: Potential for Sensing Applications

Author

Chang, Kai‐Hsin, primary, Chao, Wei‐Chih, additional, Yang, Yu‐Hsuan, additional, Wu, Cheng‐Ham, additional, Li, Zhi‐Bin, additional, Chen, Hung‐Che, additional, Chou, Yi‐Te, additional, Annie Ho, Ja‐an, additional, Li, Xin‐Cheng, additional, Peng, Yu‐Chiang, additional, Liao, Yu‐Chan, additional, Liu, Kuan‐Miao, additional, Chao, Chi‐Min, additional, and Chou, Pi‐Tai, additional

Published
2021
Full Text
View/download PDF

8. Autophagy and apoptotic machinery caused by Polygonum�cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells

Author

Wang, Yin‑Lai, primary, Horng, Chi‑Ting, additional, Hsieh, Min‑Tsang, additional, Chen, Hung‑Che, additional, Huang, Yu‑Syuan, additional, Yang, Jai‑Sing, additional, Wang, Guo‑Kai, additional, Chiang, Jo‑Hua, additional, Chen, Hul‑Han, additional, Lu, Chi‑Cheng, additional, and Chen, Fu‑An, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results