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Your search keyword '"Chen, Hsien-Chung"' showing total 21 results
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21 results on '"Chen, Hsien-Chung"'

1. Advancements and challenges: immunotherapy therapy in high-grade glioma - a meta-analysis of randomized clinical trials

Author

Palavani, Lucca B., Mitre, Lucas Pari, Camerotte, Raphael, Nogueira, Bernardo Vieira, Canto, Gisele Lúcia, Chen, Hsien-Chung, Pacheco-Barrios, Niels, Ferreira, Márcio Yuri, Batista, Sávio, Andreão, Filipi Fim, Polverini, Allan Dias, Montenegro, Thiago S., Paiva, Wellingson, Ferreira, Christian, Bertani, Raphael, and D’Amico, Randy S.

Published
2024
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3. Efficacy and safety of stereotactic radiosurgery with gamma knife machine in patients with essential tremor: a systematic review and single-arm meta-analysis

Author

Gonçalves, Ocílio Ribeiro, Lima, Hesdra Ferreira, Borges, Carlos Eduardo Silva, Júnior, Arlindo Bispo da Silva, Batista, Sávio, Romeiro, Pedro, Fukunaga, Christian Ken, Góes, Bruno Guido, Monteiro, Gabriel de Almeida, Chen, Hsien-Chung, Soares, Victor Gonçalves, Ferreira, Márcio Yuri, and Telles, João Paulo Mota

Published
2024
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14. Investigations of a Weathered and Closely Jointed Rock Slope Failure Using Back Analyses

Author

Kuo-Shih Shao, An-Jui Li, Chee-Nan Chen, Chen-Hsien Chung, Ching-Fang Lee, and Chih-Ping Kuo

Subjects
Hoek–Brown failure criterion, Environmental effects of industries and plants, Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, rainfall, TJ807-830, rock mass disturbance, finite element limit analysis, Management, Monitoring, Policy and Law, TD194-195, Renewable energy sources, Environmental sciences, GE1-350
Abstract

This study presents the case of a landslide triggered by a high groundwater level caused by several days of continuous rainfall in the northeastern region of Taiwan. The slope where this landslide occurred consists of closely jointed and weathered bedrock. By means of finite element limit analysis and the Hoek–Brown failure criterion, this study performed a slope failure simulation similar to the actual landslide and deduced the reasonable value range for the combination of key Hoek–Brown failure criterion parameters through back analyses. The results indicate that the key parameters affecting the bedrock’s slope stability were the geological strength index (GSI) and the disturbance factor (D), whereas the effects of the unconfined compressive strength (σci) were less significant. The results of the back analysis reveal that the suitable D-value range and GSI of closely jointed and weathered sandstone in the northeastern region of Taiwan are 0.8 to 0.9 and 20 to 30, respectively. These back-analyzed value ranges can serve as a reference for broader applications in the preliminary stability analysis of similar rock slopes where it is difficult to perform in situ investigation.

Published
2021

18. Novel Anodic Polyelectrochromic Aromatic Polyamides Containing Pendent Dimethyltriphenylamine Moieties

Author

Guey-Sheng Liou, Chen-Hsien Chung, and Cha-Wen Chang

Subjects
Inorganic Chemistry, Polymers and Plastics, Electrochromism, Chemistry, Organic Chemistry, Polymer chemistry, Polyamide, Materials Chemistry, Copolymer, Organic chemistry, Thermal stability, Anode
Abstract

Two series of novel aromatic polyamides containing pendent dimethyltriphenylamine moieties were prepared based on N,N-bis(4-aminophenyl)-N′,N′-di(4-methylphenyl)-1,4-phenylenediamine (4) and N,N-bi...

Published
2008

19. First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitroand In Vivo

Author

Sharma, Sachin, Wang, Shao-An, Yang, Wen-Bin, Lin, Hong-Yi, Lai, Mei-Jung, Chen, Hsien-Chung, Kao, Tzu-Yuan, Hsu, Feng-Lin, Nepali, Kunal, Hsu, Tsung-I, and Liou, Jing-Ping

Abstract

Structural analysis of tazemetostat, an FDA-approved EZH2 inhibitor, led us to pinpoint a suitable site for appendage with a pharmacophoric fragment of second-generation HSP90 inhibitors. Resultantly, a magnificent dual EZH2/HSP90 inhibitor was pinpointed that exerted striking cell growth inhibitory efficacy against TMZ-resistant Glioblastoma (GBM) cell lines. Exhaustive explorations of chemical probe 7led to several revelations such as (i) compound 7increased apoptosis/necrosis-related gene expression, whereas decreased M phase/kinetochore/spindle-related gene expression as well as CENPs protein expression in Pt3R cells; (ii) dual inhibitor 7induced cell cycle arrest at the M phase; (iii) compound 7suppressed reactive oxygen species (ROS) catabolism pathway, causing the death of TMZ-resistant GBM cells; and (iv) compound 7elicited substantial in vivoanti-GBM efficacy in experimental mice xenografted with TMZ-resistant Pt3R cells. Collectively, the study results confirm the potential of dual EZH2-HSP90 inhibitor 7as a tractable anti-GBM agent.

Published
2024
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