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Your search keyword '"Chen, Houjie"' showing total 11 results
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11 results on '"Chen, Houjie"'

3. Correction to Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Anti-Exocytosis Enhanced, Lysosome Impairment-Based Cancer Therapy

Author

Ding, Li, primary, Zhu, Xianbing, additional, Wang, Yiling, additional, Shi, Bingyang, additional, Ling, Xiang, additional, Chen, Houjie, additional, Nan, Wenhao, additional, Barrett, Austin, additional, Guo, Zilei, additional, Tao, Wei, additional, Wu, Jun, additional, and Shi, Xiaojun, additional

Published
2022
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8. Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Exocytosis-Inhibiting, Lysosome Impairment-Based Cancer Therapy

Author

Ding, Li, primary, Zhu, Xianbing, additional, Wang, Yiling, additional, Shi, Bingyang, additional, Ling, Xiang, additional, Chen, Houjie, additional, Nan, Wenhao, additional, Barrett, Austin, additional, Guo, Zilei, additional, Tao, Wei, additional, Wu, Jun, additional, and Shi, Xiaojun, additional

Published
2017
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11. Protective effects of quercetin on UVB irradiation‑induced cytotoxicity through ROS clearance in keratinocyte cells.

Author

Zhu X, Li N, Wang Y, Ding L, Chen H, Yu Y, and Shi X

Subjects
Apoptosis drug effects, Apoptosis radiation effects, Cell Line, Cell Survival drug effects, Cell Survival radiation effects, Cytochromes c metabolism, Humans, Keratinocytes metabolism, Lipid Peroxidation drug effects, Mitochondrial Membranes drug effects, Mitochondrial Membranes radiation effects, Radiation-Protective Agents pharmacology, Reactive Oxygen Species metabolism, Keratinocytes drug effects, Keratinocytes radiation effects, Quercetin pharmacology, Ultraviolet Rays adverse effects
Abstract

Human skin is the body's largest organ that protects against diverse environmental injuries. However, ultraviolet (UV) radiation, which induces a transient increase in the intracellular level of reactive oxygen species (ROS) and leads to a variety of injuries and various skin diseases, has deleterious effects on living organisms. Quercetin is a naturally occurring compound with strong antioxidant action and can successfully scavenge free radicals. In the present study, we investigated the effects and the mechanism of quercetin on UVB‑induced cytotoxicity in keratinocyte (HaCaT) cells. The results of this study showed that quercetin (20 μM) significantly blocked UVB irradiation (15 mJ/cm2)‑induced intracellular ROS generation. In addition, the ROS clearing ability of quercetin prevented cell membrane and mitochondria from ROS attack and inhibited cell membrane fluidity decrease and mitochondrial membrane depolarization. Moreover, the outflow of cytochrome c and apoptosis were markedly inhibited. These results suggest that the protective effect of quercetin against UVB irradiation‑induced toxicity is mainly mediated by the ROS scavenging ability. Thus, quercetin is a potential agent against UVB irradiation‑induced skin damage.

Published
2017
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