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The origin of cosmic rays can be deciphered by accurately measuring the components and energy spectrum in the knee region. Study of Extensive air shower (EAS) relies on information provided by secondary high energy hadrons, which generate evaporation neutrons when they interact with matter in the environment. In the early 21st century, the electron–neutron detector (EN-detector) was developed at the Institute for Nuclear Research of the Russian Academy of Science (INR RAS). The PRImary Spectrum Measurement Array (PRISMA) project was introduced to enhance the array capabilities of cosmic ray composition separation and improve measurement accuracy. Within the framework of Chinese–Russian cooperation, at the Large High Altitude Air Shower Observatory (LHAASO) at Mt. Haizi (4400 m a.s.l.) in Daocheng, Sichuan province, China, a proposal was launched to establish the EN-Detector Array (ENDA) composed of 400 detectors in area of 10000 m to measure cosmic rays up to 300 PeV. In China, in 2018, a cluster, having 16 EN-detectors, was built at Tibet University (TU, 3700 m a.s.l.) in Lhasa, Tibet, to test specification of the array, and later it was moved to the Yangbajing (YBJ) Cosmic Ray Observatory (4300 m a.s.l.) in Tibet. Since 2019, another cluster so called ENDA-16 has started running at LHAASO, and here we give the first result of thermal neutron distribution. After gaining experience from these previous works, in April 2023, we successfully extended ENDA to ENDA-64 composed of 64 EN-detectors in area of 1000 m at LHAASO to measure cosmic rays from 400 TeV to 20 PeV. Here we describe installation and running status of ENDA-64 and present first results of thermal neutron distributions at different locations and hybrid detection of cosmic ray by using ENDA and LHAASO. [ABSTRACT FROM AUTHOR]

Long noncoding RNAs (lncRNAs) have been reported to participate in regulating many biological processes, including immune response to influenza A virus (IAV). However, the association between lncRNA expression profiles and influenza infection susceptibility has not been well elucidated. Here, we analyzed the expression profiles of lncRNAs, miRNAs, and mRNAs among IAV-infected adult rat (IAR), normal adult rat (AR), IAV-infected junior rat (IJR), and normal junior rat (JR) by RNA sequencing. Compared with differently expressed lncRNAs (DElncRNAs) between AR and IAR, 24 specific DElncRNAs were found between IJR and JR. Then, based on the fold changes and P value, the top 5 DElncRNAs, including 3 upregulated and 2 downregulated lncRNAs, were chosen to establish a ceRNA network for further disclosing their regulatory mechanisms. To visualize the differentially expressed genes in the ceRNA network, GO and KEGG pathway analysis was performed to further explore their roles in influenza infection of junior rats. The results showed that the downregulated DElncRNA-target genes were mostly enriched in the IL-17 signaling pathway. It indicated that the downregulated lncRNAs conferred the susceptibility of junior rats to IAV via mediating the IL-17 signaling pathway. [ABSTRACT FROM AUTHOR]

Large quantities of bacteria, including Firmicutes, Actinobacteria, and Bacteroidetes, colonize the surface of the respiratory mucosa of healthy people. They interact and coexist with the local mucosal immune system of the human airway, maintaining the immune stability and balance of the respiratory system. While suffering from chronic respiratory diseases, the microbial population in the airway changes and the proportion of Proteobacteria is increased in patients with asthma. The abundance of the microbial population in patients with chronic obstructive pulmonary disease (COPD) is decreased, and conversely, the proportion of Firmicutes and Proteobacteria increased. The diversity of airway microorganisms in cystic fibrosis (CF) patients is decreased, while pathogenic bacteria and conditional pathogenic bacteria are proliferated in large numbers. The proportion of Firmicutes and Proteobacteria is increased in patients with upper airway cough syndrome (UACS), which replaces the dominance of Streptococcus and Neisseria in the pharynx of a normal population. Therefore, a clear understanding of the immune process of the airway flora and the immune dysfunction of the flora on the pathogenesis of chronic respiratory diseases can provide new ideas for the prevention and treatment of human respiratory diseases. [ABSTRACT FROM AUTHOR]

Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer. [ABSTRACT FROM AUTHOR]