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Objective To study the efficacy and safety of hyaluronic acid medical wound dressing on skin repair after Picoway laser treatment. Methods Thirty patients after Picoway laser treatment were randomly divided into medical wound dressing group and control group. Medical wound dressing group was treated with medical wound dressing combined with the Danrushuang made by Shanghai Dermatology Hospital immediately after treatment, while the control group was treated with the Danrushuang made by Shanghai Dermatology Hospital alone for 7 days. Results The quantitative evaluation results of skin image analyzer (VISIA-6) showed that the improvement of redness area, texture and brown spots in the medical wound dressing group was better than that in the control group(P＜0.05) after 7 days treatment. CK skin tester (MPA-580) showed that the skin water content of the medical wound dressing group was obviously higher than that of the control group at different time points after laser treatment, and the transepidermal water loss at each time point was significantly lower than that of the control group(P＜0.05). There was no significant adverse events recorded in all patients. Conclusions The use of hyaluronic acid medical wound dressing after Picoway laser treatment may promote the recovery of the skin barrier, alleviate acute inflammatory reaction and have an obvious moisturizing effect.

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been engendering enormous hazards to the world. We obtained the complete genome sequences of SARSCoV-2 from imported cases admitted to the Guangzhou Eighth People's Hospital, which was appointed by the Guangdong provincial government to treat coronavirus disease 2019 (COVID-19). The SARS-CoV-2 diversity was analyzed, and the mutation characteristics, time, and regional trend of variant emergence were evaluated. In total, 177 throat swab samples were obtained from COVID-19 patients (from October 2020 to May 2021). High-throughput sequencing technology was used to detect the viral sequences of patients infected with SARS-CoV-2. Phylogenetic and molecular evolutionary analyses were used to evaluate the mutation characteristics and the time and regional trends of variants. We observed that the imported cases mainly occurred after January 2021, peaking in May 2021, with the highest proportion observed from cases originating from the United States. The main lineages were found in Europe, Africa, and North America, and B.1.1.7 and B.1.351 were the two major sublineages. Sublineage B.1.618 was the Asian lineage (Indian) found in this study, and B.1.1.228 was not included in the lineage list of the Pangolin web. A reasonably high homology was observed among all samples. The total frequency of mutations showed that the open reading frame 1a (ORF1a) protein had the highest mutation density at the nucleotide level, and the D614G mutation in the spike protein was the commonest at the amino acid level. Most importantly, we identified some amino acid mutations in positions S, ORF7b, and ORF9b, and they have neither been reported on the Global Initiative of Sharing All Influenza Data nor published in PubMed among all missense mutations. These results suggested the diversity of lineages and sublineages and the high homology at the amino acid level among imported cases infected with SARS-CoV-2 in Guangdong Province, China. [ABSTRACT FROM AUTHOR]

Some image processing research are restudied via CNN genes with five variables, and this include edge detection, corner detection, center point extraction and horizontal-vertical line detection. Although they were implemented with nine variables, the results of computer simulation show that the effect with five variables is identical to or better than that with nine variables. [ABSTRACT FROM AUTHOR]