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842 results on '"Chen, Danyang"'

3. Tunable inductive coupler for high fidelity gates between fluxonium qubits

Author

Zhang, Helin, Ding, Chunyang, Weiss, D. K., Huang, Ziwen, Ma, Yuwei, Guinn, Charles, Sussman, Sara, Chitta, Sai Pavan, Chen, Danyang, Houck, Andrew A., Koch, Jens, and Schuster, David I.

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The fluxonium qubit is a promising candidate for quantum computation due to its long coherence times and large anharmonicity. We present a tunable coupler that realizes strong inductive coupling between two heavy-fluxonium qubits, each with $\sim50$MHz frequencies and $\sim5$ GHz anharmonicities. The coupler enables the qubits to have a large tuning range of $\textit{XX}$ coupling strengths ($-35$ to $75$ MHz). The $\textit{ZZ}$ coupling strength is $<3$kHz across the entire coupler bias range, and $<100$Hz at the coupler off-position. These qualities lead to fast, high-fidelity single- and two-qubit gates. By driving at the difference frequency of the two qubits, we realize a $\sqrt{i\mathrm{SWAP}}$ gate in $258$ns with fidelity $99.72\%$, and by driving at the sum frequency of the two qubits, we achieve a $\sqrt{b\mathrm{SWAP}}$ gate in $102$ns with fidelity $99.91\%$. This latter gate is only 5 qubit Larmor periods in length. We run cross-entropy benchmarking for over $20$ consecutive hours and measure stable gate fidelities, with $\sqrt{b\mathrm{SWAP}}$ drift ($2 \sigma$) $< 0.02\%$ and $\sqrt{i\mathrm{SWAP}}$ drift $< 0.08\%$., Comment: 16 pages, 14 figures

Published
2023

13. Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy

Author

Jiang, Lingdong, Chen, Danyang, Jin, Zhaokui, Xia, Chao, Xu, Qingqing, Fan, Mingjian, Dai, Yunlu, Liu, Jia, Li, Yuanpei, and He, Qianjun

Subjects
Medicinal and Biomolecular Chemistry, Chemical Sciences, Engineering, Biomedical Engineering, Materials Engineering, Cancer, Nanotechnology, Bioengineering, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Nitric oxide, Photodynamic therapy, Structural transformation, Peptide, Enhanced intratumoral retention, Nanomedicine, Medicinal and biomolecular chemistry, Biomedical engineering, Materials engineering
Abstract

Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects. Unfortunately, nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements. In this work, we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide (NO) release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy (PDT). The designed nanoparticle is self-assembled from a chimeric peptide monomer, TPP-RRRKLVFFK-Ce6, which contains a photosensitive moiety (chlorin e6, Ce6), a β-sheet-forming peptide domain (Lys-Leu-Val-Phe-Phe, KLVFF), an oligoarginine domain (RRR) as NO donor and a triphenylphosphonium (TPP) moiety for targeting mitochondria. When irradiated by light, the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod, enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation. More importantly, the conversion of generated NO and reactive oxygen species (ROS) in a light-responsive way to peroxynitrite anions (ONOO-) with higher cytotoxicity enables NO to sensitize PDT in cancer treatment. Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently. The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome.

Published
2022

30. ricME: Long-Read Based Mobile Element Variant Detection Using Sequence Realignment and Identity Calculation

Author

Ma, Huidong, Zhong, Cheng, Sun, Hui, Chen, Danyang, Lin, Haixiang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Guo, Xuan, editor, Mangul, Serghei, editor, Patterson, Murray, editor, and Zelikovsky, Alexander, editor

Published
2023
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39. Effect of Branching on Phase Behaviors of ABC Triblock Copolymers in Nonfrustrated Systems

Author

Chen, Danyang and Ning, Xiaowei

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

The phase behavior of linear dendritic triblock copolymer melts(AB2C4) is studied by self-consistent-field theory (SCFT) in order to find the effects of branching on the phase behavior of ABC linear triblock copolymer melts. We focus on a nonfrustrated parameters that \c{hi}NAB=\c{hi}NBC=\c{hi}NAC=40 where A/C interface will not form. Frank-Kasper phases, asymmetric alternative sphere as well as traditional phases observed in diblock copolymer melts are found to be stable in the calculation., Comment: This paper is incomplete and require further work

Published
2019

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