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9. CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis

Author

Cui, Yanmei, primary, Wu, Haiyong, additional, Liu, Zhihang, additional, Ma, Tenghui, additional, Liang, Wenfeng, additional, Zeng, Qingzhi, additional, Chen, Daici, additional, Qin, Qiyuan, additional, Huang, Binjie, additional, Wang, Michael Hu, additional, Huang, Xiaoyan, additional, He, Yanjiong, additional, Kuang, Yingyi, additional, Sugimoto, Shinya, additional, Sato, Toshiro, additional, and Wang, Lei, additional

Published
2022
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12. Dissection of Cdk1-cyclin complexes in vivo

Author

Ear, Po Hien, Booth, Michael J., Abd-Rabbo, Diala, Moreno, Jacqueline Kowarzyk, Hall, Conrad, Chen, Daici, Vogel, Jackie, and Michnick, Stephen W.

Published
2013

13. Laparoscopic Proximally Extended Colorectal Resection With Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Late Complications of Chronic Radiation Proctopathy

Author

He, Yanjiong, primary, Zhou, Zuolin, additional, Huang, Xiaoyan, additional, Guan, Qi, additional, Qin, Qiyuan, additional, Zhu, Miaomiao, additional, Wang, Huaiming, additional, Zhong, Qinghua, additional, Chen, Daici, additional, Wang, Hui, additional, Fang, Lekun, additional, and Ma, Tenghui, additional

Published
2022
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16. Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity

Author

Peng, Shaoyong, primary, Li, Yingjie, additional, Huang, Meijin, additional, Tang, Guannan, additional, Xie, Yumo, additional, Chen, Daici, additional, Hu, Yumin, additional, Yu, Tiantian, additional, Cai, Jian, additional, Yuan, Zixu, additional, Wang, Huaiming, additional, Wang, Hui, additional, Luo, Yanxin, additional, and Liu, Xiaoxia, additional

Published
2022
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17. CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.

Author

Cui, Yanmei, Wu, Haiyong, Liu, Zhihang, Ma, Tenghui, Liang, Wenfeng, Zeng, Qingzhi, Chen, Daici, Qin, Qiyuan, Huang, Binjie, Wang, Michael Hu, Huang, Xiaoyan, He, Yanjiong, Kuang, Yingyi, Sugimoto, Shinya, Sato, Toshiro, and Wang, Lei

Subjects
HEPATOCYTE growth factor, ENTERITIS, FIBROSIS, REGENERATION (Biology), RADIOTHERAPY complications, INTESTINAL tumors, RADIATION injuries
Abstract

Radiation enteritis (RE) is a prevalent complication of radiotherapy for pelvic malignant tumors, characterized by severe intestinal epithelial destruction and progressive submucosal fibrosis. However, little is known about the pathogenesis of this disease, and so far, there is no specific targeted therapy. Here, we report that CXCL16 is upregulated in the injured intestinal tissues of RE patients and in a mouse model. Genetic deletion of Cxcl16 mitigates fibrosis and promotes intestinal stem cell‐mediated epithelial regeneration after radiation injury in mice. Mechanistically, CXCL16 functions on myofibroblasts through its receptor CXCR6 and activates JAK3/STAT3 signaling to promote fibrosis and, at the same time, to transcriptionally modulate the levels of BMP4 and hepatocyte growth factor (HGF) in myofibroblasts. Moreover, we find that CXCL16 and CXCR6 auto‐ and cross‐regulate themselves in positive feedback loops. Treatment with CXCL16 neutralizing monoclonal antibody attenuates fibrosis and improves the epithelial repair in RE mouse model. Our findings emphasize the important role of CXCL16 in the progression of RE and suggest that CXCL16 signaling could be a potential therapeutic target for RE. © 2022 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/β-catenin signaling activation.

Author

Liu, Yiting, Gao, Qianling, Feng, Xingzhi, Chen, Guanxing, Jiang, Xuefei, Chen, Daici, and Yang, Zihuan

Subjects
AQUAPORINS, LIVER metastasis, UBIQUITIN ligases, METASTASIS, SMALL molecules, METASTATIC breast cancer
Abstract

Background Aquaporin 9 (AQP9) is permeable to water or other small molecules, and plays an important role in various cancers. We previously found that AQP9 was related to the efficacy of chemotherapy in patients with colorectal cancer (CRC). This study aimed to identify the role and regulatory mechanism of AQP9 in CRC metastasis. Methods The clinical significance of AQP9 was analysed by using bioinformatics and tissue microarray. Transcriptome sequencing, Dual-Luciferase Reporter Assay, Biacore, and co-immunoprecipitation were employed to demonstrate the regulatory mechanism of AQP9 in CRC. The relationship between AQP9 and CRC metastasis was verified in vitro and in vivo by using real-time cell analysis assay, high content screening, and liver metastasis models of nude mice. Results We found that AQP9 was highly expressed in metastatic CRC. AQP9 overexpression reduced cell roundness and enhanced cell motility in CRC. We further showed that AQP9 interacted with Dishevelled 2 (DVL2) via the C-terminal SVIM motif, resulting in DVL2 stabilization and the Wnt/β-catenin pathway activation. Additionally, we identified the E3 ligase neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) as a modulator regulating the ubiquitination and degradation of AQP9. Conclusions Collectively, our study revealed the important role of AQP9 in regulating DVL2 stabilization and Wnt/β-catenin signaling to promote CRC metastasis. Targeting the NEDD4L–AQP9–DVL2 axis might have therapeutic usefulness in metastatic CRC treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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21. The BioGRID interaction database: 2015 update

Author

Chatr-aryamontri, Andrew, Breitkreutz, Bobby-Joe, Oughtred, Rose, Boucher, Lorrie, Heinicke, Sven, Chen, Daici, Stark, Chris, Breitkreutz, Ashton, Kolas, Nadine, OʼDonnell, Lara, Reguly, Teresa, Nixon, Julie, Ramage, Lindsay, Winter, Andrew, Sellam, Adnane, Chang, Christie, Hirschman, Jodi, Theesfeld, Chandra, Rust, Jennifer, Livstone, Michael S., Dolinski, Kara, and Tyers, Mike

Published
2015
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22. Enhancing cancer‐associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis

Author

Peng, Shaoyong, primary, Chen, Daici, additional, Cai, Jian, additional, Yuan, Zixu, additional, Huang, Binjie, additional, Li, Yichen, additional, Wang, Huaiming, additional, Luo, Qianxin, additional, Kuang, Yingyi, additional, Liang, Wenfeng, additional, Liu, Zhihang, additional, Wang, Qian, additional, Cui, Yanmei, additional, Wang, Hui, additional, and Liu, Xiaoxia, additional

Published
2021
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26. The BioGRID interaction database: 2013 update

Author

Chatr-aryamontri, Andrew, Breitkreutz, Bobby-Joe, Heinicke, Sven, Boucher, Lorrie, Winter, Andrew, Stark, Chris, Nixon, Julie, Ramage, Lindsay, Kolas, Nadine, O’Donnell, Lara, Reguly, Teresa, Breitkreutz, Ashton, Sellam, Adnane, Chen, Daici, Chang, Christie, Rust, Jennifer, Livstone, Michael, Oughtred, Rose, Dolinski, Kara, and Tyers, Mike

Published
2013
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27. EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Author

Choi, Hyun Ho, primary, Zou, Shaomin, additional, Wu, Jian‐lin, additional, Wang, Huashe, additional, Phan, Liem, additional, Li, Kai, additional, Zhang, Peng, additional, Chen, Daici, additional, Liu, Qingxin, additional, Qin, Baifu, additional, Nguyen, Thu Anh Thai, additional, Yeung, Sai‐Ching J., additional, Fang, Lekun, additional, and Lee, Mong‐Hong, additional

Published
2020
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29. BioGRID: A Tool for Studying Biological Interactions in Yeast

Author

Oughtred, Rose, Chatr-aryamontri, Andrew, Breitkreutz, Bobby-Joe, Chang, Christie S., Rust, Jennifer M., Theesfeld, Chandra L., Heinicke, Sven, Breitkreutz, Ashton, Chen, Daici, Hirschman, Jodi, Kolas, Nadine, Livstone, Michael S., Nixon, Julie, O’Donnell, Lara, Ramage, Lindsay, Winter, Andrew, Reguly, Teresa, Sellam, Adnane, Stark, Chris, Boucher, Lorrie, Dolinski, Kara, and Tyers, Mike

Subjects
Saccharomyces cerevisiae Proteins, Yeasts, Databases, Genetic, Protein Interaction Mapping, Animals, Humans, Gene Regulatory Networks, Saccharomyces cerevisiae, Article
Abstract

The Biological General Repository for Interaction Datasets (BioGRID; www.thebiogrid.org) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface and visualization tools enable the discovery of individual gene, protein or biological network function. BioGRID houses interaction data for the major model organism species - including yeast, nematode, fly, zebrafish, mouse and human - with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of December 2014, BioGRID houses approximately 349,000 biological interactions for budding yeast, and 69,700 interactions for fission yeast. BioGRID also supports an integrated post-translational modification (PTM) viewer that incorporates over 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID (www.phosphogrid.org). This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set.

Published
2016

33. Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions

Author

Oughtred, Rose, primary, Chatr-aryamontri, Andrew, additional, Breitkreutz, Bobby-Joe, additional, Chang, Christie S., additional, Rust, Jennifer M., additional, Theesfeld, Chandra L., additional, Heinicke, Sven, additional, Breitkreutz, Ashton, additional, Chen, Daici, additional, Hirschman, Jodi, additional, Kolas, Nadine, additional, Livstone, Michael S., additional, Nixon, Julie, additional, O’Donnell, Lara, additional, Ramage, Lindsay, additional, Winter, Andrew, additional, Reguly, Teresa, additional, Sellam, Adnane, additional, Stark, Chris, additional, Boucher, Lorrie, additional, Dolinski, Kara, additional, and Tyers, Mike, additional

Published
2016
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34. BioGRID: A Resource for Studying Biological Interactions in Yeast

Author

Oughtred, Rose, primary, Chatr-aryamontri, Andrew, additional, Breitkreutz, Bobby-Joe, additional, Chang, Christie S., additional, Rust, Jennifer M., additional, Theesfeld, Chandra L., additional, Heinicke, Sven, additional, Breitkreutz, Ashton, additional, Chen, Daici, additional, Hirschman, Jodi, additional, Kolas, Nadine, additional, Livstone, Michael S., additional, Nixon, Julie, additional, O’Donnell, Lara, additional, Ramage, Lindsay, additional, Winter, Andrew, additional, Reguly, Teresa, additional, Sellam, Adnane, additional, Stark, Chris, additional, Boucher, Lorrie, additional, Dolinski, Kara, additional, and Tyers, Mike, additional

Published
2016
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35. Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo.

Author

Wu, Peihuang, Li, Li, Wang, Huaiming, Ma, Tenghui, Wu, Haiyong, Fan, Xinjuan, Yang, Zihuan, Chen, Daici, and Wang, Lei

Subjects
DELAYED radiation effects, PROCTITIS, QUALITY of life, NEOVASCULARIZATION, IMMUNOHISTOCHEMISTRY, THERAPEUTICS, FIBRINOLYTIC agents, COMPARATIVE studies, GENES, RESEARCH methodology, MEDICAL cooperation, NEOVASCULARIZATION inhibitors, RADIATION injuries, RECTAL diseases, RESEARCH, EVALUATION research, GENE expression profiling, PATHOLOGIC neovascularization, PHARMACODYNAMICS
Abstract

Background: Chronic radiation proctitis (CRP), a common complication after radiotherapy for pelvic malignancies, compromises patient quality of life. Vascular damage and aberrant angiogenesis in the mucosal layer are essential histological features, but changes to the submucosal layer are unclear. Thus, we evaluated the histological characteristics and distribution changes of key angiogenic factors in full-layered human CRP samples.Methods: Thirty paraffin-embedded CRP and twenty-nine non-CRP tissues were used to evaluate histopathological changes. Immunohistochemistry with anti-CD34 antibody was performed to calculate microvascular density (MVD). Frozen tissues from eight CRP patients and five non-CRP controls were collected and analyzed by antibody array, which contained sixty human angiogenesis-related factors. Quality controls with positive and negative controls were performed during antibody array analysis. Two differentially expressed factors were confirmed by ELISA.Results: CRP lesions showed vasculopathy, fibrosis, mucosal ulceration, edema, and inflammatory cell infiltration. Human angiogenesis antibody array and ELISA confirmed the increased angiostatin in CRP lesions. Immunohistochemical staining showed dispersed distribution of angiostatin throughout the mucosal and submucosal layers in CRP lesions, while angiostatin accumulated within the vessel lumens in non-CRP tissues. MVD significantly decreased in the submucosal layer of CRP, suggesting a potential association with increased angiostatin.Conclusions: Angiostatin increased and had a distinct distribution in CRP lesions. Compensatory telangiectasia in the mucosa, vessel stenosis, and reduced MVD might attenuate blood flow in the submucosa and contribute to CRP progression. Restoration of vascular functionality by promoting angiogenesis in the submucosal layer may help alleviate CRP in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2018
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36. The BioGRID interaction database: 2015 update

Author

Chatr-aryamontri, Andrew, primary, Breitkreutz, Bobby-Joe, additional, Oughtred, Rose, additional, Boucher, Lorrie, additional, Heinicke, Sven, additional, Chen, Daici, additional, Stark, Chris, additional, Breitkreutz, Ashton, additional, Kolas, Nadine, additional, O'Donnell, Lara, additional, Reguly, Teresa, additional, Nixon, Julie, additional, Ramage, Lindsay, additional, Winter, Andrew, additional, Sellam, Adnane, additional, Chang, Christie, additional, Hirschman, Jodi, additional, Theesfeld, Chandra, additional, Rust, Jennifer, additional, Livstone, Michael S., additional, Dolinski, Kara, additional, and Tyers, Mike, additional

Published
2014
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37. The BioGRID interaction database: 2013 update

Author

Chatr-aryamontri, Andrew, primary, Breitkreutz, Bobby-Joe, additional, Heinicke, Sven, additional, Boucher, Lorrie, additional, Winter, Andrew, additional, Stark, Chris, additional, Nixon, Julie, additional, Ramage, Lindsay, additional, Kolas, Nadine, additional, O’Donnell, Lara, additional, Reguly, Teresa, additional, Breitkreutz, Ashton, additional, Sellam, Adnane, additional, Chen, Daici, additional, Chang, Christie, additional, Rust, Jennifer, additional, Livstone, Michael, additional, Oughtred, Rose, additional, Dolinski, Kara, additional, and Tyers, Mike, additional

Published
2012
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39. Gamma Tubulin Phospho Regulation: Insights into Spindle Assembly

Author

Nazarova, Elena, primary, O’Toole, Eileen, additional, Chen, Daici, additional, Kaitna, Susi, additional, Jones, Michelle, additional, Keck, Jamie, additional, Hall, Conrad, additional, Yen, Eric, additional, Francois, Paul, additional, Winey, Mark, additional, and Vogel, Jackie, additional

Published
2012
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42. KRASand PIK3CAbi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report

Author

Luo, Qianxin, Chen, Dianke, Fan, Xinjuan, Fu, Xinhui, Ma, Tenghui, and Chen, Daici

Abstract

The coexistence of KRASand PIK3CAmutations in cells implies potential synergistic hyperactivation of the Ras/MAPKand PI3K/Aktoncogenic pathways. Therefore, it is desirable to investigate the concomitant mutations of KRASand PIK3CAin colorectal cancer (CRC) samples and whether the concomitant mutations are associated with a poor prognosis in CRC patients.

Published
2020
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