132 results on '"Chen, Christopher P L H"'
Search Results
2. Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients.
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Biesbroek, J. Matthijs, Coenen, Mirthe, DeCarli, Charles, Fletcher, Evan M., Maillard, Pauline M., Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Chen, Christopher P. L. H., Dal‐Bianco, Peter, Dewenter, Anna, Duering, Marco, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G., Franzmeier, Nicolai, Hilal, Saima, Hofer, Edith, Koek, Huiberdina L., and Maier, Andrea B.
- Abstract
INTRODUCTION: White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid‐β1‐42 (Aβ42)‐positive status. METHODS: Individual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume. RESULTS: VRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and Aß42‐positive status with WMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001). DISCUSSION: Vascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter. Highlights: Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH).We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts.Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation.Vascular risk was associated with anterior and infratentorial WMH.Amyloid pathology and vascular risk have distinct signature WMH patterns. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Strategic white matter hyperintensity locations for cognitive impairment:A multicenter lesion-symptom mapping study in 3525 memory clinic patients
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Coenen, Mirthe, Kuijf, Hugo J, Huenges Wajer, Irene M C, Duering, Marco, Wolters, Frank J, Fletcher, Evan F, Maillard, Pauline M, Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Boomsma, Jooske M F, Chen, Christopher P L H, Dal-Bianco, Peter, Dewenter, Anna, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G, Franzmeier, Nicolai, Groeneveld, Onno, Hilal, Saima, Hofer, Edith, Koek, Dineke L, Maier, Andrea B, McCreary, Cheryl R, Padilla, Catarina S, Papma, Janne M, Paterson, Ross W, Pijnenburg, Yolande A L, Rubinski, Anna, Schmidt, Reinhold, Schott, Jonathan M, Slattery, Catherine F, Smith, Eric E, Steketee, Rebecca M E, Sudre, Carole H, van den Berg, Esther, van der Flier, Wiesje M, Venketasubramanian, Narayanaswamy, Vernooij, Meike W, Xin, Xu, DeCarli, Charles, Biessels, Geert Jan, Biesbroek, J Matthijs, Coenen, Mirthe, Kuijf, Hugo J, Huenges Wajer, Irene M C, Duering, Marco, Wolters, Frank J, Fletcher, Evan F, Maillard, Pauline M, Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Boomsma, Jooske M F, Chen, Christopher P L H, Dal-Bianco, Peter, Dewenter, Anna, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G, Franzmeier, Nicolai, Groeneveld, Onno, Hilal, Saima, Hofer, Edith, Koek, Dineke L, Maier, Andrea B, McCreary, Cheryl R, Padilla, Catarina S, Papma, Janne M, Paterson, Ross W, Pijnenburg, Yolande A L, Rubinski, Anna, Schmidt, Reinhold, Schott, Jonathan M, Slattery, Catherine F, Smith, Eric E, Steketee, Rebecca M E, Sudre, Carole H, van den Berg, Esther, van der Flier, Wiesje M, Venketasubramanian, Narayanaswamy, Vernooij, Meike W, Xin, Xu, DeCarli, Charles, Biessels, Geert Jan, and Biesbroek, J Matthijs
- Abstract
INTRODUCTION: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study.METHODS: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses.RESULTS: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains.DISCUSSION: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment.HIGHLIGHTS: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
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- 2023
4. White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies
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Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Neurologie, Projectafdeling VCI, Neurologen, de Kort, Floor A S, Coenen, Mirthe, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P L H, Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C T, Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M, Verhey, Frans R J, Wardlaw, Joanna M, Xu, Xin, Yu, Kyung-Ho, Biesbroek, J Matthijs, Biessels, Geert Jan, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Neurologie, Projectafdeling VCI, Neurologen, de Kort, Floor A S, Coenen, Mirthe, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P L H, Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C T, Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M, Verhey, Frans R J, Wardlaw, Joanna M, Xu, Xin, Yu, Kyung-Ho, Biesbroek, J Matthijs, and Biessels, Geert Jan
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- 2023
5. Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke
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Neurologen, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Projectafdeling VCI, Neurologie, Neuropsychologie, Exalto, Lieza G, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Best, Jonathan G, Bordet, Régis, Chen, Christopher P L H, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kim, Jonguk, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, van Oostenbrugge, Robert J, Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xu, Xin, van Zandvoort, Martine J E, Biesbroek, J Matthijs, Chappell, Francesca M, Biessels, Geert Jan, Neurologen, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Projectafdeling VCI, Neurologie, Neuropsychologie, Exalto, Lieza G, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Best, Jonathan G, Bordet, Régis, Chen, Christopher P L H, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kim, Jonguk, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, van Oostenbrugge, Robert J, Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xu, Xin, van Zandvoort, Martine J E, Biesbroek, J Matthijs, Chappell, Francesca M, and Biessels, Geert Jan
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- 2023
6. Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke.
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Exalto, Lieza G., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Hee-Joon Bae, Best, Jonathan G., Bordet, Régis, Chen, Christopher P. L. H., van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K. L., Hilal, Saima, Huenges Wajer, Irene M. C., Jonguk Kim, Kappelle, Jaap, Beom Joon Kim, Köhler, Sebastian, de Kort, Paul L. M., and Koudstaal, Peter J.
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- 2023
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7. Deep-learning retinal vessel calibre measurements and risk of cognitive decline and dementia
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Cheung, Carol Y, primary, Wong, Win Lee Edwin, additional, Hilal, Saima, additional, Kan, Cheuk Ni, additional, Gyanwali, Bibek, additional, Tham, Yih Chung, additional, Schmetterer, Leopold, additional, Xu, Dejiang, additional, Lee, Mong Li, additional, Hsu, Wynne, additional, Venketasubramanian, Narayanaswamy, additional, Tan, Boon Yeow, additional, Wong, Tien Yin, additional, and Chen, Christopher P L H, additional
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- 2022
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8. Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients.
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Coenen, Mirthe, Kuijf, Hugo J., Huenges Wajer, Irene M. C., Duering, Marco, Wolters, Frank J., Fletcher, Evan F., Maillard, Pauline M., Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Boomsma, Jooske M. F., Chen, Christopher P. L. H., Dal‐Bianco, Peter, Dewenter, Anna, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G., Franzmeier, Nicolai, Groeneveld, Onno, and Hilal, Saima
- Abstract
Introduction: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Methods: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel‐based and region of interest tract‐based analyses. Results: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto‐occipital fasciculus were significantly related to domain‐specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. Discussion: The data show that the impact of WMH on cognition is location‐dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. Highlights: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohortsThe impact of WMH on cognition depends on locationWe identified four strategic white matter tractsA single strategic WMH score was derived from these four strategic tractsThe strategic WMH score was an independent determinant of four cognitive domains [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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9. Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke
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Projectafdeling VCI, Brain, Opleiding Neurologie, Beeldverwerking ISI, Circulatory Health, Cancer, Neurologie, Neurologen, Neuropsychologie, Structure and Connections, Biesbroek, J Matthijs, Weaver, Nick A, Aben, Hugo P, Kuijf, Hugo J, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, Biessels, Geert Jan, Projectafdeling VCI, Brain, Opleiding Neurologie, Beeldverwerking ISI, Circulatory Health, Cancer, Neurologie, Neurologen, Neuropsychologie, Structure and Connections, Biesbroek, J Matthijs, Weaver, Nick A, Aben, Hugo P, Kuijf, Hugo J, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, and Biessels, Geert Jan
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- 2022
10. Using the full span of the SPAN-100 index to predict functional outcome in the CHIMES study
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Fabiaña, Natasha L., Lee, Chun Fan, Gan, Robert, Venketasubramanian, Narayanaswamy, Wong, Lawrence K. S., Bousser, Marie-Germaine, Chen, Christopher P. L. H., and De Silva, Deidre Anne
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- 2015
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11. Comparison of small volume infarcts of lacunar and non-lacunar etiologies
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De Silva, Deidre A., Omar, Eunizar, Manzano, Jennifer J. F., Christensen, Soren, Allen, John C., Jr, Bath, Phillip M. W., Chang, Hui-Meng, Wong, Meng-Cheong, and Chen, Christopher P. L. H.
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- 2013
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12. Retinal pathology as biomarker for cognitive impairment and Alzheimerʼs disease
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Ikram, Mohammad Kamran, Cheung, Carol Y, Wong, Tien Y, and Chen, Christopher P L H
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- 2012
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13. Lower incidence of vascular events following small artery ischemic stroke
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De Silva, Deidre Anne, Manzano, Jennifer Justice Frogozo, Toh, April, Woon, Fung-Peng, Liu, Erica Yang, Omar, Eunizar, Wong, Wan-Xin, Wong, Tien-Yin, Chen, Christopher P. L. H., Chang, Hui-Meng, and Wong, Meng-Cheong
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- 2012
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14. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
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Chauhan, Ganesh, Adams, Hieab H H, Jian, Xueqiu, Sharma, Pankaj, Sudlow, Cathie L M, Rosand, Jonathan, Woo, Daniel, Cole, John W, Meschia, James F, Slowik, Agnieszka, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Malik, Rainer, Grewal, Raji P, Rundek, Tatjana, Rexrode, Kathy, Rothwell, Peter M, Arnett, Donna K, Jern, Christina, Johnson, Julie A, Benavente, Oscar R, Wasssertheil-Smoller, Sylvia, Lee, Jin-Moo, Traylor, Matthew, Wong, Quenna, Mitchell, Braxton D, Rich, Stephen S, McArdle, Patrick F, Geerlings, Mirjam I, van der Graaf, Yolanda, de Bakker, Paul I W, Asselbergs, Folkert W, Srikanth, Velandai, Thomson, Russell, Pulit, Sara L, McWhirter, Rebekah, Moran, Chris, Callisaya, Michele, Phan, Thanh, Rutten-Jacobs, Loes C A, Bevan, Steve, Tzourio, Christophe, Mather, Karen A, Sachdev, Perminder S, van Duijn, Cornelia M, Amouyel, Philippe, Worrall, Bradford B, Dichgans, Martin, Kittner, Steven J, Markus, Hugh S, Ikram, Mohammad A, Fornage, Myriam, Launer, Lenore J, Seshadri, Sudha, Longstreth, W. T., Debette, Stéphanie, Mazoyer, Bernard, Network, Stroke Genetics, Almgren, Peter, Anderson, Christopher D, Attia, John, Ay, Hakan, Brown, Robert D, Bustamante, Mariana, Zhu, Yi-Cheng, Cheng, Yu-Ching, Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul Iw, Delavaran, Hossein, Engström, Gunnar, Kaffashian, Sara, Heitsch, Laura, Holliday, Elizabeth, Ibanez, Laure, Ilinca, Andreea, Irvin, Marguerite R, Jackson, Rebecca D, Jimenez-Conde, Jordi, Jood, Katarina, Schilling, Sabrina, Kissela, Brett M, Kleindorfer, Dawn O, Labovitz, Daniel, Laurie, Cathy C, Lemmens, Robin, Levi, Christopher, Li, Linxin, Lindgren, Arne G, Beecham, Gary W, Maguire, Jane, Müller-Nurasyid, Martina, Norrving, Bo, Peddareddygari, Leema Reddy, Pera, Joanna, Satizabal, Claudia L, Montine, Thomas J, Rexrode, Kathryn, Ribasés, Marta, Roquer, Jaume, Rost, Natalia S, Sacco, Ralph L, Schmidt, Reinhold, Schellenberg, Gerard D, Soriano-Tárraga, Carolina, Stanne, Tara, Stauch, Konstantin, Stine, O. C., Sudlow, Cathie Lm, Thijs, Vincent N S, Weir, David, Williams, Stephen R, Kjartansson, Olafur, Xu, Huichun, Hyacinth, Hyacinth I, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Hansen, Bjorn, Guðnason, Vilmundur, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Sacco, Ralph, Chung, Jong-Won, Kim, Gyeong-Moon, Knopman, David S, Lubitz, Steven, Bourcier, Romain, Howson, Joanna, Granata, Alessandra, Drazyk, Anna, Markus, Hugh, Wardlaw, Joanna, Mitchell, Braxton, Cole, John, Hopewell, Jemma, Griswold, Michael E, Walters, Robin, Turnbull, Iain, Worrall, Bradford, Bis, Josh, Reiner, Alex, Dhar, Raj, Prasad, Kameshwar, Sarnowski, Chloé, Windham, B Gwen, Aparicio, Hugo Javier, Yang, Qiong, Chasman, Daniel, Phuah, Chia-Ling, Liu, Guiyou, Elkind, Mitchell, Lange, Leslie, Rost, Natalia, James, Michael, Gottesman, Rebecca F, Stewart, Jill, Vojinovic, Dina, Parati, Eugenio, Boncoraglio, Giorgio, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Grond-Ginsbach, Caspar, Strbian, Daniel, Mosley, Thomas H, Tomppo, Liisa, Sallinen, Hanne, Pfeiffer, Dorothea, Torres, Nuria, Barboza, Miguel, Laarman, Melanie, Carriero, Roberta, Soriano, Carolina, Gill, Dipender, Debette, Stephanie, Mishra, Aniket, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Tatlisumak, Turgut, Holmegaard, Lukas, Yue, Suo, Bis, Joshua C, Saba, Yasaman, Bersano, Anna, Schlicht, Kristina, Ninomiya, Toshiharu, Oberstein, Saskia Lesnik, Lee, Tsong-Hai, Schmidt, Helena, Wasselius, Johan, Drake, Mattias, Stenman, Martin, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Takeuchi, Fumihiko, Wu, Ona, Schirmer, Markus, Cramer, Steve, Golland, Polina, Brown, Robert, Meschia, James, Ross, Owen A, Pare, Guillaume, Chong, Mike, Yamaguchi, Shuhei, Gwinn, Katrina, Chen, Christopher, Koenig, Jim, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Kamatani, Yoichiro, Kubo, Michiaki, Nabika, Toru, Okada, Yukinori, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Tan, Eng King, Frid, Petrea, Lee, Chaeyoung, Tregouet, David, Leung, Thomas, Kato, Norihiro, Choy, Richard, Loo, Keat Wei, Rinkel, Gabriel, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Montaner, Joan, Kim, Helen, Rajan, Kumar B, Owolabi, Mayowa, Sofat, Reecha, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, van der Laan, Sander W, Irvin, Ryan, Sargurupremraj, Murali, Pezzini, Alessandro, Aggarwal, Neelum T, Abd-Allah, Foad, Liebeskind, David, Tan, Rhea, Danesh, John, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Sudlow, Cathie, De Jager, Philip L, Rannikmae, Kristiina, McDonough, Caitrin Wheeler, van Agtmael, Tom, Walters, Matthew, Söderholm, Martin, Lorentzen, Erik, Olsson, Sandra, Olsson, Martina, Akinyemi, Rufus, Evans, Denis A, Cotlatciuc, Ioana, McArdle, Patrick, Dave, Tushar, Kittner, Steven, Faber, James E, Millwood, Iona, Márquez, Elsa Valdés, Mancuso, Michelangelo, Vibo, Riina, Teumer, Alexander, Psaty, Bruce M, Korv, Janika, Majersik, Jennifer, DeHavenon, Adam, Alexander, Matthew, Sale, Michele, Southerland, Andrew, Owens, Debra, Psaty, Bruce, Rotter, Jerome I, Wolfe, Stacey Quintero, Langefeld, Carl, Konrad, Jan, Sheth, Kevin, Falcone, Guido, Donahue, Kathleen, Simpkins, Alexis N, Liang Byorn, Tan Wei, Rice, Kenneth, Chan, Bernard, Clatworthy, Phil, Florez, Jose, Harshfield, Eric, Hozawa, Atsushi, Hsu, Chung, Hu, Chaur-Jong, Ihara, Masafumi, Lange, Marcos, Lopez, Oscar L, Lee, Soo Ji, Lee, I-Hui, Musolino, Patricia, Nakatomi, Hirofumi, Park, Kwang-Yeol, Riley, Chris, Sung, Joohon, Suzuki, Hideaki, Vo, Katie, Liao, Jiemin, Washida, Kazuo, Ibenez, Laura Garcia, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander S F, Gschwendtner, Andreas, Vicente, Astrid M, Nordestgaard, Børge G, Carty, Cara L, Cheng, Ching-Yu, Palmer, Colin N A, Gamble, Dale M, Ringelstein, E Bernd, Valdimarsson, Einar, Davies, Gail, Wong, Tien Y, Pasterkamp, Gerard, Kuhlenbäumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillame, Ikram, Mohammad K, Aparicio, Hugo J, Deary, Ian, Hopewell, Jemma C, Liu, Jingmin, van der Lee, Sven J, Attia, John R, Ferro, Jose M, Bis, Joshua, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristina, Ikram, M Arfan, Sargurupremraj, Muralidharan, Amin, Najaf, Benn, Marianne, Farrall, Martin, Pandolfo, Massimo, Nalls, Mike, van Zuydam, Natalie R, Chouraki, Vincent, Abrantes, Patricia, Higgins, Peter, Lichtner, Peter, DeStefano, Anita L, Clarke, Robert, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Mosley, Thomas, Battey, Thomas Wk, Thorsteinsdottir, Unnur, Thijs, Vincent Ns, Zhao, Wei, Chen, Wei-Min, Romero, Jose R, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Baldwin, Clinton T, Barmada, M Michael, Barnes, Lisa L, Maillard, Pauline, Barral, Sandra, Beach, Thomas G, Becker, James T, Beekly, Duane, Bennett, David A, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, DeCarli, Charles, Boxer, Adam, Burke, James R, Burns, Jeffrey M, Buxbaum, Joseph D, Byrd, Goldie S, Cai, Guiqing, Cairns, Nigel J, Cantwell, Laura B, Cao, Chuanhai, Carlsson, Cynthia M, Wardlaw, Joanna M, Carney, Regina M, Carrasquillo, Minerva M, Carroll, Steven L, Chui, Helena C, Clark, David G, Cribbs, David H, Crocco, Elizabeth A, Hernández, Maria Del C Valdés, Demirci, F Yesim, Dick, Malcolm, Dickson, Dennis W, Duara, Ranjan, Ertekin-Taner, Nilufer, Faber, Kelley M, Fallin, M Daniele, Fallon, Kenneth B, Fardo, David W, Luciano, Michelle, Farlow, Martin R, Farrer, Lindsay A, Ferris, Steven, Foroud, Tatiana M, Frosch, Matthew P, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Hofer, Edith, Liewald, David, Go, Rodney C P, Goate, Alison M, Graff-Radford, Neill R, Green, Robert C, Griffith, Patrick, Growdon, John H, Haines, Jonathan L, Hakonarson, Hakon, Hamilton, Ronald L, Hamilton-Nelson, Kara L, Deary, Ian J, Haroutunian, Vahram, Harrell, Lindy E, Honig, Lawrence S, Huebinger, Ryan M, Hulette, Christine M, Hyman, Bradley T, Jicha, Gregory A, Jin, Lee-Way, Jun, Gyungah, Kamboh, M Ilyas, Starr, John M, Karydas, Anna, Kauwe, John S K, Kaye, Jeffrey A, Kim, Ronald, Kowall, Neil W, Kramer, Joel H, Kukull, Walter A, Kunkle, Brian W, LaFerla, Frank M, Lah, James J, Bastin, Mark E, Lang-Walker, Rosalyn, Larson, Eric B, Leverenz, James B, Levey, Allan I, Li, Ge, Lieberman, Andrew P, Logue, Mark W, Lunetta, Kathryn L, Lyketsos, Constantine G, Muñoz Maniega, Susana, Mack, Wendy J, Manly, Jennifer J, Marson, Daniel C, Martin, Eden R, Martiniuk, Frank, Mash, Deborah C, Masliah, Eliezer, Mayeux, Richard, McKee, Ann C, Mesulam, Marsel, Slagboom, P Eline, Miller, Bruce L, Miller, Carol A, Miller, Joshua W, Morris, John C, Murrell, Jill R, Naj, Adam C, Obisesan, Thomas O, Olichney, John M, Pankratz, Vernon S, Beekman, Marian, Parisi, Joseph E, Partch, Amanda, Paulson, Henry L, Pericak-Vance, Margaret A, Perry, William, Peskind, Elaine, Petersen, Ronald C, Pierce, Aimee, Poon, Wayne W, Potter, Huntington, Deelen, Joris, Quinn, Joseph F, Raj, Ashok, Raj, Towfique, Raskind, Murray, Reiman, Eric M, Reisberg, Barry, Reitz, Christiane, Ringman, John M, Roberson, Erik D, Rosen, Howard J, Uh, Hae-Won, Rosenberg, Roger N, Sager, Mark A, Sano, Mary, Saykin, Andrew J, Schneider, Julie A, Schneider, Lon S, Seeley, William W, Smith, Amanda G, Sonnen, Joshua A, Spina, Salvatore, Stern, Robert A, Swerdlow, Russell H, Tanzi, Rudolph E, Thornton-Wells, Tricia A, Trojanowski, John Q, Troncoso, Juan C, Tsuang, Debby W, Valladares, Otto, Van Deerlin, Vivianna M, Trompet, Stella, Brodaty, Henry, Van Eldik, Linda J, Vardarajan, Badri N, Vinters, Harry V, Vonsattel, Jean Paul, Wang, Li-San, Weintraub, Sandra, Welsh-Bohmer, Kathleen A, Williamson, Jennifer, Wingo, Thomas S, Wishnek, Sarah, Wright, Margaret J, Woltjer, Randall L, Wright, Clinton B, Younkin, Steven G, Yu, Chang-En, Yu, Lei, Chu, Audrey Y, Havulinna, Aki S, Ames, David, Smith, Albert Vernon, Choi, Seung Hoan, Garcia, Melissa E, Manichaikul, Ani, Gustafsson, Stefan, Bartz, Traci M, Boncoraglio, Giorgio B, Bellenguez, Céline, Vidal, Jean Sebastien, Wiggins, Kerri L, Xue, Flora, Ripatti, Samuli, Liu, Yongmei, Hoed, Marcel den, Heckbert, Susan R, Smith, Nicholas L, Buring, Julie E, Ridker, Paul M, Berr, Claudine, Dartigues, Jean-François, Beecham, Ashley H, Hamsten, Anders, Magnusson, Patrik K, Pedersen, Nancy L, Lannfelt, Lars, Lind, Lars, Lindgren, Cecilia M, Morris, Andrew P, Koudstaal, Peter J, Portegies, Marileen Lp, Blanton, Susan H, Uitterlinden, André G, de Craen, Anton Jm, Ford, Ian, Jukema, J Wouter, Stott, David J, Allen, Norrina B, Sale, Michele M, Johnson, Andrew D, White, Charles C, Paulista Markus, Marcello Ricardo, Nalls, Michael A, Beiser, Alexa, Vartiainen, Erkki, French, Curtis R, Kurth, Tobias, Harris, Tamara B, deStefano, Anita L, Schmidt, Carsten Oliver, Salomaa, Veikko, Wen, Wei, Ingelsson, Erik, Chasman, Daniel I, Verhaaren, Benjamin F J, Hilal, Saima, Thalamuthu, Anbupalam, Smith, Jennifer A, Ikram, M Kamran, Adams, Hieab H, Lopez, Lorna M, van Buchem, Mark A, Armstrong, Nicola J, van der Grond, Jeroen, Smith, Albert V, Hegenscheid, Katrin, de Andrade, Mariza, Atkinson, Elizabeth J, Beiser, Alexa S, Boerwinkle, Eric, Chong, Elizabeth, Brickman, Adam M, Bryan, R Nick, Chen, Christopher P L H, de Craen, Anton J M, Crivello, Fabrice, Schofield, Peter R, Dufouil, Carole, Elkind, Mitchell S V, Freudenberger, Paul, Habes, Mohamad, Heiss, Gerardo, Kwok, John B, Ibrahim-Verbaas, Carla A, Lewis, Cora E, Liewald, David C M, van der Lugt, Aad, Martinez, Oliver O, Nauck, Matthias, Niessen, Wiro J, Oostra, Ben A, Rice, Kenneth M, von Sarnowski, Bettina, Schreiner, Pamela J, Schuur, Maaike, Sidney, Stephen S, Sigurdsson, Sigurdur, Stott, David J M, van Swieten, John C, Töglhofer, Anna Maria, Turner, Stephen T, Vernooij, Meike W, Wang, Jing J, Wolf, Christiane, Zijdenbos, Alex, Kardia, Sharon L R, DeCarli, Charles C, Seshadri, Sudha S, Kavousi, Maryam, Franceschini, Nora, Isaacs, Aaron, Abecasis, Gonçalo R, Schminke, Ulf, Post, Wendy, Cupples, L Adrienne, Huffman, Jennifer E, Lehtimäki, Terho, Baumert, Jens, Münzel, Thomas, Dehghan, Abbas, North, Kari, Oostra, Ben, Stoegerer, Eva-Maria, Hayward, Caroline, Raitakari, Olli, Meisinger, Christa, Schillert, Arne, Sanna, Serena, Völzke, Henry, Thorsson, Bolli, Fox, Caroline S, Wittfeld, Katharina, Rivadeneira, Fernando, Nambi, Vijay, Halperin, Eran, Petrovic, Katja E, Peltonen, Leena, Wichmann, H Erich, Schnabel, Renate B, Dörr, Marcus, Parsa, Afshin, Aspelund, Thor, Grabe, Hans J, Demissie, Serkalem, Kathiresan, Sekar, Reilly, Muredach P, Taylor, Kent, Uitterlinden, Andre, Couper, David J, Sitzer, Matthias, Kähönen, Mika, Illig, Thomas, Wild, Philipp S, Hosten, Norbert, Orru, Marco, Lüdemann, Jan, Shuldiner, Alan R, Eiriksdottir, Gudny, Seissler, Jochen, Zeller, Tanja, Usala, Gianluca, Ernst, Florian, D'Agostino, Ralph B, O'Leary, Daniel H, Ballantyne, Christie, Thiery, Joachim, Ziegler, Andreas, Lakatta, Edward G, Chilukoti, Ravi Kumar, Völker, Uwe, Wolf, Philip A, Polak, Joseph F, Li, Xia, Rathmann, Wolfgang, Uda, Manuela, Klopp, Norman, Wilson, James F, Viikari, Jorma, Koenig, Wolfgang, Blankenberg, Stefan, Newman, Anne B, Witteman, Jacqueline, van Duijn, Cornelia, Scuteri, Angelo, Homuth, Georg, Gudnason, Vilmundur, O'Donnell, Christopher J, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lund University [Lund], Stroke Genetics Network (SiGN), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC), Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Peter Almgren, MSC, Christopher D. Anderson, MD, Donna K. Arnett, PhD, MSPH, John Attia, MD, PhD, FRACP, FRCPC, Hakan Ay, MD, Oscar R. Benavente, MD, Steve Bevan, PhD, Robert D. Brown, MD, Mariana Bustamante, PhD, Yu-Ching Cheng, PhD, John W. Cole, MD, MS, Ioana Cotlarciuc, PhD, Carlos Cruchaga, PhD, Paul IW. de Bakker, PhD, Hossein Delavaran, MD, PhD, Martin Dichgans, MD, Gunnar Engström, MD, PHD, PROF, Myriam Fornage, PhD, Raji P. Grewal, MD, Laura Heitsch, MD, Elizabeth Holliday, MSc, PhD, Laure Ibanez, PhD, Andreea Ilinca, MD, Marguerite R. Irvin, PhD, Rebecca D. Jackson, MD, Christina Jern, MD, PhD, Jordi Jimenez-Conde, MD, PhD, Julie A. Johnson, PharmD, Katarina Jood, MD, PhD, Brett M. Kissela, MD, MS, Steven J. Kittner, MD, Dawn O. Kleindorfer, MD, MS, Daniel Labovitz, MD, Cathy C. Laurie, PhD, Jin-Moo Lee, MD, PhD, Robin Lemmens, MD PhD, Christopher Levi, MBBS B Med Sci FRACP, Linxin Li, DPhil, Arne G. Lindgren, MD, PhD, Jane Maguire, PhD, Hugh S. Markus, FRCP, Patrick F. McArdle, PhD, Olle Melander, MD, PHD, PROF, James F. Meschia, MD, Braxton D. Mitchell, PhD, Martina Müller-Nurasyid, PhD, Bo Norrving, MD, PhD, Leema Reddy Peddareddygari, MD, Joanna Pera, MD, PhD, Sara L. Pulit, PhD, Kathryn Rexrode, MD, MPH, Marta Ribasés, PhD, BSc, Jaume Roquer, MD, PhD, Natalia S. Rost, MD, Peter M. Rothwell, FMedSci, Tatjana Rundek, MD PhD, Ralph L. Sacco, MD MS, Reinhold Schmidt, MD, Pankaj Sharma, MD PhD, Agnieszka Slowik, MD, PhD, Carolina Soriano-Tárraga, BSc, PhD, Tara Stanne, PhD, Konstantin Stauch, PhD, O C. Stine, PhD, Cathie LM. Sudlow, BMBCh, MSc, DPhil, FRCP (Ed), Vincent N.S. Thijs, MD, PhD, Sylvia Wasssertheil-Smoller, PhD, David Weir, PhD, Stephen R. Williams, PhD, Quenna Wong, PhD, Daniel Woo, MD, MS, Bradford B. Worrall, MD, MSc, Huichun Xu, MD, PhD, Sudha Seshadri, MD, Hyacinth I Hyacinth, MD, Sandro Marini, MD, Paul Nyquist, MD, PhD, Cathryn Lewis, PhD, Bjorn Hansen, MD, Bo Norrving, MD, PhD, Jonathan Rosand, MD, Alessandro Biffi, MD, Christina Kourkoulis, Bachelor, Chris Anderson, MD, MMSc, Anne-Katrin Giese, MD, Ralph Sacco, MD, MS, Pankaj Sharma, MD, PhD, Jong-Won Chung, MD, MSc, Gyeong-Moon Kim, MD, Steven Lubitz, MD, MPH, Romain Bourcier, MD, Joanna Howson, PhD, Alessandra Granata, PhD, Anna Drazyk, MRCPI, Hugh Markus, MD, Joanna Wardlaw, MD, Braxton Mitchell, MPH, PHD, John Cole, MD, MS, Jemma Hopewell, PhD, FESC, Robin Walters, MA, PhD, PgDip, Iain Turnbull, BA(Hons) MB BChir MRCP(UK) MRCGP, Bradford Worrall, MD, MSc, Josh Bis, PhD, Alex Reiner, MD, MSc, Raj Dhar, MD, Laura Heitsch, MD, Jin-Moo Lee, MD, PhD, Kameshwar Prasad, MD, DM, MMSc, FRCP(Edin), FAMS, Chloé Sarnowski, PhD, Hugo Javier Aparicio, MD, Qiong Yang, PhD, Daniel Chasman, PhD, Kathryn Rexrode, MD, MPH, Chia-Ling Phuah, MD, Guiyou Liu, PhD, Mitchell Elkind, MD, MSc, Leslie Lange, PhD, Natalia Rost, MD, Michael James, MD, Jill Stewart, PhD, Dina Vojinovic, MD, MS, Vincent Thijs, MD, PhD, Eugenio Parati, MD, Giorgio Boncoraglio, MD, Ramin Zand, MD, Philippe Bijlenga, MD, PhD, Magdy Selim, MD, PhD, Caspar Grond-Ginsbach, PhD, Daniel Strbian, MD, PhD, Liisa Tomppo, MD, Hanne Sallinen, MD, Dorothea Pfeiffer, MD, Nuria Torres, MSc, Miguel Barboza, MD, Melanie Laarman, PhD candidate, Roberta Carriero, PhD, Elizabeth Holliday, PhD, Jordi Jimenez-Conde, MD, PhD, Carolina Soriano, BSc, PhD, Dipender Gill, PhD, Stephanie Debette, MD, PhD, Aniket Mishra, PhD, Jer-Yuarn Wu, PhD, Tai-Ming Ko, PhD, Silvia Bione, PhD, Katarina Jood, MD, PhD, Turgut Tatlisumak, MD, PhD, Lukas Holmegaard, PhD, Suo Yue, system engineer, Anna bersano, MD, PhD, Joanna Pera, MD, PhD, Agnieszka Slowik, MD, PhD, Christopher Levi, MBBS B Med Sci FRACP, Kristina Schlicht, Dipl. Biol., Robin Lemmens, MD, PhD, Toshiharu Ninomiya, MD, PhD, Saskia Lesnik Oberstein, PhD, Tsong-Hai Lee, MD, PhD, Rainer Malik, PhD, Martin Dichgans, MD, Arne Lindgren, MD, PhD, Johan Wasselius, MD, PhD, Mattias Drake, student, Olle Melander, MD, PHD, Martin Stenman, MD, Andreea Ilinca, MD, Katherine Crawford, BS, Umme Lena, Bachelors of Arts, Farrah Mateen, MD, PhD, Hakan Ay, MD, Ona Wu, PhD, Markus Schirmer, PhD, Steve Cramer, MD, Polina Golland, PhD, Robert Brown, MD, MPH, James Meschia, MD, Owen A. Ross, PhD, Guillaume Pare, MD, MSc, FRCPC, Mike Chong, MSc, Tatjana Rundek, MD PhD, Katrina Gwinn, MD, Christopher Chen, BMBCh (Oxon), MRCP, FRCP, Jim Koenig, PhD, Eva Giralt, PhD, Danish Saleheen, MBBS, PhD, Frank-Erik de Leeuw, MD, PhD, Karin Klijn, MD, PhD, Yoichiro Kamatani, MD, PhD, Michiaki Kubo, MD, PhD, Yukinori Okada, MD, PhD, Annie Pedersen, MD, Maja Olsson, PhD, Juan José Martín, MD, Huichun Xu, MD, PhD, Eng King Tan, MD, Petrea Frid, MD, Chaeyoung Lee, PhD, David Tregouet, PhD, Thomas Leung, MB, ChB, MRCP, FHKCP, FHKAM, Richard Choy, BSc (Brad.), MSc(Med) (Birm.), PhD (CUHK), Christina Jern, MD, PhD, Keat Wei Loo, BSc, PhD, Gabriel Rinkel, MD, Paulo Franca, PhD, Iscia Cendes, MD, PhD, Caty Carrera, MD, Israel Fernandez-Cadenas, PhD, Joan Montaner, MD, PhD, Helen Kim, PhD, Mayowa Owolabi, MBBS, MSc, DrM, MWACP, FMCP, FAAN, FAS, Reecha Sofat, MD, Mark Bakker, PhD, Ynte Ruigrok, MD, PhD, Allard Hauer, PhD candidate, Sara L. Pulit, PhD, Sander W. van der Laan, PhD, Ryan Irvin, PhD, Murali Sargurupremraj, PhD, Alessandro Pezzini, MD, Foad Abd-Allah, MD, David Liebeskind, MD, Matthew Traylor, PhD, Rhea Tan, BSc (Hons), John Danesh, MD, DPhil, Loes Rutten-Jacobs, PhD, Amanda Donatti, PhD, student, Wagner Avelar, PhD, Joseph Broderick, MD, Daniel Woo, MD, MS, Cathie Sudlow, BMBCh, MSc, DPhil, FRCP, Kristiina Rannikmae, MD, Caitrin Wheeler McDonough, PhD, Tom van Agtmael, PhD, Matthew Walters, MD, MBChB, FRCP, Martin Söderholm, MD, PhD, Erik Lorentzen, Ph.Lic., Sandra Olsson, PhD, MSc, Tara Stanne, PhD, Martina Olsson, MSc, Rufus Akinyemi, PhD, MSc, MWACP, FMCP, Ioana Cotlatciuc, PhD, Patrick McArdle, PhD, Tushar Dave, MSc, Steven Kittner, MD, MPH, John Attia, MD, PhD, James E Faber, PhD, Iona Millwood, DPhil, Elsa Valdés Márquez, PhD, Michelangelo Mancuso, MD, PhD, Riina Vibo, MD, PhD, Janika Korv, MD, PhD, FESO, Jane Maguire, PhD, BN (Hons), BA, RN, Myriam Fornage, PhD, Jennifer Majersik, MD, Adam DeHavenon, MD, Matthew Alexander, MD, Michele Sale, PhD, Andrew Southerland, MD, MSc, Debra Owens, NNP, Bruce Psaty, MD, PhD, W. T. Longstreth, Jr, MD, MPH, Stacey Quintero Wolfe, MD, FAANS, Carl Langefeld, PhD, Carlos Cruchaga, PhD, Jan Konrad, administrative coordinator, Kevin Sheth, MD, Guido Falcone, MD, ScD, MPH, Kathleen Donahue, BS, Alexis N Simpkins, MD, PhD, Tan Wei Liang Byorn, MMBS, student, Bernard Chan, MD, Phil Clatworthy, MD, PhD, Jose Florez, MD, Eric Harshfield, PhD, Atsushi Hozawa, MD, Chung Hsu, MD, PhD, Chaur-Jong Hu, MD, PhD, Laure Ibanez, PhD, Masafumi Ihara, MD, PhD, FACP, Marcos Lange, PhD, Soo Ji Lee, PhD, MPH, I-Hui Lee, MD, PhD, Patricia Musolino, MD, PhD, Hirofumi Nakatomi, MD, PhD, Kwang-Yeol Park, MD, Stephen S Rich, PhD, Chris Riley, MBA, Joohon Sung, MD, PhD, Hideaki Suzuki, MD, PhD, Katie Vo, MD, Kazuo Washida, MD, PhD, Laura Garcia Ibenez, PhD, Agnieszka Slowik, MD, PhD, Albert Hofman, MD, PhD, Ale Algra, MD, MSc, Alex P Reiner, MD, MSc, Alexander S F Doney, PhD, Andreas Gschwendtner, MD, Andreea Ilinca, MD, Anne-Katrin Giese, MD, Arne Lindgren, MD, PhD, Astrid M Vicente, PhD, Bo Norrving, MD, PhD, Børge G Nordestgaard, MD, PhD, DMSc, Braxton D Mitchell, PhD, Bradford B Worrall, MD, MSc, Bruce M Psaty, MD, PhD, Cara L Carty, PhD, Cathie Sudlow, BMBCh, MSc, DPhil, FRCP, Christopher D Anderson, MD, Christopher Levi, MBBS B Med Sci FRACP, Claudia L Satizabal, PhD, Colin N A Palmer, PhD, Dale M Gamble, CCRP, Daniel Woo, MD, MS, Danish Saleheen, MBBS, PhD, E Bernd Ringelstein, MD, FAHA, Einar Valdimarsson, MD, Elizabeth Holliday, PhD, Gail Davies, PhD, Ganesh Chauhan, PhD, Gerard Pasterkamp, MD, PhD, Giorgio Boncoraglio, MD, Gregor Kuhlenbäumer, MD, PhD, Gudmar Thorleifsson, PhD, Guido J Falcone, MD, ScD, MPH, Guillame Pare, MD, MSc, FRCPC, Helena Schmidt, MD, PhD, Hossein Delavaran, MD, PhD, Hugh S Markus, MD, Hugo J Aparicio, MD, Ian Deary, PhD, Ioana Cotlarciuc, PhD, Israel Fernandez-Cadenas, PhD, James Meschia, MD, Jemma C Hopewell, PhD, FESC, Jingmin Liu, MSc, Joan Montaner, MD, PhD, Joanna Pera, MD, PhD, John Cole, MD, MS, John R Attia, MD, PhD, FRACP, FRCPC, Jonathan Rosand, MD, MSc, Jose M Ferro, MD, PhD, Joshua Bis, PhD, Karen Furie, MD, Kari Stefansson, MD, Klaus Berger, MD, PhD, Konstantinos Kostulas, MD, PhD, Kristina Rannikmae, MD, M Arfan Ikram, MD, PhD, Marianne Benn, MD, PhD, Martin Dichgans, MD, Martin Farrall, FRCPath, Massimo Pandolfo, MD, Matthew Traylor, PhD, Matthew Walters, MD, MBChB, FRCP, Michele Sale, PhD, Mike Nalls, PhD, Myriam Fornage, PhD, Natalie R van Zuydam, PhD, Pankaj Sharma, MD, PhD, Patricia Abrantes, PhD, Paul IW de Bakker, PhD, Peter Higgins, FRCP, Peter Lichtner, PhD, Peter M Rothwell, FMedSci, Philippe Amouyel, MD, PhD, Qiong Yang, PhD, Rainer Malik, PhD, Reinhold Schmidt, MD, Robert Clarke, MD, MRCP, FRCP, FFPH, Robin Lemmens, MD, PhD, Sander W van der Laan, PhD, Sara L Pulit, PhD, Sherine Abboud, MD, PhD, Sofia A Oliveira, PhD, Solveig Gretarsdottir, PhD, Stephanie Debette, MD, PhD, Stephen R Williams, PhD, Steve Bevan, BSc, PhD, Steven J Kittner, MD, Sudha Seshadri, MD, Thomas Mosley, PhD, Thomas WK Battey, BS, Turgut Tatlisumak, MD, PhD, Unnur Thorsteinsdottir, PhD, Vincent NS Thijs, MD, PhD, W T Longstreth, MD, Wei Zhao, MD, PhD, Wei-Min Chen, PhD, Yu-Ching Cheng, PhD, Marilyn S. Albert, PhD, Roger L. Albin, MD, Liana G. Apostolova, MD, Steven E. Arnold, MD, Sanjay Asthana, MD, Craig S. Atwood, PhD, Clinton T. Baldwin, PhD, M. Michael Barmada, PhD, Lisa L. Barnes, PhD, Sandra Barral, PhD, Thomas G. Beach, MD, PhD, James T. Becker, PhD, Gary W. Beecham, PhD, Duane Beekly, BS, David A. Bennett, MD, Eileen H. Bigio, MD, Thomas D. Bird, MD, Deborah Blacker, MD, ScD, Bradley F. Boeve, MD, Adam Boxer, MD, PhD, James R. Burke, MD, PhD, Jeffrey M. Burns, MD, MS, Joseph D. Buxbaum, PhD, Goldie S. Byrd, PhD, Guiqing Cai, MD, PhD, Nigel J. Cairns, PhD FRCPath, Laura B. Cantwell, MPH, Chuanhai Cao, PhD, Cynthia M. Carlsson, MD, MS, Regina M. Carney, MD, Minerva M. Carrasquillo, PhD, Steven L. Carroll, MD, PhD, Helena C. Chui, PhD, David G. Clark, MD, David H. Cribbs, PhD, Elizabeth A. Crocco, MD, Carlos Cruchaga, PhD, Philip L. De Jager, MD, PhD, Charles DeCarli, MD, F. Yesim Demirci, MD, Malcolm Dick, Dennis W. Dickson, MD, Ranjan Duara, Md, Nilufer Ertekin-Taner, MD, PhD, Denis A. Evans, MD, Kelley M. Faber, MS, M. Daniele Fallin, PhD, Kenneth B. Fallon, MD, David W. Fardo, PhD, Martin R. Farlow, MD, Lindsay A. Farrer, PhD, Steven Ferris, PhD, Tatiana M. Foroud, PhD, Matthew P. Frosch, MD, PhD, Douglas R. Galasko, MD, Marla Gearing, PhD, Daniel H. Geschwind, MD, PhD, Bernardino Ghetti, MD, John R. Gilbert, PhD, Rodney C.P. Go, PhD, Alison M. Goate, DPhil, Neill R. Graff-Radford, MD, Robert C. Green, MD, MPH, Patrick Griffith, MD, John H. Growdon, MD, Jonathan L. Haines, PhD, Hakon Hakonarson, MD, PhD, Ronald L. Hamilton, MD, Kara L. Hamilton-Nelson, MPH, Vahram Haroutunian, PhD, Lindy E. Harrell, MD, PhD, Lawrence S. Honig, MD, PhD, Ryan M. Huebinger, PhD, Christine M. Hulette, MD, Bradley T. Hyman, MD, PhD, Gregory A. Jicha, MD, PhD, Lee-Way Jin, MD, PhD, Gyungah Jun, PhD, M. Ilyas Kamboh, PhD, Anna Karydas, BA, John S.K. Kauwe, PhD, Jeffrey A. Kaye, MD, Ronald Kim, MD, Neil W. Kowall, MD, Joel H. Kramer, PsyD, Walter A. Kukull, PhD, Brian W. Kunkle, PhD, Frank M. LaFerla, PhD, James J. Lah, MD, PhD, Rosalyn Lang-Walker, PhD, Eric B. Larson, MD, MPH, James B. Leverenz, MD, Allan I. Levey, MD, PhD, Ge Li, MD, PhD, Andrew P. Lieberman, MD, PhD, Mark W. Logue, PhD, Oscar L. Lopez, MD, Kathryn L. Lunetta, PhD, Constantine G. Lyketsos, MD, Wendy J. Mack, PhD, Jennifer J. Manly, PhD, Daniel C. Marson, JD, PhD, Eden R. Martin, PhD, Frank Martiniuk, PhD, Deborah C. Mash, PhD, Eliezer Masliah, MD, Richard Mayeux, MD, Ann C. McKee, MD, Marsel Mesulam, MD, Bruce L. Miller, MD, Carol A. Miller, MD, Joshua W. Miller, PhD, Thomas J. Montine, MD, PhD, John C. Morris, MD, Jill R. Murrell, PhD, Adam C. Naj, PhD, Thomas O. Obisesan, MD, John M. Olichney, MD, Vernon S. Pankratz, PhD, Joseph E. Parisi, MD, Amanda Partch, MS, Henry L. Paulson, MD, PhD, Margaret A. Pericak-Vance, PhD, William Perry, BS, Elaine Peskind, MD, Ronald C. Petersen, MD, PhD, Aimee Pierce, MD, Wayne W. Poon, PhD, Huntington Potter, PhD, Joseph F. Quinn, MD, Ashok Raj, MD, Towfique Raj, PhD, Murray Raskind, MD, Eric M. Reiman, MD, Barry Reisberg, MD, Christiane Reitz, MD, PhD, John M. Ringman, MD, MS, Erik D. Roberson, MD, PhD, Howard J. Rosen, MD, Roger N. Rosenberg, MD, Mark A. Sager, MD, Mary Sano, PhD, Andrew J. Saykin, PsyD, Gerard D. Schellenberg, PhD, Julie A. Schneider, MD, MS, Lon S. Schneider, MD, MS, William W. Seeley, MD, Amanda G. Smith, MD, Joshua A. Sonnen, MD, Salvatore Spina, MD, Robert A. Stern, PhD, Russell H. Swerdlow, MD, Rudolph E. Tanzi, PhD, Tricia A. Thornton-Wells, PhD, John Q. Trojanowski, MD, PhD, Juan C. Troncoso, MD, Debby W. Tsuang, MD, Otto Valladares, MS, Vivianna M. Van Deerlin, MD, PhD, Linda J. Van Eldik, PhD, Badri N. Vardarajan, PhD, MS, Harry V. Vinters, MD, Jean Paul Vonsattel, MD, Li-San Wang, PhD, Sandra Weintraub, PhD, Kathleen A. Welsh-Bohmer, PhD, Jennifer Williamson, MS, MPH, Thomas S. Wingo, MD, Sarah Wishnek, MPH, Randall L. Woltjer, MD, PhD, Clinton B. Wright, MD, MS, Steven G. Younkin, MD, PhD, Chang-En Yu, PhD, Lei Yu, PhD, Ganesh Chauhan, PhD, Audrey Y. Chu, PhD, Myriam Fornage, PhD, Joshua C. Bis, PhD, Aki S. Havulinna, DSc, Muralidharan Sargurupremraj, PhD, Albert Vernon Smith, PhD, Hieab H.H. Adams, MSc, Seung Hoan Choi, MA, Stella Trompet, PhD, Melissa E. Garcia, MPH, Ani Manichaikul, PhD, Alexander Teumer, PhD, Stefan Gustafsson, PhD, Traci M. Bartz, MS, Céline Bellenguez, PhD, Jean Sebastien Vidal, MD, Xueqiu Jian, PhD, Olafur Kjartansson, MD, Kerri L. Wiggins, MS, Claudia L. Satizabal, PhD, Flora Xue, MS, Samuli Ripatti, PhD, Yongmei Liu, PhD, Joris Deelen, PhD, Marcel den Hoed, PhD, Susan R. Heckbert, MD, Kenneth Rice, PhD, Nicholas L. Smith, PhD, Quenna Wong, MS, Hugo J. Aparicio, MD, Julie E. Buring, ScD, Paul M Ridker, MD, Claudine Berr, MD, Jean-François Dartigues, MD, Anders Hamsten, MD, Patrik K. Magnusson, PhD, Nancy L. Pedersen, PhD, Lars Lannfelt, MD, Lars Lind, MD, Cecilia M. Lindgren, PhD, Andrew P. Morris, PhD, Albert Hofman, MD, Peter J. Koudstaal, MD, Marileen LP. Portegies, MD, André G. Uitterlinden, PhD, Anton JM de Craen, PhD, Ian Ford, MD, J. Wouter Jukema, MD, David J Stott, MD, Norrina B. Allen, PhD, Michele M. Sale, PhD, Andrew D Johnson, PhD, David A. Bennett, MD, Philip L. De Jager, MD, PhD, Charles C. White, PhD, Hans Jörgen Grabe, MD, Marcello Ricardo Paulista Markus, MD, Oscar L Lopez, MD, Jerome I. Rotter, MD, Michael A. Nalls, PhD, Rebecca F. Gottesman, MD, Michael E. Griswold, PhD, David S. Knopman, MD, B. Gwen Windham, MD, Alexa Beiser, PhD, Erkki Vartiainen, MD, Curtis R. French, PhD, Tobias Kurth, MD, Bruce M. Psaty, MD, Tamara B. Harris, MD, Stephen S Rich, PhD, Anita L. deStefano, PhD, Carsten Oliver Schmidt, PhD, Veikko Salomaa, MD, Thomas H. Mosley, PhD, Erik Ingelsson, MD, PhD, Cornelia M. van Duijn, PhD, Christophe Tzourio, MD, Lenore J Launer, PhD, M. Arfan Ikram, MD, Daniel I. Chasman, PhD, W. T. Longstreth, Jr, MD, MPH, Sudha Seshadri, MD, Stéphanie Debette, MD, Benjamin F.J. Verhaaren, MD, PhD, Stéphanie Debette, MD, PhD, Joshua C. Bis, PhD, Jennifer A. Smith, PhD, MPH, MA, M. Kamran Ikram, MD, PhD, Hieab H. Adams, MSc, Ashley H. Beecham, MSc, Kumar B. Rajan, PhD, Lorna M. Lopez, PhD, Sandra Barral, PhD, Mark A. van Buchem, MD, PhD, Jeroen van der Grond, PhD, Albert V. Smith, PhD, Katrin Hegenscheid, MD, Neelum T. Aggarwal, MD, Mariza de Andrade, PhD, Elizabeth J. Atkinson, PhD, Marian Beekman, PhD, Alexa S. Beiser, PhD, Susan H. Blanton, PhD, Eric Boerwinkle, PhD, Adam M. Brickman, PhD, R. Nick Bryan, MD, PhD, Ganesh Chauhan, PhD, Christopher P.L.H. Chen, FRCP, Vincent Chouraki, MD, PhD, Anton J.M. de Craen, PhD, Fabrice Crivello, PhD, Ian J. Deary, PhD, Joris Deelen, MSc, Philip L. De Jager, MD, PhD, Carole Dufouil, PhD, Mitchell S.V. Elkind, MD, MSc, Denis A. Evans, MD, Paul Freudenberger, MSc, Rebecca F. Gottesman, MD, PhD, Vilmundur Guðnason, MD, PhD, Mohamad Habes, PhD, Susan R. Heckbert, MD, PhD, Gerardo Heiss, MD, Saima Hilal, MBBS, Edith Hofer, PhD, Albert Hofman, MD, PhD, Carla A. Ibrahim-Verbaas, MD, David S. Knopman, MD, Cora E. Lewis, MD, MSPH, Jiemin Liao, MSc, David C.M. Liewald, BSc, Michelle Luciano, PhD, Aad van der Lugt, MD, PhD, Oliver O. Martinez, PhD, Richard Mayeux, MD, MSc, Bernard Mazoyer, MD, PhD, Mike Nalls, PhD, Matthias Nauck, MD, Wiro J. Niessen, PhD, Ben A. Oostra, PhD, Bruce M. Psaty, MD, PhD, Kenneth M. Rice, PhD, Jerome I. Rotter, MD, Bettina von Sarnowski, MD, Helena Schmidt, MD, PhD, Pamela J. Schreiner, PhD, Maaike Schuur, MD, PhD, Stephen S. Sidney, MD, MPH, Sigurdur Sigurdsson, MSc, P. Eline Slagboom, PhD, David J.M. Stott, MD, John C. van Swieten, MD, PhD, Alexander Teumer, PhD, Anna Maria Töglhofer, MSc, Matthew Traylor, PhD, Stella Trompet, PhD, Stephen T. Turner, MD, Christophe Tzourio, MD, PhD, Hae-Won Uh, PhD, André G. Uitterlinden, PhD, Meike W. Vernooij, MD, PhD, Jing J. Wang, PhD, Tien Y. Wong, MD, PhD, Joanna M. Wardlaw, MD, B. Gwen Windham, MD, Katharina Wittfeld, MS, Christiane Wolf, PhD, Clinton B. Wright, MD, Qiong Yang, PhD, Wei Zhao, MD, PhD, Alex Zijdenbos, PhD, J. Wouter Jukema, MD, PhD, Ralph L. Sacco, MD, Sharon L.R. Kardia, PhD, Philippe Amouyel, MD, PhD, Thomas H. Mosley, PhD, W. T. Longstreth, Jr, MD, MPH, Charles C. DeCarli, MD, Cornelia M. van Duijn, PhD, Reinhold Schmidt, MD, Lenore J. Launer, PhD, Hans J. Grabe, MD, Sudha S. Seshadri, MD, M. Arfan Ikram, MD, PhD, Myriam Fornage, PhD, Joshua C. Bis, PhD, Maryam Kavousi, MD, MSc, Nora Franceschini, MD, MPH, Aaron Isaacs, PhD, Gonçalo R Abecasis, PhD, Ulf Schminke, MD, Wendy Post, MD, Albert V. Smith, PhD, L. Adrienne Cupples, PhD, Hugh S Markus, MD, Reinhold Schmidt, MD, Jennifer E. Huffman, MSc, Terho Lehtimäki, MD, PhD, Jens Baumert, PhD, Thomas Münzel, MD, Susan R. Heckbert, MD, PhD, Abbas Dehghan, MD, PhD, Kari North, PhD, Ben Oostra, PhD, Steve Bevan, PhD, Eva-Maria Stoegerer, MD, Caroline Hayward, PhD, Olli Raitakari, MD, PhD, Christa Meisinger, MD, MPH, Arne Schillert, PhD, Serena Sanna, PhD, Henry Völzke, MD, Yu-Ching Cheng, PhD, Bolli Thorsson, MD, Caroline S. Fox, MD, MS, Kenneth Rice, PhD, Fernando Rivadeneira, MD, PhD, Vijay Nambi, MD, Eran Halperin, PhD, Katja E. Petrovic, MSc, Leena Peltonen, MD, PhD, H. Erich Wichmann, MD, PhD, Renate B. Schnabel, MD, MSc, Marcus Dörr, MD, Afshin Parsa, MD, MPH, Thor Aspelund, PhD, Serkalem Demissie, PhD, Sekar Kathiresan, MD, Muredach P. Reilly, MBBCH, MSCE, Kent Taylor, PhD, Andre Uitterlinden, PhD, David J. Couper, PhD, Matthias Sitzer, MD, Mika Kähönen, MD, PhD, Thomas Illig, PhD, Philipp S. Wild, MD, Marco Orru, MD, Jan Lüdemann, PhD, Alan R. Shuldiner, MD, Gudny Eiriksdottir, MSc, Charles C. White, MPH, Jerome I. Rotter, MD, Albert Hofman, MD, PhD, Jochen Seissler, MD, Tanja Zeller, PhD, Gianluca Usala, PhD, Florian Ernst, PhD, Lenore J. Launer, PhD, Ralph B. D'Agostino, Sr, PhD, Daniel H. O'Leary, MD, Christie Ballantyne, MD, Joachim Thiery, MD, MBA, Andreas Ziegler, Dr. rer. nat. habil., Edward G. Lakatta, MD, Ravi Kumar Chilukoti, MSc, Tamara B. Harris, MD, PhD, Philip A. Wolf, MD, Bruce M. Psaty, MD, PhD, Joseph F Polak, MD, MPH, Xia Li, MD, MPH, Wolfgang Rathmann, MD, MSPH, Manuela Uda, PhD, Eric Boerwinkle, PhD, Norman Klopp, PhD, Helena Schmidt, MD PhD, James F Wilson, DPhil, Jorma Viikari, MD, PhD, Wolfgang Koenig, MD, Stefan Blankenberg, Prof Dr med, Anne B. Newman, MD, MPH, Jacqueline Witteman, PhD, Gerardo Heiss, MD, PhD, Cornelia van Duijn, PhD, Angelo Scuteri, MD, PhD, Georg Homuth, PhD, Braxton D. Mitchell, PhD, Vilmundur Gudnason, MD, PhD, and Christopher J. O’Donnell, MD, MPH, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, and Berr, Claudine
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Neurology & Neurosurgery ,[SDV]Life Sciences [q-bio] ,Heilaskaði ,Clinical Neurology ,Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium ,R1 ,Article ,[SDV] Life Sciences [q-bio] ,Taugasjúkdómar ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Meta-analyses ,Brain infarcts ,GWAS ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,ddc:610 ,Erfðarannsóknir ,MRI - Abstract
Publisher's version (útgefin grein), Objective: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. Methods We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n=20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI. Results: The mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 × 10-8; and LINC00539/ZDHHC20, p = 5.82 × 10-9. Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p[BI] = 9.38 × 10-25; p [SSBI] = 5.23 × 10-14 for hypertension), smoking (p[BI]= 4.4 × 10-10; p [SSBI] = 1.2 × 10 -4), diabetes (p[BI] = 1.7 × 10 -8; p [SSBI] = 2.8 × 10 -3), previous cardiovascular disease (p [BI] = 1.0 × 10-18; p [SSBI] = 2.3 × 10-7), stroke (p [BI] = 3.9 × 10-69; p [SSBI] = 3.2 × 10 -24), and MRI-defined white matter hyperintensity burden (p [BI]=1.43 × 10-157; p [SSBI] = 3.16 × 10-106), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p ≤ 0.0022), without indication of directional pleiotropy. Conclusion: In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI., CHAP: R01-AG-11101, R01-AG-030146, NIRP-14-302587. SMART: This study was supported by a grant from the Netherlands Organization for Scientific Research–Medical Sciences (project no. 904-65–095). LBC: The authors thank the LBC1936 participants and the members of the LBC1936 research team who collected and collated the phenotypic and genotypic data. The LBC1936 is supported by Age UK (Disconnected Mind Programme grant). The work was undertaken by The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross-council Lifelong Health and Wellbeing Initiative (MR/K026992/1). The brain imaging was performed in the Brain Research Imaging Centre (https://www.ed.ac.uk/clinical-sciences/edinburgh-imaging), a center in the SINAPSE Collaboration (sinapse.ac.uk) supported by the Scottish Funding Council and Chief Scientist Office. Funding from the UK Biotechnology and Biological Sciences Research Council (BBSRC) and the UK Medical Research Council is acknowledged. Genotyping was supported by a grant from the BBSRC (ref. BB/F019394/1). PROSPER: The PROSPER study was supported by an investigator-initiated grant obtained from Bristol-Myers Squibb. Prof. Dr. J.W. Jukema is an Established Clinical Investigator of the Netherlands Heart Foundation (grant 2001 D 032). Support for genotyping was provided by the seventh framework program of the European commission (grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant 050-060-810). SCES and SiMES: National Medical Research Council Singapore Centre Grant NMRC/CG/013/2013. C.-Y.C. is supported by the National Medical Research Council, Singapore (CSA/033/2012), Singapore Translational Research Award (STaR) 2013. Dr. Kamran Ikram received additional funding from the Singapore Ministry of Health's National Medical Research Council (NMRC/CSA/038/2013). SHIP: SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs, as well as the Social Ministry of the Federal State of Mecklenburg–West Pomerania, and the network “Greifswald Approach to Individualized Medicine (GANI_MED)” funded by the Federal Ministry of Education and Research (grant 03IS2061A). Genome-wide data have been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint grant from Siemens Healthineers, Erlangen, Germany, and the Federal State of Mecklenburg–West Pomerania. Whole-body MRI was supported by a joint grant from Siemens Healthineers, Erlangen, Germany, and the Federal State of Mecklenburg–West Pomerania. The University of Greifswald is a member of the Caché Campus program of the InterSystems GmbH. OATS (Older Australian Twins Study): OATS was supported by an Australian National Health and Medical Research Council (NHRMC)/Australian Research Council (ARC) Strategic Award (ID401162) and by a NHMRC grant (ID1045325). OATS was facilitated via access to the Australian Twin Registry, which is supported by the NHMRC Enabling Grant 310667. The OATS genotyping was partly supported by a Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund Grant. NOMAS: The Northern Manhattan Study is funded by the NIH grant “Stroke Incidence and Risk Factors in a Tri-Ethnic Region” (NINDS R01NS 29993). TASCOG: NHMRC and Heart Foundation. AGES: The study was funded by the National Institute on Aging (NIA) (N01-AG-12100), Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament), with contributions from the Intramural Research Programs at the NIA, the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Neurological Disorders and Stroke (NINDS) (Z01 HL004607-08 CE). ERF: The ERF study as a part of European Special Populations Research Network (EUROSPAN) was supported by European Commission FP6 STRP grant no. 018947 (LSHG-CT-2006-01947) and also received funding from the European Community's Seventh Framework Programme (FP7/2007–2013)/grant agreement HEALTH-F4-2007-201413 by the European Commission under the programme “Quality of Life and Management of the Living Resources” of 5th Framework Programme (no. QLG2-CT-2002-01254). High-throughput analysis of the ERF data was supported by a joint grant from Netherlands Organization for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR 047.017.043). Exome sequencing analysis in ERF was supported by the ZonMw grant (project 91111025). Najaf Amin is supported by the Netherlands Brain Foundation (project no. F2013[1]-28). ARIC: The Atherosclerosis Risk in Communities study was performed as a collaborative study supported by NHLBI contracts (HHSN268201100005C, HSN268201100006C, HSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL70825, R01HL087641, R01HL59367, and R01HL086694; National Human Genome Research Institute contract U01HG004402; and NIH contract HHSN268200625226C. Infrastructure was partly supported by grant no. UL1RR025005, a component of the NIH and NIH Roadmap for Medical Research. This project was also supported by NIH R01 grant NS087541 to M.F. FHS: This work was supported by the National Heart, Lung and Blood Institute's Framingham Heart Study (contracts no. N01-HC-25195 and no. HHSN268201500001I), and its contract with Affymetrix, Inc. for genotyping services (contract no. N02-HL-6-4278). A portion of this research utilized the Linux Cluster for Genetic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center. This study was also supported by grants from the NIA (R01s AG033040, AG033193, AG054076, AG049607, AG008122, and U01-AG049505) and the NINDS (R01-NS017950, UH2 NS100605). Dr. DeCarli is supported by the Alzheimer's Disease Center (P30 AG 010129). ASPS: The research reported in this article was funded by the Austrian Science Fund (FWF) grant nos. P20545-P05, P13180, and P20545-B05, by the Austrian National Bank Anniversary Fund, P15435, and the Austrian Ministry of Science under the aegis of the EU Joint Programme–Neurodegenerative Disease Research (JPND) (jpnd.eu). LLS: The Leiden Longevity Study has received funding from the European Union's Seventh Framework Programme (FP7/2007–2011) under grant agreement no. 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), UnileverColworth, and by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). CHS: This CHS research was supported by contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, N01HC15103, and HHSN268200960009C and grants U01HL080295, R01HL087652, R01HL105756, R01HL103612, R01HL120393, R01HL085251, and R01HL130114 from the NHLBI with additional contribution from NINDS. Additional support was provided through R01AG023629 from the NIA. A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR001881, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Rotterdam Study: The generation and management of GWAS genotype data for the Rotterdam Study is supported by the Netherlands Organisation of Scientific Research (NWO) Investments (no. 175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/NWO project no. 050-060-810. The Rotterdam Study is funded by Erasmus MC Medical Center and Erasmus MC University, Rotterdam, Netherlands Organization for Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. M.A.I. is supported by an NWO Veni grant (916.13.054). The 3-City Study: The 3-City Study is conducted under a partnership agreement among the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Bordeaux, and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Mutuelle Générale de l’Education Nationale (MGEN), Institut de la Longévité, Conseils Régionaux of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques.” C.T. and S.D. have received investigator-initiated research funding from the French National Research Agency (ANR) and from the Fondation Leducq. S.D. is supported by a starting grant from the European Research Council (SEGWAY), a grant from the Joint Programme of Neurodegenerative Disease research (BRIDGET), from the European Union's Horizon 2020 research and innovation programme under grant agreements No 643417 & No 640643, and by the Initiative of Excellence of Bordeaux University. Part of the computations were performed at the Bordeaux Bioinformatics Center (CBiB), University of Bordeaux. This work was supported by the National Foundation for Alzheimer's Disease and Related Disorders, the Institut Pasteur de Lille, the Labex DISTALZ, and the Centre National de Génotypage. ADGC: The Alzheimer Disease Genetics Consortium is supported by NIH. NIH-NIA supported this work through the following grants: ADGC, U01 AG032984, RC2 AG036528; NACC, U01 AG016976; NCRAD, U24 AG021886; NIA LOAD, U24 AG026395, U24 AG026390; Banner Sun Health Research Institute, P30 AG019610; Boston University, P30 AG013846, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG017173, R01 AG025259, R01AG33193; Columbia University, P50 AG008702, R37 AG015473; Duke University, P30 AG028377, AG05128; Emory University, AG025688; Group Health Research Institute, UO1 AG06781, UO1 HG004610; Indiana University, P30 AG10133; Johns Hopkins University, P50 AG005146, R01 AG020688; Massachusetts General Hospital, P50 AG005134; Mayo Clinic, P50 AG016574; Mount Sinai School of Medicine, P50 AG005138, P01 AG002219; New York University, P30 AG08051, MO1RR00096, UL1 RR029893, 5R01AG012101, 5R01AG022374, 5R01AG013616, 1RC2AG036502, 1R01AG035137; Northwestern University, P30 AG013854; Oregon Health & Science University, P30 AG008017, R01 AG026916; Rush University, P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, R01 AG30146; TGen, R01 NS059873; University of Alabama at Birmingham, P50 AG016582, UL1RR02777; University of Arizona, R01 AG031581; University of California, Davis, P30 AG010129; University of California, Irvine, P50 AG016573, P50, P50 AG016575, P50 AG016576, P50 AG016577; University of California, Los Angeles, P50 AG016570; University of California, San Diego, P50 AG005131; University of California, San Francisco, P50 AG023501, P01 AG019724; University of Kentucky, P30 AG028383, AG05144; University of Michigan, P50 AG008671; University of Pennsylvania, P30 AG010124; University of Pittsburgh, P50 AG005133, AG030653; University of Southern California, P50 AG005142; University of Texas Southwestern, P30 AG012300; University of Miami, R01 AG027944, AG010491, AG027944, AG021547, AG019757; University of Washington, P50 AG005136; Vanderbilt University, R01 AG019085; and Washington University, P50 AG005681, P01 AG03991. The Kathleen Price Bryan Brain Bank at Duke University Medical Center is funded by NINDS grant NS39764, NIMH MH60451, and by GlaxoSmithKline. Genotyping of the TGEN2 cohort was supported by Kronos Science. The TGen series was also funded by NIA grant AG041232, the Banner Alzheimer's Foundation, The Johnnie B. Byrd Sr. Alzheimer's Institute, the Medical Research Council, and the state of Arizona and also includes samples from the following sites: Newcastle Brain Tissue Resource (funding via the Medical Research Council [MRC], local NHS trusts, and Newcastle University), MRC London Brain Bank for Neurodegenerative Diseases (funding via the Medical Research Council), South West Dementia Brain Bank (funding via numerous sources including the Higher Education Funding Council for England [HEFCE], Alzheimer's Research Trust [ART], BRACE, as well as North Bristol NHS Trust Research and Innovation Department and DeNDRoN), The Netherlands Brain Bank (funding via numerous sources including Stichting MS Research, Brain Net Europe, Hersenstichting Nederland Breinbrekend Werk, International Parkinson Fonds, Internationale Stiching Alzheimer Onderzoek), Institut de Neuropatologia, Servei Anatomia Patologica, and Universitat de Barcelona). ADNI: Funding for ADNI is through the Northern California Institute for Research and Education by grants from Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson & Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., Alzheimer's Association, Alzheimer's Drug Discovery Foundation, the Dana Foundation, and the National Institute of Biomedical Imaging and Bioengineering and NIA grants U01 AG024904, RC2 AG036535, and K01 AG030514. Support was also provided by the Alzheimer's Association (LAF, IIRG-08-89720; MAP-V, IIRG-05-14147) and the US Department of Veterans Affairs Administration, Office of Research and Development, Biomedical Laboratory Research Program. SiGN: Stroke Genetic Network (SiGN) was supported in part by award nos. U01NS069208 and R01NS100178 from NINDS. Genetics of Early-Onset Stroke (GEOS) Study was supported by the NIH Genes, Environment and Health Initiative (GEI) grant U01 HG004436, as part of the GENEVA consortium under GEI, with additional support provided by the Mid-Atlantic Nutrition and Obesity Research Center (P30 DK072488); and the Office of Research and Development, Medical Research Service, and the Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs. Genotyping services were provided by the Johns Hopkins University Center for Inherited Disease Research (CIDR), which is fully funded through a federal contract from the NIH to Johns Hopkins University (contract no. HHSN268200782096C). Assistance with data cleaning was provided by the GENEVA Coordinating Center (U01 HG 004446; PI Bruce S. Weir). Study recruitment and assembly of datasets were supported by a Cooperative Agreement with the Division of Adult and Community Health, Centers for Disease Control and Prevention, and by grants from NINDS and the NIH Office of Research on Women's Health (R01 NS45012, U01 NS069208-01). METASTROKE: ASGC: Australian population control data were derived from the Hunter Community Study. This research was funded by grants from the Australian National and Medical Health Research Council (NHMRC Project Grant ID: 569257), the Australian National Heart Foundation (NHF Project Grant ID: G 04S 1623), the University of Newcastle, the Gladys M Brawn Fellowship scheme, and the Vincent Fairfax Family Foundation in Australia. E.G.H. was supported by a Fellowship from the NHF and National Stroke Foundation of Australia (ID: 100071). J.M. was supported by an Australian Postgraduate Award. BRAINS: Bio-Repository of DNA in Stroke (BRAINS) is partly funded by a Senior Fellowship from the Department of Health (UK) to P.S., the Henry Smith Charity, and the UK-India Education Research Institutive (UKIERI) from the British Council. GEOS: Genetics of Early Onset Stroke (GEOS) Study, Baltimore, was supported by GEI Grant U01 HG004436, as part of the GENEVA consortium under GEI, with additional support provided by the Mid-Atlantic Nutrition and Obesity Research Center (P30 DK072488), and the Office of Research and Development, Medical Research Service, and the Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs. Genotyping services were provided by the Johns Hopkins University Center for Inherited Disease Research (CIDR), which is fully funded through a federal contract from the NIH to the Johns Hopkins University (contract no. HHSN268200782096C). Assistance with data cleaning was provided by the GENEVA Coordinating Center (U01 HG 004446; PI Bruce S. Weir). Study recruitment and assembly of datasets were supported by a Cooperative Agreement with the Division of Adult and Community Health, Centers for Disease Control and Prevention, and by grants from NINDS and the NIH Office of Research on Women's Health (R01 NS45012, U01 NS069208-01). HPS: Heart Protection Study (HPS) (ISRCTN48489393) was supported by the UK MRC, British Heart Foundation, Merck and Co. (manufacturers of simvastatin), and Roche Vitamins Ltd. (manufacturers of vitamins). Genotyping was supported by a grant to Oxford University and CNG from Merck and Co. J.C.H. acknowledges support from the British Heart Foundation (FS/14/55/30806). ISGS: Ischemic Stroke Genetics Study (ISGS)/Siblings With Ischemic Stroke Study (SWISS) was supported in part by the Intramural Research Program of the NIA, NIH project Z01 AG-000954-06. ISGS/SWISS used samples and clinical data from the NIH-NINDS Human Genetics Resource Center DNA and Cell Line Repository (ccr.coriell.org/ninds), human subjects protocol nos. 2003-081 and 2004-147. ISGS/SWISS used stroke-free participants from the Baltimore Longitudinal Study of Aging (BLSA) as controls. The inclusion of BLSA samples was supported in part by the Intramural Research Program of the NIA, NIH project Z01 AG-000015-50, human subjects protocol no. 2003-078. The ISGS study was funded by NIH-NINDS Grant R01 NS-42733 (J.F.M.). The SWISS study was funded by NIH-NINDS Grant R01 NS-39987 (J.F.M.). This study used the high-performance computational capabilities of the Biowulf Linux cluster at the NIH (biowulf.nih.gov). MGH-GASROS: MGH Genes Affecting Stroke Risk and Outcome Study (MGH-GASROS) was supported by NINDS (U01 NS069208), the American Heart Association/Bugher Foundation Centers for Stroke Prevention Research 0775010N, the NIH and NHLBI's STAMPEED genomics research program (R01 HL087676), and a grant from the National Center for Research Resources. The Broad Institute Center for Genotyping and Analysis is supported by grant U54 RR020278 from the National Center for Research resources. Milan: Milano–Besta Stroke Register Collection and genotyping of the Milan cases within CEDIR were supported by the Italian Ministry of Health (grant nos.: RC 2007/LR6, RC 2008/LR6; RC 2009/LR8; RC 2010/LR8; GR-2011-02347041), FP6 LSHM-CT-2007-037273 for the PROCARDIS control samples. WTCCC2: Wellcome Trust Case-Control Consortium 2 (WTCCC2) was principally funded by the Wellcome Trust, as part of the Wellcome Trust Case Control Consortium 2 project (085475/B/08/Z and 085475/Z/08/Z and WT084724MA). The Stroke Association provided additional support for collection of some of the St George's, London cases. The Oxford cases were collected as part of the Oxford Vascular Study, which is funded by the MRC, Stroke Association, Dunhill Medical Trust, National Institute of Health Research (NIHR), and the NIHR Biomedical Research Centre, Oxford. The Edinburgh Stroke Study was supported by the Wellcome Trust (clinician scientist award to C.L.M.S.) and the Binks Trust. Sample processing occurred in the Genetics Core Laboratory of the Wellcome Trust Clinical Research Facility, Western General Hospital, Edinburgh. Much of the neuroimaging occurred in the Scottish Funding Council Brain Imaging Research Centre (https://www.ed.ac.uk/clinical-sciences/edinburgh-imaging), Division of Clinical Neurosciences, University of Edinburgh, a core area of the Wellcome Trust Clinical Research Facility, and part of the SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) collaboration (sinapse.ac.uk), funded by the Scottish Funding Council and the Chief Scientist Office. Collection of the Munich cases and data analysis was supported by the Vascular Dementia Research Foundation. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreements no. 666881, SVDs@target (to M.D.) and no. 667375, CoSTREAM (to M.D.); the DFG as part of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy) and the CRC 1123 (B3) (to M.D.); the Corona Foundation (to M.D.); the Fondation Leducq (Transatlantic Network of Excellence on the Pathogenesis of Small Vessel Disease of the Brain) (to M.D.); the e:Med program (e:AtheroSysMed) (to M.D.) and the FP7/2007-2103 European Union project CVgenes@target (grant agreement no. Health-F2-2013-601456) (to M.D.). M.F. and A.H. acknowledge support from the BHF Centre of Research Excellence in Oxford and the Wellcome Trust core award (090532/Z/09/Z). VISP: The GWAS component of the Vitamin Intervention for Stroke Prevention (VISP) study was supported by the US National Human Genome Research Institute (NHGRI), grant U01 HG005160 (PI Michèle Sale and Bradford Worrall), as part of the Genomics and Randomized Trials Network (GARNET). Genotyping services were provided by the Johns Hopkins University Center for Inherited Disease Research (CIDR), which is fully funded through a federal contract from the NIH to Johns Hopkins University. Assistance with data cleaning was provided by the GARNET Coordinating Center (U01 HG005157; PI Bruce S. Weir). Study recruitment and collection of datasets for the VISP clinical trial were supported by an investigator-initiated research grant (R01 NS34447; PI James Toole) from the US Public Health Service, NINDS, Bethesda, MD. Control data obtained through the database of genotypes and phenotypes (dbGAP) maintained and supported by the United States National Center for Biotechnology Information, US National Library of Medicine. WHI: Funding support for WHI-GARNET was provided through the NHGRI GARNET (grant no. U01 HG005152). Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GARNET Coordinating Center (U01 HG005157). Funding support for genotyping, which was performed at the Broad Institute of MIT and Harvard, was provided by the GEI (U01 HG004424). R.L. is a senior clinical investigator of FWO Flanders. F.W.A. is supported by a Dekker scholarship-Junior Staff Member 2014T001–Netherlands Heart Foundation and UCL Hospitals NIHR Biomedical Research Centre.
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- 2019
15. Aggressive Behavior and Neuroleptic Medication Are Associated With Increased Number of Alpha1-Adrenoceptors in Patients With Alzheimer Disease
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Sharp, Sally I., Ballard, Clive G., Chen, Christopher P. L.-H., and Francis, Paul T.
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- 2007
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16. High Plasma Cyst(e)ine Level May Indicate Poor Clinical Outcome in Patients With Acute Stroke: Possible Involvement of Hydrogen Sulfide
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Wong, Peter T. H, Qu, Kun, Chimon, Ghislain N, Seah, Alvin B. H, Chang, Hui Meng, Wong, Meng Cheong, Ng, Yee Kong, Rumpel, Helmut, Halliwell, Barry, and Chen, Christopher P. L. H
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- 2006
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17. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study
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Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Caballero, Miguel Á A, Chappell, Francesca M, Chen, Christopher P L H, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Vom Hofe, Elise M, de Kort, Paul L M, Koudstaal, Peter J, Lam, Bonnie Y K, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, Shi, Lin, Valdés Hernández, Maria C, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, Meta VCI Map consortium, Biessels, Geert Jan, Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Caballero, Miguel Á A, Chappell, Francesca M, Chen, Christopher P L H, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Vom Hofe, Elise M, de Kort, Paul L M, Koudstaal, Peter J, Lam, Bonnie Y K, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, Shi, Lin, Valdés Hernández, Maria C, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, Meta VCI Map consortium, and Biessels, Geert Jan
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- 2019
18. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study
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ZL Algemene Neurologie Medisch, Opleiding Neurologie, Brain, Beeldverwerking ISI, Circulatory Health, Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Caballero, Miguel Á A, Chappell, Francesca M, Chen, Christopher P L H, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Vom Hofe, Elise M, de Kort, Paul L M, Koudstaal, Peter J, Lam, Bonnie Y K, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, Shi, Lin, Valdés Hernández, Maria C, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, Meta VCI Map consortium, Biessels, Geert Jan, ZL Algemene Neurologie Medisch, Opleiding Neurologie, Brain, Beeldverwerking ISI, Circulatory Health, Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Caballero, Miguel Á A, Chappell, Francesca M, Chen, Christopher P L H, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Vom Hofe, Elise M, de Kort, Paul L M, Koudstaal, Peter J, Lam, Bonnie Y K, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, Shi, Lin, Valdés Hernández, Maria C, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, Meta VCI Map consortium, and Biessels, Geert Jan
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- 2019
19. Impact of Evidence‐Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study
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Muñoz Venturelli, Paula, primary, Li, Xian, additional, Middleton, Sandy, additional, Watkins, Caroline, additional, Lavados, Pablo M., additional, Olavarría, Verónica V., additional, Brunser, Alejandro, additional, Pontes‐Neto, Octavio, additional, Santos, Taiza E. G., additional, Arima, Hisatomi, additional, Billot, Laurent, additional, Hackett, Maree L., additional, Song, Lily, additional, Robinson, Thompson, additional, Anderson, Craig S., additional, Mead, Gillian, additional, De Silva, H. Asita, additional, Pandian, Jeyaraj D., additional, Lin, Ruey‐Tay, additional, Lee, Tsong‐Hai, additional, Cui, Liying, additional, Peng, Bin, additional, Heritier, Stephane, additional, Lindley, Richard, additional, Jan, Stephen, additional, Boaden, Elizabeth, additional, Chen, Christopher P. L. H., additional, Forster, Anne, additional, Woodward, Mark, additional, Rogers, Kris, additional, Scaria, Anish, additional, Lim, Joyce Y., additional, Espinosa, Natalie, additional, McEvoy, Lucy, additional, Blackburn, Lee, additional, Richtering, Sarah S., additional, You, Shoujiang, additional, Ladwig, Simon, additional, Merritt, Gabrielle P., additional, Thomsen, Bryce, additional, Jenson, Kerry, additional, Gordon, Penelope, additional, Nguyen, Dennis Ryan, additional, Quan, Wei Wei, additional, Lo, Tessa Pei‐Yi, additional, Lim, Jonathan, additional, Goh, Selena, additional, Liu, Leibo, additional, Baig, Mirza Ahmad, additional, Singh, Ravider, additional, Donnelly, Paul, additional, Armenis, Manuela, additional, Zyl, Marna Van, additional, Monaghan, Helen, additional, Smith, Phillipa, additional, Glass, Parisa, additional, Zhou, Fanli, additional, Shen, Yun, additional, Lei, Li, additional, Li, Di, additional, Zhang, Ting, additional, Zhang, Xiaoyan, additional, Peng, Yun, additional, Feng, Lingling, additional, Ye, Zhiping, additional, Gregory, Philip, additional, Pandain, Jeyaraj D., additional, Arora, Deepti, additional, Gonzalez, Francisca, additional, Portales, Bernardita, additional, Santos‐Pontelli, Taiza, additional, Rimoli, Brunna, additional, Braga, Monica, additional, Vidal, Carolina, additional, Benadof, Dafna, additional, Rivas, Rodrigo J., additional, Carvallo, Laura, additional, Carvallo, Pamela, additional, Miranda, Rubia, additional, Pileggi, Brunna, additional, de Silva, H. Asita, additional, Weerawardena, Shalomi, additional, Jeevarajah, Thanushanthan, additional, Dharmawardena, Devaki, additional, Ranasinghe, Dumindi, additional, Dharshana, Matheesha, additional, Nandadeva, Nilesh, additional, Nawarathna, Savithri, additional, Yin, Jiu‐Haw, additional, Yeh, Shoou‐Jeng, additional, Ma, Ruei‐Jen, additional, Watkins, Caroline L., additional, Whiteley, Gemma, additional, Forshaw, Denise, additional, Lightbody, Catherine Elizabeth, additional, Cox, Joanna, additional, Fitzgerald, Jane, additional, Heney, John F., additional, Byfield, Helen, additional, Finley, Simone, additional, Tyrer, Hayley E., additional, Bruce, Carole, additional, Gibbon, Alison, additional, Jones, Brett, additional, Siracusa, Emma, additional, Gowda, Koushik, additional, Cowans, Shahla, additional, Forman, Briana, additional, Jacob, Sherin, additional, Caprecho, Kristine, additional, Khatri, Roshan, additional, Wan, Po Yi, additional, Lopez, Maria, additional, Vanika, Sifiso, additional, Bleeker, Wilhelmina, additional, Ireland, Marinka, additional, Jala, Sheila, additional, Day, Susan, additional, Ha, Eric, additional, Krause, Martin, additional, Passer, Melissa, additional, Giaccari, Sarah, additional, Burkolter, Nadia, additional, Braithwaite, Michael, additional, Tastula, Kylie, additional, Ghia, Darshan, additional, Musuka, Tapuwa, additional, Alvaro, Anthony, additional, Edmonds, Gillian, additional, O'Loughin, Nicole, additional, Phair, Rebecca, additional, Kaoutal, Joanne, additional, Blacker, David J., additional, Saint, Belinda L, additional, Parrey, Kim, additional, Coad, Michelle, additional, Kinchington, Matthew, additional, Senanayake, Nishantha, additional, Alaban, Johanna, additional, Kuehne, Irma, additional, Camilo, Millene, additional, Libardi, Milena, additional, Martins, Sheila, additional, Carlos, Batista, additional, Martins, Magda, additional, Carbonera, Leonardo, additional, Almeida, Andrea, additional, Kelin, Martin, additional, Pauli, Carla, additional, Lunardi, Mariana, additional, Silveira, Luciane, additional, Chagas, Olga, additional, Souza, Daily, additional, Braga, Gabriel, additional, Ribeiro, Priscila, additional, Luvizutto, Gustavo, additional, Polin, Marcia, additional, Winckler, Fernanda, additional, Liu, Jinfeng, additional, Wang, Zhenjiang, additional, Wang, Huibing, additional, Lin, Suying, additional, Dong, Jing, additional, Zhou, Junshan, additional, Qin, Suping, additional, Zhan, Hui, additional, Xue, Yongquan, additional, Tian, Dong, additional, Yang, Dan, additional, Yin, Yan, additional, Li, He, additional, Geng, Changming, additional, Liu, Jieyi, additional, Jiang, Xiaolin, additional, Wu, Yujun, additional, Sun, Wei, additional, Yu, Bingqi, additional, Guan, Yanmei, additional, Wang, Qin, additional, Wei, Bo, additional, Wang, Huirong, additional, Wang, Yan, additional, Tai, Liwen, additional, Zhang, Wenchao, additional, Zhao, Weili, additional, Wang, Xueying, additional, Li, Guoli, additional, Ni, Zhiming, additional, Guo, Fudong, additional, Cen, Lan, additional, Lu, Jun, additional, Chen, Zheng, additional, Yin, Guoming, additional, Wang, Yingchun, additional, Zheng, Jiping, additional, Zhou, Zhimin, additional, Wang, Hongquan, additional, Zou, Renlin, additional, Xue, Bin, additional, Li, Airu, additional, Guo, Jing, additional, Guo, Ying, additional, Jiang, Xingguo, additional, Tan, Xiuge, additional, Zhang, Chunpeng, additional, Shao, Bei, additional, Niu, Xiaoting, additional, Liu, Chunfeng, additional, Chen, Dongqin, additional, Liang, Ping, additional, Zhang, Xia, additional, Zhang, Chunqing, additional, Gong, Wenjie, additional, Huang, Zhichao, additional, Liu, Huihui, additional, Huang, Junying, additional, Shi, Rongfang, additional, Wang, Cuilan, additional, Liu, Ying, additional, Wang, Jinchao, additional, Wu, Guojun, additional, Gao, Zhihong, additional, Lin, Qunli, additional, Xu, Cong, additional, Zheng, Huile, additional, Ye, Xinghai, additional, Jin, Xiaoqiong, additional, Liu, Junyan, additional, Cao, Xiaoyun, additional, Zhang, Yan, additional, Wang, Jinyang, additional, Xu, Yuzhu, additional, Li, Yan, additional, Ma, Xin, additional, Kong, Qi, additional, Hao, Yanlei, additional, Qiao, Baojun, additional, Yan, Hui, additional, Huang, Zhiyong, additional, Chang, Baoqiang, additional, Yan, Jinjin, additional, Liao, Pinjun, additional, Zhang, Wei, additional, Liu, Ling, additional, Zhu, Tingting, additional, Liu, Xuehui, additional, Li, Yongping, additional, Dong, Ruifang, additional, Chen, Miao, additional, Ge, Xiaoli, additional, Wang, Hairong, additional, Dai, Lihua, additional, Liu, Jiafu, additional, Wang, Shixia, additional, Du, Jihui, additional, Song, Aixiu, additional, Li, Yunhai, additional, Feng, Jie, additional, Yu, Cheng, additional, Feng, Honglin, additional, Sun, Xiaojia, additional, Sun, Ruihong, additional, Liu, Weisong, additional, Liu, Jianfeng, additional, Lu, Xuesheng, additional, Chen, Enzhuo, additional, Gao, Wei, additional, Liu, Hui, additional, Wang, Heping, additional, Wang, Yanxia, additional, Song, Juan, additional, Liu, Dongqi, additional, Du, Wenhui, additional, Li, Guixia, additional, Li, Cuiling, additional, Liang, Yanling, additional, Cai, Xuekun, additional, Zhang, Jinli, additional, Tao, Xiaowei, additional, An, Pingshun, additional, Tang, Ranran, additional, Qin, Xu, additional, Wang, Yingling, additional, Zhang, Wenjun, additional, Ma, Rong, additional, Huang, Xiaoqiong, additional, Liu, Yonglin, additional, Wang, Yazhi, additional, Fan, Ping, additional, Yang, Hailan, additional, Feng, Lianyuan, additional, Zhi, Jianxia, additional, Zhang, Jiewen, additional, Zhou, Yao, additional, Wu, Danhong, additional, He, Haiyan, additional, Chen, Xiaohong, additional, Hou, Yongge, additional, Su, Xiaohui, additional, Fan, Siyuan, additional, Suárez, Luis, additional, de Dios Polanco, Juan, additional, Sotomayor, Patricio, additional, Urzúa, Ricardo, additional, Urrutia, Daniela, additional, Conejan, Nathalie, additional, Escobar, Arturo, additional, Gonzalez, Monica, additional, Vargas, Danisa, additional, Constante, Angel, additional, Vásquez, Erika, additional, Godoy, Elizabeth, additional, Figueroa, Christian, additional, Martin, Vanesa San, additional, Vidal, Nataly, additional, Muñoz, Madeleyn, additional, Spencer, María, additional, Almeida, Juan, additional, Acosta, Ignacio, additional, Guerrero, Rodrigo, additional, Lozano, Prudencio, additional, Aguayo, Camila, additional, Pizarro, Jimena, additional, Soto, Alvaro, additional, Bonilla, Flor, additional, García, Pía, additional, Castillo, Carolina Del, additional, Grandjean, Marcela, additional, Von Johnn, Alexis, additional, Gutierrez, Ignacio, additional, Rivero, Francisca, additional, López, Ignacio, additional, Silva, Federico, additional, Pachón, Marlen, additional, Mendoza, José, additional, Pabón, Alexander, additional, Kate, Mahesh, additional, Akhtar, Naushad, additional, Narang, Gibbsdeep S., additional, Deepak, Ashish, additional, Huded, Vikram, additional, De Sowza, Romnesh, additional, Sigamani, Alben, additional, Rajendran, Karthikeyan, additional, Vishwanath, Anisha, additional, K, Anusha, additional, Kumaravelu, Somasundaram, additional, Rahamath, Syed, additional, Kannneganti, Sandeep, additional, Khurana, Dheeraj, additional, Katoch, Cheena, additional, Kaur, Taranpreet, additional, Karadan, Ummer, additional, Kuriakose, Anu, additional, John, Jaison, additional, Basheer, Mumthaz, additional, Gunasekara, Harsha Hemal, additional, De Silva, Gamlath Chandima Udeni, additional, Ubeywickrama, Peetagam Harshi Lakmali, additional, Silva, Kavisha Chathumali, additional, De Silva, Eshani Anuradha, additional, Ranawaka, Udaya, additional, Mettananda, Chamila, additional, Nanayakkara, Yamuna, additional, Mendis, Tharini, additional, Fernando, Gayathri, additional, Imthikab, Ahamed, additional, Pieris, Kandula, additional, Gunatilake, Saman B., additional, Madanayake, Pamuditha M. W., additional, Paranavitane, Shiran A., additional, Senanayake, Bimsara, additional, Vishwanathan, Vaidhehi, additional, Sivapalan, Maathury, additional, Murage, Ruwangi U., additional, Chandradeva, Uthpala, additional, Liu, Yao‐Hua, additional, Lin, Chih‐Lung, additional, Lin, Hsiu‐Fen, additional, Liu, Kuan‐Ting, additional, Chen, Chien‐Fu, additional, Wu, Meng‐Ni, additional, Tsai, Su‐Hua, additional, Chen, Chi‐Ching, additional, Chen, Lan‐Yi, additional, Chang, Chien‐Hung, additional, Chang, Yeu‐Jhy, additional, Huang, Kuo‐Lun, additional, Chang, Ting‐Yu, additional, Liu, Chi‐Hung, additional, Seak, Chen‐June, additional, Lin, Yu‐Li, additional, Luo, Jia‐Yi, additional, Yang, Hsiao‐Ying, additional, Wang, Ching‐Yi, additional, Chan, Lung, additional, Hu, Chaur‐Jong, additional, Chi, Nai‐Fang, additional, Wu, Dean, additional, Huang, Yao‐Hsien, additional, Kuan, Yi‐Chun, additional, Hong, Chien‐Tai, additional, Chen, Yi‐Chun, additional, Sun, Yu, additional, Lin, Cheng‐Huai, additional, Lu, Chien‐Jung, additional, Chu, Hai‐Jui, additional, Lo, Yi‐Chia, additional, Chang, Wen‐Hui, additional, Lin, Wan‐Jung, additional, Su, Hui‐Chen, additional, Lin, Tien‐Yu, additional, Cho, Chi‐Hsuan, additional, Lu, Shu‐Lan, additional, Hsueh, Ya‐Fang, additional, Lai, Ching‐Yi, additional, Jarrett, David, additional, James, Claire, additional, Valentine, Stacey, additional, Whistler, Clare, additional, Butler, Rebecca, additional, Browning, Simone, additional, Watchurst, Caroline, additional, Erande, Renuka, additional, Elliott, Emma, additional, Patel, Krishna, additional, Brezitski, Maria, additional, Hogan, Caroline, additional, Banaras, Asra, additional, Crook, Lucinda, additional, Ahmed, Rashidat, additional, Potter, Lindsay, additional, Laird, Rosie, additional, Clarke, Natasha, additional, Loosemore, Alison, additional, Godber, J., additional, Gawned, Sara, additional, Hamilton, K. A., additional, Jones, Rachael, additional, Guyler, Paul, additional, Tysoe, Sharon, additional, Prabakaran, Raji, additional, Shah, Sweni, additional, Calver, Joanne, additional, Sztriha, Laszlo K., additional, Fitzpatrick, Maria, additional, Drysdale, Stephanie, additional, Aeron‐Thomas, John, additional, McKenzie, Emma, additional, Chitando, Belinda, additional, Willcoxson, Paul, additional, Iveson, Elizabeth, additional, Wanklyn, Peter, additional, Dyer, Natasha, additional, Keeling, Michael, additional, Rodriguez, Romina, additional, Elliott, Kerry, additional, Porteous, Mia, additional, O'Neill, Mark, additional, Orme, Sheridan, additional, Richardson, Carla, additional, Tomlinson, Janet, additional, Hawkins, Suzanne, additional, Bester, Delia, additional, Jeffs, Carol, additional, Howard, Joanne, additional, Brown, Pauline, additional, Ward, Deborah, additional, Turfrey, Jennifer, additional, Raybould, Leanne, additional, Bates, Allison, additional, O'Connell, Sue, additional, O'Connor, Margaret, additional, Williams, Samantha, additional, Emsley, Hedley C. A., additional, McLoughlin, Alison, additional, Raj, Sonia, additional, Gregary, Bindu, additional, Doyle, Donna, additional, Courtauld, G. M., additional, Schofield, C., additional, Lucas, L., additional, Lydon, A., additional, James, A., additional, Saastamoinen, Kari, additional, Howaniec, Laura, additional, Daboo, Premchand, additional, Ali, Ali N., additional, Richards, Emma, additional, Howe, Joanne, additional, Kamara, Christine, additional, Stocks, Kathy, additional, Lindert, Ralf, additional, Day, Diana J., additional, Finlay, Sarah, additional, McGee, Joanne, additional, Mitchell, Jennifer, additional, Amis, Elaine, additional, Macey, Rosemary, additional, Tauro, Suzanne, additional, Henry, Lauren, additional, Cuddy, Sarah, additional, Steele, Andrew, additional, Mullen, Kerry, additional, Kirker, Sarah, additional, Bhattad, Murudappa, additional, Carpenter, Michael, additional, Datta, Prabal, additional, Needle, Ann, additional, Jackson, Linda, additional, Ball, Julie, additional, Beckitt, Rosie, additional, Chivers, Nicola, additional, Bowring, Angela, additional, Eddy, Sara, additional, Thorpe, Kevin, additional, Keenan, Samantha, additional, Griffin, Alison, additional, Maguire, Stuart, additional, Patterson, Chris, additional, Ramadan, Hawraman, additional, Bellfield, Ruth, additional, Hooley, Michaela, additional, Stewart, Kelvin, additional, Williams, Lucy, additional, Gurney, Cara, additional, Oliver, Deborah, additional, Gardiner, Maria, additional, Grayland, Sarah, additional, Bhandari, Mohit, additional, Collas, David M., additional, Adesina, Tolu, additional, Sundayi, Saul, additional, Harvey, Ruth, additional, Pope, Emma, additional, Lam, Audrey, additional, Walker, Elaine, additional, Merrill, Colin, additional, Banerjee, Soma, additional, Harvey, Kirsten Hannah, additional, Mashate, Sheila, additional, Wilding, Peter, additional, Johnson, Linda, additional, Namushi, Robert, additional, Jacob, Patricia, additional, Andole, Sreeman, additional, Dunne, Karen, additional, Gadapa, Naveen, additional, King, Sam, additional, Siliuzaite, Sonata, additional, Dealing, Sharon, additional, Attwood, Karen, additional, Woods, Annette, additional, Sandhu, Banher, additional, Mamun, Maam, additional, Mahmood, Afzal, additional, Jones, June, additional, Ojo, Abimbola, additional, Carter‐Evans, Denise, additional, Liverpool, Royal, additional, Manoj, Aravind, additional, Fletcher, Glyn, additional, Lopez, Paula, additional, Greig, Jill, additional, Robinson, Matthew, additional, Jones, Sarah, additional, Jones, Lorinda, additional, West, Claire, additional, Tench, Helen, additional, Gascoyne, Rachel, additional, Whileman, Amanda, additional, Hall, Emily, additional, Wright, Stephanie, additional, Toms, Julie, additional, Phiri, Duke, additional, Sethuraman, Sakthivel, additional, Mohammed, Niaz, additional, Justin, Frances, additional, Tate, Margaret Louise, additional, Chauhan, Meena, additional, Haider, Syed I., additional, Nallasivan, Arumugam, additional, Webster, Tim, additional, Leason, Sandra, additional, Seagrave, Samantha, additional, Hospital, Peterborough City, additional, Owksu‐Agyei, Peter, additional, Temple, Natalie, additional, Butterworth‐Cowin, Nicola, additional, Magezi, Frederick, additional, Infirmary, Leicester Royal, additional, Khan, Shagufta, additional, Stephens, Claire, additional, Mistri, Amit, additional, Murphy, Aidan, additional, Lam, Manda, additional, Underwood, Paul, additional, Thompson, Catherine, additional, Buckley, Clare, additional, Wood, Diane, additional, Board, Sarah, additional, Howard, Linda, additional, Ahmed, Ashraf, additional, Oates, Bethany, additional, Leonard, Sara, additional, Hospital, Royal Bournemouth, additional, Bournemouth, Royal, additional, Thavanesan, Kamy, additional, Dharmasiri, Michelle, additional, Logianathan, Sathyabama, additional, Ovington, Catherine, additional, Hann, Gail, additional, Cox, Chantel, additional, Hospital, Craigavon Area, additional, Health, Southern, additional, Trust, Social Care, additional, Douglas, Catherine, additional, Goggin, Michael, additional, Fearon, Patricia, additional, Gilpin, Sara, additional, O'Hagan, Margaret, additional, Hospital, Pilgrim, additional, Hardwick, Anne, additional, Netherton, Kimberley, additional, Quinn, Judith, additional, Bozkaplan, Tulu, additional, and Jose, Josin, additional
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- 2019
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20. Presynaptic Serotonergic Markers in Community-Acquired Cases of Alzheimer's Disease: Correlations with Depression and Neuroleptic Medication
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Chen, Christopher P. L.-H., Alder, J. Tracy, Bowen, David M., Esiri, Margaret M., McDonald, Brendan, Hope, Tony, Jobst, Kim A., and Francis, Paul T.
- Published
- 1996
21. Marriage and risk of dementia: systematic review and meta-analysis of observational studies
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Chen, Christopher P L H, primary and Mok, Vincent C T, additional
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- 2017
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22. Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
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Biesbroek, J. Matthijs, primary, Weaver, Nick A., additional, Hilal, Saima, additional, Kuijf, Hugo J., additional, Ikram, Mohammad Kamran, additional, Xu, Xin, additional, Tan, Boon Yeow, additional, Venketasubramanian, Narayanaswamy, additional, Postma, Albert, additional, Biessels, Geert Jan, additional, and Chen, Christopher P. L. H., additional
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- 2016
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23. Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
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Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, Chen, Christopher P L H, Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, and Chen, Christopher P L H
- Published
- 2016
24. Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
- Author
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Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Mohammad Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, Chen, Christopher P L H, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Mohammad Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, and Chen, Christopher P L H
- Published
- 2016
25. Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
- Author
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Opleiding Neurologie, Brain, ZL Algemene Neurologie Medisch, Beeldverwerking ISI, ZL Cerebrovasculaire Ziekten Medisch, Circulatory Health, Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, Chen, Christopher P L H, Opleiding Neurologie, Brain, ZL Algemene Neurologie Medisch, Beeldverwerking ISI, ZL Cerebrovasculaire Ziekten Medisch, Circulatory Health, Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, and Chen, Christopher P L H
- Published
- 2016
26. A Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke
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Low, Hui-Qi, primary, Chen, Christopher P. L. H., additional, Kasiman, Katherine, additional, Thalamuthu, Anbupalam, additional, Ng, Seok-Shin, additional, Foo, Jia-Nee, additional, Chang, Hui-Meng, additional, Wong, Meng-Cheong, additional, Tai, E-Shyong, additional, and Liu, Jianjun, additional
- Published
- 2011
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27. Third Asia-Pacific Regional Meeting of the International Working Group on Harmonization of Dementia Drug Guidelines: Meeting Report Summary
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Senanarong, Vorapun, primary, Chen, Christopher P. L. H., additional, and Orgogozo, and Jean-Marc, additional
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- 2006
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28. Ethnic Variability in Dementia
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Ampil, Encarnita R, primary, Fook-Chong, Stephanie, additional, Sodagar, Swati N, additional, Chen, Christopher P. L. H, additional, and Auchus, Alexander P, additional
- Published
- 2005
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29. Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients
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Tsang, Shirley W. Y., primary, Lai, Mitchell K. P., additional, Francis, Paul T., additional, Wong, Peter T.-H., additional, Spence, Ian, additional, Esiri, Margaret M., additional, Keene, Janet, additional, Hope, Tony, additional, and Chen, Christopher P. L.-H., additional
- Published
- 2003
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30. Regulatory Issues: An Academic Viewpoint From Asia (Ex-Japan)
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Chen, Christopher P. L.-H., primary
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- 2003
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31. 2nd Asia-Pacific Regional Meeting of the International Working Group on Harmonization of Dementia Drug Guidelines
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Auchus, Alexander P., primary and Chen, Christopher P. L. H., additional
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- 2003
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32. Postmortem serotoninergic correlates of cognitive decline in Alzheimer??s disease
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Lai, Mitchell K. P., primary, Tsang, Shirley W. Y., additional, Francis, Paul T., additional, Keene, Janet, additional, Hope, Tony, additional, Esiri, Margaret M., additional, Spence, Ian, additional, and Chen, Christopher P. L.-H., additional
- Published
- 2002
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33. Asia Regional Meeting of the International Working Group for the Harmonization of Dementia Drug Guidelines: Meeting Report
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Auchus, Alexander P., primary and Chen, Christopher P. L. H., additional
- Published
- 2001
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34. Asia-Pacific Consensus Statement on Dementia
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Auchus, Alexander P., primary and Chen, Christopher P. L. H., additional
- Published
- 2001
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35. A Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke.
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Hui-Qi Low, Chen, Christopher P. L. H., Kasiman, Katherine, Thalamuthu, Anbupalam, Seok-Shin Ng, Jia-Nee Foo, Hui-Meng Chang, Meng-Cheong Wong, E-Shyong Tai, and Jianjun Liu
- Subjects
- *
HOMOCYSTEINE , *METABOLISM , *STROKE , *CHINESE people , *METHYLENETETRAHYDROFOLATE reductase , *GENETIC polymorphisms , *DISEASES - Abstract
Background: The effect of genetic factors, apart from 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms, on elevated plasma homocysteine levels and increasing ischemic stroke risk have not been fully elucidated. We conducted a comprehensive analysis of 25 genes involved in homocysteine metabolism to investigate association of common variants within these genes with ischemic stroke risk. Methodology/Principal Findings: The study was done in two stages. In the initial study, SNP and haplotype-based association analyses were performed using 147 tagging Single Nucleotide Polymorphisms (SNPs) in 360 stroke patients and 354 non-stroke controls of Singaporean Chinese ethnicity. Joint association analysis of significant SNPs was then performed to assess the cumulative effect of these variants on ischemic stroke risk. In the replication study, 8 SNPs were selected for validation in an independent set of 420 matched case-control pairs of Singaporean Chinese ethnicity. SNP analysis from the initial study suggested 3 risk variants in the MTRR, SHMT1 and TCN2 genes which were moderately associated with ischemic stroke risk, independent of known stroke risk factors. Although the replication study failed to support single-SNP associations observed in the initial study, joint association analysis of the 3 variants in combined initial and replication samples revealed a trend of elevated risk with an increased number of risk alleles (Joint Ptrend = 1.2610-6). Conclusions: Our study did not find direct evidence of associations between any single polymorphisms of homocysteine metabolic pathway genes and ischemic stroke, but suggests that the cumulative effect of several small to moderate risk variants from genes involved in homocysteine metabolism may jointly confer a significant impact on ischemic stroke risk. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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36. Improving Detection of Dementia in Asian Patients with Low Education: Combining the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly.
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Narasimhalu, Kaavya, Lee, June, Auchus, Alexander P., and Chen, Christopher P. L. H.
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DEMENTIA ,OLDER people ,COGNITION ,COGNITION disorders ,PATIENTS ,ALZHEIMER'S disease - Abstract
Background/Aims: Previous work combining the Mini-Mental State Examination (MMSE) and Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) has been conducted in western populations. We ascertained, in an Asian population, (1) the best method of combining the tests, (2) the effects of educational level, and (3) the effect of different dementia etiologies. Methods: Data from 576 patients were analyzed (407 nondemented controls, 87 Alzheimer’s disease and 82 vascular dementiapatients). Sensitivity, specificity and AUC values were obtained using three methods, the ‘And’ rule, the ‘Or’ rule, and the ‘weighted sum’ method. Results: The ‘weighted sum’ rule had statistically superior AUC and specificity results, while the ‘Or’ rule had the best sensitivity results. The IQCODE outperformed the MMSE in all analyses. Patients with no education benefited more from combined tests. There was no difference between Alzheimer’s disease and vascular dementia populations in the predictive value of any of the combined methods. Conclusion: We recommend that the IQCODE be used to supplement the MMSE whenever available and that the ‘weighted sum’ method be used to combine the MMSE and the IQCODE, particularly in populations with low education. As the study population selected may not be representative of the general population, further studies are required before generalization to nonclinical samples. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2007
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37. Deep Vein Thrombosis following Ischemic Stroke among Asians.
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De Silva, Deidre Anne, Huey Bee Pey, Meng Cheong Wong, Hui Meng Chang, and Chen, Christopher P. L. H.
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THROMBOSIS ,BLOOD coagulation ,ISCHEMIA ,CEREBROVASCULAR disease patients ,CARDIOVASCULAR diseases - Abstract
Background: Deep vein thrombosis (DVT) is perceived as uncommon among Asian stroke patients. However, there is a paucity of published data, and thus, we studied the frequency, characteristics and prognosis of DVT following ischemic stroke in Asian patients with lower limb paresis. Methods: Doppler ultrasound scans of the lower limbs were performed at days 7-10 and 25-30 after stroke onset. The functional status of patients was assessed at 6 months using the modified Rankin scale. Results: DVT was detected in 30% of patients at days 7-10 and in 45% of patients at days 25-30. Most thromboses were distal. There were significant associations of age and degree of weakness with the presence of DVT at days 25-30, but not at days 7-10. DVT in the first month after stroke was associated with poorer outcome at 6 months. Conclusions: DVT following ischemic stroke among Asians is common and associated with poor functional outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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38. Hydrogen sulfide is a mediator of cerebral ischemic damage.
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Qu K, Chen CPL, Halliwell B, Moore PK, Wong PT, Qu, Kun, Chen, Christopher P L H, Halliwell, Barry, Moore, Philip K, and Wong, Peter T-H
- Published
- 2006
39. Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.
- Author
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Ho GY, Eikelboom JW, Hankey GJ, Wong C, Tan S, Chan JB, Chen C, Ho, Grace Y-H, Eikelboom, John W, Hankey, Graeme J, Wong, Chen-Ru, Tan, Siew-Li, Chan, Jesscia B-C, and Chen, Christopher P L-H
- Published
- 2006
40. Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in Singaporean stroke patients.
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Kasiman K, Eikelboom JW, Hankey GJ, Lee SP, Lim JP, Lee JH, Chang HM, Wong MC, Chen CP, Kasiman, Katherine, Eikelboom, John W, Hankey, Graeme J, Lee, Samantha P-K, Lim, Joanna P-Z, Lee, Jasinda H-Q, Chang, Hui-Meng, Wong, Meng-Cheong, and Chen, Christopher P L-H
- Published
- 2009
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41. Is routine retinal examination useful in patients with acute ischemic stroke?
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De Silva DA, Wong TY, Chang HM, Ng BF, Tikellis G, Saw SM, Woon FP, Chen CP, Wong MC, De Silva, Deidre A, Wong, Tien Y, Chang, Hui-Meng, Ng, Bee-Fang, Tikellis, Gabriella, Saw, Seang Mei, Woon, Fung-Peng, Chen, Christopher P L H, and Wong, Meng-Cheong
- Published
- 2008
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42. South Asian patients with ischemic stroke: intracranial large arteries are the predominant site of disease.
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De Silva DA, Woon FP, Lee MP, Chen CP, Chang HM, Wong MC, De Silva, Deidre A, Woon, Fung-Peng, Lee, Moi-Pin, Chen, Christopher P L H, Chang, Hui-Meng, and Wong, Meng-Cheong
- Published
- 2007
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43. Marriage and risk of dementia: systematic review and meta-analysis of observational studies.
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Chen, Christopher P. L. H. and Mok, Vincent C. T.
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DEMENTIA risk factors ,MARRIAGE ,LIFESTYLES & health ,SYSTEMATIC reviews ,COGNITIVE ability ,DEMENTIA - Published
- 2018
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44. Ischemic stroke in ethnic South Asians.
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De Silva DA, Chang HM, Woon FP, Chen CP, Wong MC, De Silva, Deidre A, Chang, Hui-Meng, Woon, Fung-Peng, Chen, Christopher P L H, and Wong, Meng-Cheong
- Published
- 2009
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45. Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients.
- Author
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Petersen M, Coenen M, DeCarli C, De Luca A, van der Lelij E, Barkhof F, Benke T, Chen CPLH, Dal-Bianco P, Dewenter A, Duering M, Enzinger C, Ewers M, Exalto LG, Fletcher EF, Franzmeier N, Hilal S, Hofer E, Koek HL, Maier AB, Maillard PM, McCreary CR, Papma JM, Pijnenburg YAL, Schmidt R, Smith EE, Steketee RME, van den Berg E, van der Flier WM, Venkatraghavan V, Venketasubramanian N, Vernooij MW, Wolters FJ, Xu X, Horn A, Patil KR, Eickhoff SB, Thomalla G, Biesbroek JM, Biessels GJ, and Cheng B
- Abstract
Introduction: White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating cognitive health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH to these deficits remain unclear. We propose that lesion network mapping (LNM), enables to infer if brain networks are connected to lesions, and could be a promising technique for enhancing our understanding of the role of WMH in cognitive disorders. Our study employed this approach to test the following hypotheses: (1) LNM-informed markers surpass WMH volumes in predicting cognitive performance, and (2) WMH contributing to cognitive impairment map to specific brain networks., Methods & Results: We analyzed cross-sectional data of 3,485 patients from 10 memory clinic cohorts within the Meta VCI Map Consortium, using harmonized test results in 4 cognitive domains and WMH segmentations. WMH segmentations were registered to a standard space and mapped onto existing normative structural and functional brain connectome data. We employed LNM to quantify WMH connectivity across 480 atlas-based gray and white matter regions of interest (ROI), resulting in ROI-level structural and functional LNM scores. The capacity of total and regional WMH volumes and LNM scores in predicting cognitive function was compared using ridge regression models in a nested cross-validation. LNM scores predicted performance in three cognitive domains (attention and executive function, information processing speed, and verbal memory) significantly better than WMH volumes. LNM scores did not improve prediction for language functions. ROI-level analysis revealed that higher LNM scores, representing greater disruptive effects of WMH on regional connectivity, in gray and white matter regions of the dorsal and ventral attention networks were associated with lower cognitive performance., Conclusion: Measures of WMH-related brain network connectivity significantly improve the prediction of current cognitive performance in memory clinic patients compared to WMH volume as a traditional imaging marker of cerebrovascular disease. This highlights the crucial role of network effects, particularly in attentionrelated brain regions, improving our understanding of vascular contributions to cognitive impairment. Moving forward, refining WMH information with connectivity data could contribute to patient-tailored therapeutic interventions and facilitate the identification of subgroups at risk of cognitive disorders., Competing Interests: F.B. is supported by the NIHR biomedical research center at UCLH. M.D. received honoraria for lectures from Bayer Vital and Sanofi Genzyme, Consultant for Hovid Berhad and Roche Pharma. G.T. has received fees as consultant or lecturer from Acandis, Alexion, Amarin, Bayer, Boehringer Ingelheim, BristolMyersSquibb/Pfizer, Daichi Sankyo, Portola, and Stryker outside the submitted work.
- Published
- 2024
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46. Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients.
- Author
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Biesbroek JM, Coenen M, DeCarli C, Fletcher EM, Maillard PM, Barkhof F, Barnes J, Benke T, Chen CPLH, Dal-Bianco P, Dewenter A, Duering M, Enzinger C, Ewers M, Exalto LG, Franzmeier N, Hilal S, Hofer E, Koek HL, Maier AB, McCreary CR, Papma JM, Paterson RW, Pijnenburg YAL, Rubinski A, Schmidt R, Schott JM, Slattery CF, Smith EE, Sudre CH, Steketee RME, Teunissen CE, van den Berg E, van der Flier WM, Venketasubramanian N, Venkatraghavan V, Vernooij MW, Wolters FJ, Xin X, Kuijf HJ, and Biessels GJ
- Subjects
- Humans, Female, Middle Aged, Aged, Aged, 80 and over, Male, Amyloid beta-Peptides metabolism, Magnetic Resonance Imaging, White Matter pathology, Arteriolosclerosis pathology, Dementia pathology
- Abstract
Introduction: White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β
1-42 (Aβ42)-positive status., Methods: Individual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume., Results: VRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and Aß42-positive status with WMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001)., Discussion: Vascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter., Highlights: Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and vascular risk have distinct signature WMH patterns., (© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)- Published
- 2024
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47. White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies.
- Author
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de Kort FAS, Coenen M, Weaver NA, Kuijf HJ, Aben HP, Bae HJ, Bordet R, Cammà G, Chen CPLH, Dewenter A, Duering M, Fang R, van der Giessen RS, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kan CN, Kim J, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Lim JS, Lopes R, Mok VCT, Staals J, Venketasubramanian N, Verhagen CM, Verhey FRJ, Wardlaw JM, Xu X, Yu KH, Biesbroek JM, and Biessels GJ
- Subjects
- Humans, Female, Male, Brain diagnostic imaging, Brain pathology, Cognition, Cohort Studies, Magnetic Resonance Imaging, Infarction pathology, Neuropsychological Tests, Ischemic Stroke complications, White Matter diagnostic imaging, White Matter pathology, Brain Injuries pathology, Stroke complications, Stroke diagnostic imaging, Stroke pathology
- Abstract
Background: White matter hyperintensities (WMH) are associated with cognitive dysfunction after ischemic stroke. Yet, uncertainty remains about affected domains, the role of other preexisting brain injury, and infarct types in the relation between WMH burden and poststroke cognition. We aimed to disentangle these factors in a large sample of patients with ischemic stroke from different cohorts., Methods: We pooled and harmonized individual patient data (n=1568) from 9 cohorts, through the Meta VCI Map consortium (www.metavcimap.org). Included cohorts comprised patients with available magnetic resonance imaging and multidomain cognitive assessment <15 months poststroke. In this individual patient data meta-analysis, linear mixed models were used to determine the association between WMH volume and domain-specific cognitive functioning ( Z scores; attention and executive functioning, processing speed, language and verbal memory) for the total sample and stratified by infarct type. Preexisting brain injury was accounted for in the multivariable models and all analyses were corrected for the study site as a random effect., Results: In the total sample (67 years [SD, 11.5], 40% female), we found a dose-dependent inverse relationship between WMH volume and poststroke cognitive functioning across all 4 cognitive domains (coefficients ranging from -0.09 [SE, 0.04, P =0.01] for verbal memory to -0.19 [SE, 0.03, P <0.001] for attention and executive functioning). This relation was independent of acute infarct volume and the presence of lacunes and old infarcts. In stratified analyses, the relation between WMH volume and domain-specific functioning was also largely independent of infarct type., Conclusions: In patients with ischemic stroke, increasing WMH volume is independently associated with worse cognitive functioning across all major domains, regardless of old ischemic lesions and infarct type., Competing Interests: Disclosures Dr H.-J. Bae reports grants from Chong Gun Dang Pharmaceutical Corp and Korean Drug Co, Ltd outside of the submitted work. Dr G.J. Biessels reports grants from The Netherlands Organisation for Health Research and Development (ZonMW), during the conduct of the study. The other authors report no conflicts.
- Published
- 2023
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48. Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients.
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Coenen M, Kuijf HJ, Huenges Wajer IMC, Duering M, Wolters FJ, Fletcher EF, Maillard PM, Barkhof F, Barnes J, Benke T, Boomsma JMF, Chen CPLH, Dal-Bianco P, Dewenter A, Enzinger C, Ewers M, Exalto LG, Franzmeier N, Groeneveld O, Hilal S, Hofer E, Koek DL, Maier AB, McCreary CR, Padilla CS, Papma JM, Paterson RW, Pijnenburg YAL, Rubinski A, Schmidt R, Schott JM, Slattery CF, Smith EE, Steketee RME, Sudre CH, van den Berg E, van der Flier WM, Venketasubramanian N, Vernooij MW, Xin X, DeCarli C, Biessels GJ, and Biesbroek JM
- Subjects
- Humans, Magnetic Resonance Imaging, Cognition, Executive Function, Neuropsychological Tests, White Matter diagnostic imaging, White Matter pathology, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction pathology
- Abstract
Introduction: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study., Methods: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses., Results: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains., Discussion: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment., Highlights: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains., (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
- Published
- 2023
- Full Text
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49. Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke.
- Author
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Biesbroek JM, Weaver NA, Aben HP, Kuijf HJ, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Valdés-Hernández MDC, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, and Biessels GJ
- Subjects
- Cohort Studies, Humans, Infarction complications, Cognitive Dysfunction complications, Ischemic Stroke complications, Stroke diagnosis
- Abstract
Background: Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk prediction., Aims: To determine if the network impact score is an independent predictor of PSCI, and of cognitive recovery or decline., Methods: We pooled data from patients with acute ischemic stroke from 12 cohorts through the Meta VCI Map consortium. PSCI was defined as impairment in ≥ 1 cognitive domain on neuropsychological examination, or abnormal Montreal Cognitive Assessment. Cognitive recovery was defined as conversion from PSCI < 3 months post-stroke to no PSCI at follow-up, and cognitive decline as conversion from no PSCI to PSCI. The network impact score was related to serial measures of PSCI using Generalized Estimating Equations (GEE) models, and to PSCI stratified according to post-stroke interval (<3, 3-12, 12-24, >24 months) and cognitive recovery or decline using logistic regression. Models were adjusted for age, sex, education, prior stroke, infarct volume, and study site., Results: We included 2341 patients with 4657 cognitive assessments. PSCI was present in 398/844 patients (47%) <3 months, 709/1640 (43%) at 3-12 months, 243/853 (28%) at 12-24 months, and 208/522 (40%) >24 months. Cognitive recovery occurred in 64/181 (35%) patients and cognitive decline in 26/287 (9%). The network impact score predicted PSCI in the univariable (OR 1.50, 95%CI 1.34-1.68) and multivariable (OR 1.27, 95%CI 1.10-1.46) GEE model, with similar ORs in the logistic regression models for specified post-stroke intervals. The network impact score was not associated with cognitive recovery or decline., Conclusions: The network impact score is an independent predictor of PSCI. As such, the network impact score may contribute to a more precise and individualized cognitive prognostication in patients with ischemic stroke. Future studies should address if multimodal prediction models, combining the network impact score with demographics, clinical characteristics and other advanced brain imaging biomarkers, will provide accurate individualized prediction of PSCI. A tool for calculating the network impact score is freely available at https://metavcimap.org/features/software-tools/lsm-viewer/., (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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50. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.
- Author
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Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae HJ, Caballero MÁA, Chappell FM, Chen CPLH, Dichgans M, Duering M, Georgakis MK, van der Giessen RS, Gyanwali B, Hamilton OKL, Hilal S, Vom Hofe EM, de Kort PLM, Koudstaal PJ, Lam BYK, Lim JS, Makin SDJ, Mok VCT, Shi L, Valdés Hernández MC, Venketasubramanian N, Wardlaw JM, Wollenweber FA, Wong A, Xin X, and Biessels GJ
- Abstract
Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies., Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage., Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage., Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
- Published
- 2019
- Full Text
- View/download PDF
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