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491 results on '"Chen, Chih-Yuan"'

17. Acoustic Emission Signal Analysis for Stamping Machine Condition Monitoring and Fault Diagnosis

Author

Wang, Hsiao-Yu, Chiang, Yu-Hung, Chen, Chih-Yuan, Hon, Yu-Shiang, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Chang, Jia-Wei, editor, Yen, Neil, editor, and Hung, Jason C., editor

Published
2021
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19. Leveraging Hypotension Prediction Index to Forecast LPS-Induced Acute Lung Injury and Inflammation in a Porcine Model: Exploring the Role of Hypoxia-Inducible Factor in Circulatory Shock.

Author

Tsai, Yuan-Ming, Lin, Yu-Chieh, Chen, Chih-Yuan, Chien, Hung-Che, Chang, Hung, and Chiang, Ming-Hsien

Subjects
ADULT respiratory distress syndrome, CARDIOGENIC shock, HYPOXIA-inducible factors, OXYGEN saturation, ENZYME-linked immunosorbent assay
Abstract

Acute respiratory distress syndrome (ARDS) is a critical illness in critically unwell patients, characterized by refractory hypoxemia and shock. This study evaluates an early detection tool and investigates the relationship between hypoxia and circulatory shock in ARDS, to improve diagnostic precision and therapy customization. We used a porcine model, inducing ARDS with mechanical ventilation and intratracheal plus intravenous lipopolysaccharide (LPS) injection. Hemodynamic changes were monitored using an Acumen IQ sensor and a ForeSight Elite sensor connected to the HemoSphere platform. We evaluated tissue damage, inflammatory response, and hypoxia-inducible factor (HIF) alterations using enzyme-linked immunosorbent assay and immunohistochemistry. The results showed severe hypotension and increased heart rates post-LPS exposure, with a notable rise in the hypotension prediction index (HPI) during acute lung injury (p = 0.024). Tissue oxygen saturation dropped considerably in the right brain region. Interestingly, post-injury HIF-2α levels were lower at the end of the experiment. Our findings imply that the HPI can effectively predict ARDS-related hypotension. HIF expression levels may serve as possible markers of rapid ARDS progression. Further research should be conducted on the clinical value of this novel approach in critical care, as well as the relationship between the HIF pathway and ARDS-associated hypotension. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Calcinated gold nanoparticle arrays for on-chip, multiplexed and matrix-free mass spectrometric analysis of peptides and small molecules

Author

Hinman, Samuel S, Chen, Chih-Yuan, Duan, Jicheng, and Cheng, Quan

Subjects
Analytical Chemistry, Chemical Sciences, Physical Chemistry, Nanotechnology, Bioengineering, Gold, Mass Spectrometry, Metal Nanoparticles, Peptides, Protein Array Analysis, Physical Sciences, Technology, Nanoscience & Nanotechnology, Chemical sciences, Engineering, Physical sciences
Abstract

A patterned gold nanoparticle microarray, functionalized with a nanoscale silicate coating, has been developed for on-chip, high-throughput mass spectrometric analyses of biomolecules with minimal sample preparation and reagent costs. Fabrication was realized by the combination of layer-by-layer functionalization of the nanoparticles with suitable polyelectrolytes, followed by fluidic patterning of the glass microarray support and calcination for permanent fixation of the nano-coating. Performance of the microarray was evaluated for surface-assisted laser-desorption/ionization mass spectrometry (SALDI-MS), where the nano-silicate coating was found to enhance SALDI efficiency, resulting in comparable performance to some common organic matrices for small and medium sized molecules. Performance contributing factors of this material have been discussed; heat confinement and interband transition/plasmonic resonance may play important roles. Taking the accessibility of fabrication, performance, and reusability of this substrate together, the material developed here provides a new tool for multiplexed and chip-based mass spectrometric analysis.

Published
2016

29. Nanoglassified, Optically-Active Monolayer Films of Gold Nanoparticles for in Situ Orthogonal Detection by Localized Surface Plasmon Resonance and Surface-Assisted Laser Desorption/Ionization-MS

Author

Chen, Chih-Yuan, Hinman, Samuel S, Duan, Jicheng, and Cheng, Quan

Subjects
Bioengineering, Nanotechnology, Chemistry Techniques, Analytical, Gold, Lasers, Mass Spectrometry, Metal Nanoparticles, Surface Plasmon Resonance, Surface Properties, Analytical Chemistry, Other Chemical Sciences
Abstract

Localized surface plasmon resonance (LSPR) represents a sensitive and versatile method for detection of biomolecules in a label-free fashion, but identification of bound analytes can be challenging with LSPR alone, especially for samples in a complex medium. We report the fabrication of an optically active, plasmonic film of gold nanoparticles by using a self-assembly and calcination process, which offers orthogonal measurements enabling multifaceted characterization on the same surface with LSPR and surface-assisted laser desorption/ionization mass spectrometry. This proof-of-concept study involves plasmonic characterization of the fabricated nanofilm, real-time monitoring of vesicle-surface interactions toward formation of fluid lipid bilayer, and mass spectrometric analysis of peptides and cytochrome c digest. This multifunction-enabling surface material can yield complementary analytical information, providing new tools for comprehensive analysis of biomolecular samples.

Published
2014

37. A Thermally Friendly Bonding Scheme for 3D System Integration

Author

Kuo, Gordon, primary, Chen, Chih-Yuan, additional, Hsieh, Cheng-Chieh, additional, Lee, Chung-Ju, additional, Wu, Jason, additional, Cui, Ji James, additional, Kuo, Yen-Liang, additional, Tung, Chih-Hang, additional, Ku, Terry, additional, Tsai, Chung-Hao, additional, Yee, Kuo-Chung, additional, and Yu, Douglas C.H., additional

Published
2023
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