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The X-band phased array radar offers faster scanning speed and higher spatial resolution compared to the S-band radar, making it capable of enhancing tornado monitoring and early warning capabilities. This study analyzed the characteristics and nowcasting signals of a tornado case that occurred on June 16, 2022 in the Guangzhou region. Our findings indicate that the violent contraction of rotation radius and the dramatic increase in rotation speed were important signal characteristics associated with tornado formation. The X-band phased array radar, with its high temporal and spatial resolution, provided an opportunity to capture early warning signals from polarimetric characteristics. The X-band phased array radar demonstrated noteworthy ability to identify apparent tornado vortex signature (TVS) features in a 10-minute lead time, surpassing the capabilities of the CINRAD/SA radar. Additionally, due to its higher scanning frequency, the Xband phased-array radar was capable of consistently identifying TVS with shorter intervals, enabling a more precise tracking of the tornado's path. The application of professional radars, in this case, provides valuable insights for the monitoring of evolutions of severe local storms and even tornadoes and the issuance of early warning signals. [ABSTRACT FROM AUTHOR]

Avoidance of PCR with prior AI detection. PPC projection on UWF fundus image. AI detection of PPC projection to avoid cataract surgical catastrophe. Purpose: To test a cataract shadow projection theory and validate it by developing a deep learning algorithm that enables automatic and stable posterior polar cataract (PPC) screening using fundus images. Setting: Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei, Taiwan. Design: Retrospective chart review. Methods: A deep learning algorithm to automatically detect PPC was developed based on the cataract shadow projection theory. Retrospective data (n = 546) with ultra-wide field fundus images were collected, and various model architectures and fields of view were tested for optimization. Results: The final model achieved 80% overall accuracy, with 88.2% sensitivity and 93.4% specificity in PPC screening on a clinical validation dataset (n = 103). Conclusions: This study established a significant relationship between PPC and the projected shadow, which may help surgeons to identify potential PPC risks preoperatively and reduce the incidence of posterior capsular rupture during cataract surgery. [ABSTRACT FROM AUTHOR]

Highlights: The formation of peptide nanocapsules is facilitated by a gradient interface, where the differential solvent concentration drives the peptides to preferentially localize and assemble. The peptide nanocapsules, characterized by their hollow structures, demonstrated potential as carriers for targeted drug delivery. [ABSTRACT FROM AUTHOR]

The u -band magnitude is vital for determining stellar parameters and investigating specific astronomical objects. However, flux calibration in the u band for stars in the Galactic disc presents significant challenges. In this study, we introduce a comprehensive recalibration of u -band photometric magnitudes of the VPHAS+ Data Release 4, employing the stellar colour regression technique. By leveraging the expansive set of XP spectra and G BP photometry from Gaia Data Release 3, as well as the individual stellar extinction values provided by the literature, we have obtained precise model magnitudes of nearly 3 million stars. Our analysis identifies systematic magnitude offsets that exhibit a standard deviation of 0.063 mag across different observational visits, 0.022 mag between various CCDs, and 0.009 mag within pixel bins. We have implemented precise corrections for these observational visits, CCD chips, and pixel bins-dependent magnitude offsets. These corrections have led to a reduction in the standard deviation between the observed magnitudes and the model magnitudes from 0.088 to 0.065 mag, ensuring that the calibrated magnitudes are independent of stellar magnitude, colour, and extinction. The enhanced precision of these magnitudes substantially improves the quality of astrophysical research and offers substantial potential for furthering our understanding of stellar astrophysics. [ABSTRACT FROM AUTHOR]

Mechanism and microstructure of the CFASC device. [Display omitted] The increasing requirements for wearable and portable electronics are driving the interests of high performance fiber supercapacitor. Layered double hydroxide (LDH) is broadly used in electrode materials, owing to the adjustability of components and the unique lamellar structure. However, limited active sites and poor electrical conductivity hinder its applications. Herein, the core–shell heterostructured Ni(OH) 2 @activation Zn-Co-Ni layered double hydroxides (Ni(OH) 2 @A-ZnCoNi-LDH) electrode was fabricated by loading pseudocapacitance material on the A-ZnCoNi-LDH to improve the electrochemical performance. Significantly, benefits from the synergistic effect of the multi-metal ions and the core–shell heterostructure, the electrodes demonstrated a capacitance of 2405 mF·cm−2 at 1 mA·cm−2. Furthermore, Ni(OH) 2 @A-ZnCoNi-LDH was used as the core electrode and carbon nanotube (CNT) film coated with Fe 2 O 3 @reduced graphene oxide (rGO) was wrapped around the core electrode to assemble coaxial fiber asymmetric supercapacitor, which illustrated an ultrahigh energy density of 177.7 µWh·cm−2 at 0.75 mW·cm−2. In particular, after consecutive charging and discharging 7000 cycles, the capacitance retention of the device was 95 %, indicating the excellent cycling stability. Furthermore, the device with high flexibility can be woven into textiles in different shapes. The fabricated device has an excellent development prospect as an energy source in wearable electronic devices. [ABSTRACT FROM AUTHOR]

Stationary or mobile microwave radiometers (MRs) can measure atmospheric temperature, relative humidity, and water vapor density profiles with high spatio-temporal resolution, but cannot obtain the vertical variations of wind field. Based on a dataset of brightness temperatures (TBs) measured with a mobile MR over the Three-River-Source Region of the Tibetan Plateau from 18 to 30 July 2021, we develop a direct retrieval method for the wind profile (WP) based on the Long Short-Term Memory (LSTM) network technique, and obtain the reliable dynamic variation characteristics of the WP in the region. Furthermore, the ground-based radiative transfer model for TOVS (RTTOV-gb) was employed to validate the reliability of the TB observation, and we analyzed the impact of weather conditions, altitude, observational mode, and TB diurnal variation on the accuracy of the TB measurement and the retrieval of the WP. Results show that the TB from the mobile observation (MOTB) on clear and cloudy days are close to those of the simulated TB with the RTTOV-gb model, while TB measurements on rainy days are far larger than the modeled TBs. When compared with radiosonde observations, the WPs retrieved with the LSTM algorithm are better than the ERA5 reanalysis data, especially below 350 hPa, where the root mean square errors for both wind speed and wind direction are smaller than those of ERA5. The major factors influencing WP retrieval include the weather conditions, altitude, observational mode, and TB diurnal variation. Under clear-sky and cloudy conditions, the LSTM retrieval method can reproduce the spatio-temporal evolution of wind field and vertical wind shear characteristics. The findings of this study help to improve our understanding of meso-scale atmospheric dynamic structures, characteristics of vertical wind shear, atmospheric boundary layer turbulence, and enhance the assessment and forecasting accuracy of wind energy resources. [ABSTRACT FROM AUTHOR]

One of the major challenges we face is how to quickly and accurately create the three-dimensional (3D) density distributions of interstellar dust in the Milky Way using extinction and distance measurements of large samples of stars. In this study, we introduce a novel machine-learning approach that utilizes a convolution neural network, specifically a V-net, to infer the 3D distribution of dust density. Experiments are performed within two regions located towards the Galactic anticentre. The neural network is trained and tested using 10 000 simulations of dust density and line-of-sight extinction maps. Evaluation of the test sample confirms the successful generation of dust density maps from extinction maps by our model. Additionally, the performance of the trained network is evaluated using data from the literature. Our results demonstrate that our model is capable of capturing detailed dust density variations and can recover dust density maps while reducing the 'fingers of god' effect. Moving forward, we plan to apply this model to real observational data to obtain the fine distribution of dust at large and small scales in the Milky Way. [ABSTRACT FROM AUTHOR]

Flue gas desulfurization gypsum (FGDG), a solid waste material generated by power plants, offers a cost-effective solution for preparing backfill materials. Concurrently, given that most backfill materials are exposed to mine water erosion, an investigation into the mechanical performance degradation and damage mechanisms of FGDG backfill materials subjected to prolonged chloride salt erosion is crucial for ensuring the stability of goaf backfills (by goaf, we mean the area or space that remains underground after the extraction of valuable minerals). This study explores the mechanical properties and damage mechanisms of backfill samples treated with varying concentrations of chloride. The findings indicate that over time, the mass of the sample initially decreases, experiences a slight increase, and then gradually declines. Simultaneously, the strength and structure of the sample deteriorate rapidly, followed by a partial recovery. The rebound in sample mass is attributed to an incomplete hydration reaction that continuously transforms free water into bound water. Microstructure analysis techniques, such as X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM), reveals that the degradation in mechanical strength and structure is a consequence of chloride salt erosion. Subsequent reuse is facilitated by the formation of Friedel's salt resulting from the reaction between hydration products and chloride ions, filling voids in the sample and impeding further chloride ion erosion into the deeper regions. Notably, FGDG exhibits outstanding reuse performance in prolonged and high-concentration chloride ion environments. This study serves as a reference for understanding the deterioration mechanism and practical application of backfills in chloride-rich environments. [ABSTRACT FROM AUTHOR]

Background: Although gastrointestinal endoscopy with sedation is increasingly performed in older patients, the optimal level of sedation remains open to debate. In this study, our objective was to compare the effects of moderate sedation (MS) and deep sedation (DS) on recovery following outpatient gastroscopy in elderly patients. Methods: In this randomized, partially blinded, controlled trial, we randomly divided 270 patients older than 60 years who were scheduled for elective outpatient gastroscopy into the MS or DS group based on the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale. The primary outcome was the duration of stay in the post-anesthesia care unit (PACU). Secondary outcomes included the duration of the total hospital stay, frequency of retching, bucking, and body movements during the examination, endoscopist and patient satisfaction, and sedation-associated adverse events during the procedure. Results: A total of 264 patients completed the study, of whom 131 received MS and 133 received DS. MS was associated with a shorter PACU stay [16.15 ± 9.01 min vs. 20.02 ± 11.13 min, P < 0.01] and total hospital stay [27.32 ± 9.86 min vs. 30.82 ± 12.37 min, P < 0.05], lesser hypoxemia [2.3% (3/131) vs. 12.8% (17/133), P < 0.01], use of fewer vasoactive drugs (P < 0.001), and more retching (P < 0.001). There was no difference in the incidence of bucking and body movements or endoscopist and patient satisfaction between the two groups. Conclusion: Compared to deep sedation, moderate sedation may be a preferable choice for American Society of Anesthesiologists (ASA) Grade I–III elderly patients undergoing outpatient gastroscopies, as demonstrated by shorter PACU stays and total hospital stays, lower sedation-associated adverse events, and similar levels of endoscopist and patient satisfaction. [ABSTRACT FROM AUTHOR]

Purposes: Dilatation of cystic duct is very rare and had been classified as Todani type VI choledochal cyst. Choledochal cyst combined with dilatation of cystic duct is difficult to diagnose preoperatively. The purpose of this study is to report the rare variants and discuss the significance and laparoscopic management strategy in children. Methods: The subjects for this study were 10 consecutive patients with type VI choledochal cyst who had laparoscopic procedures at our institute between January 2009 and January 2023. Laparoscopic cholecystectomy, excision of the dilated cystic duct, and choledochal cyst were carried out, and the continuity of the biliary duct was re-established through a Roux-en-Y hepaticojejunostomy. Results: Cystic duct combined with the common bile duct dilatation was revealed in all the patients intraoperatively. Laparoscopic procedures were completed with no conversions. The postoperative recovery was uneventful. The mean follow-up duration was 27 ± 12.7 months (range 5–36 months) with no postoperative complications encountered. Conclusions: The rare entity of type VI choledochal cyst should be recognized as a distinct type of choledochal cyst and need to be given enough attention clinically. The laparoscopic procedure is a feasible option for experienced surgeons. [ABSTRACT FROM AUTHOR]

Metal–organic frameworks (MOFs), formed by the coordination of metal nodes and organic linkers, constitute a class of multifunctional materials with unprecedentedly high chemical/structural designability. Through properly harnessing the synergistic interplay between high atomic number nodes and functional linkers, radiation‐responsive MOFs have recently come on the scene, which can convert ionizing radiations (e.g., X‐ray, γ‐ray, β‐ray, α‐particle, and neutron) into electrical charges or visible light. Given the attributes of cost‐effectiveness, robust environmental stability, extensive chemical tunability, and diverse functionalities, cutting‐edge radiation‐responsive MOFs with remarkable electronic and optical properties have emerged as promising substitutes for conventional organic and inorganic radiation‐responsive substances in applications across biomedicine and technology. This review article documents recent advancements in radiation‐responsive MOFs by elucidating the foundational mechanisms governing electronic transport and photon conversion within frameworks through inherent node–linker and host–guest interactions prompted by high‐energy radiation. Furthermore, this review delves into state‐of‐the‐art applications that leverage newly formulated radiation‐responsive MOFs, capitalizing on precisely engineered component interactions to achieve efficient energy absorption, conversion, and emission. The rationale behind these developments is concluded and future opportunities for expanding the research of radiation‐responsive MOFs are simultaneously highlighted. [ABSTRACT FROM AUTHOR]

Objectives: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by progressive fibrofatty infiltration of atrial and ventricular myocardium resulting in adverse cardiac events. Atrial function has been increasingly recognized as prognostically important for cardiovascular disease. As the right atrial (RA) strain is a sensitive parameter to describe RA function, we aimed to analyze the prognostic value of the RA strain in ARVC. Methods: RA strain parameters were derived from cardiac magnetic resonance (CMR) images of 105 participants with definite ARVC. The endpoint was defined as a combination of sudden cardiac death, survival cardiac arrest, and appropriate implantable cardioverter-defibrillator intervention. Cox regression and Kaplan–Meier survival analyses were performed to evaluate the association between RA strain parameters and endpoint. Concordance index (C index), net reclassification index (NRI), and integrated discrimination improvement (IDI) were calculated to assess the incremental value of RA strain in predicting the endpoint. Results: After a median follow-up of 5 years, 36 (34.3%) reaching the endpoint displayed significantly reduced RA strain parameters. At Kaplan–Meier analysis, impaired RA reservoir (RARS) and booster strains (RABS) were associated with an increased risk of the endpoint. After adjusting for conventional risk factors, RARS (hazard ratio [HR], 0.956; p = 0.005) and RABS (HR, 0.906; p = 0.002) resulted as independent predictors for endpoint at Cox regression analyses. In addition, RARS and RABS improved prognostic value to clinical risk factors and CMR morphological and functional predictors (all p < 0.05). Conclusion: RARS and RABS were independent predictors for adverse cardiac events, which could provide incremental prognostic value for conventional predictors in ARVC. Critical relevance statement: We evaluated the prognostic value of right atrial strain in ARVC patients and suggested cardiologists consider RA strain as a predictive parameter when evaluating the long-term outcome of ARVC patients in order to formulate better clinical therapy. Key points: • Patients with ARVC had significantly reduced RA strain and strain rates compared with healthy participants. • Participants with lower RA reservoir and booster stains were associated with a significantly higher risk of adverse cardiac events. • RA booster and reservoir strain provide incremental value to conventional parameters. [ABSTRACT FROM AUTHOR]

Background: Social distancing policies were of utmost importance during the early stages of the COVID-19 pandemic. These policies aimed to mitigate the severity of local outbreaks by altering public behavior. However, if the severity of the pandemic reduces, the impact of these policies on actual behavior may decrease. This study aims to examine, from a global perspective, whether the impact of social distancing policies on actual mobility is moderated by local pandemic severity and whether this moderating effect varies across cultural value contexts. Methods: We combined multiple publicly available global datasets for structural equation model analysis. 17,513 rows of data from 57 countries included in all databases were analyzed. Multilevel moderated moderation models were constructed to test the hypotheses. Results: More stringent policies in a region mean less regional mobility (β = -0.572, p < 0.001). However, the severity of local outbreaks negatively moderated this effect (β = -0.114, p < 0.001). When the pandemic was not severe, the influence of policy intensity on mobility weakened. Furthermore, based on Schwartz's cultural values theory, cultural values of autonomy (β = -0.109, p = 0.011), and egalitarianism (β = -0.108, p = 0.019) reinforced the moderating effect of pandemic severity. On the other hand, cultural values of embeddedness (β = 0.119, p = 0.006) and hierarchy (β = 0.096, p = 0.029) attenuated the moderating effect. Conclusions: Social distancing policies aim to reduce the severity of local pandemics; however, the findings reveal that mitigating local pandemics may reduce their impact. Future policymakers should be alert to this phenomenon and introduce appropriate incentives to respond. The results also show that the moderating role of pandemic severity varies across cultures. When policies are promoted to deal with global crises, policymakers must seriously consider the resistance and potential incentives of cultural values. [ABSTRACT FROM AUTHOR]

The construction of multiple continuous fully substituted carbon centers, which serve as unique structural motif in natural products, is a challenging topic in organic synthesis. Herein, we report a hydrated [3+2] cyclotelomerization of butafulvenes to create contiguous fully substituted carbon backbone. In the presence of scandium triflate, all‐carbon skeleton with spiro fused tricyclic ring can be constructed in high diastereoselectivity by utilizing butafulvene as the synthon. Mechanistic studies suggest that this atom‐economic reaction probably proceeds through a synergistic process containing butafulvenes dimerization and nucleophilic attack by water. In addition, the tricyclic product can undergo a series of synthetic derivatizations, which highlights the potential applications of this strategy. The recyclability of Sc(OTf)3 has also been demonstrated to show its robust performance in this hydrated cyclotelomerization. [ABSTRACT FROM AUTHOR]

The construction of multiple continuous fully substituted carbon centers, which serve as unique structural motif in natural products, is a challenging topic in organic synthesis. Herein, we report a hydrated [3+2] cyclotelomerization of butafulvenes to create contiguous fully substituted carbon backbone. In the presence of scandium triflate, all‐carbon skeleton with spiro fused tricyclic ring can be constructed in high diastereoselectivity by utilizing butafulvene as the synthon. Mechanistic studies suggest that this atom‐economic reaction probably proceeds through a synergistic process containing butafulvenes dimerization and nucleophilic attack by water. In addition, the tricyclic product can undergo a series of synthetic derivatizations, which highlights the potential applications of this strategy. The recyclability of Sc(OTf)3 has also been demonstrated to show its robust performance in this hydrated cyclotelomerization. [ABSTRACT FROM AUTHOR]

(1) Background: Pathological humeral shaft fracture (PHSF) is a frequently observed clinical manifestation in the later stages of tumor metastasis. Surgical interventions are typically recommended to alleviate pain and restore functionality. Intramedullary nail fixation (INF) or plate fixation (PF) is currently recommended for the treatment of PHSF. However, there is still no standard for optimal surgical treatment. Thus, we conducted a meta-analysis comparing the clinical outcomes of INF with PF for PHSF treatment. (2) Methods: We conducted searches in databases, such as Scopus, EMBASE, and PubMed, for studies published prior to May 2023. In total, nine studies with 485 patients were reviewed. (3) Results: There were no significant differences noted in the incidence of fixation failure, local recurrence, wound complication or overall complication. However, the INF group demonstrated a significantly lower incidence of postoperative radial nerve palsy than the PF group (OR, 5.246; 95% CI, 1.548–17.774; p = 0.008). A subgroup analysis indicated that there were no statistically significant differences in fixation failure or local recurrence among subgroups categorized by the design of intramedullary nail. (4) Conclusions: Considering the short life expectancy of end-stage patients, the choice of surgical method depends on the patient's individual condition, fracture and lesion patterns, the surgeon's experience, and comprehensive discussion between the surgeon and patient. [ABSTRACT FROM AUTHOR]

Recent studies have shown that a pro-inflammatory diet and dysbiosis, especially a high level of trimethylamine-N-oxide (TMAO), are associated with various adverse health conditions. Cardiovascular diseases and pancreatic diseases are two major morbidities in the modern world. Through this narrative review, we aimed to summarize the association between a pro-inflammatory diet, gut microbiota, and cardiovascular and pancreatic diseases, along with their underlying mechanisms. Our review revealed that TMAO is associated with the development of cardiovascular diseases by promoting platelet aggregation, atherosclerotic plaque formation, and vascular inflammation. TMAO is also associated with the development of acute pancreatitis. The pro-inflammatory diet is associated with an increased risk of pancreatic cancer and cardiovascular diseases through mechanisms that include increasing TMAO levels, activating the lipopolysaccharides cascade, and the direct pro-inflammatory effect of certain nutrients. Meanwhile, an anti-inflammatory diet decreases the risk of cardiovascular diseases and pancreatic cancer. [ABSTRACT FROM AUTHOR]

Benefiting from cloud computing's elasticity, scalability, and pay-per-use model, more and more scientific applications are deployed in or migrated to the cloud. Workflow scheduling still faces many challenges due to the growing scales of workflows and the diversified user QoS requirements. In this work, we propose a Mutation-driven and population Grouping Poor and Rich Optimization algorithm (MG-PRO) for scheduling workflows in the cloud to minimize makespan while satisfying the budget constraints. Specifically, we first adopt the middle-class sub-population into the original Poor and Rich Optimization algorithm (PRO), and develop the update strategies for rich and middle-class sub-populations to increase the randomness and search diversity. Secondly, the update mechanism for rich individuals is enriched, and the middle-class sub-population is guided by elite rich individuals, which enhances the information exchange and sharing among sub-populations. Finally, an evolution-aware mutation strategy is designed, where the mutation probability is adjusted adaptively as the dynamic monitoring of the population update process, and the two-point and triangular crossover-based mutations are used alternately to intervene the evolution trajectory according to the degree of objective optimization, resulting in a better balance between exploration and exploration. Extensive experiments are conducted on well-known scientific workflows with different types and scales through WorkflowSim. The experimental results show that, in most cases, MG-PRO outperforms existing algorithms in terms of constraint satisfiability, solution quality and stability. It can generate near-optimal solutions with the different budget constraints satisfied in a relatively short time, for example, the makespan resulting from MG-PRO is at most 59.95% shorter than other meta-heuristic algorithms, and at least 7.33% shorter than all its peers. [ABSTRACT FROM AUTHOR]

With the opening of the Stock Connect programs, the mainland China and Hong Kong stock markets are becoming more closely linked. In this paper, we develop a China's stock market risk early warning system. The proposed early warning system consists of three components. First, we use value at risk (VaR) to identify the stock market risk in which stock market risk is divided into multiple categories instead of two categories. Second, we construct a comprehensive indicator system in which basic indicators, technical indicators, overseas return rate indicators, and macroeconomic indicators are considered simultaneously. Third, we use four machine learning models, namely long short-term memory (LSTM), gate recurrent unit (GRU), multilayer perceptron (MLP), and EXtreme Gradient Boosting algorithm (XGBoost), to predict China's stock market risk. Experimental results show that: (1) Considering the macroeconomic indicators and basic indicators of Shanghai Composite Index (SSEC), ShenZhen Component Index (SZCZ) and Hang Seng Index (HSI) can significantly improve the performance of predicting China's stock market risk. (2) The opening of SH-HK Stock Connect program improves the predictive performance, but the opening of SZ-HK Stock Connect program decreases the predictive performance. (3) The indicators related to Hong Kong become more important after the SZ-HK Stock Connect program. [ABSTRACT FROM AUTHOR]

Multi-party reversible data hiding over ciphered images (MRDH-CI) has high restorability since the image is split into multiple ciphered images by secret sharing. However, the MRDH-CI methods either fail to produce satisfied results, or only work well for conventional images. This paper introduces a multi-party reversible data-hiding approach over ciphered overexposed images. First, the pixels of the overexposed images are decomposed into two parts, each of which can be used for secret sharing. Then, the decomposed overexposed images are converted into multiple ciphered overexposed images by using a modified secret sharing method, in which the differences of the ciphered overexposed images are retained. The symmetry of the difference retaining makes the secret data conceal within the ciphered overexposed images such that the marked ciphered overexposed images can be created. Finally, by collecting sufficient marked ciphered overexposed images, it is possible to symmetrically reconstruct the concealed data and primitive overexposed image. Experimental results illustrate that the presented method can efficiently deal with overexposed images while maintaining a low computational overhead. [ABSTRACT FROM AUTHOR]

Objective: A motor complete spinal cord injury (SCI) results in the loss of voluntary motor control below the point of injury. Some of these patients can regain partial motor function through inpatient rehabilitation; however, there is currently no biomarker to easily identify which patients have this potential. Evidence indicates that spasticity could be that marker. Patients with motor complete SCI who exhibit spasticity show preservation of descending motor pathways, the pathways necessary for motor signals to be carried from the brain to the target muscle. We hypothesized that the presence of spasticity predicts motor recovery after subacute motor complete SCI. Methods: Spasticity (Modified Ashworth Scale and pendulum test) and descending connectivity (motor evoked potentials) were tested in the rectus femoris muscle in patients with subacute motor complete (n = 36) and motor incomplete (n = 30) SCI. Motor recovery was assessed by using the International Standards for Neurological Classification of Spinal Cord Injury and the American Spinal Injury Association Impairment Scale (AIS). All measurements were taken at admission and discharge from inpatient rehabilitation. Results: We found that motor complete SCI patients with spasticity improved in motor scores and showed AIS conversion to either motor or sensory incomplete. Conversely, patients without spasticity showed no changes in motor scores and AIS conversion. In incomplete SCI patients, motor scores improved and AIS conversion occurred regardless of spasticity. Interpretation: These findings suggest that spasticity represents an easy‐to‐use clinical outcome that might help to predict motor recovery after severe SCI. This knowledge can improve inpatient rehabilitation effectiveness for motor complete SCI patients. ANN NEUROL 2024;95:71–86 [ABSTRACT FROM AUTHOR]

Copper indium sulfide (CuInS2) is a ternary A(I)B(III)X (VI)2 -type semiconductor featuring a direct bandgap with a high absorption coefficient. In attempts to explore their practical applications, nanoscale CuInS2 has been synthesized with crystal sizes down to the quantum confinement regime. The merits of CuInS2 nanocrystals (NCs) include wide emission tunability, a large Stokes shift, long decay time, and eco-friendliness, making them promising candidates in photoelectronics and photovoltaics. Over the past two decades, advances in wet-chemistry synthesis have achieved rational control over cation–anion reactivity during the preparation of colloidal CuInS2 NCs and post-synthesis cation exchange. The precise nano-synthesis coupled with a series of hybridization strategies has given birth to a library of CuInS2 NCs with highly customizable photophysical properties. This review article focuses on the recent development of CuInS2 NCs enabled by advanced synthetic and hybridization techniques. We show that the state-of-the-art CuInS2 NCs play significant roles in optoelectronic and biomedical applications. [ABSTRACT FROM AUTHOR]

Introduction: Infectious mononucleosis (IM) is a common infectious disease in children mainly caused by Epstein–Barr virus (EBV) infection, followed by abnormal immune response, and resulting in serious complications. However, there are few clinical analyses of immune responses in children with IM at different stages. Methods: This study combined EBV serological test and EBV DNA test to diagnose the infection status of children with IM, and the infection status was divided into primary acute IM infection (AIM), primary late IM infection (LIM) and reactivation IM infection (RIM). Results: The results revealed that the absolute numbers of leukocytes and CD8+ T lymphocytes in primary IM infection were significantly higher than those in reactivation infection, while the frequencies of CD4+ T lymphocytes and B cells were significantly lower than those in reactivation infection. In addition, the activities of ALT, AST, α‐HBDH and LDH in liver function indicators in primary infection were significantly increased compared with reactivation infection. Similarly, the EBV DNA levels of the primary infection were significantly higher than that of the reactivation infection. Conclusion: There are differences in immune response at different stages of infection, which can provide guidance for effective treatment in children with IM infection. [ABSTRACT FROM AUTHOR]

Objective: The current study aimed to explore a deep convolutional neural network (DCNN) model that integrates multidimensional CMR data to accurately identify LV paradoxical pulsation after reperfusion by primary percutaneous coronary intervention with isolated anterior infarction. Methods: A total of 401 participants (311 patients and 90 age-matched volunteers) were recruited for this prospective study. The two-dimensional UNet segmentation model of the LV and classification model for identifying paradoxical pulsation were established using the DCNN model. Features of 2- and 3-chamber images were extracted with 2-dimensional (2D) and 3D ResNets with masks generated by a segmentation model. Next, the accuracy of the segmentation model was evaluated using the Dice score and classification model by receiver operating characteristic (ROC) curve and confusion matrix. The areas under the ROC curve (AUCs) of the physicians in training and DCNN models were compared using the DeLong method. Results: The DCNN model showed that the AUCs for the detection of paradoxical pulsation were 0.97, 0.91, and 0.83 in the training, internal, and external testing cohorts, respectively (p < 0.001). The 2.5-dimensional model established using the end-systolic and end-diastolic images combined with 2-chamber and 3-chamber images was more efficient than the 3D model. The discrimination performance of the DCNN model was better than that of physicians in training (p < 0.05). Conclusions: Compared to the model trained by 2-chamber or 3-chamber images alone or 3D multiview, our 2.5D multiview model can combine the information of 2-chamber and 3-chamber more efficiently and obtain the highest diagnostic sensitivity. Clinical relevance statement: A deep convolutional neural network model that integrates 2-chamber and 3-chamber CMR images can identify LV paradoxical pulsation which correlates with LV thrombosis, heart failure, ventricular tachycardia after reperfusion by primary percutaneous coronary intervention with isolated anterior infarction. Key Points: • The epicardial segmentation model was established using the 2D UNet based on end-diastole 2- and 3-chamber cine images. • The DCNN model proposed in this study had better performance for discriminating LV paradoxical pulsation accurately and objectively using CMR cine images after anterior AMI compared to the diagnosis of physicians in training. • The 2.5-dimensional multiview model combined the information of 2- and 3-chamber efficiently and obtained the highest diagnostic sensitivity. [ABSTRACT FROM AUTHOR]

Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD. [ABSTRACT FROM AUTHOR]

A medial meniscus posterior root tear (MMPRT) contributes to knee joint degeneration. Arthroscopic transtibial pullout repair (ATPR) may restore biomechanical integrity for load transmission. However, degeneration persists after ATPR in certain patients, particularly those with preoperative subchondral insufficiency fracture of the knee (SIFK). We explored the relationship between preoperative SIFK and osteoarthritis (OA) progression in retrospectively enrolled patients who were diagnosed as having an MMPRT and had received ATPR within a single institute. Based on their preoperative magnetic resonance imaging (MRI), these patients were then categorized into SIFK and non-SIFK groups. OA progression was evaluated by determining Kellgren–Lawrence (KL) grade changes and preoperative and postoperative median joint widths. SIFK characteristics were quantified using Image J (Version 1.52a). Both groups exhibited significant post-ATPR changes in medial knee joint widths. The SIFK group demonstrated significant KL grade changes (p < 0.0001). A larger SIFK size in the tibia and a greater lesion-to-tibia length ratio in the coronal view were positively correlated with more significant KL grade changes (p = 0.008 and 0.002, respectively). Thus, preoperative SIFK in patients with an MMPRT was associated with knee OA progression. Moreover, a positive correlation was observed between SIFK lesion characteristics and knee OA progression. [ABSTRACT FROM AUTHOR]

This paper characterizes the efficacy of borax on different properties of alkali-activated materials (AAMs). Fly ash (FA) and ground granulated blast slag (GGBS) were used as base substances at different ratios. The effects of borax on workability, compressive strength, efflorescence formation and crack resistance are the main ideas of the study. The results indicated the positive effects of borax on the properties of one-part fly ash/slag-based alkali-activated materials such as increasing workability and decreasing efflorescence. The microscopic images and scanning electron microscope (SEM) showed that the addition of borax reduced the cracks and a higher amount of slag made the samples denser with less unreacted raw materials, respectively. The compressive strength test results showed that borax had a detrimental impact at early ages with a positive effect at later ages. Binders with borax and 20-25% replacement of FA with GGBS were found to have the best performance when workability, compressive strength, efflorescence formation, and cracks on the samples were taken into account. [ABSTRACT FROM AUTHOR]

(1) Background: Recent studies suggest an association between pancreatitis and cardiovascular disease. This article aims to review the available evidence linking cardiovascular disease with acute and chronic pancreatitis. (2) Methods: A comprehensive search was conducted on the PubMed/MEDLINE database from inception to April 2022 using Medical Subject Heading and keywords related to pancreatitis and cardiovascular disease. The search was limited to English-language literature involving human subjects, and various study types, including observational studies, case–control studies, cohort studies, and clinical trials, were screened for eligibility. Following data extraction, the authors conducted a narrative synthesis of the studies. (3) Results: Longitudinal studies indicate that a history of acute pancreatitis is associated with an increased risk of acute atherosclerotic cardiovascular disease and acute coronary syndrome. Elevated triglyceride levels (>2000 mg/dL) have a temporal relationship with acute pancreatitis. Cross-sectional studies have shown that acute pancreatitis is associated with cardiac injury during the acute phase. Based on longitudinal studies, chronic pancreatitis is associated with an increased risk of cerebrovascular diseases. However, data regarding the relationship between chronic pancreatitis and myocardial infarction are conflicting. (4) Conclusions: Based on the available evidence, having a history of acute pancreatitis appears to increase the risk of acute atherosclerotic cardiovascular disease. However, there is insufficient evidence to conclude whether chronic pancreatitis is associated with cardiovascular disease, and no definitive studies have yielded conflicting results. [ABSTRACT FROM AUTHOR]

Social media is emerged as a powerful communication tool over the past ten years. The Z generation's green buying habits and purchase intentions are being reshaped by social media, which is helping to advance the development of a sustainable environment. The consumption of non-organic products has raised carbon emissions, so changing consumption patterns and purchase intentions is necessary for a more sustainable future. Moreover, earlier literature has the absence of a comprehensive behavior change model that explains the mechanism through which social media influences sustainable behaviors This study explores that how social media affects patterns of consumption for Z generation of China while considering the role of environmental concerns, subjective norms, eco-branding and eco-labeling on the basis of theory of planned behavior. A questionnaire is used to get information from the 563 Z generation respondents of China. The data is analyzed using Smart-PLS and empirical outcomes show that social media has a statistically significant influence on shaping and affecting green consumption behavior of China's Z generation because it has the potential to reach a vast audience and spread awareness about environmental issues, leading to increased intention towards a sustainable environment and reduction in carbon emissions. It also provides a platform for individuals to express their opinions and engage in discussions on environmental issues. These developments are promising for the future of environmental sustainability as they indicate a growing interest in preserving the planet among the Z generation of China. It can be recommended as a policy tool that government and other organizations should support the development of informative content on social media platforms, highlighting the importance of environmental sustainability and eco-friendly habits. [ABSTRACT FROM AUTHOR]

Background: The combination of drug delivery with immune checkpoint targeting has been extensively studied in cancer therapy. However, the clinical benefit for patients from this strategy is still limited. B7 homolog 3 protein (B7-H3), also known as CD276 (B7-H3/CD276), is a promising therapeutic target for anti-cancer treatment. It is widely overexpressed on the surface of malignant cells and tumor vasculature, and its overexpression is associated with poor prognosis. Herein, we report B7H3 targeting doxorubicin (Dox)-conjugated gold nanocages (B7H3/Dox@GNCs) with pH-responsive drug release as a selective, precise, and synergistic chemotherapy-photothermal therapy agent against non-small-cell lung cancer (NSCLC). Results: In vitro, B7H3/Dox@GNCs exhibited a responsive release of Dox in the tumor acidic microenvironment. We also demonstrated enhanced intracellular uptake, induced cell cycle arrest, and increased apoptosis in B7H3 overexpressing NSCLC cells. In xenograft tumor models, B7H3/Dox@GNCs exhibited tumor tissue targeting and sustained drug release in response to the acidic environment. Wherein they synchronously destroyed B7H3 positive tumor cells, tumor-associated vasculature, and stromal fibroblasts. Conclusion: This study presents a dual-compartment targeted B7H3 multifunctional gold conjugate system that can precisely control Dox exposure in a spatio-temporal manner without evident toxicity and suggests a general strategy for synergistic therapy against NSCLC. [ABSTRACT FROM AUTHOR]

As the high-entropy design concept applied to the diboride ceramic system, high-entropy diboride ceramics with a wide range of composition control, is expected to become a new high-performance material for extreme high-temperature environments. Herein, the effects of four transition metal elements (Nb, Ti, Cr, W) on the phase stability and properties of (Hf, Zr, Ta)B 2 -based high-entropy diboride ceramics are systematically investigated via the first-principles calculations. All components were identified as thermodynamically, mechanically and dynamically stable from enthalpy of formation, elastic and phonon spectrum calculations. Among these, compared with the (Hf, Zr, Ta)B 2 ceramics, the addition of Nb and Ti on the metal sublattice is beneficial to improve the mechanical properties of ceramics, including Young's modulus, hardness and fracture toughness, while the introduction of Cr and W weakens the strength of covalently and ionic bonds inside the material, reducing its mechanical properties. The predicted thermophysical properties show that the high-entropy diboride ceramics containing Nb and Ti have better high-temperature comprehensive performance, including higher Debye temperature, thermal conductivity and lower thermal expansion characteristics, which is conducive to the application in extreme high-temperature environments. This research will provide important guidance for the design and development of new high-performance high-entropy diboride ceramics. [ABSTRACT FROM AUTHOR]

Anthropogenic heat release (AHR) is the release of heat generated by anthropogenic energy consumption. The global mean flux of AHR is 0.03 W m−2, while AHR is geographically concentrated and fundamentally correlates with economic activity; furthermore, AHR can reach a level sufficient for impacting regional even large-scale climate. In this study, the impacts of AHR on the summer European heatwaves (EHWs) are examined by using the Community Earth System Model version 1 (CESM1). The results show that in Europe, AHR increases the summer mean 2-m temperature by 0.26 °C and the surface minimum and maximum temperatures by 0.14 °C and 0.41 °C, respectively. AHR exacerbates the extreme high temperatures in the summer in Europe, increasing EHW days by 1–2 days in central and eastern Europe in the summer annually from 1992 to 2013. AHR strengthens the surface wind that flows from the ocean to the land in Europe by increasing the land surface temperatures. AHR decreases the lower-troposphere stability (LTS) and reduces the low-cloud amounts in Europe, which leads to more solar shortwave radiation reaching the surface. AHR affects water vapor and the surface energy balance in Europe, which impacts on European summer heatwaves further. AHR acts as a non-negligible factor for summer extreme high temperature in Europe and a potential factor impacting EHW days. [ABSTRACT FROM AUTHOR]

In this paper, the design and experimental validation of a knee exoskeleton are presented. The exoskeleton can capture the negative work from the wearer's knee motion while decreasing the muscle activities of the wearer. First, the human knee biomechanics during the normal walking is described. Then, the design of the exoskeleton is presented. The exoskeleton mainly includes a left one-way transmission mechanism, a right one-way transmission mechanism, and a front transmission mechanism. The left and right one-way transmission mechanisms are designed to capture the negative work from the wearer's knee motion in the stance and swing phases, respectively. The front transmission mechanism is designed to transform the bidirectional rotation of the wearer's knee joint into the generator unidirectional rotation. Additionally, the modeling and analysis of the energy harvesting of the exoskeleton is described. Finally, walking experiments are performed to validate the effectiveness of the proposed knee exoskeleton. The testing results verify that the developed knee exoskeleton can output a maximum power of 5.68 ± 0.23 W and an average power of 1.45 ± 0.13 W at a speed of 4.5 km/h in a gait cycle. The average rectus femoris and semitendinosus activities of the wearers in a gait cycle are decreased by 3.68% and 3.40%, respectively. [ABSTRACT FROM AUTHOR]

Objectives: Serious COVID-19 nosocomial infection has demonstrated a need to design our health services in a different manner. Triggered by the current crisis and the interest in rapid deployable hospital, this article discusses how hospital building layouts can be improved to streamline the patient pathways and thus to reduce the risk of hospital-related infections. Another objective of this work is to explore the possibility to develop flexible and scalable hospital building layouts through modular construction. This enables hospitals to better cope with different future demands and thereby enhance the resilience of the healthcare facilities. Background: During the first wave of COVID-19, approximate one-seventh to one-fifth COVID-19 patients and majority of infected healthcare workers acquired the disease in NHS hospitals. Similar issues emerged during the Crimean War (1853–1856) when more soldiers died from infectious diseases rather than of battlefield casualties in Scutari Hospital. This led to an important collaborative work between Florence Nightingale, who looked into this problem statistically, and Isambard Kingdom Brunel, who designed the rapid deployment Renkioi Hospital which yielded a death rate 90% lower than that in Scutari Hospital. While contemporary medical research and practice have moved beyond Nightingale's concept of contagion, challenges of optimizing hospital building layouts to support healing and effectively combat nosocomial infections still pose elusive problems that require further investigation. Methods: Through case study investigations, this article evaluates the risk of nosocomial infections of airborne transmissions under different building layouts, and this provides essential data for infection control in the new-build or refurbished healthcare projects. Results: Improved hospital layout can be achieved through reconfiguration of rooms and concourse. Design interventions through evidence-based infection risk analysis can reduce congestion and provide extra separation and compartmentalization which will contribute the reduced nosocomial infection rate. Conclusions: A resilient hospital shall be able to cope with unexpected circumstances and be flexible to change when new challenges arise, without compromising the safety and well-being of frontline medical staff and other patients. Such an organizational resilience depends on not only flexible clinical protocols but also flexible hospital building layouts. The latter allows hospitals to get better prepared for rapidly changing patient expectations, medical advances, and extreme weather events. The reconfigurability of an existing healthcare facility can be further enhanced through modular construction, standardization of building components, and additional space considered. [ABSTRACT FROM AUTHOR]

We present a highly integrated point-of-care testing (POCT) device capable of immediately and accurately screening bovine mastitis infection based on somatic cell counting (SCC). The system primarily consists of a homemade cell-counting chamber and a miniature fluorescent microscope. The cell-counting chamber is pre-embedded with acridine orange (AO) in advance, which is simple and practical. And then SCC is directly identified by microscopic imaging analysis to evaluate the bovine mastitis infection. Only 4 μL of raw bovine milk is required for a simple sample testing and accurate SCC. The entire assay process from sampling to result in presentation is completed quickly within 6 min, enabling instant "sample-in and answer-out." Under laboratory conditions, we mixed bovine leukocyte suspension with whole milk and achieved a detection limit as low as 2.12 × 104 cells/mL on the system, which is capable of screening various types of clinical standards of bovine milk. The fitting degrees of the proposed POCT system with manual fluorescence microscopy were generally consistent (R2 > 0.99). As a proof of concept, four fresh milk samples were used in the test. The average accuracy of somatic cell counts was 98.0%, which was able to successfully differentiate diseased cows from healthy ones. The POCT system is user-friendly and low-cost, making it a potential tool for on-site diagnosis of bovine mastitis in resource-limited areas. [ABSTRACT FROM AUTHOR]

This study aims to isolate collagen peptides from waste sturgeon fish skin, and prepare nanoemulsions for studying their anti-diabetic and wound-healing effects in mice. Collagen peptides were extracted and purified by acetic acid with sonication, followed by two-stage hydrolysis with 0.1% pepsin and 5% flavourzyme, and ultrafiltration with 500 Da molecular weight (MW) cut-off dialysis membrane. Animal experiments were performed with collagen peptides obtained by pepsin hydrolysis (37 kDa) and pepsin plus flavourzyme hydrolysis (728 Da) as well as their nanoemulsions prepared at two different doses (100 and 300 mg/kg/day). The mean particle size of low-MW and low-dose nanoemulsion, low-MW and high-dose nanoemulsion, high-MW and low-dose nanoemulsion and high-MW and high-dose nanoemulsion was, respectively, 16.9, 15.3, 28.1 and 24.2 nm, the polydispersity index was 0.198, 0.215, 0.231 and 0.222 and zeta potential was −61.2, −63.0, −41.4 and −42.7 mV. These nanoemulsions were highly stable over a 90-day storage period (4 °C and 25 °C) and heating at 40–100 °C (0.5–2 h). Experiments in mice revealed that the low-MW and high-dose nanoemulsion was the most effective in decreasing fasting blood glucose (46.75%) and increasing wound-healing area (95.53%). Collectively, the sturgeon fish skin collagen peptide-based nanoemulsion is promising for development into a health food or wound-healing drug. [ABSTRACT FROM AUTHOR]

Background: An aberrant vascular anatomy might present a technical pitfall for biliary atresia (BA) surgery. The purpose of this study was to report the rare cases and discuss the significance and management strategy for BA with an aberrant right hepatic artery (ARHA) by laparoscopic Kasai procedure in children. Methods: The subjects for this study were 10 consecutive type III BA patients with an ARHA who had laparoscopic Kasai procedure at our institute between January 2012 and August 2021. The common bile duct was mobilized between the right hepatic artery and the right branch of portal vein, and then lifted to the liver hilum. The fibrous cord was transected and then the laparoscopic Kasai was carried out. Results: All patients survived the laparoscopic Kasai without any intraoperative complications. The mean operative time was 235 minutes for each laparoscopic Kasai. The mean follow-up time was 32.6 months. The total and direct bilirubin dropped to normal within 4 months of surgery in 7 patients. One patient died of repeated cholangitis and liver failure 1 year after surgery. In the additional 2 patients the bilirubin levels dropped significantly after the surgery but elevated again because of repeated cholangitis and requiring ongoing observation and intermittent treatment. Conclusions: With the perfect laparoscopic skills, the common bile duct could be safely mobilized between the right hepatic artery and right branch of portal vein for the infants with type III BA associated with an ARHA, and laparoscopic Kasai could be carried out safely and successfully. [ABSTRACT FROM AUTHOR]

This paper presents a novel framework combining the state-based peridynamics (SBPD) with the extended finite element method (XFEM) for crack propagation in two-dimensional solids. Numerical examination is conducted fulfilling both the quasi-static and time-dependent loading conditions. The computational domain is partitioned into two regions: (a) SPBD region: the vicinity of crack tips and potential region where the crack is likely to propagate, and (b) XFEM region: the area behind the crack tip and the rest of the body. The salient features of the developed framework include: (a) avoiding requirement of a priori knowledge of enrichment functions like the conventional XFEM; (b) without fracture criteria for crack propagation; (c) no restriction on the value of Poisson's ratio like the bond-based peridynamics; and (d) higher computational efficiency than the pure peridynamics. The efficiency and accuracy of the proposed framework are systematically demonstrated through benchmark examples involving quasi-static crack growth and dynamic crack branching problems. [ABSTRACT FROM AUTHOR]

X‐ray imaging technology has been widely used in the fields of environmental monitoring, safety inspection, nondestructive examination, space exploration, and medical diagnosis, among which scintillation materials play a vital role in indirectly converting X‐ray to visible photons. Here, a zero‐dimensional organic–inorganic hybrid halide C50H44P2SbCl5 crystal is prepared via a facile antisolvent precipitation method at room temperature. The single crystal of C50H44P2SbCl5 displays a strong yellow broadband emission centered at 592 nm with a near‐unity photoluminescence quantum yield of 98.42%. Importantly, C50H44P2SbCl5 crystals show great environmental stability and irradiation stability. Radioluminescence characterization indicates that C50H44P2SbCl5 crystals exhibit a good linear response to X‐ray dose rates along with an excellent light yield of 44 460 photons MeV−1, surpassing that of commercial inorganic LuAG:Ce scintillator. The spatial resolution of the C50H44P2SbCl5‐based scintillating screen is determined to be 8.2 lp mm−1. In conjunction with polymer thin film, the excellent scintillating feature of organic–inorganic hybrid halides offers exciting opportunities for achieving high‐quality flexible X‐ray imaging. [ABSTRACT FROM AUTHOR]

Accumulating studies have shown the effects of gut microbiota management tools in improving depression. We conducted a meta-analysis to evaluate the effects of prebiotics, probiotics, and synbiotics on patients with depression. We searched six databases up to July 2022. In total, 13 randomized controlled trials (RCTs) with 786 participants were included. The overall results demonstrated that patients who received prebiotics, probiotics or synbiotics had significantly improved symptoms of depression compared with those in the placebo group. However, subgroup analysis only confirmed the significant antidepressant effects of agents that contained probiotics. In addition, patients with mild or moderate depression could both benefit from the treatment. Studies with a lower proportion of females reported stronger effects for alleviating depressive symptoms. In conclusion, agents that manipulate gut microbiota might improve mild-to-moderate depression. It is necessary to further investigate the benefits of prebiotic, probiotic and synbiotic treatments relative to antidepressants and follow up with individuals over a longer time before these therapies are implemented in clinical practice. [ABSTRACT FROM AUTHOR]

Celiac disease (CD) is a chronic autoimmune disorder that affects the small intestine in genetically predisposed individuals. Previous studies have investigated the potential link between CD and cardiovascular disease (CVD); however, the findings have been inconsistent. We aimed to provide an updated review of the literature on the association between CD and CVD. PubMed was searched from inception to January 2023 using keywords including CD, cardiovascular disease, coronary artery disease, cardiac arrhythmia, heart failure, cardiomyopathy, and myocarditis. We summarized the results of the studies, including meta-analyses and original investigations, and presented them according to the different forms of CVD. Meta-analyses published in 2015 provided mixed results regarding the relationship between CD and CVD. However, subsequent original investigations have shed new light on this association. Recent studies indicate that individuals with CD are at a higher risk of developing overall CVD, including an increased risk of myocardial infarction and atrial fibrillation. However, the link between CD and stroke is less established. Further research is needed to determine the link between CD and other cardiac arrhythmias, such as ventricular arrhythmia. Moreover, the relationship between CD and cardiomyopathy or heart failure, as well as myopericarditis, remains ambiguous. CD patients have a lower prevalence of traditional cardiac risk factors, such as smoking, hypertension, hyperlipidemia, and obesity. Therefore, it is important to discover strategies to identify patients at risk and reduce the risk of CVD in CD populations. Lastly, it is unclear whether adherence to a gluten-free diet can diminish or increase the risk of CVD among individuals with CD, necessitating further research in this area. To fully comprehend the correlation between CD and CVD and to determine the optimal prevention strategies for CVD in individuals with CD, additional research is necessary. [ABSTRACT FROM AUTHOR]

In this paper, consensus analysis and design are investigated for discrete-time multi-agent systems (MASs) with consecutive packet losses in communication links of directed communication topology. It is assumed that at each transmitted instant, the packet loss is stochastic and described by Bernoulli distribution, but during a given time window, the data could be successfully transmitted to the agent from each of its neighbors. First, we utilize the incidence matrix of a directed spanning tree of the communication topology to construct a linear transformation matrix so that the consensus problem is equivalently transformed into a mean square asymptotic stability problem of a reduced-order system. Second, by using Lyapunov–Krasovskii functional approach, we derive some sufficient conditions of consensus criterion in terms of linear matrix inequalities (LMIs). These conditions express the relationship among the control gain matrix, packet loss rate, and the number of consecutive packet losses. Based on the conditions, gain matrix in the consensus protocol is designed to guarantee the MAS with stochastic packet losses to achieve mean square asymptotic consensus. Moreover, for the special case of undirected communication topology, by using the matrix decomposition method, the variables of LMIs are transformed into the low-order conditions independent of the network size. Finally, some numerical examples are given to show the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

The invasion of cancer cells into interstitial tissues in a cohesive unit is termed collective invasion, and it is important for the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). However, the underlying mechanisms regulating SACC collective invasion are still poorly understood. Here, we found that SACC tissues exhibited remarkable FAT1 downregulation and YAP1 upregulation at the invasive front, which was closely associated with collective invasion and distant metastasis. Decreasing FAT1 expression significantly activated the YAP1 signaling pathway and promoted collective invasion. Moreover, miR-183-5p was identified as the candidate regulator of FAT1 by bioinformatic analysis and an online database algorithm. A dual luciferase reporter experiment further confirmed that miR-183-5p directly targeted the FAT1 3′-UTR to reduce FAT1 expression. Increasing or decreasing miR-183-5p expression promoted or attenuated collective invasion, which was reversed by YAP1 siRNA or FAT1 siRNA, respectively. In addition, knocking down miR-183-5p reduced tumor burden and attenuated collective invasion in vivo. Together, these results suggest that the miR-183-5p/FAT1/YAP1 signaling pathway is a critical driver of SACC collective invasion, revealing a novel therapeutic target. [Display omitted] • FAT1 downregulation and YAP1 upregulation are related to metastasis. • Multicellular and single cell methods were used to evaluate collective invasion. • miR-183-5p can directly target the FAT1 3′-UTR to activate the YAP1 signaling pathway. • Knocking down miR-183-5p prevented tumor growth and collective invasion in vivo. [ABSTRACT FROM AUTHOR]

Aim: Circular RNAs (circRNAs) are a novel class of noncoding RNAs and are conserved in various species. Although numerous circRNAs have been identified, their role in cancer remains unclear. Methods: The expression of circTMEM181 in 90 paired human hepatocellular carcinoma (HCC) and adjacent nontumor tissues were detected using quantitative reverse transcription–polymerase chain reaction. Transwell assay was performed for functional analysis of HCC cell migration and invasion. Luciferase reporter assay was used to verify the combination of circTMEM181 and miR‐519a‐5p. Results: In this study, we identified a novel circRNA, named circTMEM181, was downregulated in HCC tissues. Decreased expression of circTMEM181 was associated with shorter overall survival of patients with HCC. CircTMEM181 overexpression reduced HCC cell migration and invasion abilities, while circTMEM181 knockdown increased cell motility. Mechanically, circTMEM181 could directly bind to miR‐519a‐5p and subsequently upregulate ARHGAP29 protein expression. Conclusion: These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR‐519a‐5p/ARHGAP29 axis in HCC development. [ABSTRACT FROM AUTHOR]

In this paper, we discuss the circumradius of reduced convex polygons and Reuleaux polygons. We prove that from amongst all reduced convex n-gons of a fixed thickness, only the regular n-gon has the minimal circumradius. For Reuleaux polygons, we show that from amongst all n-th Reuleaux polygons, only the regular n-th Reuleaux polygon has the minimal circumradius. [ABSTRACT FROM AUTHOR]

This document is a reply to a letter regarding an article titled "Spasticity Predicts Motor Recovery for Patients with Subacute Motor Complete Spinal Cord Injury." The authors thank Dr. Jing for her comments and provide additional information about their methodologies. They explain that the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) examination was conducted by experienced professionals, and they used both the Modified Ashworth Scale (MAS) and the pendulum test to assess spasticity. They also address the potential effect of antispastic medications on their measurements and report that motor recovery was observed in patients despite the use of these medications. [Extracted from the article]

Objectives: This study aimed to investigate the influence of microvascular impairment on myocardial characteristic alterations in remote myocardium at multiple time points, and its prognostic significance after acute ST-segment elevation myocardial infarction (STEMI). Methods: Patients were enrolled prospectively and performed CMR at baseline, 30 days, and 6 months. The primary endpoint was major adverse cardiac events (MACE): death, myocardial reinfarction, malignant arrhythmia, and hospitalization for heart failure. Cox proportional hazards regression modeling was analyzed to estimate the correlation between T1 mapping of remote myocardium and MACE in patients with and without microvascular obstruction (MVO). Results: A total of 135 patients (mean age 60.72 years; 12.70% female, median follow-up 510 days) were included, of whom 86 (63.70%) had MVO and 26 (19.26%) with MACE occurred in patients. Native T1 values of remote myocardium changed dynamically. At 1 week and 30 days, T1 values of remote myocardium in the group with MVO were higher than those without MVO (p = 0.030 and p = 0.001, respectively). In multivariable cox regression analysis of 135 patients, native1w T1 (HR 1.03, 95%CI 1.01–1.04, p = 0.002), native30D T1 (HR 1.05, 95%CI 1.03–1.07, p < 0.001) and LGE (HR 1.10, 95%CI 1.05–1.15, p < 0.001) were joint independent predictors of MACE. In multivariable cox regression analysis of 86 patients with MVO, native30D T1 (HR 1.05, 95%CI 1.04–1.07, p < 0.001) and LGE (HR 1.10, 95%CI 1.05–1.15, p < 0.001) were joint independent predictors of MACE. Conclusions: The evolution of native T1 in remote myocardium was associated with the extent of microvascular impairment after reperfusion injury. In patients with MVO, native30D T1 and LGE were joint independent predictors of MACE. Key points: Microvascular impairment correlated with native T1 of remote myocardium. Native T1 values of remote myocardium changed dynamically. Native30D T1 and LGE were joint independent predictors of MACE. [ABSTRACT FROM AUTHOR]

The dysregulation of the dopamine system contributes to depressive-like behaviors in rats, and the neurological functions regulated by hypocretin are severely affected in depression. However, whether suvorexant plays a role in alleviating depression by affecting the dopamine system is unclear. To preliminarily explore the mechanism of suvorexant (10 mg/kg) in the treatment of depression, the mRNA and protein expression of TH, Drd2, Drd3, GluN2A, DAT, and GluN2B in the striatum of rats was quantified by qPCR and western blotting. The plasma hypocretin-1 and dopamine levels and the striatal dopamine levels were determined by ELISA. i) Compared to those of the control group, chronic unpredictable mild stress (CUMS) rats showed depressive-like behaviors, which were subsequently reversed by treatment with suvorexant. ii) The mRNA and protein expressions of TH, Drd2, Drd3, GluN2A, and GluN2B in the striatum of CUMS were significantly increased compared with those in the controls, but decreased after suvorexant treatment. iii) Compared with those in the control group, the plasma and striatal dopamine levels of CUMS decreased while plasma hypocretin-1 levels increased, which was reversed after suvorexant treatment. i) The suvorexant is a dual hypocretin receptor antagonist; however, the responsible receptor is unclear. ii) We only focused on related factors in the striatum but did not explore other brain regions, nor did we directly explore the relationship among these factors. Depressive-like behaviors induced by CUMS can be reversed by suvorexant, and the therapeutic effects of suvorexant may be mediated by affecting the dopamine system. • Suvorexant, a dual hypocretin antagonist, was effective in treating depression-like behavior in rats, suggesting the antagonists of hypocretin receptors have a great prospect in the treatment of depression and other neurological diseases. • The hypocretin system may play a role in the treatment of depression by regulating the balance of the dopamine system. • Hypocretin might modulates the balance of the dopamine system and then exerts an antidepressant effect by affecting the expression of GluN2A and GluN2B through the dopamine pathway. [ABSTRACT FROM AUTHOR]