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12 results on '"Chen, Aoxiang"'

1. Variational inference based on a subclass of closed skew normals

Author

Tan, Linda S. L. and Chen, Aoxiang

Subjects
Statistics - Methodology
Abstract

Gaussian distributions are widely used in Bayesian variational inference to approximate intractable posterior densities, but the ability to accommodate skewness can improve approximation accuracy significantly, when data or prior information is scarce. We study the properties of a subclass of closed skew normals constructed using affine transformation of independent standardized univariate skew normals as the variational density, and illustrate how it provides increased flexibility and accuracy in approximating the joint posterior in various applications, by overcoming limitations in existing skew normal variational approximations. The evidence lower bound is optimized using stochastic gradient ascent, where analytic natural gradient updates are derived. We also demonstrate how problems in maximum likelihood estimation of skew normal parameters occur similarly in stochastic variational inference, and can be resolved using the centered parametrization. Supplemental materials are available online., Comment: keywords: Closed skew normal; Gaussian variational approximation; natural gradient; centered parametrization; LU decomposition

Published
2023

4. Neoadjuvant dalpiciclib, exemestane, and goserelin in premenopausal women with HR-positive, HER2-negative breast cancer: A prospective, multicenter, randomized two-group, non-controlled phase 2 clinical trial.

Author

Yang, Zhengjun, primary, Wang, Xin, additional, Chen, Aoxiang, additional, Meng, Ran, additional, Zhao, Ying, additional, Liu, Hong, additional, Ge, Jie, additional, Huang, Ruixue, additional, Bai, Jianping, additional, and Cao, Xucheng, additional

Published
2024
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5. Variational Inference based on a Subclass of Closed Skew Normals.

Author

Tan, Linda S. L. and Chen, Aoxiang

Subjects
*MAXIMUM likelihood statistics, *AFFINE transformations, *BAYESIAN field theory, *DENSITY
Abstract

AbstractGaussian distributions are widely used in Bayesian variational inference to approximate intractable posterior densities, but the ability to accommodate skewness can improve approximation accuracy significantly, when data or prior information is scarce. We study the properties of a subclass of closed skew normals constructed using affine transformation of independent standardized univariate skew normals as the variational density, and illustrate how it provides increased flexibility and accuracy in approximating the joint posterior in various applications, by overcoming limitations in existing skew normal variational approximations. The evidence lower bound is optimized using stochastic gradient ascent, where analytic natural gradient updates are derived. We also demonstrate how problems in maximum likelihood estimation of skew normal parameters occur similarly in stochastic variational inference, and can be resolved using the centered parameterization. Supplementary materials for this article are available online. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The clinical efficacy and safety of acupuncture intervention on cancer-related insomnia: A systematic review and meta-analysis

Author

Yu, HaiXin, Liu, CaiYun, Chen, Bo, Zhai, JingBo, Ba, DongSheng, Zhu, Zheng, Li, NingCen, Loh, PeiYong, Chen, AoXiang, Wang, Bin, Guo, Yi, Liu, YangYang, and Chen, ZeLin

Subjects
General Neuroscience
Abstract

ObjectiveTo evaluate the efficacy and safety of acupuncture in treating symptoms for Cancer-related Insomnia(CRI) patients.MethodsSeven databases were searched from the time of database establishment to 31 March 2022. Randomized Controlled Trials (RCTs) on acupuncture intervention for CRI were collected. Literature screening and data extraction were performed independently by two researchers. Meta-analysis was performed using RevMan 5.4 software.ResultsA total of 13 articles with 1,109 participants were included. Five hundred and seventeen in the treatment group and 592 in the control group. Ten of the RCTs used the PSQI rating scale and four randomized controlled trials used the ISI rating scale, and the PSQI and ISI were analyzed together as continuous data. The results of the meta-analysis were: MD = −1.83, 95%CI = [−2.71, −0.94], P < 0.0001, indicating a significant improvement in PSQI scores in patients with CRI by acupuncture intervention; MD = 0.79, 95%CI = [−0.46, 2.03], P = 0.22. Acupuncture was not statistically significant on ISI scores for patients with CRI compared to controls, which does not yet indicate that acupuncture is effective for symptoms in patients with CRI. The results of the meta-analysis of the other 4 items using sleep disorder logs as efficacy analysis data were as follow, relative risk RR = 0.47, 95%CI = [0.33, 0.66], P < 0.0001. The difference was statistically significant, indicating that acupuncture can improve the symptoms of CRI patients compared to control group.ConclusionAcupuncture can improve the symptoms of patients with CRI to some extent, but due to the relatively small number and low quality of the included literature in this study, more high-quality clinical trials are needed as supplement the evidences in future.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/.

Published
2022
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10. Triple-Negative Breast Cancer with Dermatomyositis: A Case Report and Literature Review

Author

Chen,Xiao, Chen,Aoxiang, Liu,Chaoqi, and Zhang,Bin

Subjects
Cancer Management and Research, skin and connective tissue diseases
Abstract

Xiao Chen, Aoxiang Chen, Chaoqi Liu, Bin Zhang The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of ChinaCorrespondence: Bin Zhang, The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin, 300060, People’s Republic of China, Email eeflying@163.comPurpose: Dermatomyositis (DM) is an autoimmune inflammatory myopathy, the onset of which is sometimes associated with some malignancies and sometimes appears as a symptom of paraneoplastic syndrome. The main symptoms include progressive proximal muscle weakness, extra muscular manifestations such as dyspnea or dysphagia, and skin changes. There is currently no standardized treatment for breast cancer associated with DM.Patients and Methods: We report a 45-year-old woman with a palpable mass over the left external breast along with diffuse erythema on the shoulder, orbital edema, voice hoarseness, dyspnea, and weakness of the extremities. Needle aspiration biopsy and imaging suggested malignancy. Thus, breast-conserving surgery and pectoral myotomy biopsy+ skin excision biopsy were performed. Pathology confirmed triple-negative breast cancer (TNBC) and DM. Two days after surgery, the patient’s orbital edema, voice hoarseness, dyspnea, and weakness of the extremities were significantly reduced, and the erythema subsided significantly. Left axillary lymph node dissection was performed after postoperative adjuvant chemotherapy, and the nodes were negative. The patient was recovering well, and follow-up showed no signs of recurrence or metastasis.Conclusion: Be alert for the presence of malignancy when a breast cancer patient presents with DM, a test for dermatologists, rheumatologists, and oncologists. This case demonstrated the effectiveness of breast-conserving surgery combined with radiotherapy for early-stage triple-negative breast cancer with DM, even without further treatment for DM to reduce the symptoms. In conclusion, the treatment plan for these patients depends on the presentation of the tumor and DM.Keywords: dermatomyositis, triple-negative breast cancer, paraneoplastic syndrome, breast-conserving surgery, case report

Published
2022

12. [Investigation on cognition for insomnia and preference for acupuncture in breast cancer survivors: a in-depth interview study].

Author

Ba D, Guo Y, Chen B, Zhai J, Lv X, Wang B, Chen A, Fu L, Chen Z, and Guo Y

Subjects
Humans, Female, Middle Aged, Adult, Aged, Sleep, Patient Preference, Sleep Initiation and Maintenance Disorders therapy, Sleep Initiation and Maintenance Disorders etiology, Sleep Initiation and Maintenance Disorders psychology, Acupuncture Therapy, Breast Neoplasms therapy, Breast Neoplasms complications, Breast Neoplasms psychology, Cancer Survivors psychology, Cognition
Abstract

Objective: To understand the cognition for insomnia and preference for acupuncture in breast cancer survivors based on the in-depth interview., Methods: Thirty breast cancer survivors with insomnia symptoms were collected for in-depth interview. The interview questions included three aspects, i.e. sleep expectation, cognition for insomnia (discomfort caused by insomnia, and underlying inducing factors of insomnia) and the preference for acupuncture (treatment methods used in the past, the reasons for not choosing acupuncture, and the tendency of acupuncture treatment). Using Colaizzi content analysis method, the data was analyzed., Results: Regarding sleep expectation, most breast cancer survivors with insomnia symptoms were able to maintain normal activity in daytime. Insomnia symptoms often led to fatigue, and the inducing factors of insomnia referred to the treatment with endocrine therapy, anticipatory anxiety and inadequate sleep hygiene. All of the patients had received pharmacotherapy. The use proportion of non-pharmacological therapies was relatively low, and acupuncture was not chosen due to "not familiar with" and "fear of pain". Concerning to the preference for acupuncture, patients preferred the therapeutic methods of acupuncture with mild pain sensation and gentle stimulation; and the treatment should be more acceptable if delivered 2 or 3 times a week., Conclusion: Breast cancer survivors have the expectations for sleep, and are willing to receive the treatment with medication for their sleep disorders. Because of lack of the knowledge for acupuncture effect on insomnia and fear of strong needling sensation, a part of patients are unwilling to be treated with acupuncture therapy, but they are expected to receive the treatment with acupuncture while feeling more comfortable.

Published
2024
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