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BackgroundMethodologyResultsConclusions\nPlain Language SummaryOncological systemic treatments such as cytotoxic chemotherapy, radiation therapy or treatment with biological response modifiers can alter the quality of life (QoL) of cancer patients.The aim of this study is to assess the effects of cardiologic magnetic and optical stimulation (CMOS) on QoL in patients with advanced cancer receiving systemic treatment. For this purpose, we designed a non-invasive device that can reproduce and dynamically modulate stimulations of the same nature as the biological electromagnetic emissions specific to the body (cardiac). These crafted emissions were sent back to the body in perfect synchronization with the Electrocardiogram (ECG) in order to foster resonance mechanisms.In the phase pilot EPHEME, the experimental group received sessions of exposure to CMOS and control group without exposure to CMOS.This study was conducted on hospitalized patients suffering from anxiety and depression. The improvement of the global Hospital Anxiety and Depression (HAD) score being the primary end-point, was completed before and after 3 sessions of CMOS treatment over a period of 10 days. The secondary objective is to evaluate the quality of life, by using the EQ-5D questionnaire which covers mobility, autonomy, usual activities, pain/discomfort, and anxiety/depression. Additionally, patient satisfaction was measured for the two groups.The patient outcomes in the experimental group treated with CMOS demonstrated notable improvements. The variation in the Hospital Anxiety and Depression (HAD) scores before and after treatment showed a significant decrease (p < 0.001). Similarly, the quality of life, as measured by the EQ-5D questionnaire, exhibited significant enhancement (p = 0.004). Conversely, in the control group, no significant improvement in either anxiety and depression symptoms or quality of life. Throughout the study, sessions were well tolerated, and there were no reports of serious side effects in either group.The cardiologic magnetic and optical emissions provided by the CMOS device subjectively improved the quality of life in cancer patients receiving systemic treatment compared to those receiving sham stimulation. A prospective randomized study using a larger patient sample could bring more robust results. More research is needed to understand potential positives effects of low frequencies/heart-like electromagnetic waves in treatment of cancer-related fatigue.Cancer treatments, such as chemotherapy and radiotherapy, can significantly impact patients’ quality of life. In response to this challenge, our study explored the efficacy of a non-invasive device, the Cardiologic Magnetic and Optical Stimulation (CMOS), designed to enhance the well-being of cancer patients undergoing systemic treatments. The CMOS device emits electromagnetic and optical signals that emulate the body’s natural signals, aiming to synchronize with the heart’s electrical activity to improve patients’ quality of life. In this pilot study, we enrolled 37 hospitalized cancer patients who were assigned to either the experimental group, receiving active CMOS sessions, or the control group, where the device was switched off. Our focus was primarily on patients experiencing anxiety and depression, with the primary objective to evaluate whether CMOS could alleviate these conditions and enhance overall quality of life. The findings revealed that patients in the experimental group reported significant reductions in anxiety and depression, alongside improvements in quality of life metrics, compared to the control group. The CMOS treatment was well-tolerated by participants, with no serious adverse effects reported, indicating its safety. These preliminary results suggest that CMOS has the potential to ameliorate the psychological burdens faced by cancer patients during treatment. Nevertheless, further research involving a larger study is essential to validate these findings comprehensively. Future studies should also investigate the potential of CMOS’s low-frequency electromagnetic waves in mitigating cancer-related fatigue. Overall, this study provides promising insights into improving cancer patients’ well-being throughout their treatment journey. [ABSTRACT FROM AUTHOR]

The research article addresses, a novel natural cellulosic fiber namely Doum Palm Leaf Stalk Fibers (DPLSF) were extracted from Doum palm tree (Chamaerops humilis L.) are rich in cellulose, relatively inexpensive, and readily available in Algeria. The characteristic analysis on morphological, physiochemical, thermal and mechanical proprieties of the extracted raw and treated DPLSF with 20% sodium bicarbonate at various times of treatment were exanimated by optical microscope and scanning electron microscopy (SEM), X-ray diffraction method (XRD), Fourier transform infrared (FTIR) spectroscopy, thermos gravimetric analysis (TGA/DTG), differential scanning calorimetry (DSC). The SEM micrographs of the longitudinal topographic surface of the DPLSF after chemical treatment with sodium bicarbonate at various times treatment indicated that the removed the waxy layer and impurities from surface and formed a roughened surface. XRD analysis further confirmed the treatment's positive effect on the fibers, with the crystallinity index increasing from 71.43% to 81.03%. However, FTIR analysis showed minimal changes in the peak position and intensity of transmittance. The TGA/DTG results revealed a significant mass loss in treated DPLSF, while thermal stability improved from 290°C to 330°C. Additionally, we analyzed the mechanical tensile properties of the treated fibers and observed that fibers treated at 20% NaHCO3 for 24 h exhibited the highest Young's modulus 8.63 GPa. To validate the experimental findings, we compared individual DPLSF results to a numerical simulation using ABAQUS code. This study underscores the potential of DPLSF as a sustainable and eco-friendly alternative to synthetic fibers, offering immense promise for diverse applications. [ABSTRACT FROM AUTHOR]