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170 results on '"Chefer, Svetlana"'

1. Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Author

Justinova, Zuzana, Panlilio, Leigh V, Moreno-Sanz, Guillermo, Redhi, Godfrey H, Auber, Alessia, Secci, Maria E, Mascia, Paola, Bandiera, Tiziano, Armirotti, Andrea, Bertorelli, Rosalia, Chefer, Svetlana I, Barnes, Chanel, Yasar, Sevil, Piomelli, Daniele, and Goldberg, Steven R

Subjects
Behavioral and Social Science, Neurosciences, Brain Disorders, Prevention, Drug Abuse (NIDA only), Tobacco Smoke and Health, Tobacco, Substance Misuse, Basic Behavioral and Social Science, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Benzamides, Biphenyl Compounds, Brain, Carbamates, Cues, Dopamine, Dose-Response Relationship, Drug, Drug-Seeking Behavior, Extinction, Psychological, Male, Mixed Function Oxygenases, Models, Animal, Nicotine, Nicotinic Agonists, Rats, Rats, Sprague-Dawley, Recurrence, Reward, Saimiri, Self Administration, Time Factors, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Inhibition of the enzyme fatty acid amide hydrolase (FAAH) counteracts reward-related effects of nicotine in rats, but it has not been tested for this purpose in non-human primates. Therefore, we studied the effects of the first- and second-generation O-arylcarbamate-based FAAH inhibitors, URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) and URB694 (6-hydroxy-[1,1'-biphenyl]-3-yl-cyclohexylcarbamate), in squirrel monkeys. Both FAAH inhibitors: (1) blocked FAAH activity in brain and liver, increasing levels of endogenous ligands for cannabinoid and α-type peroxisome proliferator-activated (PPAR-α) receptors; (2) shifted nicotine self-administration dose-response functions in a manner consistent with reduced nicotine reward; (3) blocked reinstatement of nicotine seeking induced by reexposure to either nicotine priming or nicotine-associated cues; and (4) had no effect on cocaine or food self-administration. The effects of FAAH inhibition on nicotine self-administration and nicotine priming-induced reinstatement were reversed by the PPAR-α antagonist, MK886. Unlike URB597, which was not self-administered by monkeys in an earlier study, URB694 was self-administered at a moderate rate. URB694 self-administration was blocked by pretreatment with an antagonist for either PPAR-α (MK886) or cannabinoid CB1 receptors (rimonabant). In additional experiments in rats, URB694 was devoid of THC-like or nicotine-like interoceptive effects under drug-discrimination procedures, and neither of the FAAH inhibitors induced dopamine release in the nucleus accumbens shell--consistent with their lack of robust reinforcing effects in monkeys. Overall, both URB597 and URB694 show promise for the initialization and maintenance of smoking cessation because of their ability to block the rewarding effects of nicotine and prevent nicotine priming-induced and cue-induced reinstatement.

Published
2015

2. Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates

Author

Justinova, Zuzana, Mangieri, Regina A, Bortolato, Marco, Chefer, Svetlana I, Mukhin, Alexey G, Clapper, Jason R, King, Alvin R, Redhi, Godfrey H, Yasar, Sevil, Piomelli, Daniele, and Goldberg, Steven R

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Substance Misuse, Basic Behavioral and Social Science, Neurosciences, Drug Abuse (NIDA only), Behavioral and Social Science, Cannabinoid Research, Good Health and Well Being, Amidohydrolases, Analysis of Variance, Animals, Arachidonic Acids, Behavior, Animal, Benzamides, Brain, Cannabinoid Receptor Modulators, Carbamates, Chromatography, Liquid, Cocaine, Dose-Response Relationship, Drug, Dronabinol, Endocannabinoids, Male, Polyunsaturated Alkamides, Rats, Rats, Wistar, Reinforcement Schedule, Reinforcement, Psychology, Saimiri, Self Administration, Anandamide, FAAH, reinstatement, self-administration, URB597, 2-arachidonoylglycerol, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundCB(1) cannabinoid receptors in the brain are known to participate in the regulation of reward-based behaviors. However, the contribution of each of the endocannabinoid transmitters, anandamide and 2-arachidonoylglycerol (2-AG), to these behaviors remains undefined. To address this question, we assessed the effects of URB597, a selective anandamide deactivation inhibitor, as a reinforcer of drug-seeking and drug-taking behavior in squirrel monkeys.MethodsWe investigated the reinforcing effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597 in monkeys trained to intravenously self-administer Delta(9)-tetrahydrocannabinol (THC), anandamide, or cocaine and quantified brain endocannabinoid levels using liquid chromatography/mass spectrometry. We measured brain FAAH activity using an ex vivo enzyme assay.ResultsURB597 (.3 mg/kg, intravenous) blocked FAAH activity and increased anandamide levels throughout the monkey brain. This effect was accompanied by a marked compensatory decrease in 2-AG levels. Monkeys did not self-administer URB597, and the drug did not promote reinstatement of extinguished drug-seeking behavior previously maintained by THC, anandamide, or cocaine. Pretreatment with URB597 did not modify self-administration of THC or cocaine, even though, as expected, it significantly potentiated anandamide self-administration.ConclusionsIn the monkey brain, the FAAH inhibitor URB597 increases anandamide levels while causing a compensatory down-regulation in 2-AG levels. These effects are accompanied by a striking lack of reinforcing properties, which distinguishes URB597 from direct-acting cannabinoid agonists such as THC. Our results reveal an unexpected functional heterogeneity within the endocannabinoid signaling system and suggest that FAAH inhibitors might be used therapeutically without risk of abuse or triggering of relapse to drug abuse.

Published
2008

13. Early-life stress induces long-term morphologic changes in primate brain

Author

Spinelli, Simona, Chefer, Svetlana, Suomi, Stephen J., Higley, J. Dee, Barr, Christina S., and Stein, Elliot

Subjects
Acute stress disorder -- Development and progression, Acute stress disorder -- Risk factors, Acute stress disorder -- Research, Primates -- Physiological aspects, Primates -- Research, Brain -- Physiological aspects, Brain -- Demographic aspects, Brain -- Research, Health, Psychology and mental health
Published
2009

15. Cigarette smoking saturates brain (alpha sub 4 beta sub 2) nicotinic acetylcholine receptors

Author

Brody, Arthur L., Mandelkern, Mark A., London, Edythe D., Olmstead, Richard E., Farahi, Judah, Scheibal, David, Jou, Jennifer, Allen, Valerie, Tiongson, Emmanuelle, Chefer, Svetlana I., Koren, Andrei O., and Mukhin, Alexey G.

Subjects
Smoking -- Physiological aspects, Smoking -- Research, Nicotinic receptors -- Physiological aspects, Nicotinic receptors -- Research, Health, Psychology and mental health
Published
2006

16. Reviewers for Volume 2

Author

Adams, Robert J., primary, Anderson, David M., additional, Baker, Stuart, additional, Banks, Matthew L., additional, Baze, Wallace B., additional, Carlson, Cathy S., additional, Chefer, Svetlana, additional, Christe, Kari L., additional, Cline, J. Mark, additional, Colman, Ricki, additional, Comuzzie, Tony, additional, DiCarlo, Cheryl D., additional, Doane, Cynthia J., additional, Eberle, Richard, additional, Elmore, David B., additional, Everitt, Jeffrey, additional, Fahey, Michele A., additional, Ford, Elizabeth W., additional, Fox, James G., additional, Galland, G. Gale, additional, Gee, Melaney K., additional, Gozalo, Alfonso S., additional, Halliday, Lisa C., additional, Hasselschwert, Dana L., additional, Huerkamp, Michael J., additional, Kessler, Matthew J., additional, Langermans, Jans, additional, Lee-Parritz, David E., additional, Mankowski, Joseph L., additional, Marini, Robert P., additional, Martinot, Amanda, additional, McArthur, Mark J., additional, Miller, Andrew, additional, Morenko, Brandy, additional, Negus, S. Stevens, additional, Nolan, Thomas E., additional, Sasseville, Vito, additional, Swearengen, James R., additional, Trichel, Anita M., additional, and Weiss, Deborah E., additional

Published
2012
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25. Contributors

Author

Abi-Dargham, Anissa, primary, Abrunhosa, A.J., additional, Aigner, T.G., additional, Alpert, Nathaniel M., additional, Andermann, Mark, additional, Anderson, J.R., additional, Andersson, Jesper L. R,, additional, Andreason, Paul, additional, Antonini, A., additional, Arai, Hiroyuki, additional, Ardekani, B.A., additional, Ashburner, John, additional, Ashworth, S., additional, Bailey, D.L., additional, Bánáti, Richard B., additional, Baron, J.C., additional, Barrio, Jorge R., additional, Bauer, R., additional, Beattie, Bradley J., additional, Bergmann, R., additional, Berman, Karen Faith, additional, Berzdorf, A., additional, Besret, L., additional, Blasberg, Ronald G., additional, Bloomfìeld, P.M., additional, Bonab, Ali A., additional, Bowery, A., additional, Brady, F., additional, Brooks, David J., additional, Brühlmeier, M., additional, Brust, P., additional, Budinger, T.F., additional, Byrne, Helen, additional, Carson, Richard E., additional, Chan, G.L. Y., additional, Chatziioannou, Arion, additional, Chefer, Svetlana I., additional, Chen, Chin-Tu, additional, Cherry, Simon R., additional, Cheung, K., additional, Chugani, Diane C., additional, Chugani, Harry T., additional, Cooper, Malcolm, additional, Cunningham, Vincent J., additional, Dagher, Alain, additional, Dahlbom, M., additional, Danielsen, E.H., additional, DaSilva, J.N., additional, Davis, James, additional, de Lima, J.J., additional, DeJesus, O.T., additional, Derenzo, S.E., additional, Dhawan, V., additional, Dogan, A.S., additional, Doudet, D.J., additional, Drevets, W., additional, Duncan, John, additional, Eidelberg, D., additional, Ellmore, Timothy M., additional, Endres, Christopher J., additional, English, C., additional, Esposito, Giuseppe, additional, Evans, Alan C., additional, Farahani, K., additional, Feng, Dagan, additional, Ficaro, Edward P., additional, Fischer, N., additional, Fischman, Alan J., additional, Fiset, Pierre, additional, Frey, Kirk A., additional, Friston, K.J., additional, Füchtner, F., additional, Fukushi, K., additional, Gee, A.D., additional, Ghaemi, M., additional, Ghez, C., additional, Ghilardi, M.F., additional, Gillispie, Steven B., additional, Gjedde, Albert, additional, Graf, R., additional, Grafton, Scott T., additional, Graham, Michael M., additional, Grasby, Paul M., additional, Greenwald, E., additional, Gunn, Roger N., additional, Günther, I., additional, Hansen, L.K., additional, Hansen, Søren B., additional, Heiss, W.-D., additional, Herholz, K., additional, Higuchi, Makoto, additional, Hirani, E., additional, Ho, D., additional, Hoffman, John M., additional, Holden, J.E., additional, Holt, Daniel, additional, Holt, John L., additional, Hommer, Daniel W., additional, Horwitz, Barry, additional, Houle, Sylvain, additional, Huang, Sung-Cheng, additional, Huang, Yiyun, additional, Huesman, R.H., additional, Hume, S.P., additional, Hussey, D., additional, Ibazizene, M., additional, Ido, Tatsuo, additional, Ilmberger, J., additional, Inaba, T., additional, Innis, Robert B., additional, Irie, T., additional, Ishii, Kenji, additional, Ito, K., additional, Itoh, Masatoshi, additional, Iyo, M., additional, Jivan, S., additional, Johannsen, B., additional, Johannsen, Peter, additional, Jones, Terry, additional, Kanno, Iwao, additional, Kapur, S., additional, Kawashima, Ryuta, additional, Kazumata, K., additional, Kilbourn, Michael R., additional, Klein, Denise, additional, Klein, G.J., additional, Koepp, Matthias, additional, Koeppe, Robert A., additional, Kuhl, David E., additional, Kumura, E., additional, Künig, G., additional, Labbé, Claire, additional, Lammertsma, Adriaan A., additional, Landeau, B., additional, Lange, N., additional, Larson, Steve M., additional, Laruelle, Marc, additional, Lau, K.K., additional, Law, I., additional, Leenders, K.L., additional, Lin, K.P., additional, Litt, Harold, additional, Livieratos, L., additional, Lockwood, Geoff, additional, London, Edythe D., additional, Lopresti, Brian, additional, Löttgen, J., additional, Luthra, S.K., additional, Ma, Yilong, additional, MacLeod, A.M., additional, Marenco, S., additional, Marrett, S., additional, Mason, N. Scott, additional, Mathis, Chester A., additional, Matthews, Julian C., additional, Mawlawi, Osama R., additional, Meadors, Ken, additional, Meikle, S.R., additional, Meyer, Ernst, additional, Miller, David H., additional, Miller, M.P., additional, Minoshima, Satoshi, additional, Missimer, J., additional, Moeller, J.R., additional, Moore, A.H., additional, Moran, L., additional, Moreno-Cantú, Jorge J., additional, Morris, Evan D., additional, Morris, H., additional, Morrish, P.K., additional, Morrison, K.S., additional, Moses, W.W., additional, Muzi, Mark, additional, Muzik, Otto, additional, Myers, Ralph, additional, Nagatsuka, S., additional, Namba, H., additional, Nguyen, Thinh B., additional, O'Sullivan, Finbarr, additional, Oakes, T.R., additional, Oda, Keiichi, additional, Ohta, K., additional, Okamura, Nobuyuki, additional, Opacka-Juffry, J., additional, Osman, S., additional, Østergaard, Leif, additional, Paulesu, Eraldo, additional, Paulson, O.B., additional, Paus, T., additional, Pawlik, G., additional, Perevuznik, Jennifer, additional, Petit-Taboué, M.C., additional, Phelps, Michael E., additional, Pietrzyk, U., additional, Price, Julie C., additional, Price, Pat M., additional, Psylla, M., additional, Raffel, D.M., additional, Rakshi, J.S., additional, Raleigh, Michael J., additional, Rawlings, Robert R., additional, Rehm, K., additional, Reulen, H. -J., additional, Reutens, David C., additional, Reutter, B.W., additional, Richardson, Mark, additional, Rio, Daniel, additional, Rottenberg, D.A., additional, Rousset, Olivier G., additional, Ruszkiewicz, James, additional, Ruth, T.J., additional, Ruttimann, Urs E., additional, Sadato, Norihiro, additional, Sasaki, Hidetada, additional, Schaper, K.A., additional, Schumann, P., additional, Schuster, A., additional, Senda, Michio, additional, Shao, Yiping, additional, Shen, Chenggang, additional, Shinotoh, H., additional, Silverman, Robert W., additional, Simpson, N.R., additional, Siu, Wan-Chi, additional, Slates, R., additional, Smith, D.F., additional, Smith, Gwenn S., additional, Snyder, Scott E., additional, Sobesky, J., additional, Søiling, Thomas, additional, Sossi, V., additional, Spinks, Terry J., additional, Steinbach, J., additional, Stout, David B., additional, Strother, S.C., additional, Sudo, Y., additional, Sugita, M., additional, Suhara, T., additional, Suzuki, K., additional, Tatsumi, Itaru, additional, Teng, X., additional, Thiel, A., additional, Thompson, Christopher J., additional, Thorpe, John, additional, Toussaint, P.-J., additional, Toyama, Hinako, additional, Uema, T., additional, Vafaee, M.S., additional, Van Horn, John Darrell, additional, Venkatachalam, T.K., additional, Virador, P.R.G., additional, von Stockhausen, H.-M., additional, Vontobel, P., additional, Vorwieger, G., additional, Votaw, John R., additional, Walter, B., additional, Wienhard, K., additional, Wilson, A.A., additional, Wong, Dean F., additional, Wong, Koon-Pong, additional, Wu, Chi-Ming, additional, Wu, L.C., additional, Yamaki, Atsushi, additional, Yanai, Kazuhiko, additional, Yang, J., additional, Yap, Jeffrey T., additional, Yokoi, Fuji, additional, Young, A.R., additional, Yu, C.L., additional, and Zatorre, Robert J., additional

Published
1998
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29. The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis

Author

Chefer, Svetlana, primary, Seidel, Jurgen, additional, Cockrell, Adam S., additional, Yount, Boyd, additional, Solomon, Jeffrey, additional, Hagen, Katie R., additional, Liu, David X., additional, Huzella, Louis M., additional, Kumar, Mia R., additional, Postnikova, Elena, additional, Bohannon, J. Kyle, additional, Lackemeyer, Matthew G., additional, Cooper, Kurt, additional, Endlich-Frazier, Ariel, additional, Sharma, Heema, additional, Thomasson, David, additional, Bartos, Christopher, additional, Sayre, Philip J., additional, Sims, Amy, additional, Dyall, Julie, additional, Holbrook, Michael R., additional, Jahrling, Peter B., additional, Baric, Ralph S., additional, and Johnson, Reed F., additional

Published
2018
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31. [18F]-Fluorodeoxyglucose Uptake in Lymphoid Tissue Serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Virus Infection

Author

Dyall, Julie, primary, Johnson, Reed F., additional, Chefer, Svetlana, additional, Leyson, Christopher, additional, Thomasson, David, additional, Seidel, Jurgen, additional, Ragland, Dan R., additional, Byrum, Russell, additional, Jett, Catherine, additional, Cann, Jennifer A., additional, St. Claire, Marisa, additional, Jagoda, Elaine, additional, Reba, Richard C., additional, Hammoud, Dima, additional, Blaney, Joseph E., additional, and Jahrling, Peter B., additional

Published
2017
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32. Additional file 3: Figure S1. of Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Author

Chefer, Svetlana, Thomasson, David, Seidel, Jurgen, Reba, Richard, J. Bohannon, Lackemeyer, Mathew, Bartos, Chris, Sayre, Philip, Bollinger, Laura, Hensley, Lisa, Jahrling, Peter, and Johnson, Reed

Subjects
respiratory system
Abstract

Changes in [18F]-FDG uptake and monocytes fraction in the blood after MERS-CoV aerosol challenge. (a) SUVs in mediastinal LNs (y-axis on the left) and monocyte fraction in the blood (y-axis on the right) at different days prior to and after MERS-CoV exposure. Each column represents mean ± SD (n = 4). (b) SUVs in bone marrow and axillary LNs on different days prior to and after MERS-CoV exposure. Post hoc analysis by Bonferroni’s multiple comparison test specified a statistically significant increase in SUV in mediastinal LNs up to days +14 or +15 post-exposure compared with the SUVs prior to virus challenge (adjusted p = 0.0006 on day +3 or +4, p

Published
2015
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43. Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge.

Author

Chefer, Svetlana, Thomasson, David, Seidel, Jurgen, Reba, Richard C., Bohannon, J. Kyle, Lackemeyer, Mathew G., Bartos, Chris, Sayre, Philip J., Bollinger, Laura, Hensley, Lisa E., Jahrling, Peter B., and Johnson, Reed F.

Abstract

Background: The pathogenesis and immune response to Middle East respiratory syndrome (MERS) caused by a recently discovered coronavirus, MERS-CoV, have not been fully characterized because a suitable animal model is currently not available. 18F-Fluorodeoxyglucose ([18F]-FDG)-positron emission tomography/computed tomography (PET/CT) as a longitudinal noninvasive approach can be beneficial in providing biomarkers for host immune response. [18F]-FDG uptake is increased in activated immune cells in response to virus entry and can be localized by PET imaging. We used [18F]-FDG-PET/CT to investigate the host response developing in nonhuman primates after MERS-CoV exposure and applied kinetic modeling to monitor the influx rate constant (Ki) in responsive lymphoid tissue. Methods: Multiple [18F]-FDG-PET and CT images were acquired on a PET/CT clinical scanner modified to operate in a biosafety level 4 environment prior to and up to 29 days after MERS-CoV aerosol exposure. Time activity curves of various lymphoid tissues were reconstructed to follow the [18F]-FDG uptake for approximately 60 min (3,600 s). Image-derived input function was used to calculate Ki for lymphoid tissues by Patlak plot. Results: Two-way repeated measures analysis of variance revealed alterations in Ki that was associated with the time point (p < 0.001) after virus exposure and the location of lymphoid tissue (p = 0.0004). As revealed by a statistically significant interaction (p < 0.0001) between these two factors, the pattern of Ki changes over time differed between three locations but not between subjects. A distinguished pattern of statistically significant elevation in Ki was observed in mediastinal lymph nodes (LNs) that correlated to Ki changes in axillary LNs. Changes in LNs Ki were concurrent with elevations of monocytes in peripheral blood. Conclusions: [18F]-FDG-PET is able to detect subtle changes in host immune response to contain a subclinical virus infection. Full quantitative analysis is the preferred approach rather than semiquantitative analysis using standardized uptake value for detection of the immune response to the virus. [ABSTRACT FROM AUTHOR]

Published
2015
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44. Modeling [F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge.

Author

Chefer, Svetlana, Thomasson, David, Seidel, Jurgen, Reba, Richard, Bohannon, J., Lackemeyer, Mathew, Bartos, Chris, Sayre, Philip, Bollinger, Laura, Hensley, Lisa, Jahrling, Peter, and Johnson, Reed

Abstract

Background: The pathogenesis and immune response to Middle East respiratory syndrome (MERS) caused by a recently discovered coronavirus, MERS-CoV, have not been fully characterized because a suitable animal model is currently not available. F-Fluorodeoxyglucose ([F]-FDG)-positron emission tomography/computed tomography (PET/CT) as a longitudinal noninvasive approach can be beneficial in providing biomarkers for host immune response. [F]-FDG uptake is increased in activated immune cells in response to virus entry and can be localized by PET imaging. We used [F]-FDG-PET/CT to investigate the host response developing in nonhuman primates after MERS-CoV exposure and applied kinetic modeling to monitor the influx rate constant ( K) in responsive lymphoid tissue . Methods: Multiple [F]-FDG-PET and CT images were acquired on a PET/CT clinical scanner modified to operate in a biosafety level 4 environment prior to and up to 29 days after MERS-CoV aerosol exposure. Time activity curves of various lymphoid tissues were reconstructed to follow the [F]-FDG uptake for approximately 60 min (3,600 s). Image-derived input function was used to calculate K for lymphoid tissues by Patlak plot. Results: Two-way repeated measures analysis of variance revealed alterations in K that was associated with the time point ( p < 0.001) after virus exposure and the location of lymphoid tissue ( p = 0.0004). As revealed by a statistically significant interaction ( p < 0.0001) between these two factors, the pattern of K changes over time differed between three locations but not between subjects. A distinguished pattern of statistically significant elevation in K was observed in mediastinal lymph nodes (LNs) that correlated to K changes in axillary LNs. Changes in LNs K were concurrent with elevations of monocytes in peripheral blood. Conclusions: [F]-FDG-PET is able to detect subtle changes in host immune response to contain a subclinical virus infection. Full quantitative analysis is the preferred approach rather than semiquantitative analysis using standardized uptake value for detection of the immune response to the virus. [ABSTRACT FROM AUTHOR]

Published
2015
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45. Aging and Caloric Restriction in Nonhuman Primates

Author

Ingram, Donald K., primary, Chefer, Svetlana, additional, Matochik, John, additional, Moscrip, Tammy D., additional, Weed, James, additional, Roth, George S., additional, Londonb, Edythe D., additional, and Lane, Mark A., additional

Published
2006
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47. Pharmacological and Toxicological Evaluation of 2-Fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a Ligand for Imaging Cerebral Nicotinic Acetylcholine Receptors with Positron Emission Tomography

Author

Vaupel, D. Bruce, primary, Tella, Srihari R., additional, Huso, David L., additional, Wagner, Valentine O., additional, Mukhin, Alexey G., additional, Chefer, Svetlana I., additional, Horti, Andrew G., additional, London, Edythe D., additional, Koren, Andrei O., additional, and Kimes, Alane S., additional

Published
2004
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48. 5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography

Author

Zhang, Yi, primary, Pavlova, Olga A., additional, Chefer, Svetlana I., additional, Hall, Andrew W., additional, Kurian, Varughese, additional, Brown, LaVerne L., additional, Kimes, Alane S., additional, Mukhin, Alexey G., additional, and Horti, Andrew G., additional

Published
2004
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49. 2 [ 18 F]F‐A85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans

Author

Kimes, Alane S., primary, Horti, Andrew G., additional, London, Edythe D., additional, Chefer, Svetlana I., additional, Contoreggi, Carlo, additional, Ernst, Monique, additional, Friello, Phyllis, additional, Koren, Andrei O., additional, Kurian, Varughese, additional, Matochik, John A., additional, Pavlova, Olga, additional, Bruce Vaupel, D., additional, and Mukhin, Alexey G., additional

Published
2003
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