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5. A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML.

Author

Sahib, Noor Rashidha Binte Meera, Mohamed, Jameelah Sheik, Rashid, Masturah Bte Mohd Abdul, Jayalakshmi, Lin, Yihao Clement, Chee, Yen Lin, Fan, Bingwen Eugene, De Mel, Sanjay, Ooi, Melissa Gaik Ming, Jen, Wei‐Ying, and Chow, Edward Kai‐Hua

Subjects
ACUTE myeloid leukemia, INDIVIDUALIZED medicine, TURNAROUND time, DRUG resistance, DRUG use testing
Abstract

Background: Despite advances made in targeted biomarker‐based therapy for acute myeloid leukemia (AML) treatment, remission is often short and followed by relapse and acquired resistance. Functional precision medicine (FPM) efforts have been shown to improve therapy selection guidance by incorporating comprehensive biological data to tailor individual treatment. However, effectively managing complex biological data, while also ensuring rapid conversion of actionable insights into clinical utility remains challenging. Methods: We have evaluated the clinical applicability of quadratic phenotypic optimization platform (QPOP), to predict clinical response to combination therapies in AML and reveal patient‐centric insights into combination therapy sensitivities. In this prospective study, 51 primary samples from newly diagnosed (ND) or refractory/relapsed (R/R) AML patients were evaluated by QPOP following ex vivo drug testing. Results: Individualized drug sensitivity reports were generated in 55/63 (87.3%) patient samples with a median turnaround time of 5 (4–10) days from sample collection to report generation. To evaluate clinical feasibility, QPOP‐predicted response was compared to clinical treatment outcomes and indicated concordant results with 83.3% sensitivity and 90.9% specificity and an overall 86.2% accuracy. Serial QPOP analysis in a FLT3‐mutant patient sample indicated decreased FLT3 inhibitor (FLT3i) sensitivity, which is concordant with increasing FLT3 allelic burden and drug resistance development. Forkhead box M1 (FOXM1)—AKT signaling was subsequently identified to contribute to resistance to FLT3i. Conclusion: Overall, this study demonstrates the feasibility of applying QPOP as a functional combinatorial precision medicine platform to predict therapeutic sensitivities in AML and provides the basis for prospective clinical trials evaluating ex vivo‐guided combination therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Abstract P21: Single Cell Resolution Spatial Modeling Uncovers Survival-associated Phenotypes in Diffuse Large B Cell Lymphoma

Author

Sridhar, Shruti, primary, Hoppe, Michal Marek, additional, Liu, Min, additional, Jaynes, Patrick, additional, Peng, Yanfen, additional, De Mel, Sanjay, additional, Poon, Limei, additional, Chan, Esther Hian Li, additional, Lee, Joanne, additional, Nagarajan, Chandramouli, additional, Grigoropoulos, Nicholas F., additional, Tan, Soo-Yong, additional, Hue, Susan Swee-Shan, additional, Li, Shaoying, additional, Khoury, Joseph D., additional, Farinha, Pedro, additional, Mottok, Anja, additional, Scott, David W., additional, Kumar, Gayatri, additional, Kannan, Kasthuri, additional, Chng, Wee Joo, additional, Chee, Yen Lin, additional, Ng, Siok-Bian, additional, Tripodo, Claudio, additional, and Jeyasekharan, Anand D., additional

Published
2024
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9. Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Author

Koh, Cho Yeow, Shih, Norrapat, Yip, Christina Y. C., Li, Aaron Wei Liang, Chen, Weiming, Amran, Fathiah S., Leong, Esther Jia En, Iyer, Janaki Krishnamoorthy, Croft, Grace, Mazlan, Muhammad Ibrahim Bin, Chee, Yen-Lin, Yap, Eng-Soo, Monroe, Dougald M., Hoffman, Maureane, Becker, Richard C., de Kleijn, Dominique P. V., Verma, Vaishali, Gupta, Amita, Chaudhary, Vijay K., Richards, A. Mark, Kini, R. Manjunatha, and Chan, Mark Y.

Published
2021
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14. Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma

Author

de Mel, Sanjay, Rashid, Masturah B. M., Zhang, Xi Yun, Goh, Jasmine, Lee, Chun Tsu, Poon, Li Mei, Chan, Esther H. L., Liu, Xin, Chng, Wee Joo, Chee, Yen Lin, Lee, Joanne, Yuen, Yi Ching, Lim, Jing Quan, Chia, Burton K. H., Laurensia, Yurike, Huang, DaChuan, Pang, Wan Lu, Cheah, Daryl Ming Zhe, Wong, Esther Kam Yin, Ong, Choon Kiat, Tang, Tiffany, Lim, Soon Thye, Ng, Siok Bian, Tan, Soo Yong, Loi, Hoi-Yin, Tan, Lip Kun, Chow, Edward K., and Jeyasekharan, Anand D.

Published
2020
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16. Data from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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17. Figure 6 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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18. Table 1 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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19. Supplementary tables from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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20. Figure 3 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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21. Supplementary appendix from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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22. Figure 4 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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23. Figure 1 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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24. Figure 5 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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25. Figure 2 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, primary, Shuangyi, Fan, primary, Peng, Yanfen, primary, Sridhar, Shruti, primary, Hoang, Phuong Mai, primary, Liu, Clementine Xin, primary, De Mel, Sanjay, primary, Poon, Limei, primary, Chan, Esther Hian Li, primary, Lee, Joanne, primary, Ong, Choon Kiat, primary, Tang, Tiffany, primary, Lim, Soon Thye, primary, Nagarajan, Chandramouli, primary, Grigoropoulos, Nicholas F., primary, Tan, Soo-Yong, primary, Hue, Susan Swee-Shan, primary, Chang, Sheng-Tsung, primary, Chuang, Shih-Sung, primary, Li, Shaoying, primary, Khoury, Joseph D., primary, Choi, Hyungwon, primary, Harris, Carl, primary, Bottos, Alessia, primary, Gay, Laura J., primary, Runge, Hendrik F.P., primary, Moutsopoulos, Ilias, primary, Mohorianu, Irina, primary, Hodson, Daniel J., primary, Farinha, Pedro, primary, Mottok, Anja, primary, Scott, David W., primary, Pitt, Jason J., primary, Chen, Jinmiao, primary, Kumar, Gayatri, primary, Kannan, Kasthuri, primary, Chng, Wee Joo, primary, Chee, Yen Lin, primary, Ng, Siok-Bian, primary, Tripodo, Claudio, primary, and Jeyasekharan, Anand D., primary

Published
2023
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26. Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Author

Hoppe, Michal Marek, primary, Jaynes, Patrick, additional, Shuangyi, Fan, additional, Peng, Yanfen, additional, Sridhar, Shruti, additional, Hoang, Phuong Mai, additional, Liu, Clementine Xin, additional, De Mel, Sanjay, additional, Poon, Limei, additional, Chan, Esther Hian Li, additional, Lee, Joanne, additional, Ong, Choon Kiat, additional, Tang, Tiffany, additional, Lim, Soon Thye, additional, Nagarajan, Chandramouli, additional, Grigoropoulos, Nicholas F., additional, Tan, Soo-Yong, additional, Hue, Susan Swee-Shan, additional, Chang, Sheng-Tsung, additional, Chuang, Shih-Sung, additional, Li, Shaoying, additional, Khoury, Joseph D., additional, Choi, Hyungwon, additional, III, Carl Harris, additional, Bottos, Alessia, additional, Gay, Laura J., additional, Runge, Hendrik F.P., additional, Moutsopoulos, Ilias, additional, Mohorianu, Irina, additional, Hodson, Daniel J., additional, Farinha, Pedro, additional, Mottok, Anja, additional, Scott, David W., additional, Pitt, Jason J., additional, Chen, Jinmiao, additional, Kumar, Gayatri, additional, Kannan, Kasthuri, additional, Chng, Wee Joo, additional, Chee, Yen Lin, additional, Ng, Siok-Bian, additional, Tripodo, Claudio, additional, and Jeyasekharan, Anand D., additional

Published
2023
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27. Spatially-Resolved Transcriptomics Define Clinically Relevant Subsets of Macrophages in Diffuse Large B-cell Lymphoma

Author

Liu, Min, primary, Bertolazzi, Giorgio, additional, Mulder, Kevin, additional, Sridhar, Shruti, additional, Lee, Rui Xue, additional, Jaynes, Patrick, additional, Hoppe, Michal Marek, additional, Fan, Shuangyi, additional, Peng, Yanfen, additional, Thng, Jocelyn, additional, Chua, Reiya, additional, De Mel, Sanjay, additional, Poon, Limei, additional, Chan, Esther, additional, Lee, Joanne, additional, Hue, Susan Swee-Shan, additional, Ng, Siok-Bian, additional, Chandy, K George, additional, Ginhoux, Florent, additional, Chee, Yen Lin, additional, Tripodo, Claudio, additional, and Jeyasekharan, Anand D., additional

Published
2023
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29. A Non-Coding Variant in LOC105371512 Confers Susceptibility to Bleomycin-Induced Lung Injury

Author

Lee, Joanne, primary, Tabatabaeian, Hossein, additional, Poon, Michelle Limei, additional, Somasundaram, Nagavalli, additional, Xin, Liu, additional, Yuen, Yi Ching, additional, Teoh, Chia Meng, additional, Yan, Benedict, additional, Chan, Esther Hian Li, additional, Chee, Yen Lin, additional, De Mel, Sanjay, additional, Zhang, Bin, additional, Chew, Xiao Hong, additional, Tang, Tiffany, additional, Khor, Chiea Chuen, additional, Ngeow, Joanne Yuen Yie, additional, Ong, Choon Kiat, additional, Lim, Soon Thye, additional, Chng, Wee Joo, additional, Tai, E Shyong, additional, Ngiam, Kee Yuan, additional, Lee, Soo Chin, additional, Goh, Boon Cher, additional, Jeyasekharan, Anand Devaprasath D., additional, Tay, Yvonne, additional, and Aminkeng, Folefac, additional

Published
2022
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31. Treatment outcomes of T and natural‐killer/T‐cell lymphoma with ifosfamide, carboplatin and etoposide chemotherapy

Author

Tay, Tricia, primary, Somasundaram, Nagavalli, additional, Lim, Cindy, additional, Khoo, Lay Poh, additional, Goh, Allan Zhi Kai, additional, Lee, Yuh Shan, additional, Liu, Xin, additional, Tao, Miriam, additional, Quek, Richard, additional, Farid, Mohamad, additional, Poon, Eileen, additional, Chan, Jason Y. S., additional, Chang, Esther W. Y., additional, Yang, Valerie S. W., additional, Goh, Yeow Tee, additional, Tan, Daryl, additional, Diong, Colin, additional, Grigoropoulos, Nicholas F., additional, Nagarajan, Chandramouli, additional, Poon, Michelle, additional, de Mel, Sanjay, additional, Jeyasekharan, Anand, additional, Chan, Esther H. L., additional, Lee, Joanne, additional, Chee, Yen Lin, additional, Lim, Soon Thye, additional, and Tang, Tiffany, additional

Published
2022
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34. Cepp in Previously Untreated Patients with Mature T Cell Lymphomas

Author

Chan, Hian Li Esther, primary, Lee, Joanne, additional, De Mel, Sanjay, additional, Jeyasekharan, Anand Devaprasath D., additional, Chee, Yen Lin, additional, Khoo, Lay Poh, additional, Chan, Yong Sheng Jason, additional, Lim, Soon Thye, additional, Poon, Michelle, additional, and Somasundaram, Nagavalli, additional

Published
2021
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35. Clinical Application of an Ex-Vivo Platform to Guide the Choice of Drug Combinations in Relapsed/Refractory Lymphoma; A Prospective Study

Author

De Mel, Sanjay, primary, Goh, Jasmine, additional, Rashid, Masturah, additional, Hoppe, Michal, additional, Zhang, Xi Yun, additional, Jaynes, Patrick, additional, Ng, Esther KY, additional, Rahmat, Nur Atiqa Diana Binte, additional, Liu, Xin, additional, Poon, Michelle, additional, Chan, Hian Li Esther, additional, Lee, Joanne, additional, Chee, Yen-Lin, additional, Koh, Liang Piu, additional, Tan, Lip Kun, additional, Soh, Teck Guan, additional, Yuen, Yi Ching, additional, Loi, Hoi Yin, additional, Ng, Siok Bian, additional, Goh, Xueying, additional, Tan, Daryl, additional, Cheah, Daryl Ming Zhe, additional, Pang, Wan Lu, additional, Huang, Dachuan, additional, Somasundaram, Nagavalli, additional, Tang, Tiffany, additional, Chan, Jason Yongsheng, additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Chng, Wee Joo, additional, Chow, Edward KH, additional, and Jeyasekharan, Anand, additional

Published
2021
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39. Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma

Author

Mustafa, Nurulhuda, primary, Nee, Adina Huey Fang, additional, Chooi, Jing Yuan, additional, Toh, Sabrina Hui Min, additional, Chung, Tae-Hoon, additional, Selvarajan, Viknesvaran, additional, Fan, Shuangyi, additional, Ng, Siok Bian, additional, Poon, Michelle, additional, Chan, Esther, additional, Lee, Joanne, additional, Chee, Yen Lin, additional, Jeyasekharan, Anand D, additional, Zhou, Longen, additional, Yang, Jennifer, additional, and Chng, Wee Joo, additional

Published
2021
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40. An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma.

Author

Goh, Jasmine, De Mel, Sanjay, Hoppe, Michal M., Mohd Abdul Rashid, Masturah Bte, Zhang, Xi Yun, Jaynes, Patrick, Ka Yan Ng, Esther, Rahmat, Nur'Atiqa Diana Binti, Jayalakshmi, Liu, Clementine Xin, Poon, Limei, Chan, Esther, Lee, Joanne, Chee, Yen Lin, Koh, Liang Piu, Tan, Lip Kun, Soh, Teck Guan, Yuen, Yi Ching, Loi, Hoi-Yin, and Ng, Siok-Bian

Subjects
NON-Hodgkin's lymphoma, COMBINATION drug therapy, B cells, DRUG efficacy, T cells, ALEMTUZUMAB
Abstract

Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), combination treatment chosen for an individual patient is empirical, and response rates remain poor in individuals with chemotherapy-resistant disease. Here, we evaluate an experimental-analytic method, quadratic phenotypic optimization platform (QPOP), for prediction of patient-specific drug combination efficacy from a limited quantity of biopsied tumor samples. In this prospective study, we enrolled 71 patients with RR-NHL (39 B cell NHL and 32 NK/T cell NHL) with a median of two prior lines of treatment, at two academic hospitals in Singapore from November 2017 to August 2021. Fresh biopsies underwent ex vivo testing using a panel of 12 drugs with known efficacy against NHL to identify effective single and combination treatments. Individualized QPOP reports were generated for 67 of 75 patient samples, with a median turnaround time of 6 days from sample collection to report generation. Doublet drug combinations containing copanlisib or romidepsin were most effective against B cell NHL and NK/T cell NHL samples, respectively. Off-label QPOP-guided therapy offered at physician discretion in the absence of standard options (n = 17) resulted in five complete responses. Among patients with more than two prior lines of therapy, the rates of progressive disease were lower with QPOP-guided treatments than with conventional chemotherapy. Overall, this study shows that the identification of patient-specific drug combinations through ex vivo analysis was achievable for RR-NHL in a clinically applicable time frame. These data provide the basis for a prospective clinical trial evaluating ex vivo–guided combination therapy in RR-NHL. Predicting possibilities with PDXs: Patients with non-Hodgkin's lymphomas (NHLs) often relapse after frontline treatment, and interpatient heterogeneity make personalized combination treatment difficult. Goh et al. have developed a hybrid experimental-analytic method that they call quadratic phenotypic optimization platform, or QPOP, to identify personalized drug combination therapies using ex vivo patient samples to improve patient outcomes. In a prospective cohort, physicians were able to alter treatment according to drug combinations identified using QPOP after 6 days to achieve complete responses in 5 of 17 patients with NHL. This is a promising step for providing new hope for patients who have relapsed NHL and provides a foundation for further clinical trials. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Development of a Novel Artificial Intelligence Tool to Measure Psoas Volumes in Patients with Diffuse Large B Cell Lymphoma

Author

Thong, Edwin Wei Sheng, Makmur, Andrew, Chee, Yen-Lin, Hallihan, James, Cheng, Lenith Tai Jit, Barr Kumarakulasinghe, Nesaretnam, Jeyasekharan, Anand Devaprasath, Lee, Joanne Shu Xian, De Mel, Sanjay, Chan, Esther Hian Li, Poon, Michelle, Chng, Wee-Joo, Jayalakshmi, Ali, Melati Dewi, Jen, Wei-Ying, and Lim, Desmond Shi Wei

Published
2023
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42. Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Author

Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Infection & Immunity, Koh, Cho Yeow, Shih, Norrapat, Yip, Christina Y.C., Li, Aaron Wei Liang, Chen, Weiming, Amran, Fathiah S., Leong, Esther Jia En, Iyer, Janaki Krishnamoorthy, Croft, Grace, Mazlan, Muhammad Ibrahim Bin, Chee, Yen Lin, Yap, Eng Soo, Monroe, Dougald M., Hoffman, Maureane, Becker, Richard C., de Kleijn, Dominique P.V., Verma, Vaishali, Gupta, Amita, Chaudhary, Vijay K., Richards, A. Mark, Kini, R. Manjunatha, Chan, Mark Y., Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Infection & Immunity, Koh, Cho Yeow, Shih, Norrapat, Yip, Christina Y.C., Li, Aaron Wei Liang, Chen, Weiming, Amran, Fathiah S., Leong, Esther Jia En, Iyer, Janaki Krishnamoorthy, Croft, Grace, Mazlan, Muhammad Ibrahim Bin, Chee, Yen Lin, Yap, Eng Soo, Monroe, Dougald M., Hoffman, Maureane, Becker, Richard C., de Kleijn, Dominique P.V., Verma, Vaishali, Gupta, Amita, Chaudhary, Vijay K., Richards, A. Mark, Kini, R. Manjunatha, and Chan, Mark Y.

Published
2021

46. Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore

Author

Tan, Chuen Wen, primary, Fan, Bingwen Eugene, additional, Teo, Winnie Z.Y., additional, Tung, Moon Ley, additional, Shafi, Humaira, additional, Christopher, Dheepa, additional, Zheng, Shuwei, additional, Peh, Wee Ming, additional, Chan, Stephrene Seok Wei, additional, Chong, Vanessa Cui Lian, additional, Gallardo, Christian Aledia, additional, Chang, Cheng Chieh Ray, additional, Ling, Li Min, additional, Tan, Jing Yuan, additional, Lee, Ken Cheah Hooi, additional, Phua, Ghee Chee, additional, Cherng, Benjamin Pei Zhi, additional, Low, Jenny Guek Hong, additional, Ho, Vui Kian, additional, Prasad, Vishnu, additional, Wong, Lester Jung Long, additional, Lim, Cheryl Xiu Qi, additional, Chee, Yen Lin, additional, Ong, Kiat Hoe, additional, Lee, Lai Heng, additional, Ng, Heng Joo, additional, and Yap, Eng Soo, additional

Published
2021
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49. Autologous Stem Cell Transplantation (ASCT) for T-Cell Non Hodgkin Lymphoma (T-NHL) Patients Who Achieve Complete Remission with First-Line Treatment: A Systematic Review and Meta-Analysis

Author

Koh, Yin Jie, primary, Girard, Louis-Pierre, additional, Chan, Hian Li Esther Hian Li, additional, Lee, Joanne Shu Xian, additional, Chee, Yen-Lin, additional, Jeyasekharan, Anand, additional, de Mel, Sanjay, additional, Soekojo, Cinnie Yentia, additional, Liu, Xin, additional, Koh, Liang Piu, additional, Poon, Michelle, additional, and Samuel, Miny, additional

Published
2020
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50. Thrombotic Complications in COVID-19 Patients: Low Incidence of Thrombotic Complications Among Critically Ill COVID-19 Patients in Singapore

Author

Lim, Cheryl XQ, primary, Tan, Chuen Wen, additional, Fan, Bingwen Eugene, additional, Teo, Winnie, additional, Tung, Moon Ley, additional, Shafi, Humaira, additional, Christopher, Dheepa, additional, Zheng, Shuwei, additional, Peh, Wee Ming, additional, Chan, Stephrene, additional, Chong, Vanessa CL, additional, Gallardo, Christian Aledia, additional, Chang, Cheng Chieh Ray, additional, Ling, Li Min, additional, Tan, Jing Yuan, additional, Lee, Ken Cheah Hooi, additional, Phua, Ghee Chee, additional, Cherng, Benjamin, additional, Low, Jenny Guek-Hong, additional, Ho, Vui Kian, additional, Prasad, Vishnu, additional, Wong, Lester Jung Long, additional, Chee, Yen-Lin, additional, Ong, Kiat Hoe, additional, Lee, Lai Heng, additional, Ng, Heng Joo, additional, and Yap, Eng Soo, additional

Published
2020
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